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The Ontology for Biomedical Investigations (OBI) is an ontology that provides terms with precisely defined meanings to describe all aspects of how investigations in the biological and medical domains are conducted. OBI re-uses ontologies that provide a representation of biomedical knowledge from the Open Biological and Biomedical Ontologies (OBO) project and adds the ability to describe how this knowledge was derived. We here describe the state of OBI and several applications that are using it, such as adding semantic expressivity to (...) existing databases, building data entry forms, and enabling interoperability between knowledge resources. OBI covers all phases of the investigation process, such as planning, execution and reporting. It represents information and material entities that participate in these processes, as well as roles and functions. Prior to OBI, it was not possible to use a single internally consistent resource that could be applied to multiple types of experiments for these applications. OBI has made this possible by creating terms for entities involved in biological and medical investigations and by importing parts of other biomedical ontologies such as GO, Chemical Entities of Biological Interest (ChEBI) and Phenotype Attribute and Trait Ontology (PATO) without altering their meaning. OBI is being used in a wide range of projects covering genomics, multi-omics, immunology, and catalogs of services. OBI has also spawned other ontologies (Information Artifact Ontology) and methods for importing parts of ontologies (Minimum information to reference an external ontology term (MIREOT)). The OBI project is an open cross-disciplinary collaborative effort, encompassing multiple research communities from around the globe. To date, OBI has created 2366 classes and 40 relations along with textual and formal definitions. The OBI Consortium maintains a web resource providing details on the people, policies, and issues being addressed in association with OBI. (shrink)

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A comprehensive treatment of the concept of causation in evolutionary biology that makes clear its central role in both historical and contemporary debates. Most scientific explanations are causal. This is certainly the case in evolutionary biology, which seeks to explain the diversity of life and the adaptive fit between organisms and their surroundings. The nature of causation in evolutionary biology, however, is contentious. How causation is understood shapes the structure of evolutionary theory, and historical and contemporary debates in evolutionary biology (...) have revolved around the nature of causation. Despite its centrality, and differing views on the subject, the major conceptual issues regarding the nature of causation in evolutionary biology are rarely addressed. This volume fills the gap, bringing together biologists and philosophers to offer a comprehensive, interdisciplinary treatment of evolutionary causation. Contributors first address biological motivations for rethinking evolutionary causation, considering the ways in which development, extra-genetic inheritance, and niche construction challenge notions of cause and process in evolution, and describing how alternative representations of evolutionary causation can shed light on a range of evolutionary problems. Contributors then analyze evolutionary causation from a philosophical perspective, considering such topics as causal entanglement, the commingling of organism and environment, and the relationship between causation and information. Contributors John A. Baker, Lynn Chiu, David I. Dayan, Renée A. Duckworth, Marcus W Feldman, Susan A. Foster, Melissa A. Graham, Heikki Helanterä,Kevin N. Laland, Armin P. Moczek, John Odling-Smee, Jun Otsuka, Massimo Pigliucci, Arnaud Pocheville, Arlin Stoltzfus, Karola Stotz, Sonia E. Sultan, Christoph Thies, Tobias Uller, Denis M. Walsh, Richard A. Watson. (shrink)

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Sixty‐one million Americans and approximately a billion people worldwide live with some form of disability that limits one or more major life activities. The field of precision medicine continues to grapple with how to best serve disability communities. In this paper, we suggest that precision medicine faces an ethical tension between its goal to treat or cure disabling conditions and views that consider disability as a marginalized identity. We appeal to the concepts of recognition justice and distributive justice to argue (...) that the ELSI community should take a more proactive role in promoting disability inclusion in precision medicine's practice and research. We also highlight two priorities for the ELSI community moving forward: facilitating greater collaboration between genetics and genomic professionals and disability communities and advocating for inclusive research design and disability accommodations in the research process. (shrink)

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This collection brings together cutting-edge research on the metaphysics of human nature and soul-body dualism.Kevin Corcoran's collection, Soul, Body, and ...

