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Volume 20, Issue 4, May 2020, Page 35-37.

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We advocate for an integrative long-term perspective on time, noting that culture changes on timescales amenable to behavioral genetic study with appropriate design and modeling extensions. We note the need for replications of behavioral genetic studies to examine model invariance across long-term timescales, which would afford examination of specified as well as unspecified cultural moderators of behavioral genetic effects.

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Nonsense‐mediated RNA decay (NMD) represents an established quality control checkpoint for gene expression that protects cells from consequences of gene mutations and errors during RNA biogenesis that lead to premature termination during translation. Characterization of NMD‐sensitive transcriptomes has revealed, however, that NMD targets not only aberrant transcripts but also a broad array of mRNA isoforms expressed from many endogenous genes. NMD is thus emerging as a master regulator that drives both fine and coarse adjustments in steady‐state RNA levels in the (...) cell. Importantly, while NMD activity is subject to autoregulation as a means to maintain homeostasis, modulation of the pathway by external cues provides a means to reprogram gene expression and drive important biological processes. Finally, the unanticipated observation that transcripts predicted to lack protein‐coding capacity are also sensitive to this translation‐dependent surveillance mechanism implicates NMD in regulating RNA function in new and diverse ways. (shrink)

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Cramer et al. articulate a novel perspective on comorbidity. However, their network models must be compared with more parsimonious latent variable models before conclusions can be drawn about network models as plausible accounts of comorbidity. Latent variable models have proven generative in studying psychopathology and its external correlates, and we doubt network models will prove as useful for psychopathology research.

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Counterfactual causal interpretations of family genetic effects are appropriate, but neglect an important feature: Provision of unique information about expected outcomes following an independent decision, such as a decision to intervene. Counterfactual causality criteria are unlikely to resolve controversies about behavioral genetic findings; such controversies are likely to continue until counterfactual inferences are translated into interventional hypotheses and designs.

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Caesarean delivery is a common and life-saving intervention. However, it involves an overall increased risk for short-term and long-term complications for both mother and child compared with vaginal delivery. From a medical point of view, healthcare professionals should, therefore, not recommend caesarean sections without any anticipated medical benefit. Consequently, caesarean sections requested by women for maternal reasons can cause conflict between professional recommendations and maternal autonomy. How can we assure ethically justified decisions in the case of caesarean sections on maternal (...) request in healthcare systems that also respect patients’ autonomy and aspire for shared decisions? In the maternal–professional relationship, which can be characterised in terms of reciprocal obligations and rights, women may not be entitled to demand a C-section. Nevertheless, women have a right to respect for their deliberative capacity in the decision-making process. How should we deal with a situation of non-agreement between a woman and healthcare professional when the woman requests a caesarean section in the absence of obvious medical indications? In this paper, we illustrate how the maternal–professional relationship is embedded in a nexus of power, trust and risk that reinforces a structural inferiority for women. To accommodate for beneficial use of power, these decision processes need to be trustworthy. We propose a framework, inspired by Lukes’ three-dimensional notion of power, which serves to facilitate trust and allows for beneficial power in shared processes of decision-making about the delivery mode for women requesting planned C-sections. (shrink)

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Cappelen et al. (2015) open their paper, “Fairness is intuitive,” with the observation, “A key question in the social sciences is whether it is intuitive to behave in a fair manner or whether fair behavior requires active self-control” (p. 2). They purport to offer “evidence showing that fair behavior is intuitive to most people” (p. 1). Their premise is that deciding by intuition is faster than deciding by deliberation. While this premise in and on itself is rather uncontroversial—the conclusion that (...) they draw from it is not: “Since a decision that relies on intuition is typically made faster than a decision that relies on deliberation, the response time of a fair decision relative to a selfish decision provides an important indication of the intuitiveness of fair behavior” (p. 2). This reasoning, in fact, amounts to a reverse inference fallacy. ‘Intuitive’ may mean ‘fast’, but this would not imply that ‘fast’ means ‘intuitive’. However, we may ask, under which empirical conditions might we be allowed to draw the inference of ‘intuitive’ from ‘fast’? Naturally, these conditions would require that ‘fast’ rule out ‘deliberative’. To achieve this, we would need information beyond relative response speed alone—such as absolute decision times. And this begs the question, which range of decision times would rule out ‘deliberative’—or at the very least, render it improbable? Although the precise cut-off for deliberative decisions may be difficult to establish (see e.g., Schnei... (shrink)

