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We review state‐of‐the‐art computational methods for constructing, from image data, generative statistical models of cellular and nuclear shapes and the arrangement of subcellular structures and proteins within them. These automated approaches allow consistent analysis of images of cells for the purposes of learning the range of possible phenotypes, discriminating between them, and informing further investigation. Such models can also provide realistic geometry and initial protein locations to simulations in order to better understand cellular and subcellular processes. To determine the structures (...) of cellular components and how proteins and other molecules are distributed among them, the generative modeling approach described here can be coupled with high throughput imaging technology to infer and represent subcellular organization from data with few a priori assumptions. We also discuss potential improvements to these methods and future directions for research. (shrink)

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ObjectiveWe aim to investigate the feasibility of using diffusion tensor imaging to evaluate changes in extraocular muscles and lacrimal gland in patients with thyroid-associated ophthalmopathy and to evaluate disease severity.Materials and MethodsA total of 74 participants, including 17 healthy controls, 22 patients with mild TAO, and 35 patients with moderate-severe TAO, underwent 3-Tesla DTI to measure fractional anisotropy and mean diffusivity of the EOMs and LG. Ophthalmological examinations, including visual acuity, exophthalmos, intraocular pressure, and fundoscopy, were performed. FA and MD (...) values were compared among patients with different disease severity. Multiple linear regression was adopted to predict the impact of clinical variables on DTI parameters of orbital soft tissue.ResultsTAO patients’ EOMs and LG showed significantly lower FA values and higher MD compared to HCs’. Moderate-severe TAO patients’ EOMs and LG had dramatically lower FA and higher MD compared with HCs. In addition, only the DTI parameters of the medial rectus were considerably different between mild and moderate-severe TAO patients. Multiple linear regression showed that disease severity had a significant impact on the DTI parameters of orbital soft tissue.ConclusionDTI is a useful tool for detecting microstructural changes in TAO patients’ orbital soft tissue. DTI findings, especially medial rectus DTI parameters, can help to indicate the disease severity in TAO patients. (shrink)

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[v. 1. Basic theories]--v. 2. Applications.--v. 3. Theory of plants and other essays.

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AbstractHume is perhaps the most skeptical of all the great philosophers; and so it might reasonably have been assumed that he would have doubted the existence of a standard of taste in an area of human activity, the arts, where very many people, not ordinarily considered of a skeptical turn of mind, have doubted the existence of any standard according to his 1757 essay Of the Standard of Taste.

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本研究得到国家社会科学基金“法制与法治国家”重大项目、教育部“社会变迁中的中国法治的理论与实践”项目以及北京大学“985”项目的资助.

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Journal of Chinese Philosophy, EarlyView.

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A neural network is a model of the brain’s cognitive process, with a highly interconnected multiprocessor architecture. The neural network has incredible potential, in the view of these artificial neural networks inherently having good learning capabilities and the ability to learn different input features. Based on this, this paper proposes a new chaotic neuron model and a new chaotic neural network model. It includes a linear matrix, a sine function, and a chaotic neural network composed of three chaotic neurons. One (...) of the chaotic neurons is affected by the sine function. The network has rich chaotic dynamics and can produce multiscroll hidden chaotic attractors. This paper studied its dynamic behaviors, including bifurcation behavior, Lyapunov exponent, Poincaré surface of section, and basins of attraction. In the process of analyzing the bifurcation and the basins of attraction, it was found that the network demonstrated hidden bifurcation phenomena, and the relevant properties of the basins of attraction were obtained. Thereafter, a chaotic neural network was implemented by using FPGA, and the experiment proved that the theoretical analysis results and FPGA implementation were consistent with each other. Finally, an energy function was constructed to optimize the calculation based on the CNN in order to provide a new approach to solve the TSP problem. (shrink)

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The last two decades have witnessed the rising prevalence of both co-publishing and retraction. Focusing on research collaboration, this paper utilizes a unique dataset to investigate factors contributing to retraction probability and elapsed time between publication and retraction. Data analysis reveals that the majority of retracted papers are multi-authored and that repeat offenders are collaboration prone. Yet, all things being equal, collaboration, in and of itself, does not increase the likelihood of producing flawed or fraudulent research, at least in the (...) form of retraction. That holds for all retractions and also retractions due to falsification, fabrication, and plagiarism. The research also finds that publications with authors from elite universities are less likely to be retracted, which is particularly true for retractions due to FFP. China stands out with the fastest retracting speed compared to other countries. Possible explanations, limitations, and policy implications are also discussed. (shrink)

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The current president of the Czech Republic, Vaclav Havel, is an outstanding thinker of our times. He first became famous as a dramatist, then later became a prominent dissident and philosopher; and, following a series of revolutions in Czechoslovakia and other Central European states after the fall of the Berlin Wall in 1989, he was elected president of the Czech Republic, [a post that] he has now [held] for nine years.

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This article compares Masao Abe's Buddhist view of ultimate reality in terms of dynamic Sunyata with certain concepts in the process thought of Alfred North Whitehead and John Cobb.

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The Chinese have a 5000 years history and with it goes its Chinese philosophy. However, Chinese philosophy differs from western philosophy in more than one way. Western philosophy's famous “why” questions and free thinking were not part of Chinese philosophy. Acceptance was the rule and Confucius is known to be the source for this philosophy. The 20th century brought changes both in thinking generally as well as how sports were perceived. The main reasons for this were the opening to the (...) west and improving economic situations for the general population. This led to research in the field of sport philosophy on academic levels both in Taiwan and China. This article tries to put the achievements in this field in on the map. (shrink)

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EDITOR’S ABSTRACTSeeing New Qing History as a “malicious attack on a sovereign country” by “Western imperialists,” Li explicitly differentiates between a “wrong” and a “right” perspective on Qing history. In his view, the only legitimate standpoint is one that takes the People’s Republic of China’s territorial reach and “ethnic unity” as a necessary and natural result of history.