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Thinking about truth can be more dangerous than it looks. Of course, our concept of truth is the source of one of the most frustrating and impenetrable paradoxes humans have ever contemplated, the liar paradox, but that is just the beginning of its treachery. In an effort to understand why one of the most beloved and revered members of our conceptual repertoire could cause us so much trouble, philosophers have for centuries proposed “solutions” to the liar paradox. However, it seems (...) that our concept of truth takes offense to our efforts to understand it because it appears to retaliate against those who propose “solutions” to the liar. It takes its revenge on us by creating new paradoxes from our own attempts to find resolution. That is, most proposed solutions to the liar paradox give rise to new, more insidious paradoxes—often called revenge paradoxes. For our attempts at understanding, truth rewards us with inconsistent theories, untenable logics, and a deep feeling of bewilderment. It is as if our concept of truth lashes out at us because it wants to remain a mystery. After a few run-ins with truth, many philosophers have the good sense to keep their distance. Far from being the serene, profound concept most people take it to be, those of us who think much about the liar paradox know truth to be a vengeful bully—a conceptual misanthrope. (shrink)

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Sports such as surfing, mountaineering, and backcountry skiing are often grouped together. But what exactly it is that they share, and the implications of their common characteristics, have not been explained clearly. I refer to such sports as ‘nature sports’ and argue that they share a fundamental structure in which human beings and features of the natural world are brought together. The principal claim I make is that nature sports are those sports in which a particular natural feature, or combination (...) of natural features, plays at least one of the primary roles that human competitors or partners play in traditional or standard sports. This article is a detailed explanation of that claim. (shrink)

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I provide a method of measuring the inconsistency of a set of sentences from 1-consistency, corresponding to complete consistency, to 0-consistency, corresponding to the explicit presence of a contradiction. Using this notion to analyze the lottery paradox, one can see that the set of sentences capturing the paradox has a high degree of consistency (assuming, of course, a sufficiently large lottery). The measure of consistency, however, is not limited to paradoxes. I also provide results for general sets of sentences.

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'if AI is outside your field, or you know something of the subject and would like to know more then Artificial Intelligence: The Basics is a brilliant primer.' - Nick Smith, Engineering and Technology Magazine November 2011 Artificial Intelligence: The Basics is a concise and cutting-edge introduction to the fast moving world of AI. The authorKevin Warwick, a pioneer in the field, examines issues of what it means to be man or machine and looks at advances in robotics (...) which have blurred the boundaries. Topics covered include: how intelligence can be defined whether machines can 'think' sensory input in machine systems the nature of consciousness the controversial culturing of human neurons. Exploring issues at the heart of the subject, this book is suitable for anyone interested in AI, and provides an illuminating and accessible introduction to this fascinating subject. (shrink)

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Many philosophers of sport maintain that athletics can contribute to our understanding of ourselves and the environments in which we live. It may be relatively easy to offer accounts of how athletes might acquire self-knowledge through sport; however, it is far more difficult to see how sport could add to the general understanding of human individuals, cultural frameworks or the material world. The study of sport as a way of worldmaking is helpful in understanding how sport can contribute to the (...) pursuit of knowledge in such areas. The position I present is based on arguments made by Gunter Gebauer in his 1993 presidential address to the Philosophic Society for the Study of Sport, 'Sport, theater, and ritual: Three ways of worldmaking', and in my explanation and interpretation of Gebauer's position, I rely heavily on Nelson Goodman's Ways of worldmaking . Gebauer's work is focused on traditional sports, and he argues that such sports create worlds that represent fundamental attitudes and values of the cultures that produce them. I argue that alternative sports are well suited to create new and original worlds that instantiate value systems in opposition to mainstream culture. I argue further that nature sports such as climbing and surfing represent relationships between humans and natural features, and that such sports, as a subcategory of alternative sports, are in a position to create new and original frameworks that can help us to better comprehend our relationships with natural environments. (shrink)

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Russell McCutcheon is one of the foremost proponents of what he calls “the critical study of religion,” that is, the shift to reflect critically on the concepts used in the academic study of religion, who invented them, and why. The critical study of religion leads to the realization that the concepts with which we think were invented by particular people, at a particular historical location, for a particular purpose. What are the philosophical implications of this? McCutcheon defends a debunking or (...) non-realist answer and contrasts this with my realist approach, and he is right to do so. This paper argues that those involved in the critical study of religion therefore face a choice between a non-realist and a realist metaphysics, that McCutcheon’s arguments against realism fail, and that those who wish to offer any kind of materialist account in which religious social structures shape human agency and subjectivity should adopt a critical study of religion that is also realist. (shrink)

