Endogenous retroviruses in mammals: An emerging picture of how ERVs modify expression of adjacent genes.LukeIsbel &Emma Whitelaw -2012 -Bioessays 34 (9):734-738.detailsEndogenous retrovirsuses (ERVs) have long been known to influence gene expression in plants in important ways, but what of their roles in mammals? Our relatively sparse knowledge in that area was recently increased with the finding that ERVs can influence the expression of mammalian resident genes by disrupting transcriptional termination. For many mammalian biologists, retrotransposition is considered unimportant except when it disrupts the reading frame of a gene, but this view continues to be challenged. It has been known for some (...) time that integration into an intron can create novel transcripts and integration upstream of a gene can alter the expression of the transcript, in many cases producing phenotypic consequences and disease. The new findings on transcriptional termination extend the opportunities for retrotransposons to play a role in human disease. (shrink)
The Difference We Make.Andrew T. Forcehimes &Luke Semrau -2015 -Journal of Ethics and Social Philosophy 9 (2):1-7.detailsFelix Pinkert has proposed a solution to the no-difference problem for AC. He argues that AC should be supplemented with a requirement that agents’ optimal acts be modally robust. We disagree.
IRBs and the Protection-Inclusion Dilemma: Finding a Balance.Phoebe Friesen,Luke Gelinas,Aaron Kirby,David H. Strauss &Barbara E. Bierer -2022 -American Journal of Bioethics 23 (6):75-88.detailsInstitutional review boards, tasked with facilitating ethical research, are often pulled in competing directions. In what we call the protection-inclusion dilemma, we acknowledge the tensions IRBs face in aiming to both protect potential research participants from harm and include under-represented populations in research. In this manuscript, we examine the history of protectionism that has dominated research ethics oversight in the United States, as well as two responses to such protectionism: inclusion initiatives and critiques of the term vulnerability. We look at (...) what we know about IRB decision-making in relation to protecting and including “vulnerable” groups in research and examine the lack of regulatory guidance related to this dilemma, which encourages protection over inclusion within IRB practice. Finally, we offer recommendations related to how IRBs might strike a better balance between inclusion and protection in research ethics oversight. (shrink)
Updating on the Credences of Others: Disagreement, Agreement, and Synergy.Kenny Easwaran,Luke Fenton-Glynn,Christopher Hitchcock &Joel D. Velasco -2016 -Philosophers' Imprint 16 (11):1-39.detailsWe introduce a family of rules for adjusting one's credences in response to learning the credences of others. These rules have a number of desirable features. 1. They yield the posterior credences that would result from updating by standard Bayesian conditionalization on one's peers' reported credences if one's likelihood function takes a particular simple form. 2. In the simplest form, they are symmetric among the agents in the group. 3. They map neatly onto the familiar Condorcet voting results. 4. They (...) preserve shared agreement about independence in a wide range of cases. 5. They commute with conditionalization and with multiple peer updates. Importantly, these rules have a surprising property that we call synergy - peer testimony of credences can provide mutually supporting evidence raising an individual's credence higher than any peer's initial prior report. At first, this may seem to be a strike against them. We argue, however, that synergy is actually a desirable feature and the failure of other updating rules to yield synergy is a strike against them. (shrink)
The Ordinary Concept of Happiness (and Others Like It).Jonathan Phillips,Luke Misenheimer &Joshua Knobe -2011 -Emotion Review 3 (3):929-937.detailsConsider people’s ordinary concept of belief. This concept seems to pick out a particular psychological state. Indeed, one natural view would be that the concept of belief works much like the concepts one finds in cognitive science – not quite as rigorous or precise, perhaps, but still the same basic type of notion. But now suppose we turn to other concepts that people ordinarily use to understand the mind. Suppose we consider the concept happiness. Or the concept love. How are (...) these concepts to be understood? One obvious hypothesis would be that they are best understood as being more or less like the concept of belief. Maybe these concepts, too, pick out a particular mental state and thereby enable people to predict, explain and understand others’ behavior. We will argue that this hypothesis is mistaken. Instead, we suggest that the different concepts people use to understand the mind are fundamentally different from each other. Some of these concepts do indeed serve simply to pick out a particular mental state, but others allow a role for evaluative judgments. So, for example, our claim will be that when people are wondering whether a given agent is truly ‘happy’ or ‘in love,’ they are not merely trying to figure out whether this agent has a particular sort of mental state. They are also concerned in a central way with evaluating the agent herself. In short, our aim is to point to a striking sort of difference between the different concepts that people use to pick out psychological attitudes. We will be.. (shrink)