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What kind of futures does agro-food imaginaries enable and who can get involved in the making of agro-food futures? In this respect, what can the increasingly influential idea of circular economy potentially offer in terms of enabling more sustainable agrofood futures? We approach this task by first outlining the interconnected challenges that the agro-food system is facing related to environmental degradation, economic crises and social problems. Then we consider the way these challenges are being addressed in agro-food studies. We argue (...) that agro-food research in recent years has seen important contributions in relation to studies of alternative food networks and the “quality” turn. These research agendas have challenged the current logic of the food system in terms of offering alternative visions of future development. We highlight two examples from the literature—the eco-economy and the integrated territorial agri-food paradigm—that develop broader frameworks for rethinking the future of the agro-food system and which have distinguished themselves in contrast to the industrialized and globalized conventional food system. We find that with respect to reorienting and reconfiguring economic structures and relations all three approaches share a common goal, but circular economy stands out in relation to the actors that are included by, for example, emphasizing collaborations and partnerships with extant agro-food businesses. Also with regards to scalar politics, it would be prudent to consider the potentials offered by the increasingly influential ideas around circular economy. (shrink)

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Proponents of large-scale land acquisitions (LaSLA) argue that poor countries could benefit from foreign direct investment in land (World Bank 2011), while opponents argue that LaSLA is nothing more than neo-colonial theft of poor peasants’ livelihoods, i.e., land grabbing (Borras and Franco in Yale Hum Rights Dev L J, 13: 507–523, 2010a). To ensure responsible agricultural investments (RAI), a voluntary “code of conduct” for land acquisitions has been proposed by the World Bank (2011) and the FAO (2012). A critical reaction (...) to the “code of conduct” approach is the proposal for a set of minimum human rights principles, suggested by the UN Special Rapporteur on the Right to Food, De Schutter (2009). Even more critical of the “code of conduct” approach are Borras and Franco in Yale Hum Rights Dev L J, 13(2): 507–523, 2010a, who propose empowering small-scale farmers by giving them land sovereignty so that they are assured control over their land. This paper is a review of the governance and ethics issues connected to LaSLA. It has four main objectives: First, it offers a critical presentation of three major governance approaches to LaSLA: the “liberal code of conduct” (FAO and the World Bank), the ‘critical liberal human rights’ approach (De Schutter) and the ‘Marxist’ approach (Borras and Franco). Second, it discusses the notion of a human right to land, with reference to John Locke’s theory of appropriating land. Third, it discusses the issue of ensuring an inclusive process in LaSLA. Finally, an argument is made for instituting a (global) obligation to refrain from participating in or benefitting from institutional schemes that facilitate negative land grabbing (Pogge in Politics as usual: what lies behind the pro-poor rhetoric? Polity Press, Cambridge 2010). (shrink)