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In today's business world, ethics is not simply a peripheral concern of executive boards or a set of supposed constraints on free enterprise. Ethics stands at the very core of our working lives and of society as a whole, defining the public image of the business community and the ways in which individual companies and people behave. What people do at work--and how they think about work--determines their attitudes and aspirations, affecting and even structuring their personal lives and habits. Working (...) from this premise, Honest Work: A Business Ethics Reader provides a practical overview of business ethics that concentrates on the ethical problems and dilemmas students are most likely to face in their prospective work environments. Classic and recent articles and cases cover a broad spectrum of issues and concerns--from private ethical dilemmas to larger considerations of corporate values--and propose guidelines for thinking about the business world in a moral context. Each reading and case is followed by lively questions for discussion. Offering a welcome alternative to the impersonal tone of most business ethics texts, the editors address students in an appealing and conversational manner. They provide engaging chapter introductions that include personal narratives and also present the ideas of great philosophers in a unique way--as emails. Ideal for introductory undergraduate and MBA courses in business ethics, Honest Work: A Business Ethics Reader can be read as a coherent narrative but also offers instructors great flexibility, as its various chapters, readings, and cases can be pursued in almost any order. A Companion Website featuring chapter objectives and summaries, study questions, self-tests, and off-site links of interest will soon be available. An Instructor's Manual with Test Bank is available to adopters. (shrink)

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A non-technical guide to some of the popular methods and tests for assessing how well students are acquiring critical thinking skills in their courses, programs, or college careers.

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In Morals by Agreement David Gauthier proposes four criteria for classifying a society's advancement toward ‘higher stages of human development.' Significantly, these criteria — material well-being, breadth of opportunity, average life-span, and density of population — do not include as an equally valuable achievement the society's capacity to sustain its standard of living. Nonetheless Gauthier presents three arguments intended to show that a community founded on his distributive theory will view depletionary resource policies as unreasonable and unacceptable. I shall contend (...) that these arguments do not succeed in motivating sustainable rates of resource exploitation. Furthermore, I argue that if truly just and rational resource use policies can be arrived at, such policies could only succeed by employing a conception of property rights substantially different from Gauthier's. (shrink)

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One of the most interesting challenges facing paleobiologists is explaining the Cambrian explosion, the dramatic appearance of most metazoan animal phyla in the Early Cambrian, and the subsequent stability of these body plans over the ensuing 530 million years. We propose that because phenotypic variation decreases through geologic time, because microRNAs (miRNAs) increase genic precision, by turning an imprecise number of mRNA transcripts into a more precise number of protein molecules, and because miRNAs are continuously being added to metazoan genomes (...) through geologic time, miRNAs might be instrumental in the canalization of development. Further, miRNAs ultimately allow for natural selection to elaborate morphological complexity, because by reducing gene expression variability, miRNAs increase heritability, allowing selection to change characters more effectively. Hence, miRNAs might play an important role in shaping metazoan macroevolution, and might be part of the solution to the Cambrian conundrum. (shrink)

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Kevin Mulligan; VI*—Justification, Rule-breaking and the Mind1, Proceedings of the Aristotelian Society, Volume 99, Issue 1, 1 June 1999, Pages 123–140, https:/.

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With a few exceptions, F.H. Bradley has become a forgotten figure in the history of philosophy. I argue that Bradley’s thoughts on relations are at least relevant to assessing the status of nonreductive physicalism as a comprehensive metaphysic and, moreover, that they can be seen to raise some nontrivial challenges to nonreductive physicalism so understood. In pursuing this line of thought, I consider two of Bradley’s regresses in Appearance and Reality – the better-known “chain” regress and the lesser known “fission” (...) regress – and explain their relevance to nonreductive physicalism. (shrink)

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I consider three aspects in which machine learning and philosophy of science can illuminate each other: methodology, inductive simplicity and theoretical terms. I examine the relations between the two subjects and conclude by claiming these relations to be very close.

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Leading archaeologists and historians provide new studies of slavery, slave resistance and the economic, environmental and political consequences of slave trading in Africa, from the first millennium AD through to the nineteenth century.

