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© 2017. The American Astronomical Society. All rights reserved.We present new observations of the low-mass companion to HD 984 taken with the Gemini Planet Imager as a part of the GPI Exoplanet Survey campaign. Images of HD 984 B were obtained in the J and H bands. Combined with archival epochs from 2012 and 2014, we fit the first orbit to the companion to find an 18 au orbit with a 68% confidence interval between 14 and 28 au, an eccentricity (...) of 0.18 with a 68% confidence interval between 0.05 and 0.47, and an inclination of 119°with a 68% confidence interval between 114°and 125°. To address the considerable spectral covariance in both spectra, we present a method of splitting the spectra into low and high frequencies to analyze the spectral structure at different spatial frequencies with the proper spectral noise correlation. Using the split spectra, we compare them to known spectral types using field brown dwarf and low-mass star spectra and find a best-fit match of a field gravity M6.5 ±1.5 spectral type with a corresponding temperature of K. Photometry of the companion yields a luminosity of log=2.88 ± 0.07 dex with DUSTY models. Mass estimates, again from DUSTY models, find an age-dependent mass of 34 ±1 to 95 ±4 M Jup. These results are consistent with previous measurements of the object. (shrink)

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The collapse of the Saddam regime in March 2003 saw the publication of a number of articles or more encompassing works devoted to the situation of the Christian communities in Iraq. The majority of these focus on ecclesiastical issues and much less on political developments. However, it is clear that it would be artificial to separate the religious from the political: some religious leaders actively participate in the political debate and express views on the ethnic profile of their community, which (...) has consequences for the role they want their communities to play in the Iraqi society. The present article tries to describe and understand some political developments, focusing on three interrelated themes: the divided political landscape, the position of the Christians in Kurdistan and their relations with the Kurdish Regional Government and the Central Federal Government and the discussion on political and cultural “autonomy” for the Christian communities and the creation of a Christian “homeland”. (shrink)

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BackgroundHuman infection studies (HIS) are valuable in vaccine development. Deliberate infection, however, creates challenging questions, particularly in low and middle-income countries (LMICs) where HIS are new and ethical challenges may be heightened. Consultation with stakeholders is needed to support contextually appropriate and acceptable study design. We examined stakeholder perceptions about the acceptability and ethics of HIS in Malawi, to inform decisions about planned pneumococcal challenge research and wider understanding of HIS ethics in LMICs.MethodsWe conducted 6 deliberative focus groups and 15 (...) follow-up interviews with research staff, medical students, and community representatives from rural and urban Blantyre. We also conducted 5 key informant interviews with clinicians, ethics committee members, and district health government officials.ResultsStakeholders perceived HIS research to have potential population health benefits, but they also had concerns, particularly related to the safety of volunteers and negative community reactions. Acceptability depended on a range of conditions related to procedures for voluntary and informed consent, inclusion criteria, medical care or support, compensation, regulation, and robust community engagement. These conditions largely mirror those in existing guidelines for HIS and biomedical research in LMICs. Stakeholder perceptions pointed to potential tensions, for example, balancing equity, safety, and relevance in inclusion criteria.ConclusionsOur findings suggest HIS research could be acceptable in Malawi, provided certain conditions are in place. Ongoing assessment of participant experiences and stakeholder perceptions will be required to strengthen HIS research during development and roll-out. (shrink)

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What explains the unexpected, uneven, but unquestionably pervasive trend toward re-familialization in the rich OECD countries? The usual arguments about political responses to rising income inequality, unstable families, and unstable employment predicted that the state would increasingly shelter people against risk, producing greater individuation and de- rather than re-familialization. By contrast, we argue three things. First, re-familialization has replaced de-familialization. Second, unequal access to housing drives a large part of re-familialization. Rather than becoming more “Anglo-Nordic,” countries are becoming more “southern (...) European” in the way that younger cohorts access housing. Third, this inequality-driven insecurity and unequal access is felt differently not only between generational cohorts but also within cohorts. (shrink)

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Reply to article 'Political Perception and Ensemble of Macro Objectives and Measures: The Paradox of the Index for Sustainable Economic Welfare' by Rafael Ziegler in Environmental Values vol.16 no.1, pp.43-60.