Intergroup Aggression in Chimpanzees and War in Nomadic Hunter-Gatherers.Richard W. Wrangham &Luke Glowacki -2012 -Human Nature 23 (1):5-29.detailsChimpanzee and hunter-gatherer intergroup aggression differ in important ways, including humans having the ability to form peaceful relationships and alliances among groups. This paper nevertheless evaluates the hypothesis that intergroup aggression evolved according to the same functional principles in the two species—selection favoring a tendency to kill members of neighboring groups when killing could be carried out safely. According to this idea chimpanzees and humans are equally risk-averse when fighting. When self-sacrificial war practices are found in humans, therefore, they result (...) from cultural systems of reward, punishment, and coercion rather than evolved adaptations to greater risk-taking. To test this “chimpanzee model,” we review intergroup fighting in chimpanzees and nomadic hunter-gatherers living with other nomadic hunter-gatherers as neighbors. Whether humans have evolved specific psychological adaptations for war is unknown, but current evidence suggests that the chimpanzee model is an appropriate starting point for analyzing the biological and cultural evolution of warfare. (shrink)
Causation.Luke Fenton-Glynn -2021 - Cambridge University Press.detailsThis Element provides an accessible introduction to the contemporary philosophy of causation. It introduces the reader to central concepts and distinctions and to key tools drawn upon in the contemporary debate. The aim is to fuel the reader's interest in causation, and to equip them with the resources to contribute to the debate themselves. The discussion is historically informed and outward-looking. 'Historically informed' in that concise accounts of key historical contributions to the understanding of causation set the stage for an (...) examination of the latest research. 'Outward looking' in that illustrations are provided of how the philosophy of causation relates to issues in the sciences, law, and elsewhere. The aim is to show why the study of causation is of critical importance, besides being fascinating in its own right. (shrink)
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Plantinga Redux: Is the Scientific Realist Committed to the Rejection of Naturalism?Abraham Graber &Luke Golemon -2020 -Sophia 59 (3):395-412.detailsWhile Plantinga has famously argued that acceptance of neo-Darwinian theory commits one to the rejection of naturalism, Plantinga’s argument is vulnerable to an objection developed by Evan Fales. Not only does Fales’ objection undermine Plantinga’s original argument, it establishes a general challenge which any attempt to revitalize Plantinga’s argument must overcome. After briefly laying out the contours of this challenge, we attempt to meet it by arguing that because a purely naturalistic account of our etiology cannot explain the correlation between (...) our preference for simplicity and simplicity’s ability to serve as a veridical method of theory selection, the scientific realist is committed to the rejection of naturalism. (shrink)
Corporate Responsibility for Economic, Social and Cultural Rights: Rights in Search of a Remedy?Justine Nolan &Luke Taylor -2009 -Journal of Business Ethics 87 (2):433 - 451.detailsIt is no longer a revelation that companies have some responsibility to uphold human rights. However, delineating the boundaries of the relationship between business and human rights is more vexed. What is it that we are asking corporations to assume responsibility for and how far does that responsibility extend? This article focuses on the extent to which economic, social and cultural rights fall within a corporation's sphere of responsibility. It then analyses how corporations may be held accountable for violations of (...) such rights. Specifically, the article considers the use of soft law as a protective mechanism; it also details how victims of harmful corporate behaviour are using litigation (pursuant to ATCA and common law domestic causes of action) to seek redress and recognition of the harms they have directly or indirectly experienced. The article concludes with an analysis of Professor Ruggie's (the United Nations Special Representative on the issue of transnational corporations and human rights) 2008 and 2009 Reports in which it is suggested that a respect-based framework must be interpreted as imposing proactive requirements on companies to prevent the infringement of human rights. Future efforts must also be directed towards the recognition of a specialised complementary corporate responsibility to protect human rights. (shrink)
Relativity, Quantum Entanglement, Counterfactuals, and Causation.Luke Fenton-Glynn &Thomas Kroedel -2015 -British Journal for the Philosophy of Science 66 (1):45-67.detailsWe investigate whether standard counterfactual analyses of causation imply that the outcomes of space-like separated measurements on entangled particles are causally related. Although it has sometimes been claimed that standard CACs imply such a causal relation, we argue that a careful examination of David Lewis’s influential counterfactual semantics casts doubt on this. We discuss ways in which Lewis’s semantics and standard CACs might be extended to the case of space-like correlations.