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McGovern,Kevin Benedict XVI released his third encyclical on 29 June 2009. Its Latin title is 'Caritas in Veritate;' its English title is 'On Integral Human Development in Charity and Truth.' This article explores the significant teachings of this encyclical.

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Ever since, while continuing to develop his liguistic theories, he has been the most prominent US critic both of his country's foreign policy and of the intellectuals and media that give it overwhelming consensual support. "The Responsibility of Intellectuals" was followed by a series of ever more devastating attacks on American policy in Vietnam (collected in American Power and the New Mandarins and At War With Asia ): by 1970, he was far and away the best known intellectual opponent of (...) the US war effort. (shrink)

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This article explores issues surrounding celibacy that have been amplified by the exposure of the sexual abuse crisis within the Catholic Church, which, for some, has called such a lifestyle into question. Taking the view that celibacy can be healthy and life-giving, provided that it is discerned well, the authors consider the ways in which an unintegrated celibate life can and does cause harm and has contributed to the scandal, though not the cause of it in and of itself. Moreover, (...) when celibacy is a gift of the Spirit, it can help to bring about a renewed, deepened understanding of sexuality needed for the Church and the world. (shrink)

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In his recent _The Parmenidean Ascent_, Michael Della Rocca develops a regress-theoretic case, reminiscent of F. H. Bradley’s famous argument in _Appearance and Reality_, against the intelligibility of relations and in favor of a monistic conception of reality. I argue that Della Rocca illicitly supposes that “internal” relations — in one sense of that word — lead to a “chain” regress, a regress of relations relating relations and relata. In contrast, I contend that if “internal” or grounded relations lead to (...) a regress at all, it is a kind of “fission” regress within the relata themselves, and that a chain regress for relations only arises, if at all, for so-called “external” relations, relations not grounded in their relata. In this way, I contend that Della Rocca pursues a regress for so-called “internal” or grounded relations that only arise, if at all, for so-called “external” relations, relations not grounded in their relata. I compare Della Rocca’s case against relations with Bradley’s reasoning in _Appearance and Reality_ and suggest in this context that Bradley may, perhaps, have the upper hand. (shrink)

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Thomas Lynch has proposed that scholars of religion can profitably follow Sally Haslanger’s lead and treat “religion,” as she treats race, as a social construction. He argues that this proposal resembles my treatment of “religion” in Philosophy and the Study of Religions, but it goes further by treating “religion” as what Haslanger calls a strongly pragmatic social construction, that is, a category that is solely the product of the use of the concept and which does not capture any feature in (...) the world. In this response, I clarify that this argument can be made in a way that is stronger and closer to that of Haslanger if one adopts the position she calls “promiscuous realism.”. (shrink)

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The topic of conductive arguments, as a separate category of reasoning, is experiencing a revival. In 2010, the University of Windsor’s Centre for Research in Reasoning, Argumentation, and Rhetoric dedicated a two-day symposium to the topic and recently published the proceedings. In this article, I argue against the existence of conductive arguments as a distinct type and argue against a popular analysis of the structure of conductive arguments.