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The purpose of this paper is to consider some aspects of the question of how difficult it should be to amend or change constitutional laws through formal amendment procedures. The point of departure of my discussion is an amendment procedure that has recently been suggested by the prominent legal and political philosopher Bruce Ackerman. He defends a three-step amendment procedure – where a re-elected president is authorised to propose amendments that must thereafter be approved first by a two-thirds majority of (...) the legislature, and then by a simple majority of the citizens at the next two presidential elections. I propose and defend an alternative amendment procedure that can be termed the four-step procedure. According to this procedure, the right to propose amendments is granted both to legislators and voters via citizen initiatives. Thereafter, the proposed amendments should be placed before the legislature, where they must be approved by a simple majority in two successive parliaments, and there must be an interval of no less than one year between the two votes. If passed by the legislative assembly, the amendment(s) should be approved by a simple majority of the electorate in a referendum. However, a submajority of the legislators (i.e. a one-third minority) should be empowered to require an additional referendum on the proposed amendment(s), and this final referendum should be held two years after the first popular vote. In order to assess the outlined amendment procedures, I primarily focus on the following factors or criteria of evaluation, which I group under three headings: (1) Central ideas and ideals in deliberative democratic theory and the fact of persistent disagreement in modern pluralist societies (this includes considerations of how well alternative amendment procedures deal with disagreement among citizens); (2) rule of law values, stability and flexibility; and (3) the value of checks and balances that can guard against the abuse of power (or more precisely, whether the amendment procedures under consideration provide adequate checks and balances between courts, political actors and citizens). (shrink)

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This paper discusses trust between stakeholders, with special emphasis on a new theory from the social sciences and ends up by focusing on a multidimensional dilemma between trust and control. Harald Grimen, an influential philosopher, social scientist and ethicist in Norway, defined trust as a communicative action between a trust-giver and a trust-receiver, characterized by the giver taking few precautions. This first part of his theory provides the basis for a specified interpretation of trust as a collective undertaking among stakeholders (...) in modern organizations, such as financial companies, constituting chains of trust. The phenomenon of cooperation is fundamental in such chains. Grimen’s theoretical focus on trust as a single action, and on the chain of cooperation as several interconnected actions, represents a corrective to the psychological and individualistic profile of mainstream research on trust and converges toward principal-agent theories. The paper uses Grimen’s theory to work out a hypothesis about a chain of trust between stakeholders in the financial industry, promoting a multi-efficient cooperation between them. The multi-efficiency of chains of trust is also discussed in connection with the risk of violating different ethical norms. The risk brings to focus the corresponding need for chains of control as a means to reduce the risk of violations of norms. But the chain of control has not only this advantage, but also a disadvantage. The inefficiency of chains of control is a severe hindrance to the efficiency of the chain of trust, even if it reduces the risk of violation of norms. The paper ends by underscoring a multidimensional dilemma typical for cooperation between stakeholders in modern organizations, i.e. the fundamental dilemma between the advantages and disadvantages of both chains of trust and chains of control. (shrink)

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The purpose of this chapter is to consider the question of whether respect for persons requires toleration of the expression of any extremist political or religious viewpoint within public discourse. The starting point of my discussion is Steven Heyman and Jonathan Quong’s interesting defences of a negative answer to this question. They argue that respect for persons requires that liberal democracies should not tolerate the public expression of extremist speech that can be regarded as recognition-denying or respect-denying speech – that (...) is, speech or other expressive conduct that expresses viewpoints that explicitly reject that all persons should be regarded and treated as free and equal persons or citizens. According to Heyman and Quong, recognition-denying speech falls outside the scope of the right to participate in public discourse (i.e. what it is a right to). In contrast to Heyman and Quong, one can argue that a strong case can be made for viewpoint neutrality on the basis of what can be called a libertarian or Nozickean status-based theory of rights. According to this theory, toleration in a liberal democracy requires respect for the status of persons as thinking agents, and respect for thinking agents and their sovereignty over their own mind requires viewpoint neutrality – that is, a basic right to participate in public discourse as speakers and listeners free from state-imposed viewpoint-based restrictions. All persons should have a basic right to express, hear and consider any viewpoint within public discourse. This doctrine of viewpoint neutrality requires that citizens in liberal democracies ought to have a legal free speech right to do moral wrong – that is, a legal right to express and defend any viewpoint within public discourse, even if it is morally wrong to express, or expose others to, such views. (shrink)

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The Stalin Years: A Reader. Edited by Christopher Read (Hampshire, UK: Palgrave Macmillan, 2003), xv?+?241 pp. ?14.99 paper. The Russian Revolution from Lenin to Stalin, 1917?1929. By E. H. Carr, with a new introduction by R. W. Davies (Hampshire, UK: Palgrave Macmillan, 2004), xxxix?+?200 pp. ?14.99 paper.