Introduction to Special Issue on 'Actual Causation'.Michael Baumgartner &Luke Glynn -2013 -Erkenntnis 78 (1):1-8.detailsAn actual cause of some token effect is itself a token event that helped to bring about that effect. The notion of an actual cause is different from that of a potential cause – for example a pre-empted backup – which had the capacity to bring about the effect, but which wasn't in fact operative on the occasion in question. Sometimes actual causes are also distinguished from mere background conditions: as when we judge that the struck match was a cause (...) of the fire, while the presence of oxygen was merely part of the relevant background against which the struck match operated. Actual causation is also to be distinguished from type causation: actual causation holds between token events in a particular, concrete scenario; type causation, by contrast, holds between event kinds in scenario kinds. (shrink)
Ensuring the Scientific Value and Feasibility of Clinical Trials: A Qualitative Interview Study.Walker Morrell,Luke Gelinas,Deborah Zarin &Barbara E. Bierer -2023 -AJOB Empirical Bioethics 14 (2):99-110.detailsBackground Ethical and scientific principles require that clinical trials address an important question and have the resources needed to complete the study. However, there are no clear standards for review that would ensure that these principles are upheld.Methods We conducted semi-structured interviews with a convenience sample of nineteen experts in clinical trial design, conduct, and/or oversight to elucidate current practice and identify areas of need with respect to ensuring the scientific value and feasibility of clinical trials prior to initiation and (...) while ongoing. We used a priori and grounded theory to analyze the data and constant comparative method to induce higher order themes.Results Interviewees perceived determination of scientific value as the responsibility of the investigator and, secondarily, other parties who review or oversee research. Interviewees reported that ongoing trials are rarely reevaluated due to emerging evidence from external sources, evaluation is complex, and there would be value in the development of standards for monitoring and evaluating evidence systematically. Investigators, IRBs, and/or data monitoring committees (DMCs) could undertake these responsibilities. Feasibility assessments are performed but are typically inadequate; potential solutions are unclear.Conclusions There are three domains where current approaches are suboptimal and in which further guidance is needed. First, who has the responsibility for conducting scientific review, whether it be the investigator, IRB, and/or DMC is often unclear. Second, the standards for scientific review (e.g., appropriate search terms, data sources, and analytic plan) should be defined. Third, guidance is needed on the evaluation of ongoing studies in light of potentially new and evolving evidence, with particular reference to evidence from outside the trial itself. (shrink)
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A Proposed Probabilistic Extension of the Halpern and Pearl Definition of ‘Actual Cause’.Luke Fenton-Glynn -2017 -British Journal for the Philosophy of Science 68 (4):1061-1124.detailsABSTRACT Joseph Halpern and Judea Pearl draw upon structural equation models to develop an attractive analysis of ‘actual cause’. Their analysis is designed for the case of deterministic causation. I show that their account can be naturally extended to provide an elegant treatment of probabilistic causation. 1Introduction 2Preemption 3Structural Equation Models 4The Halpern and Pearl Definition of ‘Actual Cause’ 5Preemption Again 6The Probabilistic Case 7Probabilistic Causal Models 8A Proposed Probabilistic Extension of Halpern and Pearl’s Definition 9Twardy and Korb’s Account 10Probabilistic (...) Fizzling 11Conclusion. (shrink)
Freire 2.0: Pedagogy of the digitally oppressed.Antony Farag,Luke Greeley &Andrew Swindell -2022 -Educational Philosophy and Theory 54 (13):2214-2227.detailsThis paper reinvents Freire’s concepts of ‘banking education’ and ‘literacy’ within the context of the exponential growth of digital instruction in the 21st century. We argue that digital learning (i.e. online or technology enhanced) undoubtedly increases access to education globally, but also can intensify some of the worst problems described in Freire’s banking model. Accordingly, we draw from postdigital theory to scrutinize the specific structures and functions of common digital Learning Management Systems (LMSs) used by schools (i.e. Blackboard and Google (...) Classroom) to reveal a type of learning that further exacerbates the teacher-student dichotomy without liberating either party in a Freirean sense. We then use a Foucauldian lens to bring an awareness to how the accelerated use of these systems at scale, in part caused by the COVID-19 pandemic, can further entrench a data-driven, dehumanized educational experience which increases corporate profitability perhaps over the needs of students. Finally, we use these insights to modernize Freire’s concept of ‘literacy’ by building on Critical Medial Literacy (CML) in order to help educators address LMSs, (mis)information facilitated by digital content, and schooling in a (post)pandemic and postdigital world. (shrink)
