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It is often held that to have a conscious experience presupposes having some form of implicit self-awareness. The most dominant phenomenological view usually claims that we essentially perceive experiences as our own. This is the so called “mineness” character, or dimension of experience. According to this view, mineness is not only essential to conscious experience, it also grounds the idea that pre-reflective self-awareness constitutes a minimal self. In this paper, we show that there are reasons to doubt this constituting role (...) of mineness. We argue that there are alternative possibilities and that the necessity for an adequate theory of the self within psychopathology gives us good reasons to believe that we need a thicker notion of the pre-reflective self. To this end, we develop such a notion: the Pre-Reflective Situational Self. To do so, we will first show how alternative conceptions of pre-reflective self-awareness point to philosophical problems with the standard phenomenological view. We claim that this is mainly due to fact that within the phenomenological account the mineness aspect is implicitly playing several roles. Consequently, we argue that a thin interpretation of pre-reflective self-awareness—based on a thin notion of mineness—cannot do its needed job within, at least within psychopathology. This leads us to believe that a thicker conception of pre-reflective self is needed. We, therefore, develop the notion of the pre-reflective situational self by analyzing the dynamical nature of the relation between self-awareness and the world, specifically through our interactive inhabitation of the social world. (shrink)

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We are living through a new phase in human development where much of everyday life – at least in the most technologically developed parts of the world – has come to depend upon our interaction with “smart” artefacts. Alongside this increasing adoption and ever-deepening reliance on intelligent machines, important changes have been taking place, often in the background, as to how we think of ourselves and how we conceptualize our relationship with technology. As we design, create and learn to live (...) with a new order of artefacts which exhibit behavior that, were it to be carried out by human beings would be seen as intelligent, the ways in which we conceptualize intelligence, minds, reasoning and related notions such as self and agency are undergoing profound shifts. We argue that the basic background assumptions informing our concepts of mind, and the underlying conceptual scheme structuring our reasoning about minds has recently been transformed in the process. This shift has changed the nature and quality of both our folk understanding of mind, our scientific psychology, and the philosophical problems that the interaction of these realms produce. Many of the traditional problems in the philosophy of mind have become reconfigured in the process. This introduction sets the scene for our book that treats this reconfiguration of our concepts of mind and of technology, and the new casting of philosophical problems this reconfiguration engenders. (shrink)

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According to Enactivism, cognition should be understood in terms of a dynamic interaction between an acting organism and its environment. Further, this view holds that organisms do not passively receive information from this environment, they rather selectively create this environment by engaging in interaction with the world. Radical Enactivism adds that basic cognition does so without entertaining representations and hence that representations are not an essential constituent of cognition. Some proponents think that getting rid of representations amounts to a revolutionary (...) alternative to standard views about cognition. To emphasize the impact, they claim that this ‘radicalization’ should be applied to all enactivist friendly views, including, another current and potentially revolutionary approach to cognition: predictive processing. In this paper, we will show that this is not the case. After introducing the problem, we will argue that ‘radicalizing’ predictive processing does not add any value to this approach. After this, we will analyze whether or not radical Enactivism can count as a revolution within cognitive science at all and conclude that it cannot. Finally, in section 5 we will claim that cognitive science is better off when embracing heterogeneity. (shrink)

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2006 wurde an der Washington University in St.Louis, USA, ein Seminar veranstaltet, das sich mit der Rezeption von Kelsens Lehre in verschiedenen Staaten befasste. Einige der Referenten stellten ihre Beiträge für diesen Band zur Verfügung.

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Over the last decades, Interdisciplinarity (ID) has become one of the leading research practices. Traditionally, cognitive science is considered one of the most prominent examples of ID research by including disciplines such as philosophy, psychology, artificial intelligence (AI), neuroscience, anthropology and linguistics. Recently, however the ID character of cognitive science has become under pressure. According to a study by Leydesdorff and Goldstone (2013), research in this domain gets more and more absorbed by cognitive psychology and the interdisciplinary character of cognitive (...) science is steadily fading away. In this paper, we will examine this claim and argue that its conclusion is premature. We will show that there are reasons to think that the interdisciplinary character of cognitive science is more robust and that the configuration of ID relations may be more dynamic than portrayed by ID skeptics. The reason, or so we will argue, is that ID research is a consequence of the theoretical framework(s) in place, i.e. it is in the nature of ID that fluctuations occur depending on what is held to be the nature of cognition. Our findings are twofold. On the one hand, we will show that the reintegration of cognitive science into cognitive psychology – and with it an approximation towards biology and neuroscience – is, as a matter of fact, the fruit of past ID research. On the other hand, we will demonstrate that novel conceptual frameworks open the possibility for restoring ID relations and foster new ID research. (shrink)