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Callicles holds a desire-fulfilment conception of happiness; it is something like, that is, the continual satisfaction of desires that constitutes happiness for him. He claims that leading the happy life consists in having many desires, letting them grow as strong as possible and then being able to satisfy them (e.g. 491e, 494c). For Callicles, this life of maximum pursuit of desires consists in a kind of absolute freedom, where there is very little practice of restraint; happiness consists of luxury, unrestraint, (...) and freedom (492b-c). Socrates develops his objections to Callicles’ life of freedom by appealing to two myths once told to him by a wise man. I draw out what I think are the two primary objections and consider to what extent they might be seen to damage Callicles’ position. I conclude that Callicles’ view on freedom can adequately meet one of Socrates’ objections but not the other. (shrink)

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This article attempts to read the Transcendental Dialectic through Meillassoux’s model of the absolute contingency of being in order to rethink some of its central difficulties. Specifically, this concerns better understanding the role played by the categories of relation and modality in the empirical use of the ideas of reason, which underlies their regulative use that is directed at an absolute unity of reason. It will be discussed which questions are implied in the central claim of Meillassoux’s ontology, i.e., that (...) it is possible to derive from the necessity of contingency the existence and noncontradictory being of the thing in itself. First, I will retrace basic points of Meillassoux’s critique of “correlationism”, by means of which he reconfigures the divisions between metaphysics, physics, and ontology. Second, against the background of the Kantian concept of hope, I will examine a relation between the Transcendental Dialectic and ethics, as, respectively, conceived of in Kant and in Meillassoux’s reinterpretation. Third, I will critically ask in how far absolute contingency can be understood as grounding a concept of experience and in which sense the idea of the antinomy chapter in the Transcendental Dialectic contains an argument more complex than Meillassoux’s model suggests. (shrink)

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Proponents of using genetically modified (GM) crops and food in the developing world often claim that it is unjust not to use GMOs (genetically modified organisms) to alleviate hunger and malnutrition in developing countries. In reply, the critics of GMOs claim that while GMOs may be useful as a technological means to increase yields and crop quality, stable and efficient institutions are required in order to provide the benefits from GMO technology. In this debate, the GMO proponents tend to rely (...) on a simple utilitarian type of calculus that highlights the benefits of GMOs to the poor, but that overlooks the complex institutional requirements necessary for GMO production. The critics, recognizing the importance of institutional conditions, focus primarily on the negative impacts of institutional deficiencies, thereby overlooking the basically Rawlsian claim that institutions per se may generate claims to justice. This article investigates how GMOs might generate claims to global justice and what type of justice is involved. The paper argues that the debate on GMOs and global justice can be categorized into three views, i.e., the cosmopolitan, the pluralist, and the sceptic. The cosmopolitan holds that GMOs can and should be used for alleviating global hunger, whereas the sceptic rejects this course of action. I will argue here for a moderately cosmopolitan approach, relying on the pluralist view of institutions and the need to exploit the benefits of GMOs. This argument rests on the premise that global cooperation on GMO production provides the relevant basis for assessing the use of GMOs by the standard of global distributive justice. (shrink)

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We argue that two well-known examples (strawberry distribution and Konigsberg bridges) generally considered genuine cases of distinctively _mathematical_ explanation can also be understood as cases of distinctively _generic_ explanation. The latter answer resemblance questions (e.g., why did neither person A nor B manage to cross all bridges) by appealing to ‘generic task laws’ instead of mathematical necessity (as is done in distinctively mathematical explanations). We submit that distinctively generic explanations derive their explanatory force from their role in ontological unification. Additionally, (...) we argue that distinctively generic explanations are better seen as standardly mathematical instead of distinctively mathematical. Finally, we compare and contrast our proposal with the work of Christopher Pincock on abstract explanations in science and the views of Michael Strevens on abstract causal event explanations. (shrink)

