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The potential to instrumentalize drug use based upon the detection of very many different drug states undoubtedly exists, and such states may play a role in psychiatric and many other drug uses. Nevertheless, nonaddictive drug use is potentially more parsimoniously explained in terms of sensation seeking/impulsivity and drug expectations. Cultural factors also play a major role in nonaddictive drug use.

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Jeffery Aubin ,Marie Chantal ,DianneCole ,Julio Chaves ,Cathelyne Duchesne ,Christel Freu ,Steve Johnston ,Brice Jones ,Amaury Levillayer ,Stéphanie Machabée ,Paul-Hubert Poirier ,Philippe Therrien ,Jonathan von Kodar ,Martin Voyer ,Jennifer Wees ,Eric Crégheur.

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Until comparatively recently, say the middle of the last century, spinal cord injury was fatal as pressure sores and other infections took their toll. Those with severe brain injuries, unable to move or even communicate, fared even worse; without movement or feeding such patients were nursed until nature took its course. Over the last few decades medical and nursing advances have enabled some of these vegetative patients to survive for considerable time, provoking, at times, ethical and legal dilemmas. Though they (...) survived, without overt behaviour or clear communication their carers were frequently unsure how much residual function remained. Now real progress is occurring in this area thanks to the application of neuro-scientific methods by some outstanding groups of workers. Subjects with severe brain injury may begin in complete, unresponsive coma but then ‘lighten’ to one of three categories. In vegetative state (VS), patients are apparently awake but without evidence of voluntary behaviour and have no apparent awareness of self or environment, whilst in minimally conscious state (MCS) patients have some behaviour beyond the reflex but are not able to communicate effectively. These conditions usually result from widespread brain damage at either or both cortical and subcortical levels due to injury or anoxia, though they can also be seen in end stage neurological conditions like Alzheimer’s. In locked in syndrome (LIS), patients ‘awake’ from coma, usually due to stroke, aware of their surroundings and their situation but unable to speak or move, beyond eye lid control and eye movement. For many, LIS will be recognised from Bauby’s extraordinary account in ‘The Diving Bell and the Butterfly,’ though, incidentally, it was presaged in Samuel Beckett’s novella ‘The Unnameable.’ LIS reflects a profound disconnection between brain and body, except for the upper cranial nerves involved in eyelid movement. The overriding question is how much awareness these patients have.. (shrink)

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The computer has increasingly become the principal model for the mind, which means our most basic experience of ""reality"" is as mediated through a screen, or stored in a cloud. As a result, we are losing a sense of the concrete and imposing presence of the real, and the fundamental claim it makes on us, a claim that Iris Murdoch once described as the essence of love. In response to this postmodern predicament, the present book aims to draw on the (...) classical philosophical tradition in order to articulate a robust philosophical anthropology, and a new appreciation of the importance of the ""transcendental properties"" of being: beauty, goodness, and truth. The book begins with a reflection on the importance of metaphysics in our contemporary setting, and then presents the human person's relation to the world under the signs of the transcendentals: beauty is the gracious invitation into reality, goodness is the self-gift of freedom in response to this invitation, and truth is the consummation of our relation to the real in knowledge. The book culminates in an argument for why love is ultimately a matter of being, and why metaphysical reason in indispensable in faith. ""Philosopher D. C. Schindler defies the dragon of modernity, whose dominant thought patterns induce a life- and culture-threatening loss of reality and self. He offers life-giving proposals regarding love, being, and the transcendentals to restore us profoundly to the world and to ourselves as humans. Buy the book--you may divest yourself of others. Digest it, and revel in your already-involvement with a responsive reality--an involvement of intimate encounter and communion; a reality that is love, fraught with beauty, goodness, and truth."" --Esther Lightcap Meek, Geneva College ""Love and the Postmodern Predicament is a treasure trove of philosophical riches. Schindler does not merely indicate the need to return to metaphysics to wrestle successfully with what he carefully and accurately describes as our postmodern predicament, but in fact leads us out of that predicament. His profound and original reflections on love, grounded in the transcendental properties of being, are a radical refashioning of traditional metaphysical principles."" --Jonathan J. Sanford, University of Dallas ""In this rewarding little text, Schindler accomplishes something too rare among works of philosophy: he accommodates a wide audience and yet deftly draws the reader into deep metaphysical waters, into a consideration of some of the most profound and perennial philosophical concerns. Throughout, the timeliness of his reflections on love, beauty, God, and the good remains in clear view. This is a highly recommended work by an author of capacious intellect and generous spirit."" --Lee M.Cole, Hillsdale College D. C. Schindler is Associate Professor of Metaphysics and Anthropology at The John Paul II Institute at The Catholic University of America. He is the author of The Perfection of Freedom: Schiller, Schelling, and Hegel between the Ancients and the Moderns (2013). (shrink)