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In recent years, the idea of mind uploading has left the genre of science fiction. Uploading our minds as a form of immortality, or so it has been argued, is now within our reach. Of course, this depends on the assumption that our mind is nothing more than some sort of computer software running on the brain as hardware paving the way for a standard procedure of mind uploading, namely instantaneous destructive uploading – where the brain is simulated on a (...) computer - or gradual destructive uploading – where brain regions are gradually replaced by micro-chips. Lately, however, there has been sustained doubts that things are so simple. In this volume alone Susan Schneider & Joe Corabi and Gualtiero Piccinini argue that a person cannot survive standard procedures of mind uploading. The main reasons are that the uploading process violates identity criteria for the person and that it is unclear that conscious mental states can be uploaded. In this article, we argue that while the sceptics about the standard methods of uploading are probably right, there are more options to be evaluated. We introduce what we call slow continuous mind uploading as an alternative procedure. Slow continuous uploading is based on the extended mind thesis which claims that artefacts can under specific circumstances come to count as part of the realization basis for an individual’s mind. In this context, we explore a form of mind uploading which may already be being innovated today through our deep reliance upon cognitive incorporation of “smart” internet technologies. We will argue that this process may give us the right kind of tools to survive mind uploading, or more minimally, to create an agent that can be considered a psychological continuity of an individual. We think that, at least, the objections so far developed in the literature do not rule this out. (shrink)

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Formal axiology is based on the logical nature of meaning, namely intension, and on the structure of intension as a set of predicates. It applies set theory to this set of predicates. Set theory is a certain kind of mathematics that deals with subsets in general, and of finite and infinite sets in particular. Since mathematics is objective and a priori, formal axiology is an objective and a priori science; and a test based on it is an objective test based (...) on an objective standard.1. (shrink)

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Ethik-Komitees gehören zum festen Bestandteil des Ethikmanagements und der Organisationsethik in klinischen Einrichtungen des Gesundheitswesens. Entsprechende Ethikstrukturen und die damit verbundenen Angebote stoßen hinsichtlich ihrer Wirksamkeit allerdings an ihre Grenzen. Ihre Arbeitsweisen sind häufig reaktiv und eine Verankerung in den entsprechenden Organisationsebenen fehlt. Ausgehend von diesen Limitationen der klinischen Ethikberatung hat sich die multiprofessionelle „Arbeitsgruppe Ethik“ am Universitätsklinikum Tübingen um die Konzeption und Implementierung eines neuen Ansatzes zur nachhaltigen Integration von ethischen Reflexions- und Entscheidungsprozessen auf den Stationen des UKT bemüht. (...) Mit dem Tübinger Modell der Ethikbeauftragten der Station verfolgt sie ein Pilotprojekt, das speziell geschulte Pflegekräfte aus allen Stationen des UKT als AnsprechpartnerInnen für ethische Fragen einsetzt. Damit stellen die Ethikbeauftragten eine Erweiterung zu etablierten Strukturen der Ethikberatung dar und ergänzen vorhandene Top-Down-Strategien. Der vorliegende Beitrag stellt die Zielsetzungen des Tübinger Modells dar und schildert erste Erfahrungen in der Umsetzung. Neben der Einbettung in organisationale Strukturen der Ethikberatung werden die stationsinternen und stationsübergreifenden Aufgaben der Ethikbeauftragten dargestellt. Zudem wird das Qualifikationsprogramm für Ethikbeauftragte sowie ein Train-the-Trainer-Konzept vorgestellt, welche eine vertiefende Entwicklung von pflege- und medizinethischer Kompetenzen unterstützen und Sicherheit in den stationsbezogenen Reflexions- und Entscheidungsprozessen vermitteln. (shrink)