Ceteris Paribus Laws and Minutis Rectis Laws.Luke Fenton-Glynn -2016 -Philosophy and Phenomenological Research 93 (2):274-305.detailsSpecial science generalizations admit of exceptions. Among the class of non-exceptionless special science generalizations, I distinguish minutis rectis generalizations from the more familiar category of ceteris paribus generalizations. I argue that the challenges involved in showing that mr generalizations can play the law role are underappreciated, and quite different from those involved in showing that cp generalizations can do so. I outline a strategy for meeting the challenges posed by mr generalizations.
Imprecise Chance and the Best System Analysis.Luke Fenton-Glynn -2019 -Philosophers' Imprint 19.detailsMuch recent philosophical attention has been devoted to the prospects of the Best System Analysis of chance for yielding high-level chances, including statistical mechanical and special science chances. But a foundational worry about the BSA lurks: there don’t appear to be uniquely correct measures of the degree to which a system exhibits theoretical virtues, such as simplicity, strength, and fit. Nor does there appear to be a uniquely correct exchange rate at which the theoretical virtues trade off against one another (...) in the determination of an overall best system. I argue that there’s no robustly best system for our world – no system that comes out best under every reasonable measure of the theoretical virtues and exchange rate between them – but rather a set of ‘tied-for-best’ systems: a set of very good systems, none of which is robustly best. Among the tied-for-best systems are systems that entail differing high-level probabilities. I argue that the advocate of the BSA should conclude that the high-level chances for our world are imprecise. (shrink)
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Children’s Gender Stereotypes in STEM Following a One-Shot Growth Mindset Intervention in a Science Museum.Fidelia Law,Luke McGuire,Mark Winterbottom &Adam Rutland -2021 -Frontiers in Psychology 12.detailsWomen are drastically underrepresented in science, technology, engineering, and mathematics and this underrepresentation has been linked to gender stereotypes and ability related beliefs. One way to remedy this may be to challenge male bias gender stereotypes around STEM by cultivating equitable beliefs that both female and male can excel in STEM. The present study implemented a growth mindset intervention to promote children’s incremental ability beliefs and investigate the relation between the intervention and children’s gender stereotypes in an informal science learning (...) site. Participants were visitors to a science museum who took part in an interactive space science show. Participants who were exposed to a growth mindset intervention, compared to the participants in the control condition, reported significantly less gender stereotyping around STEM by reporting equitably in the stereotype awareness measure. Relatedly, participants in the control condition reported male bias gender stereotype in the stereotype awareness measure. Further, children between 5 and 8-years-old reported greater male bias stereotypes awareness and stereotype flexibility in space science compared to children between 9 and 12-years-old. Lastly, children demonstrated in-group bias in STEM ability. Male participants reported gender bias favoring males’ ability in stereotype flexibility and awareness measures, while female participants reported bias toward females’ ability in stereotype flexibility and awareness measures. These findings document the importance of a growth mindset intervention in buffering against STEM gender stereotyping amongst children, as well as the significant role a growth mindset intervention can play within an informal science learning site. (shrink)