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Between Physics of Organism and Organismic Physics: Object and Method of Biology. In the history of biological theory one can observe an oscillation between two tendencies of thinking, namely the biologistic and the physicalistic point of view. Both aim at a general or unified theory of nature that is relevant for scientific research as well as for philosophical reflection. In terms of a pluralistic approach these two ways of theory-formation must be rejected. Biology e.g. as a specific natural science, characterized (...) by its mid-position between ‘nomothetic’ and ‘idiographic’ thinking (Windelband), is much more than a subordinate branch of physical knowledge. This very autonomy of biology does not only result from a special methodology or from a specific theoretical framework. On the contrary, the methodological and functional autonomy of biology is due to the very features of the phenomena investigated. These features include multitude, individuality and wholeness. (shrink)

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Many types of everyday and specialized reasoning depend on diagrams: we use maps to fnd our way, we draw graphs and sketches to communicate concepts and prove geometrical theorems, and we manipulate diagrams to explore new creative solutions to problems. While the linear and symbolic character of verbal language has long served as the predominant model of human thought, it is remarkable how — through a range of contexts — thinking and communication critically depend on manipulations of external, ofen non-linear, (...) and manipulable iconic-diagrammatic vehicles. In this issue of Pragmatics and Cognition we explore such diagrammatic reasoning, that is, of individual and intersubjectively distributed cognitive processes relying on external representations (i.e. diagrams in a broad sense) as tools for thinking and communicating. (shrink)

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We argue for the epistemic and ethical advantages of pluralism in Reinforcement Learning from Human Feedback (RLHF) in the context of Large Language Models (LLMs). Drawing on social epistemology and pluralist philosophy of science, we suggest ways in which RHLF can be made more responsive to human needs and how we can address challenges along the way. The paper concludes with an agenda for change, i.e. concrete, actionable steps to improve LLM development.

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O objetivo deste artigo é, primeiro, apresentar e considerar as críticas de Paley com mais detalhes e, em seguida, discutir algumas das aplicações significativas da fenomenologia que muitas vezes foram negligenciadas pelos pesquisadores qualitativos. Como foi amplamente demonstrado ao longo dos anos, a fenomenologia pode não apenas fazer a diferença no manuseio, análise e interpretação dos dados disponíveis, mas também em como os dados são obtidos em primeiro lugar, por exemplo, através de técnicas especiais de entrevista. Consideraremos algumas figuras centrais (...) da psicologia fenomenológica clássica e da psiquiatria fenomenológica e apresentaremos alguns dos desenvolvimentos mais recentes na ciência cognitiva. Em seguida, discutiremos três casos concretos que demonstram como a fenomenologia foi aplicada no trabalho clínico com pacientes com esquizofrenia, paralisia cerebral e negligência hemispatial. (shrink)

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In conversation, individuals work together to achieve communicative goals, complementing and aligning language and body with each other. An important emerging question is whether interlocutors entrain with one another equally across linguistic levels (e.g., lexical, syntactic, and semantic) and modalities (i.e., speech and gesture), or whether there are complementary patterns of behaviors, with some levels or modalities diverging and others converging in coordinated fashions. This study assesses how kinematic and linguistic entrainment interact with one another across levels of measurement, and (...) according to communicative context. We analyzed data from two matched corpora of dyadic interaction between—respectively—Danish and Norwegian native speakers engaged in affiliative conversations and task‐oriented conversations. We assessed linguistic entrainment at the lexical, syntactic, and semantic level, and kinetic alignment of the head and hands using video‐based motion tracking and dynamic time warping. We tested whether—across the two languages—linguistic alignment correlates with kinetic alignment, and whether these kinetic‐linguistic associations are modulated either by the type of conversation or by the language spoken. We found that kinetic entrainment was positively associated with low‐level linguistic (i.e., lexical) entrainment, while negatively associated with high‐level linguistic (i.e., semantic) entrainment, in a cross‐linguistically robust way. Our findings suggest that conversation makes use of a dynamic coordination of similarity and complementarity both between individuals as well as between different communicative modalities, and provides evidence for a multimodal, interpersonal synergy account of interaction. (shrink)