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This book is concerned with Aristotle’s definition of the human capacity for rational thinking (nous) offered in De anima. For Aristotle, nous is the principle, and ultimate explanans, of all the phenomena of human thinking. The book presents an in-depth interpretation of De anima III 4–8 as a single and coherent philosophical argument. More specifically, the book argues for the following views: (i) Rationalism. Humans come to know the world via two fundamentally different cognitive powers: nous and perception. They are (...) fundamentally different cognitive powers because the nature of their corresponding object is fundamentally different; -/- (ii) Essentialism. The human power for thinking is defined as a capacity for directly grasping the essences of everything there is, including itself. It is this very capacity that Aristotle shows to be the principle of all other kinds of human thinking; -/- (iii) Separatism. Human nous is unmixed with the body, has no dedicated bodily organ, and is separable from the body. As a result, it cannot be assimilated to any of the other parts of the soul. While nous belongs to our essence as human beings, it is not part of the natural world; -/- (iv) Embeddedness in the cognitive soul. Human nous is embedded in a cognitive soul. Among other things, this means that the distinctive activity of human nous—thinking—can only take place in the context of a larger set of activities which are common to the body and the soul. (shrink)

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In recent years we have seen the rise of a new framework within the study of the mind, namely Predictive Processing. This framework essentially holds that the brain is a prediction machine constantly postulating perceptual models which are tested against incoming information. At the same time, the notion of the minimal or core self has become very influential as a way of explaining, or explaining away, pre-reflective self-awareness. The four most widely discussed alternatives for thinking through the metaphysical implications the (...) pre-reflective sense of self are the standard phenomenological view, the substance view, the no-self view and by now the relational view. In this paper, it is our objective to rethink the notion of the sense of self in the context of PP. Now, PP is often held to be a unifying framework that offers a new integrated account of perception, cognition, imagination, and indeed the pre-reflective sense of self. We will show, however, that PP has been taken to endorse rather too many different metaphysical accounts of self: that is, views about how we should regard the ultimate nature of self. What we need to do, if possible, is to use PP to constrain the theories on offer. Here we focus upon two central constraints that we think PP implies. These are, the mutability constraint and the multi-layereredness constraint. We argue that self-views laid out in terms of the PP framework are usually – to some degree – located within the four standard metaphysical accounts of self. However, we think that realist versions of self-accounts seem to have more trouble in respecting the PP constraints or requirements. The reason, or so we believe, is PP’s mutability constraint. This does not have to be the case and we, therefore, propose an alternative realist view – namely the pre-reflective situational self view – which is more adequate to fit the PP framework. (shrink)

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Providing the most thorough coverage available in one volume, this comprehensive, broadly based collection offers a wide variety of selections in four major genres, and also includes a section on film. Each of the five sections contains a detailed critical introduction to each form, brief biographies of the authors, and a clear, concise editorial apparatus. Updated and revised throughout, the new Fourth Edition adds essays by Margaret Mead, Russell Baker, Joan Didion, Annie Dillard, and Alice Walker; fiction by Nathaniel Hawthorne, (...) Ursula K. LeGuin, Anton Chekov, James Joyce, Katherine Mansfield, F. Scott Fitzgerald, William Faulkner, Alice Walker, Louise Erdrich, Donald Barthelme, and James McPherson; poems by John Donne,Robert Browning, Walt Whitman, Edwin Arlington Robinson, e.e. cummings, Langston Hughes, W.H. Auden, Philip Levine, and Louise Gluck; and plays by August Wilson, Marsha Norman, Wendy Wasserstein, and Vaclav Havel. The chapter devoted to film examines the relation of film to literature and gives the complete screenplay for Citizen Kane plus close analysis of a scene from the film. With its innovative structure, comprehensive coverage, and insightful and stimulating presentation of all kinds of literature, this is an anthology readers will turn to again and again. (shrink)

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This latest volume of BACAP Proceedings contains some innovative research by international scholars on Plato, Aristotle, and Sophocles. It covers such themes as Plato on the philosopher ruler, and Aristotle on essence and necessity in science. This publication has also been published in paperback, please click here for details.