Swedish and Norwegian Police Interviewers' Goals, Tactics, and Emotions When Interviewing Suspects of Child Sexual Abuse.Mikaela Magnusson,Malin Joleby,Timothy J.Luke,Karl Ask &Marthe Lefsaker Sakrisvold -2021 -Frontiers in Psychology 12:606774.detailsAs the suspect interview is one of the key elements of a police investigation, it has received a great deal of merited attention from the scientific community. However, suspect interviews in child sexual abuse (CSA) investigations is an understudied research area. In the present mixed-methods study, we examine Swedish (n= 126) and Norwegian (n= 52) police interviewers' self-reported goals, tactics, and emotional experiences when conducting interviews with suspected CSA offenders. The quantitative analyses found associations between the interviewers' self-reported goals, tactics, (...) and emotions during these types of suspect interviews. Interviewers who reported experiencing more negative emotions were more likely to employ confrontational tactics. Specifically, anger was positively associated with the goal of obtaining a confession and with aggressive tactics like raising one's voice and emphasizing the seriousness of the crime. Frustration and disgust displayed similar patterns. Somewhat contrasting these quantitative results, the thematic analysis identified a strong consensus that emotions should not and do not affect the police interviewers' work. Furthermore, the police interviewers described a range of strategies for managing emotions during the interview and for processing their emotional reactions afterwards. The present findings highlight the relevance of emotional processes in CSA suspect interviews and provide an initial exploration of the potentially complex relationship between the goals, tactics, and emotional experiences of police interviewers who question CSA suspects. (shrink)
Merricks’s Soulless Savior.Luke Van Horn -2010 -Faith and Philosophy 27 (3):330-341.detailsTrenton Merricks has recently argued that substance dualist accounts of embodiment and humanness do not cohere well with the Incarnation. He has also claimed that physicalism about human persons avoids this problem, which should lead Christians to be physicalists. In this paper, I argue that there are plausible dualist accounts of embodiment and humanness that avoid his objections. Furthermore, I argue that physicalism is inconsistent with the Incarnation.
An Ecological Approach to Semiotics.W.Luke Windsor -2004 -Journal for the Theory of Social Behaviour 34 (2):179-198.detailsThis paper proposes an ecological approach to the perception and interpretation of signs. The theory draws upon the ecological approach of James Gibson . It is proposed that cultural and natural perception can both be explained in terms of the direct pick-up of structured information and the Gibsonian concept of affordances without having to invoke a sharp distinction between direct and indirect perception. The application of the theory is exemplified through attention to language and to the visual and audio arts.
Frege and the Logic of the Historical Proposition.Luke O’Sullivan -2023 -Journal of the Philosophy of History 18 (1):68-93.detailsThis article argues that history played a larger role in the thought of Gottlob Frege than has usually been acknowledged. Frege’s logical writings frequently employed statements about the past as examples that included references to historical persons. Frege also described history as a science and argued that historical propositions could support valid inferences and reliably identify historical persons and events. But Frege’s eternalist theory of reference, designed primarily for formal concepts and objects, struggled to accommodate such propositions. Identifying an objective (...) referent for the subjectivity of historical actors was particularly problematic. The article suggests that Frege’s writings are interesting for the philosopher of history for at least two reasons: first, his work is clarificatory when considering the key features that historical propositions must have to count as objective knowledge, and second, it foreshadowed the issues with historicity that analytical philosophy experienced in the twentieth century. It concludes that the problems Frege raised exposed the need for a new concept of inter-subjectivity to replace his own Platonic foundation for objectivity. (shrink)
Are There Distinctively Moral Reasons?Andrew T. Forcehimes &Luke Semrau -2018 -Ethical Theory and Moral Practice 21 (3):699-717.detailsA dogma of contemporary normative theorizing holds that some reasons are distinctively moral while others are not. Call this view Reasons Pluralism. This essay looks at four approaches to vindicating the apparent distinction between moral and non-moral reasons. In the end, however, all are found wanting. Though not dispositive, the failure of these approaches supplies strong evidence that the dogma of Reasons Pluralism is ill-founded.