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In the exploratory study reported here, we tested the efficacy of an intervention designed to train teenagers with Möbius syndrome (MS) to increase the use of alternative communication strategies (e.g., gestures) to compensate for their lack of facial expressivity. Specifically, we expected the intervention to increase the level of rapport experienced in social interactions by our participants. In addition, we aimed to identify the mechanisms responsible for any such increase in rapport. In the study, five teenagers with MS interacted with (...) three naïve participants without MS before the intervention, and with three different naïve participants without MS after the intervention. Rapport was assessed by self-report and by behavioral coders who rated videos of the interactions. Individual non-verbal behavior was assessed via behavioral coders, whereas verbal behavior was automatically extracted from the sound files. Alignment was assessed using cross recurrence quantification analysis and mixed-effects models. The results showed that observer-coded rapport was greater after the intervention, whereas self-reported rapport did not change significantly. Observer-coded gesture and expressivity increased in participants with and without MS, whereas overall linguistic alignment decreased. Fidgeting and repetitiveness of verbal behavior also decreased in both groups. In sum, the intervention may impact non-verbal and verbal behavior in participants with and without MS, increasing rapport as well as overall gesturing, while decreasing alignment. (shrink)

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In this paper, we discuss the development of robot use cases in an elderly care facility in the context of exploring the method of Integrative Social Robotics when used on top of a user-centered design approach. Integrative Social Robotics is a new proposal for how to generate responsible, i.e. culturally and ethically sustainable, social robotics applications. Starting point for the discussion are the five principles that characterize an ISR approach, which are discussed in application to the three use cases for (...) robot support in a Danish elderly care facility developed within the smooth project. The discussion by an interdisciplinary design team explores what attention to the five principles of ISR can offer for use case development. We report on the consequences of this short-time exposure to the basic ideas of ISR for use case development and discuss the value of approaching robot development from an ISR perspective. (shrink)

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There are profound methodological challenges facing microdosing research. One way we can address some of these methodological issues is by understanding how psilocybin microdosing fits in the broader existential context of people’s lives. We recruited participants who underwent psilocybin microdosing on their own and consented to being monitored for harm mitigation purposes. We combined momentary ecological assessment and detailed retrospective interviews. Participants reported loosening of mental structures (i.e., less intense strength of thoughts, tangential stream of consciousness), increased salience of external (...) stimuli (varyingly associated with greater interest in otherwise mundane activities, as well as sensory overload), an increase in flexible cognition, a decrease in stable cognition, and various ego-dystonic contents. Highly structured environments were conducive to positive appraisal of experiences and vice versa. Momentary ecological assessment and retrospective interviews yielded differing accounts of microdosing experience. We relate our findings to stable and flexible cognition, as well as the notion of salience. We point out the necessity for systematic mixed methods studies to better characterize the lived experience of taking low doses of psilocybin. (shrink)

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The papers in Richard Vallée's Words and Contents span twenty-one years. The author navigates the discovery and exploration of different expressions and perspectives on language in this volume. Beginning with referring expressions and later addressing context sensitivity, the book examines how specific words contribute to the contents of utterances and the philosophical issues that surround them.

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Resenha: KARASCH, Mary C. Before Brasília: frontier life in Central Brazil. Albuquerque: University of New Mexico Press, 2016.

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Reflections on death, chiefly reminiscences on the death of some Malayalis, author's associates, including Malayalam authors.

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ACESSO À JUSTIÇA: DELINEAMENTOS GERAIS E ANÁLISE NO PROJETO DE NOVO CÓDIGO PROCESSUAL CIVIL.

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