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This edited book deepens the engagement between 21st century philosophy of mind and the emerging technologies which are transforming our environment. Many new technologies appear to have important implications for the human mind, the nature of our cognition, our sense of identity and even perhaps what we think human beings are. They prompt questions such as: Would an uploaded mind be 'me'? Does our reliance on smart phones, or wearable gadgets enhance or diminish the human mind? and: How does our (...) deep reliance upon ambient artificial intelligence change the shape of the human mind? Readers will discover the best philosophical analysis of what current and near future 21st technology means for the metaphysics of mind. Important questions are addressed on matters relating to the extended mind and the distributed self. Expert authors explore the role that the ubiquitous smart phone might have in creating new forms of self-knowledge. They consider machine consciousness, brain enhancement and smart ambient technology, and what they can tell us about phenomenal consciousness. While ideas of artificial general intelligence, cognitive enhancements and the smart environment are widely commented on, serious analysis of their philosophical implications is only getting started. These contributions from top scholars are therefore very timely, and are of particular relevance to students and scholars of the philosophy of mind, philosophy of technology, computer science and psychology. (shrink)

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Convergence research is driven by specific and compelling problems and requires deep integration across disciplines. The potential of convergence research is widely recognized, but questions remain about how to design, facilitate, and assess such research. Here we analyze a seven-year, twelve-million-dollar convergence project on sustainable climate risk management to answer two questions. First, what is the impact of a project-level emphasis on the values that motivate and tie convergence research to the compelling problems? Second, how does participation in convergence projects (...) shape the research of postdoctoral scholars who are still in the process of establishing themselves professionally? We use an interview-based approach to characterize what the project specifically enabled in each participant’s research. We find that (a) the project pushed participants’ research into better alignment with the motivating concept of convergence research and that this effect was stronger for postdoctoral scholars than for more senior faculty. (b) Postdocs’ self-assessed understanding of key project themes, however, appears unconnected to metrics of project participation, raising questions about training and integration. Regarding values, (c) the project enabled heightened attention to values in the research of a large minority of participants. (d) Participants strongly believe in the importance of explicitly reflecting on values that motivate and pervade scientific research, but they question their own understanding of how to put value-focused science into practice. This mismatch of perceived importance with poor understanding highlights an unmet need in the practice of convergence science. (shrink)

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When developing computational models to analyze the tradeoffs between climate risk management strategies (i.e., mitigation, adaptation, or geoengineering), scientists make explicit and implicit decisions that are influenced by their beliefs, values and preferences. Model descriptions typically include only the explicit decisions and are silent on value judgments that may explain these decisions. Eliciting scientists’ mental models, a systematic approach to determining how they think about climate risk management, can help to gain a clearer understanding of their modeling decisions. In order (...) to identify and represent the role of values, beliefs and preferences on decisions, we used an augmented mental models research approach, namely values-informed mental models (ViMM). We conducted and qualitatively analyzed interviews with eleven climate risk management scientists. Our results suggest that these scientists use a similar decision framework to each other to think about modeling climate risk management tradeoffs, including eight specific decisions ranging from defining the model objectives to evaluating the model’s results. The influence of values on these decisions varied between our scientists and between the specific decisions. For instance, scientists invoked ethical values (e.g., concerns about human welfare) when defining objectives, but epistemic values (e.g., concerns about model consistency) were more influential when evaluating model results. ViMM can (i) enable insights that can inform the design of new computational models and (ii) make value judgments explicit and more inclusive of relevant values. This transparency can help model users to better discern the relevance of model results to their own decision framing and concerns. (shrink)

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Climate risks are growing. Research is increasingly important to inform the design of risk-management strategies. Assessing such strategies necessarily brings values into research. But the values assumed within research (often only implicitly) may not align with those of stakeholders and decision makers. These misalignments are often invisible to researchers and can severely limit research relevance or lead to inappropriate policy advice. Aligning strategy assessments with stakeholders' values requires a holistic approach to research design that is oriented around those values from (...) the start. Integrating values into research in this way requires collaboration with stakeholders, integration across disciplines, and attention to all aspects of research design. Here we describe and demonstrate a qualitative conceptual tool called a values-informed mental model (ViMM) to support such values-centered research design. ViMMs map stakeholders' values onto a conceptual model of a study system to visualize the intersection of those values with coupled natural-human system dynamics. Through this mapping, ViMMs integrate inputs from diverse collaborators to support the design of research that assesses risk-management strategies in light of stakeholders' values. We define a visual language for ViMMs, describe accompanying practices and workflows, and present an illustrative application to the case of flood-risk management in a small community along the Susquehanna river in the Northeast United States. (shrink)