Oppression, Forgiveness, and Ceasing to Blame.Per-Erik Milam &Luke Brunning -2018 -Journal of Ethics and Social Philosophy 14 (2).detailsWrongdoing is inescapable. We all do wrong and are wronged; and in response we often blame one another. But if blame is a defining feature of our social lives, so is ceasing to blame. We might excuse, justify, or forgive an offender; or simply let the offence go. Each mode of ceasing to blame is a social practice and each has characteristic norms that influence when and how we do it, as well as how it’s received. We argue that how (...) we relinquish blame, and how effective we are, depends on many circumstances only partially within our control. Like any norm-governed practice, one can do it well or poorly, appropriately or inappropriately, successfully or unsuccessfully. To successfully participate in a practice, one’s action must be done for the right reasons and secure uptake. We argue that social and material circumstances can compromise one’s ability to effectively cease to blame in the manner one prefers. But if one can fail, then one can lack access to particular ceasing to blame practices if one is regularly prevented from effectively relinquishing blame. However, uncooperative social and material circumstances do not only arise by chance. Our central argument is that circumstances of oppression can systematically compromise one’s ability and opportunities to effectively perform a variety of ceasing to blame practices. This deprivation is an insidious facet of oppression that is neglected both in theories of oppression and of forgiveness but which has significant implications for how we understand the power and purpose of forgiveness. (shrink)
Militarising the body politic: New media as weapons of mass instruction.P. W. Graham &A.Luke -2003 -Body and Society 9 (4):149-168.detailsAs militarization of bodies politic continues apace the world over, as military organizations again reveal themselves as primary political, economic and cultural forces in many societies, we argue that the emergent and potentially dominant form of political economic organization is a species of neo-feudal corporatism. Drawing upon Bourdieu, we theorize bodies politic as living habitus. Bodies politic are prepared for war and peace through new mediations, powerful means of public pedagogy. The process of militarization requires the generation of new, antagonistic (...) evaluations of other bodies politic. Such evaluations are inculcated via these mediations, the movement of meanings across time and space, between formerly disparate histories, places, and cultures. New mediations touch new and different aspects of the body politic: its eyes, its ears, its organs, but they are consistently targeted at the formation of dispositions, the prime movers of action. (shrink)
Brain estrogen signaling effects acute modulation of acoustic communication behaviors: A working hypothesis.Luke Remage-Healey -2012 -Bioessays 34 (12):1009-1016.detailsAlthough estrogens are widely considered circulating “sex steroid hormones” typically associated with female reproduction, recent evidence suggests that estrogens can act as local modulators of brain circuits in both males and females. The functional implications of this newly characterized estrogen signaling system have begun to emerge. This essay summarizes evidence in support of the hypothesis that the rapid production of estrogens in brain circuits can drive acute changes in both the production and perception of acoustic communication behaviors. These studies have (...) revealed two fundamental neurobiological concepts: (1) estrogens can be locally produced in brain circuits, independent of levels in nearby circuits and in the circulation and (2) estrogens can have very rapid effects within these brain circuits to modulate social vocalizations, acoustic processing, and sensorimotor integration. This vertebrate‐wide span of research, including vocalizing fishes, amphibians, and birds, emphasizes the importance of comparative model systems in understanding principles of neurobiology. (shrink)
Beneficence: Does Agglomeration Matter?Andrew T. Forcehimes &Luke Semrau -2017 -Journal of Applied Philosophy 36 (1):17-33.detailsWhen it comes to the duty of beneficence, a formidable class of moderate positions holds that morally significant considerations emerge when one's actions are seen as part of a larger series. Agglomeration, according to these moderates, limits the demands of beneficence, thereby avoiding the extremely demanding view forcefully defended by Peter Singer. This idea has much appeal. What morality can demand of people is, it seems, appropriately modulated by how much they have already done or will do. Here we examine (...) a number of recent proposals that appeal to agglomeration. None of them, we argue, succeeds. (shrink)
Realism, Postmodernism and/as Metanarrative.Luke O’Sullivan -2024 -Journal of the Philosophy of History 18 (2):223-233.detailsThe question of how realism and metanarratives are related in the philosophy of history does not seem to have been widely discussed. Whereas there are distinct philosophical and political senses of ‘realism’, contrasting with ‘idealism’ and ‘utopianism’ respectively, ‘metanarrative’ has a singular meaning based on Jean-François Lyotard’s sceptical definition of postmodernism as “incredulity towards metanarratives”. Lyotard defined metanarratives as philosophies of history that serve some legitimatory function, but claimed that their importance was waning. From this point of view, postmodernism can (...) be described as a species of philosophical ‘realism’. But the appearance of Francis Fukuyama’s ‘end of history’ thesis, which explicitly presented itself as a neo-Hegelian critique of political realism, suggested that Lyotard had underestimated the enduring power of metanarrative insofar as it served the interests of the American liberal-democratic capitalist order. For Jacques Derrida, Fukuyama’s work thus underlined the importance of breaking with what he called ‘onto-theological’ visions of history, although Derrida himself could be seen as authoring a metanarrative in the service of European social democracy. But if so, Derrida’s approach to metanarratives was very different in kind to contemporary religious and nationalistic versions. One way to resolve the difficulty is to make a distinction between modern ‘utopian’ and postmodern ‘realist’ versions of metanarratives. (shrink)
Acknowledging Complexity and Reimagining IRBs: A Reply to Discussions of the Protection–Inclusion Dilemma.Phoebe Friesen,Luke Gelinas,Aaron Kirby,David H. Strauss &Barbara E. Bierer -2023 -American Journal of Bioethics 23 (9):1-8.detailsWe are grateful to everyone who took the time to offer such insightful comments with regard to the protection–inclusion dilemma in research oversight. Nearly all respondents agreed that this dilemm...