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It is argued that both neuroscience and physics point towards a similar re-assessment of our concepts of space, time and 'reality', which, by removing some apparent paradoxes, may lead to a view which can provide a natural place for consciousness and language within biophysics. There are reasons to believe that relationships between entities in experiential space and time and in modern physicists' space and time are quite different, neither corresponding to our geometric schooling. The elements of the universe may be (...) better described not as 'particles' but as dynamic processes giving rise, where they interface with each other, to the transfer, and at least in some cases experience, of 'pure'or 'active'information, the mental and physical just reflecting different standpoints. Although this analy-sis draws on general features of quantum dynamics, it is argued that purely quantum level events (and their 'interpretations') are unlikely to be relevant to the understanding of consciousness. The processes that might be able to give rise, within brain cells, to an experience like ours are briefly reviewed. It is suggested that the elementary signals that are integrated to generate a spatial experience may have features more in common with words than pixels. It is further suggested that the laws of integration of words in language may provide useful clues to the way biophysical integration of signals in neurons relates to integration of elements in experiential space. (shrink)

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We perceive colour, shape, sound and touch 'bound together' in a single experience. The following arguments about this binding phenomenon are raised: (1) The individual signals passing from neurone to neurone are not bound together, whether as elements of information or physically. (2) Within a single cell, binding in terms of bringing together of information is potentially feasible. A physical substrate may also be available. (3) It is therefore proposed that a bound conscious experience must be a property of an (...) individual cell, not of a group of cells. Since it is unlikely that one specific neurone is conscious, it is suggested that every neurone has a version of our consciousness, or at least some form of sentience. However absurd this may seem it appears to be consistent with the available evidence; arguably the only explanation that is. It probably does not alter the way we should expect to experience the world, but may help to explain the ways we seem to differ from digital computers and some of the paradoxes seen in mental illness. It predicts non-digital features of intracellular computation, for which there is already evidence, and which should be open to further experimental exploration. The arguments given may well prove flawed or the conclusion biologically or physically untenable, but the idea is raised for discussion not least because a formal demonstration that it is invalid may help to identify more fruitful avenues. (shrink)

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The Indian Buddhist philosopher Vasubandhu is known for his critical contribution to Buddhist Abhidharma thought, his turn to the Mahayana tradition, and his concise, influential Yogacara-Vijñanavada texts. _Paving the Great Way_ reveals another dimension of his legacy: his integration of several seemingly incompatible intellectual and scriptural traditions, with far-ranging consequences for the development of Buddhist epistemology and the theorization of tantra. Most scholars read Vasubandhu's texts in isolation and separate his intellectual development into distinct phases. Featuring close studies of Vasubandhu's (...) _Abhidharmakosabhasya_, _Vyakhyayukti_, _Vimsatika_, and _Trisvabhavanirdesa_, among other works, this book identifies recurrent treatments of causality and scriptural interpretation that unify distinct strands of thought under a single, coherent Buddhist philosophy. In Vasubandhu's hands, the Buddha's rejection of the self as a false construction provides a framework through which to clarify problematic philosophical issues, such as the nature of moral agency and subjectivity under a broadly causal worldview. Recognizing this continuity of purpose across Vasubandhu's diverse corpus recasts the interests of the philosopher and his truly innovative vision, which influenced Buddhist thought for a millennium and continues to resonate with today's philosophical issues. An appendix includes extensive English-language translations of the major texts discussed. (shrink)

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The Consensus Statement of the Third International Congress on Concussion in Sport in November 2008 defined concussion as a “complex pathophysiologic process affecting the brain, induced by traumatic biochemical forces.” Definitions of concussion vary slightly between various professional organizations of neurosurgeons, neurologists, and orthopedic surgeons, but all share the common characteristics of trauma affecting the head or body resulting in transient neurologic deficits or symptoms. Underlying the symptoms of concussion is a complex pathophysiologic process at the cellular level. While concussion (...) is typically thought of as resulting from a direct impact to the head, a concussion can also be sustained as a result of an impact to the body causing the force of the impact to be transmitted to and absorbed by the brain. (shrink)