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Traditional eschatology clashes with the theory of entropy. Trying to bridge the gap,Robert John Russell assumes that theology and science are based on contradictory, yet equally valid, metaphysical assumptions, each one capable of questioning and impacting the other. The author doubts that Russell's proposal will convince empirically oriented scientists and attempts to provide a viable alternative. Historical‐critical analysis suggests that biblical future expectations were redemptive responses to changing human needs. Apocalyptic visions were occasioned by heavy suffering in postexilic (...) times. Interpreted in realistic terms, they have since proved to be untenable. The expectation of a new creation without evil, suffering, and death is not constitutive for the substantive content of the biblical message as such. Biblical future expectations must be reconceptualized in terms of best contemporary insight and in line with a dynamic reading of the biblical witness as God's vision of comprehensive optimal well‐being that operates like a shifting horizon and opens up ever new vistas, challenges, and opportunities. (shrink)

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In this paper the author criticizes the wayRobert Alexy reconstructs the relationship between legal and practical reasoning. The core of Alexy's argumentation (Alexy 1978) is considered the claim that legal argumentation is a “special case” of general practical discourse. In order to question this claim, the author analyzes three different types of argument: (1) that legal reasoning is needed by general practical discourse itself, (2) that there are similarities between legal argumentation and general practical discourse, (3) that there (...) is a correspondence between certain types of argument in general practical discourse and in legal argumentation.**. (shrink)

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In lieu of an abstract, here is a brief excerpt of the content:Bibliography of Resources by and about André E. Hellegers*Compiled by Doris Mueller Goldstein (bio)This bibliography is derived from the holdings of the National Reference Center for Bioethics Literature and the BIOETHICSLINE© database (both of which are at the Kennedy Institute of Ethics and supported by the National Library of Medicine); the archives of Lauinger Library, Georgetown University; the Medline databases of the National Library of Medicine; the WorldCat database (...) of OCLC, Dublin, Ohio, and selected Internet sites.Primarily comprised of writings by Dr. Hellegers, the list also includes interviews and media programs in which he participated, as well as writings about him that were written following his death. The arrangement within each section is by date. The 231 authored pieces reflect the transition from Dr. Hellegers’s early career as a researcher in fetal physiology at Johns Hopkins Medical School, where he published his first research report at the age of 29, to the early years of the Kennedy Institute, where he produced so many provocative columns on bioethical issues that influenced the growth of the field.Due to the diversity of sources and the 40-year time span covered, there are some variations in bibliographic style. Time and availability constraints precluded verifying all of the citations with the original documents. Any additions or corrections should be submitted to the compiler.Works Authored by André E. HellegersNo Date Ethical Issues in Sterilization of the Retarded. Unpublished paper.1956Vitamin B12 Serum Level and Pregnancy. American Journal of Clinical Nutrition 4: 440+, 1956. [With Bacon F. Chow and Kunio Okuda] [End Page 89]1957Vitamin B12 Absorption in Pregnancy and in the Newborn. American Journal of Clinical Nutrition 5: 327+, 1957. [With Bacon F. Chow,Robert E. L. Nesbitt, Kunio Okuda, and David W. Smith]1958The Effects of Acute Hypoxia on the Osmotic Pressure of the Plasma. Quarterly Journal of Experimental Physiology 43: 197+, 1958. [With Donald H. Barron, Frederick C. Battaglia, and Giacomo Meschia]Studies on the Absorption of Vitamin B12 in Human Pregnancy with Especial Reference to the Effect of D-Sorbitol. American Journal of Obstetrics and Gynecology 76: 91+, 1958. [With Bacon F. Chow, Harry Prystowsky, and Vernon Wong]1959The Alveolar PCO2 and PO2 in Pregnant and Nonpregnant Women at Altitude. Proceedings of the Society for Clinical Investigation 38: 1010+, 1959. [With Donald Barron, William Huckabee, Giacomo Meschia, James Metcalfe, and Harry Prystowsky]A Comparison of the Oxygen Dissociation Curves of the Bloods of Maternal and Fetal Goats at Various pHs. Quarterly Journal of Experimental Physiology 44: 215–21, July 1959. [With Donald Barron, Giacomo Meschia, Harry Prystowsky, and A. Stark Wolkoff]Fetal Blood Studies. XII. On the Relationship Between the Position of the Oxygen Dissociation Curve of Human Fetal Blood and Adult Fetal Hemoglobin. American Journal of Obstetrics and Gynecology 77: 585+, 1959. [With Paul D. Bruns, Julian Cotter, and Harry Prystowsky]Fetal Blood Studies. XIV. A Comparative Study of the Oxygen Dissociation Curve of Nonpregnant, Pregnant and Fetal Human Blood. American Journal of Obstetrics and Gynecology 78: 489–93, September 1959. [With Paul D. Bruns and Harry Prystowsky]Fetal Blood Studies. XVI. On the Changes in Total Osmotic Pressure and Sodium and Potassium Concentration of Amniotic Fluid During the Course of Human Gestation. Surgery, Gynecology and Obstetrics 109: 509–12, October 1959. [With Frederick Battaglia, Paul D. Bruns, Harry Prystowsky, and Clayton Smisson]Further Observations on the Metabolism of Vitamin B12 in Human Pregnancy. American Journal of Obstetrics and Gynecology 77: 1+, 1959. [With Bacon F. Chow, Harry Prystowsky, Bruno Ranke, and Elma Ranke]The Oxygen Dissociation Curves of the Bloods of Adult and Fetal Llamas. Federation Proceedings 18, 1959. [With Donald Barron, William Huckabee, Giacomo Meschia, James Metcalfe, and Harry Prystowsky] [End Page 90]Transfer of Oxygen Across the Sheep Placenta at High Altitude. Federation Proceedings 18, 1959. [With Donald Barron, William Huckabee, Giacomo Meschia, and Harry Prystowsky]Uterine Blood Flow and Metabolism in Pregnant Sheep at High Altitude. Federation Proceedings 18, 1959. [With Donald Barron, William Huckabee, Giacomo Meschia, James Metcalfe, and Harry Prystowsky]Uterine Blood Flow and Metabolism in Unanesthetized Pregnant Sheep. Federation Proceedings 18, 1959. [With Donald Barron, William Huckabee, Giacomo... (shrink)