Relationship Sensitive Consequentialism Is Regrettable.Andrew T. Forcehimes &Luke Semrau -2020 -Social Theory and Practice 46 (2):257-276.detailsPersonal relationships matter. Traditional Consequentialism, given its exclusive focus on agent-neutral goodness, struggles to account for this fact. A recent variant of the theory—one incorporating agent-relativity—is thought to succeed where its traditional counterpart fails. Yet, to secure this advantage, the view must take on certain normative and evaluative commitments concerning personal relationships. As a result, the theory permits cases in which agents do as they ought, yet later ought to prefer that they had done otherwise. That a theory allows such (...) cases is a serious defect. We thus conclude that, in terms of how the theories handle personal relationships, agent-relative consequentialism fairs no better than its traditional counterpart. (shrink)
The Correspondence of Jeremy Bentham:Volume 12: July 1824 to June 1828: Volume 12: July 1824 to June 1828.Luke O'Sullivan &the Late Catherine Fuller (eds.) -1968 - Clarendon Press.detailsJeremy Bentham, the philosopher and reformer, was at the height of his fame and influence in the 1820s. The 301 letters in this volume, many of which are previously unpublished, contain correspondence with international leaders such as Simn Bolvar, the 'Liberator', and Bernardino Rivadavia of Buenos Aires, British statesmen such as Robert Peel and Henry Brougham, and leading intellectuals such as John Stuart Mill and Sarah Austin.
Argument schemes and visualization software for critical thinking about international politics.Nancy L. Green,Michael Branon &Luke Roosje -2018 -Argument and Computation 10 (1):41-53.detailsCritical thinking about international politics often involves reasoning about the beliefs, goals, appraisals, actions, and plans of actors such as countries, governments, politicians, etc. We analyzed arguments in interpretive reports about international politics, in order to develop a prototype argument diagramming tool for this domain, AVIZE (Argument Visualization and Evaluation). The purpose of AVIZE is to aid users in the construction and self-evaluation of real-world arguments in the domain of international politics. AVIZE provides a set of argument schemes as cognitive (...) building blocks for constructing argument diagrams. Most of the schemes are related to concepts from the field of automated plan recognition in artificial intelligence. While some currently available argument diagramming tools provide schemes, they are not tailored to the domain of international politics. This paper describes the argument schemes for this domain and the design of the argument diagramming tool. (shrink)
Non-Compliance Shouldn't Be Better.Andrew T. Forcehimes &Luke Semrau -2019 -Australasian Journal of Philosophy 97 (1):46-56.detailsAgent-relative consequentialism is thought attractive because it can secure agent-centred constraints while retaining consequentialism's compelling idea—the idea that it is always permissible to bring about the best available outcome. We argue, however, that the commitments of agent-relative consequentialism lead it to run afoul of a plausibility requirement on moral theories. A moral theory must not be such that, in any possible circumstance, were every agent to act impermissibly, each would have more reason to prefer the world thereby actualized over the (...) world that would have been actualized if every agent had instead acted permissibly. (shrink)
Well-Being: Reality's Role.Andrew T. Forcehimes &Luke Semrau -2016 -Journal of the American Philosophical Association 2 (3):456-68.detailsA familiar objection to mental state theories of well-being proceeds as follows: Describe a good life. Contrast it with one identical in mental respects, but lacking a connection to reality. Then observe that mental state theories of well-being implausibly hold both lives in equal esteem. Conclude that such views are false. Here we argue this objection fails. There are two ways reality may be thought to matter for well-being. We want to contribute to reality, and we want our experience of (...) the world to be veridical. Yet, if one accepts that reality matters in either of these ways, one must posit differences in well-being where no such differences exist. (shrink)
Faith in a Hard Ground: Essays on Religion, Philosophy and Ethics.Mary Geach &Luke Gormally (eds.) -2008 - Imprint Academic.detailsElizabeth Anscombe's forthright philosophy speaks directly to many religious and ethical issues of current concern.This collection of her essays forms a companion volume to the critically acclaimed _Human Life, Action and Ethics_ published in 2005.