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Some of the basic terminology of Yogācāra philosophy needs reevaluation. Whereas commentaries almost universally gloss the term dvaya ('duality') with some version of the phrase grāhya grāhaka ca (lit. 'grasped and grasper', but usually translated as 'subject and object'), in fact this gloss is absent from the earliest strata. The term and its gloss are derived from separate streams of Yogācāra reasoning - one from discussions of linguistic conceptualization and the other from discussions of perception. Once we see that these (...) two are distinct, it becomes clear that the commentarial literature asserts their identity in order to philosophically unify Yogācāra thought. One upshot of this is that even in this later assertion 'duality' refers not to the distinction between internal and external reality (as in 'textbook' Yogācāra), but to the falsely projected distinction between mental subjects and mental objects. (shrink)

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This book explores the religious concerns of Enlightenment thinkers from Thomas Hobbes to Thomas Jefferson. Using an innovative method, the study illuminates the intellectual history of the age through interpretations of Jesus between c.1650 and c.1826. The book demonstrates the persistence of theology in modern philosophy and the projects of social reform and amelioration associated with the Enlightenment. At the core of many of these projects was a robust moral-theological realism, sometimes manifest in a natural law ethic, but always associated (...) with Jesus and a commitment to the sovereign goodness of God. This ethical orientation in Enlightenment discourse is found in a range of different metaphysical and political identities which intersect with earlier ‘heretical’ tendencies in Christian thought. This intellectual matrix helped to produce the discourses of irenic toleration which are a legacy of the Enlightenment at its best. (shrink)

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This paper describes a pilot study of a new model for narrative medicine training, “community-based participatory narrative medicine”, which centers on shared narrative work between healthcare trainees and patients. Nine medical students and eight patients participated in one of two, five-week-long pilot workshop series. A case study of participants’ experiences of the workshop series identified three major themes: the reciprocal and collaborative nature of participants’ relationships; the interplay between self-reflection and receiving feedback from others; and the clinical and pedagogical implications (...) of the CBPNM model. Principles and proposed outcomes of the CBPNM model are presented. (shrink)

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In the exceptional book _Divine Holiness and Divine Action_, Mark Murphy defends what he calls the _holiness framework _for divine action. The purpose of our essay-response to Murphy’s book is to consider an alternative framework for divine action, what we call the _agapist framework_. We argue that the latter framework is more probable than Murphy’s holiness framework with respect to_ select _theological desiderata.

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Many Christian traditions affirm a doctrine of assurance. According to this doctrine, those who are saved have assurance of their own salvation; that is, the doctrine of assurance tells us that the elect can know their status as elect. In this paper, I explore two developments of the doctrine of assurance by theologians (i.e. John Calvin & Kenneth Keathley) and argue that they fail to accommodate the fallibilistic nature of human knowing. I then develop a fallibilistic doctrine of assurance, which (...) makes such assurance available to most Christians, and respond to an objection from the camp of pragmatic encroachment. (shrink)

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The hemidesmosome is a complex junction containing many proteins. The keratin cytoskeleton attaches to its cytoplasmic plaque, while its transmembrane elements interact with components of the extracellular matrix. Hemidesmosome assembly involves recruitment of α6β4 integrin heterodimers, as well as cytoskeletal elements and cytoskeleton-associated proteins to the cell surface. In our cell culture models, these phenomena appear to be triggered by laminin-5 in the extracellular matrix. Cell interaction with laminin-5 apparently induces both phosphorylation and dephosphorylation of subunits of α6β4 integrin. There (...) is emerging evidence that such events are necessary for subsequent cytoskeleton anchorage to the hemidesmosome cytoplasmic plaque. Once assembled, the hemidesmosome plays an essential role in maintaining firm epithelial adhesion to the basement membrane, with hemidesmosome disruption being a hallmark of certain devastating blistering diseases. However, the hemidesmosome is more than just a stable anchor, as it may also be the site of signal transduction, mediated by its α6β4 integrin component. This review discusses our current knowledge of the structure and assembly of the hemidesmosome. BioEssays 20:488–494, 1998. © 1998 John Wiley & Sons, Inc. (shrink)

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In a recent exchange with prominent skeptical theists, Paul Draper has argued that skeptical theism bears no relevance to Humean versions of the argument from suffering. His argument rests, however, on a particular way of construing epistemically rational updating procedures that is not adopted by all forms of skeptical theism. In particular, a perspectival variety of skeptical theism, I argue, is relevant to his Humean arguments. I then generalize this result and explain how any argument from evil employing probabilistic premises (...) is similarly threatened. (shrink)