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Sex is a fundamentally important biological variable. Recent years have seen significant progress in the integration of sex in many aspects of basic and clinical research, including analyses of sex differences in brain function. Significant advances in the technology available for studying the endocrine and nervous systems are now coupled with a more sophisticated awareness of the interconnections of these two communication systems of the body. A thorough understanding of the current knowledge, conceptual approaches, methodological capabilities, and challenges is a (...) prerequisite to continued progress in research and therapeutics in this interdisciplinary area. Sex Differences in the Brain provides scientists with the basic tools for investigating sex differences in brain and behavior and insight into areas where important progress in understanding physiologically relevant sex differences has already been made. This book was edited and co-authored by members of the Isis Fund Network on Sex, Gender, Drugs and the Brain, sponsored by the Society for Womens Health Research. The book is arranged in three parts. The first part of the book introduces the study of sex differences in the brain, with an overview of how the brain, stress systems, and pharmacogenetics differ in males and females and how this information is important for the study of behavior and neurobiology of both genders. The second part presents examples of sex differences in neurobiology and behavior from both basic and clinical research perspectives, covering both humans and nonhuman animals. The final part discusses sex differences in the neurobiology of disease and neurological disorders. For interested individuals as well as those who are considering conducting research at the intersections of endocrinology, neuroscience, and other areas of biomedicine, the study of sex differences offers exciting and challenging questions and perspectives. This book is intended as a guide and resource for clinicians, scientists, and students. (shrink)

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Most prions (infectious proteins) are self‐propagating amyloids (filamentous protein multimers), and have been found in both mammals and fungal species. The prions [URE3] and [PSI+] of yeast are disease agents of Saccharomyces cerevisiae while [Het‐s] of Podospora anserina may serve a normal cellular function. The parallel in‐register beta‐sheet structure shown by prion amyloids makes possible a templating action at the end of filaments which explains the faithful transmission of variant differences in these molecules. This property of self‐reproduction, in turn, allows (...) these proteins to act as de facto genes, encoding heritable information. BioEssays 30:955–964, 2008. © 2008 Wiley Periodicals, Inc. (shrink)

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The rapid pace of technological development often outstrips the ability of legislators and regulators to establish proper guardrails on emerging technologies. A solution is for those who develop, deploy, and use these technologies to develop themselves as moral agents—i.e., as agents capable of steering the course of emerging technologies in a direction that will benefit humanity. However, there is a dearth of literature discussing how to foster moral agency in computer science courses, and little if any research on the effectiveness (...) of such courses in computer science. This paper addresses this gap by providing an overview of an undergraduate course on technology ethics. It then shares and discusses a subset of data collected from a mixed-methods study using a pre-post design that sought to examine the course’s effectiveness in developing students’ moral, intellectual, and civic virtues, as well as related dispositions. (shrink)

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One variety of love is familiar in everyday life and qualifies in every reasonable sense as a reactive attitude. ‘Reactive love’ is paradigmatically (a) an affectionate attachment to another person, (b) appropriately felt as a non-self-interested response to particular kinds of morally laudable features of character expressed by the loved one in interaction with the lover, and (c) paradigmatically manifested in certain kinds of acts of goodwill and characteristic affective, desiderative and other motivational responses (including other-regarding concern and a desire (...) to be with the beloved). ‘Virtues of intimacy’ as expressed in interaction with the lover are agent-relative reasons for reactive love, and like other reactive attitudes, reactive love generates reasons in its own right. Within a broad conception of the virtues, reactive love sheds light on the reactive attitudes more generally. (shrink)

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The US neutrino community gathered at the Workshop on the Intermediate Neutrino Program at Brookhaven National Laboratory February 4-6, 2015 to explore opportunities in neutrino physics over the next five to ten years. Scientists from particle, astroparticle and nuclear physics participated in the workshop. The workshop examined promising opportunities for neutrino physics in the intermediate term, including possible new small to mid-scale experiments, US contributions to large experiments, upgrades to existing experiments, R&D plans and theory. The workshop was organized into (...) two sets of parallel working group sessions, divided by physics topics and technology. Physics working groups covered topics on Sterile Neutrinos, Neutrino Mixing, Neutrino Interactions, Neutrino Properties and Astrophysical Neutrinos. Technology sessions were organized into Theory, Short-Baseline Accelerator Neutrinos, Reactor Neutrinos, Detector R&D and Source, Cyclotron and Meson Decay at Rest sessions.This report summarizes discussion and conclusions from the workshop. (shrink)