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Logic, Truth and Meaning: Writings of G. E. M. Anscombe.Mary Geach &Luke Gormally (eds.) -2015 - Imprint Academic.detailsThis fourth and final volume of writings by Elizabeth Anscombe reprints her _ Introduction to Wittgenstein's Tractatus_, together with a number of later essays on thought and language in which she explores issues of reason, representation, truth and existence. As with previous volumes this gathers hitherto inaccessible publications and previously unpublished texts. Singly and collectively the four volumes provide for a broader and deeper understanding of the thought of one of the twentieth century's most important anglophone philosophers.
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The Neural Correlates of Cued Reward Omission.Jessica A. Mollick,Luke J. Chang,Anjali Krishnan,Thomas E. Hazy,Kai A. Krueger,Guido K. W. Frank,Tor D. Wager &Randall C. O’Reilly -2021 -Frontiers in Human Neuroscience 15.detailsCompared to our understanding of positive prediction error signals occurring due to unexpected reward outcomes, less is known about the neural circuitry in humans that drives negative prediction errors during omission of expected rewards. While classical learning theories such as Rescorla–Wagner or temporal difference learning suggest that both types of prediction errors result from a simple subtraction, there has been recent evidence suggesting that different brain regions provide input to dopamine neurons which contributes to specific components of this prediction error (...) computation. Here, we focus on the brain regions responding to negative prediction error signals, which has been well-established in animal studies to involve a distinct pathway through the lateral habenula. We examine the activity of this pathway in humans, using a conditioned inhibition paradigm with high-resolution functional MRI. First, participants learned to associate a sensory stimulus with reward delivery. Then, reward delivery was omitted whenever this stimulus was presented simultaneously with a different sensory stimulus, the conditioned inhibitor. Both reward presentation and the reward-predictive cue activated midbrain dopamine regions, insula and orbitofrontal cortex. While we found significant activity at an uncorrected threshold for the CI in the habenula, consistent with our predictions, it did not survive correction for multiple comparisons and awaits further replication. Additionally, the pallidum and putamen regions of the basal ganglia showed modulations of activity for the inhibitor that did not survive the corrected threshold. (shrink)
Observing resuscitative practice. A novice researcher’s experience of obtaining ethics approval.Katherine Riley,Luke Molloy,Val Wilson &Rebekkah Middleton -2023 -Nursing Ethics 30 (7-8):1190-1198.detailsUndertaking research involving vulnerable groups, such as those requiring resuscitation involves careful analysis during the ethical review process. When a person lacks the capacity to make an informed choice about their participation in a research study, a waiver of consent offers an alternative. This paper is based on a doctoral research study using ethnography to explore the resuscitative practices and experiences of rural nurses through observation and interviews. This paper aims to explore the ethical issues raised by the Human Research (...) Ethics Committee relating to consent of vulnerable patients requiring resuscitation within a rural context. In particular, the challenges of addressing risk (privacy) vs benefit (public) associated with a waiver of consent. This paper will consider why the rural context should be championed during the ethical review process, when decisions about public benefit are being deliberated. Utilising a communitarianism approach that advocates for greater rural representation during the ethical review processes will ensure that rural research involving vulnerable groups can be addressed safely and benefit not only the experiences and practices of rural nurses but also the wider rural communities they serve. (shrink)