Arrested development: Understanding v‐abl.Lawrence D. Kerr -1994 -Bioessays 16 (7):453-455.detailsThe protein tyrosine kinase activity of the v‐abl oncogene has been demonstrated to subvert the normal second messenger systems used by lymphoid cells for growth and differentiation. Transformation of bone marrow with the Abelson murine leukemia virus results in the appearance of B cell lineage cells arrested at the pre‐B cell stage. Recent reports have characterized these cells expressing high v‐abl kinase activity as deficient in detectable NF‐kB DNA binding activity and low level RAG gene expression. These observations suggest that (...) v‐abl may be inhibiting the differentiation of B cells by blocking these two crucial elements in the maturation pathway. (shrink)
The Fabulous Imagination: On Montaigne's Essays.Lawrence D. Kritzman -2009 - Columbia University Press.details"This is one of the few books on Montaigne that fuses analytical skill with humane awareness of why Montaigne matters."Harold Bloom, Sterling Professor of Humanities, Yale University "In this exhilarating and learned book on Montaigne's essays,Lawrence D. Kritzman _contemporizes_ the great writer. Reading him from today's deconstructive America, Kritzman discovers Montaigne always already deep into a dialogue with Jacques Derrida and psychoanalysis. One cannot but admire this fabulous act of translation."Hélène Cixous "Throughout his career,Lawrence D. Kritzman (...) has demonstrated an intimate knowledge of Montaigne's essays and an engagement with French philosophy and critical theory. _The Fabulous Imagination_ sheds precious new light on one of the founders of modern individualism and on his crucial quest for self-knowledge."Jean Starobinski, professor emeritus of French literature, University of Geneva Michel de Montaigne's (1533-1592) _Essais_ was a profound study of human subjectivity. More than three hundred years before the advent of psychoanalysis, Montaigne embarked on a remarkable quest to see and imagine the self from a variety of vantages. Through the questions How shall I live? How can I know myself? he explored the significance of monsters, nightmares, and traumatic memories; the fear of impotence; the fragility of gender; and the act of anticipating and coping with death. In this book,Lawrence D. Kritzman traces Montaigne's development of the Western concept of the self. For Montaigne, imagination lies at the core of an internal universe that influences both the body and the mind. Imagination is essential to human experience. Although Montaigne recognized that the imagination can confuse the individual, "the fabulous imagination" can be curative, enabling the mind's "I" to sustain itself in the face of hardship. Kritzman begins with Montaigne's study of the fragility of gender and its relationship to the peripatetic movement of a fabulous imagination. He then follows with the essayist's examination of the act of mourning and the power of the imagination to overcome the fear of death. Kritzman concludes with Montaigne's views on philosophy, experience, and the connection between self-portraiture, ethics, and oblivion. His reading demonstrates that the mind's I, as Montaigne envisioned it, sees by imagining that which is not visible, thus offering an alternative to the logical positivism of our age. (shrink)
Health Reform in America: The Mystery of the Missing Moral Momentum.Lawrence D. Brown -1998 -Cambridge Quarterly of Healthcare Ethics 7 (3):239-246.detailsExamining health policy and its recent reform misadventures in the United States from a moral viewpoint is painful. That the nation devotes 14% of its Gross Domestic Product to health servicesand yet lets more than 40 million citizens go without health coverage strikes critics, both foreign and domestic, as a disgrace explicable only by ethical deficiencies distinctive to the American value system. There is certainly merit in this critique, which understandably incites fire and brimstone about the urgent moral imperative of (...) getting the nation on the path of righteousness at last. (shrink)
How Reference Works: Explanatory Models for Indexicals, Descriptions, and Opacity.Lawrence D. Roberts -1993 - SUNY Press.detailsIf some aspects of human behavior are too murky to see into, others are too close and transparent to examine; one that has eluded both scientists and philosophers is how speakers of natural languages make words and expressions refer to specific objects in the world. Marshalling his expertise in philosophy, computers, and system science (State U. of.
The relation of children's early word acquisition to abduction.Lawrence D. Roberts -2004 -Foundations of Science 9 (3):307-320.detailsThe paper discusses how abduction relates tochildren's early acquisition of words, and has three sections: (a) a brief description of Peirce's notion of abduction; (b) a developmentof a hypothesis for the content-related symbolic functioning of words; and (c)arguments that children's knowledge of such functioning involves two kinds of abduction. In (b), children's knowledge of the content-related symbolic functioning of words is argued to consist in practical knowledge ofhow to use words to direct attention to kindsof things. To acquire such knowledge, (...) a childmust form a practical causal hypothesis aboutthe kind of thing to which a word directs attention. I argue that forming such ahypothesis involves abduction. On the basis of empirical work of several developmentalists, I also argue that children use abduction notmerely in forming practical hypotheses for the functioning of their earliest words, but also in forming theoretical hypotheses about core(as contrasted perceptual and functional)features of natural and artificial kinds. (shrink)
Intuitions and Ambiguity Tests.Lawrence D. Roberts -1987 -Canadian Journal of Philosophy 17 (1):189 - 197.detailsArnold Zwicky and Jerrold Sadock object to my test for distinguishing ambiguity from generality by offering a counterexample and general criticisms about the use of intuitions in the test. Though I disagree with their criticisms, their paper has helped me to become aware of the unclarity of my earlier paper in regard to generality.