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In 2018-2019, at the Keck School of Medicine of the University of Southern California, we developed and piloted a narrative-based health systems science intervention for patients living with HIV and medical students in which medical students co-wrote patients’ life narratives for inclusion in the electronic health record. The pilot study aimed to assess the acceptability of the “life narrative protocol” from multiple stakeholder positions and characterize participants’ experiences of the clinical and pedagogical implications of the LNP. Students were recruited from (...) KSOM. Patients and staff were recruited from the Maternal, Child, and Adolescent/Adult Center for Infectious Disease and Virology at Los Angeles County+USC Medical Center. Ten patients, seventeen students, and ten MCA staff participated in the pilot study. Qualitative methods were used to gather data from students’, patients’, and staff’s perspectives. Three themes emerged from the thematic analysis: patients’ life narratives conveyed their unique life experiences and voices; the protocol could result in wide-ranging effects on HIV care; the LNP enabled students to contribute value to patients’ healthcare. Across groups, participants considered the LNP an acceptable intervention. The LNP, its limitations, and implications for HIV care, narrative medicine, and health information technology are presented. (shrink)

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It was love at first sight whenJonathan Calvert saw the Matterhorn in 1953. Something in the way the mountain held sway over him inspired a lifelong passion for natural beauty and adventure. Over the next fifty years, Calvert climbed, hiked, trekked, sailed, kayaked, and dog-sledded in wild places across the globe, following his urge to know. And he hasn t quit yet. In July 2014, he will spend a month in Central Asia traveling the Silk Road through the (...) Pamirs and Tian Shan mountains. In 2015 Calvert returns to the Antarctic in a sailboat to kayak and camp. This book is a record of his adventures, told through memoir, journals, and photographs. Calvert has devoted his life to exploring the world and himself, and he has never gotten to the bottom of the wellspring that is curiosity. Calvert has walked in the footsteps of early explorers, camped above the clouds, come face-to-tusk with a walrus, and, within yards of a summit, talked down the inner voice that cajoled him to quit. He has stumbled into crevasses, kayaked in quiet waters above whales, suffered altitude sickness, and called his family via radio and cell phone relay from a precipitous ledge to say, I made it. Discovering early in life that striking out by himself got the job done best, Calvert is no stranger to singular travels and travails. Yes, he adventures with comrades roped in as a team, paddling together, or taking his turn at the ship s helm but ultimately the journey is one s own. Throughout his life, Calvert has jumped at chance after chance, among them: climbing Alaska s Mount McKinley, Argentina s Aconcagua, and mountains in Switzerland, France, Tanzania, and Nepal; trekking in Tibet, Bhutan, England, and Pakistan; and kayaking the coast of Greenland and the Zhupanova River in the Kamchatka Peninsula. Where s that? Explore these pages, and then you will know.". (shrink)

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In this paper, I argue that no strong doctrine of the Fall can undermine the propriety of epistemic self-trust. My argument proceeds by introducing a common type of philosophical methodology, known as reflective equilibrium. After a brief exposition of the method, I introduce a puzzle for someone engaged in the project of self-reflection after gaining a reason to distrust their epistemic selves on the basis of a construal of a doctrine of the Fall. I close by introducing the worry as (...) a formal argument and demonstrate the self-undermining nature of such an argument. (shrink)

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The goal of this paper is to examine the impact of leadership and promotion regulatory focus on employees’ willingness to engage in unethical pro-organizational behavior . Building from a person–situation interactionist perspective, we investigate the interaction of leadership style and how leaders frame messages, as well as test a three-way interaction with promotion focus. Using an experimental design, we found that inspirational and charismatic transformational leaders elicited higher levels of UPB than transactional leaders when the leaders used loss framing, but (...) not gain framing. Furthermore, followers’ promotion regulatory focus moderated this relationship such that the effect held for followers with low promotion focus, but not for individuals with high promotion focus. Our findings extend the understanding of UPB, offer theoretical mechanisms to explain when this behavior occurs, and contribute to leadership theory and research on ethical decision making. (shrink)

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Giving an account of the relation between evolution and consciousness is painted as posing a dilemma between panpsychism, with minimal consciousness in every grain of matter, and radical emergence, with consciousness appearing as from nowhere in living structures. Panpsychism has been seen as suffering from a combination problem and radical emergence as unjustified in physics. The underpinning of physics now lies in field theory, which may provide a way out on both sides. Only, and always, in a field theory account (...) do influences at different points in spacetime combine in the same indivisible event. Radical emergence is also inherent to field theory. Moreover, by providing rich patterns of influence involving both discrete identities and quantitative values, field theory might provide a basis for sensed propositional meaning with subjects and predicates. Ordered condensed matter within living tissue may support unusual emergent dynamic units uniquely suited to building representations of the world with sensed meaning. The evolution of consciousness may then be seen as a tractable biological problem centred on increasingly sophisticated ways for external world dynamics to be mirrored by internal representations with semantic content, based in field relations within condensed matter with genetically encoded complex order. (shrink)