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Contemporary engineering education recognises the need for engineering ethics content in undergraduate programmes to extend beyond concepts that form the basis of professional codes to consider relationality and context of engineering practice. Yet there is debate on how this might be done, and we argue that the design and pedagogy for engineering ethics has to consider what and to whom ethics is taught in a particular context. Our interest is in the possibilities and challenges of pursuing the dual imperatives of (...) socialization and critique. Socialization involves creating opportunities for all, in a diverse cohort of students, to access and engage with the dominant professional engineering ethics knowledge, while critique involves engaging with a range of ways of knowing, valuing, being and using language as relevant in contemporary engineering practice. We identify conceptual tools from engineering ethics and ethical pedagogy in education scholarship for our context. We illustrate how we use these tools systematically to strengthen our reflective practice in a first-year university engineering ethics module to a deeper form of reflexivity. Specifically, we explore the ways in which we attend to the dual imperatives and also highlight opportunities that we miss. We identify as key opportunities design choices such as how we formulated questions and prompts, and how we attended to content, context and language in selecting classroom texts. Other key opportunities were pedagogical choices of when and how to use student contributions in discussion, and what was made explicit in the classroom and assessment. We share our plans to take our learnings forward in our practice and consider the generative possibilities of these learnings and the concepts in other contexts. (shrink)

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At the forefront of international concerns about global legislation and regulation, a host of noted environmentalists and business ethicists examine ethical issues in consumption from the points of view of environmental sustainability, economic development, and free enterprise.

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Hva vil det si å ha kunnskap om noe? Hva slags ting finnes i verden, og hva går det an å vite noe om? Hvordan bør vi leve? Hva er verdifullt? I denne boka søkes svar på disse spørsmålene gjennom eksempler fra filosofi- og vitenskapshistorien og fra etikk. Boka har 20 kapitler fordelt på tre deler. Del 1 – vite – stiller spørsmål om kunnskap. Del 2 – være – tar utgangspunkt i hva som er virkelig. Del 3 – gjøre (...) – er viet etikk. Hvert kapittel har en introduksjon samt én til to originaltekster som er skrevet av tenkere fra vår samtid og fra filosofi- og vitenskapshistorien. Hvert kapittel har også studiespørsmål og en opplisting av det du bør ha lært, etter å ha lest kapittelet. -/- [Dette er den eneste godkjent boken som dekker pensum til examen philosophicum ved Universitetet i Oslo]. (shrink)

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In this comprehensive collection of essays, most of which appear for the first time, eminent scholars from many disciplines—philosophy, economics, sociology, political science, demography, theology, history, and social psychology—examine the causes, nature, and consequences of present-day consumption patterns in the United States and throughout the world.

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The article describes the development of adolescents for a sense of self in a lesbian home, in order to compile guidelines for lesbian parents as well as pastoral counsellors to help and guide adolescents to develop a healthy sense of self. From the research results, it appears that there are certain positive and negative aspects of a lesbian home that influence adolescents’ sense of self. Where both parents are involved with the adolescents, share household duties equally and have a quality (...) relationship with each other and the adolescents, the adolescents are generally well-adapted, happy and able to handle challenges in order to develop a healthy sense of self. The positive influence that Christian religious certainty has on the overall development of the adolescents was also confirmed by this study. On the other hand, adolescents experience particular aspects as challenging and impeding in their development of a healthy sense of self: Conflict and criticism from the companion parents are humiliating and destructive. Stigmatising, teasing and rejection from the hetero-normative society, as a result of their parents’ sexual orientation, appear to be the largest obstacles in their psychosocial development. They react in a shy, negative and evasive way to the stigmatisation and withdraw themselves from situations that could be painful and humiliating. It also appears that the absence of a father figure and financial tension in lesbian families are impeding the adolescents’ healthy development of a sense of self. (shrink)

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Social studies and social studies education is in the midst of what aptly can be described as a crisis of relevancy. In today's post-‘No Child Left Behind’ curriculum defined by test scores and proficiency targets, social studies has, as some have said, “been placed on the backburner” to make room for seemingly more important (tested) subjects such as reading and mathematics. The purpose of this study is to provide a picture of the state of social studies in South Carolina, a (...) state which tests social studies in elementary grades, while trying to understand the impact of state-mandated testing in greater depth. Its focus is on elementary teachers' beliefs about the role of social studies in the curriculum and their perception of time spent on social studies instruction. (shrink)