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In lieu of an abstract, here is a brief excerpt of the content:Journal of the History of Philosophy 38.2 (2000) 221-238 [Access article in PDF] Hume's Iterative Probability Argument: A Pernicious ReductioKevin Meeker University of South Alabama In this essay I want to look afresh at David Hume's iterative probability argument, found in the section entitled "Of Scepticism with regard to Reason" in his A Treatise of Human Nature.1 Interestingly enough, after years of comparative neglect,2 this argument has (...) been basking in the glow of scholarly sunshine lately.3 But to what can we attribute its extended hiatus? The convergence of three major factors seems responsible. First, philosophers have oftentimes flung this argument into the ocean of obscurity because of its perceived inadequacies.4 Second, and on a related note, many assume that Hume himself permitted this argument to drown because it never resurfaces again in his writings. Most suspiciously, Hume's Enquiry Concerning Human Understanding, which is his popular (and preferred) presentation of the epistemological sections [End Page 221] of the Treatise, does not contain this argument.5 Last, but certainly not least, for a long time this argument sat uncomfortably with the naturalist interpretation of Hume6 that has gained ascendancy in the twentieth century. For prior to this century, Hume was almost unanimously regarded as a sceptic. Despite a few waves from those who interpreted Hume as a logical positivist earlier in this century, Norman Kemp Smith charted a new course for Humean interpretations with his emphasis on Hume's naturalism.7 And this is the current according to which most Hume interpreters set their sails today.Because the naturalist reading of Hume relies so heavily on the system he attempts to set forth in the Treatise, though, naturalists have come to see the importance of reading this argument in a naturalistically acceptable way. William E. Morris best expresses the significance of this argument from a naturalistic perspective in the following manner: If we ever are to understand Hume's view of the role of reason, it stands to reason that we should first figure out how to integrate "Of scepticism with regard to reason" into the picture. Only then will we be ready to move to a consideration of Hume's positive views about reason. These views are the least understood of any of Hume's doctrines. Gaining an adequate understanding of them is both the most pressing and the most difficult problem facing Hume studies today.8While I agree with Morris about the importance of getting a clear understanding of the reasoning of I, iv, 1, I will argue that a correct reading of this section reveals the implausibility of major naturalistic interpretations of Hume.This paper has four major sections. In the first important section, I will highlight the crucial aspects of the iterative argument that will be the focus of this paper and deal with a preliminary but important interpretive issue. In the second section, I will briefly look at Annette Baier's naturalistic reading of Hume's philosophy to show how this particular passage bears on broader [End Page 222] interpretive issues. The third main section will focus on explicating Morris' similar but more detailed interpretation. Finally in the last part I will show that while it is legitimate to characterize the argument here as a reductio (as Baier and Morris both do), the argument still yields, contrary to what naturalists have recently suggested, a very sceptical conclusion. 1. The Arguments of Section I, IV, 1 of the TreatiseHume's "Of Scepticism with regard to Reason" contains at least two important arguments. While Hume agrees that knowledge involves certainty (whereas beliefs based on probability are by their very nature uncertain9 ), the conclusion of his first argument is that "all knowledge resolves itself into probability" (Treatise, 181). His point here is simply that all of our beliefs are fallible. That is, nothing is absolutely certain; thus none of our beliefs attain the exalted status of certain knowledge. But once this consequence of our fallibility is recognized, he then argues roughly that the probability that any particular belief... (shrink)

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With a few exceptions, F. H. Bradley has become a forgotten figure in the history of philosophy. The author argues that Bradley's thoughts on relations are at least relevant to assessing the status of nonreductive physicalism as a comprehensive metaphysic and, moreover, that they can be seen to raise some nontrivial challenges to nonreductive physicalism so understood. In pursuing this line of thought, he considers two of Bradley's regresses in Appearance and Reality —the better known "chain" regress and the lesser (...) known "fission" regress—and explains their relevance to nonreductive physicalism. (shrink)

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The categorical imperative inherent in Kant’s ethics has had indubitable historical influence on societies worldwide whether in the form of laws, democracy or public deliberation. The Toronto Van Attack of 2018 and its subsequent legal trial is a case example that shows how the categorical imperative can be applied to assist in understanding the reasoning for the case’s guilty verdict. This paper will convey the applicability of the categorical imperative for examining criminal case studies by closing the gap between ethical (...) theory and practice. Such closure will be shown to assist in understanding why a perpetrator of a crime can be found guilty of following a hypothetical imperative to base their actions. The rationale for the verdict in this case will be shown to be based on the perpetrator’s responsibility in the form of maintaining autonomy despite having an autism diagnosis. The perpetrator will be shown to have acted on an irrational will and yet was treated in the legal sense as a rational individual. Such rationality was maintained despite complications with their autonomy in the form of relativism and ethical solipsism. (shrink)

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The Watson-Glaser Critical Thinking Appraisal Test is one of the oldest, most frequently used, multiple-choice critical-thinking tests on the market in business, government, and legal settings for purposes of hiring and promotion. I demonstrate, however, that the test has serious construct-validity issues, stemming primarily from its ambiguous, unclear, misleading, and sometimes mysterious instructions, which have remained unaltered for decades. Erroneously scored items further diminish the test’s validity. As a result, having enhanced knowledge of formal and informal logic could well result (...) in test subjects receiving lower scores on the test. That’s not how things should work for a CT assessment test. (shrink)