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We provide an overview of a transdisciplinary project about sustainable forest management under climate change. Our project is a partnership with members of the Menominee Nation, a Tribal Nation located in northern Wisconsin, United States. We use immersive virtual experiences, translated from ecosystem model outcomes, to elicit human values about future forest conditions under alternative scenarios. Our project combines expertise across the sciences and humanities as well as across cultures and knowledge systems. Our management structure, governance, and leadership behaviors have (...) both fostered and constrained our work and must be continuously responsive to changing group dynamics. Our project presents opportunities for substantial contributions to society, including insights and knowledge about complementary ways of knowing, skills training, and professional development, and opportunities for reflexive learning about effective transdisciplinary, translational, and transformative scientific processes. (shrink)

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Regular musical activity as a complex multimodal lifestyle activity is proposed to be protective against age-related cognitive decline and Alzheimer’s disease. This cross-sectional study investigated the association and interplay between musical instrument playing during life, multi-domain cognitive abilities and brain morphology in older adults from the DZNE-Longitudinal Cognitive Impairment and Dementia Study study. Participants reporting having played a musical instrument across three life periods were compared to controls without a history of musical instrument playing, well-matched for reserve proxies of education, (...) intelligence, socioeconomic status and physical activity. Participants with musical activity outperformed controls in global cognition, working memory, executive functions, language, and visuospatial abilities, with no effects seen for learning and memory. The musically active group had greater gray matter volume in the somatosensory area, but did not differ from controls in higher-order frontal, temporal, or hippocampal volumes. However, the association between gray matter volume in distributed frontal-to-temporal regions and cognitive abilities was enhanced in participants with musical activity compared to controls. We show that playing a musical instrument during life relates to better late-life cognitive abilities and greater brain capacities in OA. Musical activity may serve as a multimodal enrichment strategy that could help preserve cognitive and brain health in late life. Longitudinal and interventional studies are needed to support this notion. (shrink)