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© JNCCN-Journal of the National Comprehensive Cancer Network.Background: Next-generation tumor sequencing panels, which include multiple established and novel targets across cancers, are emerging in oncology practice, but lack formal positive coverage by US payers. Lack of coverage may impact access and adoption. This study identified challenges of NGTS coverage by private payers.Methods: We conducted semi-structured interviews with 14 NGTS experts on potential NGTS benefits, and with 10 major payers, representing more than 125,000,000 enrollees, on NGTS coverage considerations. We used the (...) framework approach of qualitative research for study design and thematic analyses and simple frequencies to further describe findings.Results: All interviewed payers see potential NGTS benefits, but all noted challenges to formal coverage: 80% state that inherent features of NGTS do not fit the medical necessity definition required for coverage, 70% view NGTS as a bundle of targets versus comprehensive tumor characterization and may evaluate each target individually, and 70% express skepticism regarding new evidence methods proposed for NGTS. Fifty percent of payers expressed sufficient concerns about NGTS adoption and implementation that will preclude their ability to issue positive coverage policies.Conclusions: Payers perceive that NGTS holds significant promise but, in its current form, poses disruptive challenges to coverage policy frameworks. Proactive multidisciplinary efforts to define the direction for NGTS development, evidence generation, and incorporation into coverage policy are necessary to realize its promise and provide patient access. This study contributes to current literature, as possibly the first study to directly interview US payers on NGTS coverage and reimbursement. (shrink)

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The Queensland fruit fly (Bactrocera tryoni) is a generalist pest that poses a significant threat to the Australian horticultural industry. This species has become broadly established across latitudes that encompass tropical to temperate climates, and hence populations occupy diverse thermal niches. Successful expansion across this range may have been brokered by evolutionarily labile features of breeding phenology, physiology and/or behaviour. We explored the potential role of behavioural flexibility by characterizing variation in adult thermal preference using a novel gradient apparatus. Flies (...) oriented within this apparatus essentially at random in the absence of thermal variation, but sought and maintained precise positions when presented with an established gradient. Male and female flies from an ‘old’ colony (>300 generations) and a ‘young’ (F7) colony were compared. Whereas we found no difference between the sexes, flies from the young colony preferred higher temperatures (30.93 ± 7.30 °C) and had greater individual variation than their counterparts from the old colony (28.16 ± 5.63 °C). Given that B. tryoni are routinely maintained at 25 °C in the laboratory, a lower mean preference of the old colony is consistent with thermal adaptation. This is further supported by their reduced phenotypic variance, which follows as a logical consequence of stabilising selection given long-term environmental constancy. These results demonstrate that B. tryoni seek to thermoregulate via adult behaviour, and that individual temperature preference can be precisely measured using a gradient apparatus. The evidence for adaptive tuning of this behaviour has importance for both the design of captive rearing protocols as well as the prediction of invasive potential and species biogeography under future climatic variation. -/- . (shrink)

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We welcome Blair's argument that the relationship between fluid cognition and other aspects of intelligence should be an important focus of research, but are less convinced by his arguments that fluid intelligence is dissociable from general intelligence. This is due to confusions between (a) crystallized skills and g, and (b) universal and differential constructs. (Published Online April 5 2006).

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Cyclin-dependent kinase 5 has been implicated in Alzheimer's disease pathogenesis. Here, we demonstrate that overexpression of p25, an activator of cdk5, led to increased levels of BACE1 mRNA and protein in vitro and in vivo. A p25/cdk5 responsive region containing multiple sites for signal transducer and activator of transcription was identified in the BACE1 promoter. STAT3 interacts with the BACE1 promoter, and p25-overexpressing mice had elevated levels of pSTAT3 and BACE1, whereas cdk5-deficient mice had reduced levels. Furthermore, mice with a (...) targeted mutation in the STAT3 cdk5 responsive site had lower levels of BACE1. Increased BACE levels in p25 overexpressing mice correlated with enhanced amyloidogenic processing that could be reversed by a cdk5 inhibitor. These data demonstrate a pathway by which p25/cdk5 increases the amyloidogenic processing of APP through STAT3-mediated transcriptional control of BACE1 that could have implications for AD pathogenesis. (shrink)