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L'enseignement viennois de Brentano a faconne les philosophies exactes du XXe siecle, au travers de ses eleves Husserl, Meinong, Twardowski, Stumpf, Ehrenfels ou Marty. Si la theorie de l'intentionnalite, l'ontologie et la logique de Brentano ont fait l'objet de discussions approfondies, son anatomie d'une grande variete d'actes mentaux - choisir, hair, juger, percevoir, preferer, remarquer, savoir, sentir, souffrir, toucher, voir - demeure encore trop ignoree. Ce livre est consacre a cette analyse descriptive minutieuse et foisonnante. Outre son interet historique, celle-ci (...) permet de renouveler bon nombre de debats contemporains en philosophie des emotions, en epistemologie, en philosophie du langage, ainsi qu'en philosophie de l'esprit. (shrink)

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We further develop the mathematical theory of causal interventions, extending earlier results of Korb, Twardy, Handfield, & Oppy, (2005) and Spirtes, Glymour, Scheines (2000). Some of the skepticism surrounding causal discovery has concerned the fact that using only observational data can radically underdetermine the best explanatory causal model, with the true causal model appearing inferior to a simpler, faithful model (cf. Cartwright, (2001). Our results show that experimental data, together with some plausible assumptions, can reduce the space of viable explanatory (...) causal models to one. (shrink)

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We argue that for theorists with a post-institutional conception of property, e.g., Rawlsians, there is no principled reason to limit the domain of distributive justice to tax and transfer-both tax policy and the rules of the private law are constructed in service to distributive aims. Such theorists cannot maintain a commitment to a normative conception of private law independent of their overarching distributive principles. In contrast, theorists with a pre-institutional conception of property can derive the private law from sectors of (...) morality independent of distributive justice. Nevertheless, we argue, this does not entail that the private law, for pre-institutional theorists, must be sanitized of equity-oriented values. Non-libertarian pre-institutional theorists holding principled commitments to equity-oriented values are free to invoke either tax and transfer or the rules of the private law to attain them. Footnotesa We are grateful to John G. Bennett, Harry Dolan, Edward McCaffery, and Ellen Frankel Paul for written comments on a previous draft and to Eric Mack, Fred Miller, Jeffrey Paul, A. John Simmons, and the other contributors to this volume for valuable discussions. (shrink)

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The conflict between aesthetic experience and the modern vision of the world frames aesthetic experience as a defender of the plurality derived from the perspectives of individuals. This signifies that aesthetic experience confronts the unilateralism of modernity’s vision. This article propounds that this role of aesthetic experience is based on its defense of subjectivity and individuality. This defense, when investigated, reveals the compatibility between phenomenology and pragmatism. This compatibility also demonstrates that aesthetic experience should be understood as a phenomenological experience. (...) Therefore, phenomenology and pragmatism reveal a comradery that permits them to work in tandem, defending subjectivity and pluralism in the face of modernity. (shrink)

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Human beings working in fields involving life, death, and morality are going to have fundamental and occasionally irreconcilable differences of opinion regarding goals, values, and actions. This has been true from the beginning of civilization. Along the way, civilized peoples have created laws that accommodate these differences so that a diverse population can coexist peaceably in one pluralistic society. As such, the Law is the practical, inchoate expression of that society's combined morals.For more than a decade, scholarly articles about conscientious (...) objection in medical care have tended to involve one group of people telling other groups what they must value and how they must behave in order to be good... (shrink)

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Since its publication in the year 2000, M. Cathleen Kaveny’s article “Appropriation of Evil: Cooperation’s Mirror Image” has had a notable influence upon several scholars who appear to agree with its central argument— namely, that the theory of cooperation with evil needs to be supplemented by a concept that Kaveny calls “appropriation.” The main point of the present article is that Kaveny misrepresents the traditional theory regarding cooperation with evil and that appropriation, as she understands it, is therefore not the (...) mirror image of cooperation, although it is granted that Kaveny mentions cases that the traditional theory of cooperation with evil is unsuited to deal with—and that they need to be dealt with. (shrink)

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I present two measures of information for both consistentand inconsistent sets of sentences in a finite language ofpropositional logic. The measures of information are based onmeasures of inconsistency developed in Knight (2002).Relative information measures are then provided corresponding to thetwo information measures.

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