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Background: Although convolutional neural networks (CNNs) achieve high diagnostic accuracy for detecting Alzheimer’s disease (AD) dementia based on magnetic resonance imaging (MRI) scans, they are not yet applied in clinical routine. One important reason for this is a lack of model comprehensibility. Recently developed visualization methods for deriving CNN relevance maps may help to fill this gap as they allow the visualization of key input image features that drive the decision of the model. We investigated whether models with higher accuracy (...) also rely more on discriminative brain regions predefined by prior knowledge. Methods: We trained a CNN for the detection of AD in N = 663 T1-weighted MRI scans of patients with dementia and amnestic mild cognitive impairment (MCI) and verified the accuracy of the models via cross-validation and in three independent samples including in total N = 1655 cases. We evaluated the association of relevance scores and hippocampus volume to validate the clinical utility of this approach. To improve model comprehensibility, we implemented an interactive visualization of 3D CNN relevance maps, thereby allowing intuitive model inspection. Results: Across the three independent datasets, group separation showed high accuracy for AD dementia versus controls (AUC ≥ 0.91) and moderate accuracy for amnestic MCI versus controls (AUC ≈ 0.74). Relevance maps indicated that hippocampal atrophy was considered the most informative factor for AD detection, with additional contributions from atrophy in other cortical and subcortical regions. Relevance scores within the hippocampus were highly correlated with hippocampal volumes (Pearson’s r ≈ −0.86, p< 0.001). Conclusion: The relevance maps highlighted atrophy in regions that we had hypothesized a priori. This strengthens the comprehensibility of the CNN models, which were trained in a purely data-driven manner based on the scans and diagnosis labels. The high hippocampus relevance scores as well as the high performance achieved in independent samples support the validity of the CNN models in the detection of AD-related MRI abnormalities. The presented data-driven and hypothesis-free CNN modeling approach might provide a useful tool to automatically derive discriminative features for complex diagnostic tasks where clear clinical criteria are still missing, for instance for the differential diagnosis between various types of dementia. (shrink)

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In his essay Tracy Lupher (henceforth, TL) is concerned withRobert Kane's (1984) version of the modal ontological argument (MOA). As he correctly points out, Kane's argument is valid only if the accessibility relation between possible worlds is assumed to be symmetric. TL's remarks pave the way to thinking that the MOA is intended to establish the existence of a perfect being as a matter of logical necessity. Moreover, given TL's undisputed supposition (even shared by Kane) that S5 - (...) in which the accessibility relation is symmetric - captures the notion of logical necessity, the real issue becomes whether the premise of the MOA is true. Contrary to TL's main claim, the discussion thus shifts back from technical arguments for why the appropriate modal logic must have a symmetric accessibility relation to metaphysical, theological, or conceptual considerations about the notion of a perfect being itself. I argue that it is only due to such considerations that we even start to ponder the question of what modal logic is the appropriate one to choose. (shrink)

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Child psychologist Mallory James returns to Moonglade, the Australian plantation where she was raised, to care for her beloved uncleRobert, who has had a heart attack. Having left the area years earlier after being betrayed by her fiancâe, Jason Cartwright, Mallory is shocked and dismayed to find that Jason and his decidedly disturbed twin sister, Jessica, have been hired on at her uncle's estate. Her longtime friend and occasional adversary, Blaine Forrester, is also nearby. As Mallory settles back (...) into her old home, she can't help but begin to love Jason's feisty young daughter, Ivy. She and Blaine begin to wander down the path of romance, but it's obvious that their happiness won't come easily. (shrink)

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We present a one per cent measurement of the cosmic distance scale from the detections of the baryon acoustic oscillations in the clustering of galaxies from the Baryon Oscillation Spectroscopic Survey, which is part of the Sloan Digital Sky Survey III. Our results come from the Data Release 11 sample, containing nearly one million galaxies and covering approximately 8500 square degrees and the redshift range 0.2< z< 0.7. We also compare these results with those from the publicly released (...) DR9 and DR10 samples. Assuming a concordance Λ cold dark matter cosmological model, the DR11 sample covers a volume of 13 Gpc3 and is the largest region of the Universe ever surveyed at this density. We measure the correlation function and power spectrum, including density-field reconstruction of the BAO feature. The acoustic features are detected at a significance of over 7σ in both the correlation function and power spectrum. Fitting for the position of the acoustic features measures the distance relative to the sound horizon at the drag epoch, rd, which has a value of rd,fid = 149.28 Mpc in our fiducial cosmology. We find DV = at z = 0.32 and DV = at z = 0.57. At 1.0 per cent, this latter measure is the most precise distance constraint ever obtained from a galaxy survey. Separating the clustering along and transverse to the line of sight yields measurements at z = 0.57 of DA = and H =. Our measurements of the distance scale are in good agreement with previous BAO measurements and with the predictions from cosmic microwave background data for a spatially flat CDM model with a cosmological constant. © 2014 The Author Published by Oxford University Press on behalf of the Royal Astronomical Society. (shrink)

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Jerry Fodor has consistently cited the persistence of illusions--especially the M.

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