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This article presents a critique of Paulo Freire's philosophical perspective on human nature in the context of a doctoral research study to explore “muchness” or nurses’ subjective experience of well‐being; and demonstrates how this critique has informed the refinement of the theoretical principles used to inform research methodology and methods. Engaging in philosophical groundwork is essential for research coherence and integrity. Through this groundwork, largely informed by Freire's critical pedagogy and his ideas on humanization, I recognized the need to clarify (...) my understanding of the concepts of persons and personhood and how this related to Freire's use of the term human beings. This clarification process is essential to ensure congruence between the theoretical principles that I draw from his work and my beliefs about persons, personhood and person‐centredness. The article begins with a brief introduction to the research, followed by an overview of Freire's philosophical perspectives, and subsequently, the critique process is presented and discussed. This process involved engaging with the vast literature and debates about what it means to be a person, to make sense of the often complex and contradictory arguments. Eventually, three headings emerged that helped me to frame my evolving understanding: Our species: human beings; The kind that we are: human nature; and This person that I am: personhood. Through this process of exploration, I recognized that Freire's perspective on human nature (a) foregrounded cognitive rationality, which presented itself as a limitation when considering my ontological beliefs and the focus of my research, leading me to draw on the work of Mark Johnson and his ideas about embodiment to help me to further develop my theoretical principles; (b) focused on the “collective” rather than individuals, which is a shortcoming in relation to person‐centred research that acknowledges the uniqueness of participants. (shrink)

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The article investigates the issue and the mechanisms of censorship and self-censorship in Soviet philosophy. The major forms of censorship are described and analyzed together with their epistemological implications and the peculiar policy of truth. The philosophical problem of defining and describing “facts” and ideological judgments during the “double” technique of reading and re-reading was exposed in the articles of V.F. Asmus and V.V. Bibikhin, thinkers, who experienced the self-censorship and reflected upon this in their texts. Analyzing the complex relation (...) between the “dogmatic” or “critical” foreword and the original word is important, as is reconstructing and deconstructing the way we can reread the ideologically biased foreword, which might be a certain reliquary or protective camouflage, acting as, potentially, either a deactivator or an inhibitor of the reader’s own interpreting efforts. The given case of an attentive reading of V. Asmus’ foreword to the Tractatus Logicus-Philosophicus can itself become an interesting philosophical language game. Interpretation of the foreword may reveal a hidden sense and references and encourage reflection based on the “common sense” assessments and perception of text. These hermeneutical exercises on reading forewords may paradoxically provoke starting the dialogue with the alternative foreword by B. Russell and the text of L. Wittgenstein himself, on one hand, and Marxism-Leninism and its variations in the form of historical materialism and Soviet dialectical materialism, on another. The situation of attentive reading with “a throat, strangled by ideology” is opposed to the power of imaginative “broadening of vocal ranges of the Others” thinking, whereas an inattentive reading of the text leaves a complete disability to object, or reply, to the censorship. (shrink)

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Our starting point is a somewhat obscure incident which has lately attracted some attention. The year is 429 B.C., and the place is Athens in the third year of the Peloponnesian war. The plague, which had broken out only a year before, was still claiming its victims. Yet military operations were in full swing, and the general Phormio operating in the Corinthian gulf against a Peloponnesian fleet was able to score an impressive victory. The Lacedaemonians were deeply dissatisfied. This was (...) the first sea-fight they had been engaged in, and they found it hard to believe that their fleet was so much inferior to that of the Athenians. They dispatched three advisers to Knemos, the admiral in charge, instructing them to make better preparations for another sea-fight. Additional ships were solicited from the allies, and those already at hand were prepared for battle. It is at this point that the incident in question occurred. Not to prejudge the issue, I quote the text in full leaving the controversial phrases untranslated: 4. And Phormio on his part sent messengers to Athens to give information of the enemy's preparations and to tell about the battle which they had won, urging them also to send to him speedily as many ships as possible, since there was always a prospect that a battle might be fought any day. 5. So they sent him twenty ships, but gave τ δ κυμξοντι special orders to sail first to Crete. Nικας γρ Kρς Γορτνιος πρξενος ν persuaded them to sail against Cydonia, a hostile town, promising to bring it over to the Athenians; but he was really asking them to intervene to gratify the people of Polichne, who are neighbours of the Cydonians. 6. So μν λαβν τς νας. went to Crete, and helped the Polichnitans to ravage the lands of the Cydonians, and by reason of winds and stress of weather wasted not a little time. (shrink)

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