The generality of specificity: Some lessons from audiovisual speech.Lawrence D. Rosenblum &Michael S. Gordon -2001 -Behavioral and Brain Sciences 24 (2):239-240.detailsThe global array might prove to be an important and even necessary concept for explaining some multi-modal phenomena from the specificational perspective. However, we suspect that specification exists in energy arrays detectable by single or multiple sensory systems. We argue for a more general modality-neutral perspective and review results from recent research on audiovisual speech perception.
Board oversight of community benefit: An ethical imperative.Gerard Magill &Lawrence D. Prybil -2011 -Kennedy Institute of Ethics Journal 21 (1):25-50.detailsBoard oversight of community benefit constitutes an ethical imperative for nonprofit health care organizations. By "ethical imperative" we mean a health care organization's duty to fulfill value-based obligations that transcend compliance requirements in order to be consistent with its basic sense of purpose. We consider three points here: the existence of a distinctively ethical imperative for board oversight, the fact that the imperative is organizational in nature, and practical ways to fulfill its obligations. To explain the meaning of ethical imperative, (...) offer analytical clarification, and provide evidence-based guidelines we adopt an organizational ethics paradigm. Because community benefit for tax-exempt .. (shrink)
Differences in Health-Related Physical Fitness and Academic School Performance in Male Middle-School Students in Qatar: A Preliminary Study.Souhail Hermassi,Lawrence D. Hayes,Nilihan E. M. Sanal-Hayes &René Schwesig -2022 -Frontiers in Psychology 13.detailsThis study examined the differences in the level of physical fitness and academic performance among male middle-school children based on different body status categories. A total of 69 male children [age: 12.4 ± 0.7 years; body mass: 58.5 ± 7.2 kg; height: 1.62 ± 0.09 m; and body mass index : 22.4 ± 3.3 kg/m2] participated and were divided into BMI age-adjusted groups. Height, mass, BMI, stork test of static balance, 10 and 15 m sprint as an indicator for speed, (...) hand-grip strength test, agility T-half test, medicine ball throw, and the Yo-Yo Intermittent Recovery Test level 1 were assessed. School records were retrieved for grade point averages of mathematics, science, and Arabic. We found significant group differences regarding anthropometric, physical, and academic performance parameters. The largest difference correlation between parameters of different dimensions was found. In conclusion, the highest BMI group exhibited similar physical and academic performances than the lowest group. Thus, these data emphasize the importance and appropriateness to engage young Qatari schoolchildren in physical activity as it associates with superior academic performance. (shrink)
Physical Fitness and Academic Performance in Normal Weight, Overweight, and Obese Schoolchild Handball Players in Qatar: A Pilot Study.Souhail Hermassi,Lawrence D. Hayes,Nicola Luigi Bragazzi &René Schwesig -2021 -Frontiers in Psychology 11.detailsThis study aimed to investigate the relationships between physical fitness and academic performance in youth handball players of different BMI classifications. Thirty-three male handball players were recruited from the Qatar handball first league and were assigned to their BMI age-adjusted groups. Measurements included anthropometric data and body fat percentage, and physical performance tests: agility T-half test; squat jump, and countermovement jump, 10 and 15 m sprint; medicine ball throw. Aerobic capacity was evaluated using the Yo-Yo Intermittent Recovery Test level 1. (...) Academic achievement was assessed through school records of grades point average of Mathematics, Science and Arabic. None academic performance parameter and four physical performance parameters were different between BMI related groups. In 43% of performance parameters and all academic parameters, the normal weight group showed the highest performance level, whereas the overweight group had the best performance in both sprint tests. The obese group was only superior in the medicine ball throw, but not at the p 0.5) between academic and physical performance parameters was only found between Yo-Yo IR 1 and science. A relevant correlation were found between CMJ and BMI. The agility T-half test was correlated with CMJ and 10 m sprint. These findings suggest being overweight or obese are related to science academic performance among schoolchildren athletes in Qatar. Possibly, a normal BMI could positively influence academic performance. Physical education teachers, staff, and administrators should be cognizant that health promotion interventions improving composition may have the additional potential to improve dimensions of academic performance. (shrink)
Lawrence Kohlberg's Approach to Moral Education.F. Clark Power,Ann Higgins-D'Alessandro &Lawrence Kohlberg -1989detailsLawrence Kohlberg's Approach to Moral Education presents what the lateLawrence Kohlberg regarded as the definitive statement of his educational theory. Addressing the sociology and social psychology of schooling, the authors propose that school culture become the center of moral education and research. They discuss how schools can develop as just and cohesive communities by involving students in democracy, and they focus on the moral decisions teachers and students face as they democratically resolve problems. As the authors put (...) it: "...we propose an educational renewal of our democratic society.... We have attempted to establish schools that do more than just teach about democratic citizenship, that are themselves democratic societies.". (shrink)