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This essay defends a Buddhist answer to the question of how a skeptical tradition might account for its moral position. Two domains in Buddhist thought and practice are often considered to be dissimilar, perhaps contradictory. On the one hand, there is an aspiration to nirvana and a philosophy that describes everything as “emptiness” and rejects, with apparent universality, “attachment to views.” On the other hand, Buddhist traditions of practice recommend actions based in compassion and loving kindness, and the cultivation of (...) contentment, introspective awareness, and peace of mind. It is argued that these arenas are not in conflict, but are linked through Buddhist psychology, wherein the proven limitations of concepts are quite explicitly leveraged to show that beings hampered by such limits ought to think and act with epistemic humility. The result is not nihilism, but a method for improving our perspectives on ourselves and our society—a method that may serve as a model for humanistic research. (shrink)

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This book explores and expounds upon questions of paradox and contradiction in theology with an emphasis on recent contributions from analytic philosophical theology. It addresses questions such as: What is the place of paradox in theology? Where might different systems of logic (e.g., paraconsistent ones) find a place in theological discourse (e.g., Christology)? What are proper responses to the presence of contradiction(s) in one's theological theories? Are appeals to analogical language enough to make sense of paradox? Bringing together an impressive (...) line-up of theologians and philosophers, the volume offers a range of fresh perspectives on a central topic. It is valuable reading for scholars of theology and philosophy of religion. (shrink)

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A Critique of Western Buddhism: Ruins of the Buddhist Real, by Glenn Wallis. Bloomsbury Publishing, 2019. 232 pp., Hb. £90.00, ISBN-13: 9781474283557; Pb. £26.99, ISBN-13: 9781350155213.

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Although psychologist impairment has received attention from researchers, there is a paucity of empirical data aimed at determining the point at which such impairment necessitates action. The purpose of this study was to provide such empirical data. Members of Division 42 ( n = 285) responded to vignettes describing a psychologist whose symptoms of either depression or substance abuse varied across five levels of severity. Results identified specific levels of impairment at which psychologists were deemed too impaired to practice psychotherapy, (...) as well as significant differences between ratings of increasingly severe impairment. Practical and ethical implications of these results are discussed. (shrink)

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Performing Difference is a compilation of seventeen essays from some of the leading scholars in history, criticism, film, and theater studies. Each author examines the portrayal of groups and individuals that have been traditionally marginalized or excluded from dominant historical narratives. As a meeting point of several fields of study, this book is organized around three meta-themes: race, gender, and genocide. Included are analyses of films and theatrical productions from the United States, as well as essays on cinema from Southern (...) and Central America, Europe, and the Middle East. Topically, the contributing authors write about the depiction of race, ethnicities, gender and sexual orientation, and genocides. This volume assesses how the performing arts have aided in the social construction of the "other" in differing contexts. Its fundamental premise is that performance is powerful, and its unifying thesis is that the arts remain a major forum for advancing a more nuanced and humane vision of social outcasts, not only in the realm of national imaginations, but in social relations as well."--Jacket. (shrink)

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Several types of amygdala-dependent learning can be blocked by local infusion of NMDA antagonists into the amygdala. This blockade shows anatomical, pharmacological, temporal, and behavioral specificity, providing a pattern of data more consistent with a role for NMDA receptors in learning than in arousal or attention, and supporting the contention that an “LTP-like” process is a neural substrate for memory formation.

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This article provides a comparative institutional analysis between El Niño/southern Oscillation forecasting systems in the Pacific and southern Africa with a focus on how scientific information is connected to the decision-making process. With billions of dollars in infrastructure and private property and human health and well-being at risk during ENSO events, forecasting systems have begun to be embraced by managers and firms at multiple levels. The study suggests that such systems need to consciously support the coproduction of knowledge. A critical (...) component of such coproduction seems to be managing the boundaries between science and policy and across disciplines, scale, and knowledges to create information that is salient, credible, and legitimate to multiple audiences. This research suggests institutional mechanisms that appear to be useful in managing such boundaries, including mechanisms for structuring convening, translation, collaboration, and mediation functions. (shrink)

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Recent works in theology—including Beall (The Contradictory Christ and Divine Contradiction) and essays in Rutledge (Paradox and Contradiction in Theology)—have articulated or defended contradictory or contradictory-like theologies. Given the use of contemporary formal logic in setting out these theologies, a natural question concerning the existence of historical precedents to contradictory or contradictory-like theologies has arisen. In this article we present a short, accessible overview of contradictory and contradictory-like theologies alongside an attempt to address the question of historical precedents for such (...) views. (shrink)

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