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Der »politische« Leibniz als großer Denker mit zukunftsweisenden Vorstellungen für die Gestaltung von Staat, Gesellschaft und Wissenschaft.

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Prior research suggests that participating in corporate social responsibility (CSR) activities can lead to higher future productivity. However, the empirical evidence is still scarce. The purpose of this study is to examine the relationship between CSR and future firm productivity in the U.S. chemical industry. Specifically, this study examines the relationship between CSR in year t and firm productivity in year (t + 1), (t + 2), and (t + 3). We use Data Envelopment Analysis, a non-parametric method, to measure (...) firm productivity. Results from the regression analysis support a significantly positive relationship between CSR and future firm productivity, suggesting that CSR can lead to higher productivity in the chemical industry. The findings add to the validity of the proposition in prior research. (shrink)

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Rawls's recent articulation of his theory of justice in Political Liberalism (1993) carries on the contractarian approach to defining justice, which was first laid out in A Theory of Justice (1971). However, this approach is now characterised as ‘political’, not metaphysical. It is intended to appeal to those who are deeply divided by cultural, religious, and moral beliefs: it is to explain how justice can be stable in a divided society. This ‘political’approach, nevertheless, has narrowed its appeal. Since it relies (...) on the shared ideas in democratic societies, its appeal becomes political and cultural. Morever, this theory's requirement of equal basic liberties for a just society calls for a relatively developed economy and social institutions. It fails to provide guidance to societies that, owing to their lesser development, cannot afford to guarantee the worth of equal basic liberties. The structual insufficiency of Rawls's ‘political’theory explains the failure of his continuing efforts to extend his liberal theory of justice to the international terrain. This essay analyses this insufficiency and the narrow applicability of Rawls's ‘political’theory of justice. (shrink)

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Chenyang Li responds to Yat-hung Leung by pointing out Leung draws on three distinct notions of benevolence, or ren, none of which on its own is a serious contender against harmony as the concept of central importance to Confucian philosophy. Ren cannot be all three of these at once, and no particular conception of ren in fact has all these qualities. Li further clarifies that it is not his aim to establish that harmony is of exclusively highest importance among Confucian (...) concepts and values, but rather merely to restore its place among the various central Confucian values. He elaborates on the essential role harmony plays when one properly values the virtue of benevolence, which itself requires or implies harmony, specifically harmonious coordination, in its practice and realization. Finally, Li argues that we cannot see the Confucian conceptions of benevolence Leung champions as possessing more practical value for contemporary life than the Confucian conception of harmony, and identifies the fundamental grounds and motivation of Leung’s criticisms to lie in allegiance to Song-Ming neo-Confucian orthodoxy, which grounds itself in philosophically empty postulates. (shrink)

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Since the beginning of human history, there has been no society that did not have any religion. Man meets his need to believe, encoded in his nature by turning to God. God has not left humans alone in their journey on earth, and from time to time, He has intervened in the world through his prophets. The prophethood, which constitutes one of the main subjects of theology, is an important institution in God-human communication. The messengers chosen by God convey to (...) people the information that they received through revelation and offer teachings that will bring them to salvation. The idea of salvation by God when suffering or feeling helpless has driven people to the expectation of a savior. Nearly all religions except Shintoism have the awaited savior belief in the world. Accordingly, the savior will emerge in an environment of chaos where disasters are experienced, and a moral collapse is observed. The expected savior will drive people away from this turmoil, bring them happiness, well-being, and lead them to salvation. Although there is a savior belief in Judaism and Christianity, Muslims claim that the awaited savior in these religions is Muhammad. Muslim thinkers who believe that Muhammad was heralded in previous scripts, tried to find evidence on the subject from the Bible. One of the Islamic scholars who did researches for this purpose is Shamsuddin al-Samarqandi. Shamsuddin Mohammed b. Ashraf al-Husayni al-Samarqandi is an important Turkish-Islamic scholar who lived in Turkestan at the end of the 7th century and the first quarter of the 8th century. Samarqandi is a versatile scholar who produced important works in various fields such as philosophy, logic, mathematics, discussion, debate and astronomy. Shamsuddin al-Samarqandi is one of the eminent scholars who have written his name in the history of science and philosophy with his works. He adopted a critical and analytical style in almost every field, putting the science of logic at the center of his system. His constructive criticisms had an important function in understanding and interpreting the ideas of numerous thinkers, from Greek philosophers to Islamic philosophers and representatives of philosophical theology. In addition to all these, Samarqandi did not hesitate to criticize the Christian and Jewish belief systems, religions such as Sanawiyyah and Zoroastrianism, and the teachings of the naturalist philosophers regarding the relationship between God and the world in the light of rational and scriptural evidence. Samarqandi, who distinguished himself in rational sciences, also showed himself with his background in theology. Due to his exceptional intellectual interest, he analyzes some key concepts and divine codes related to the Bible, making original inferences about the loyalty of Muhammad, the prophet of Islam. Samarqandi interprets some passages of the Torah and the New Testament, which he considers as signs of Muhammad's prophethood, in the axis of language, logic and the rules of shariah, and concludes that Muhammad is the last prophet to be announced. The conceptual framework that he mostly focuses on in this regard contains Mount Paran, Paraklite, comparison with Moses, and the good news given to the Ishmaelites. Samarqandi makes inferences about the environment in which Muhammad appeared, his qualities, and his lineage, based on the aforementioned concepts. Samarqandi also responds to the criticisms raised by the Ahl al-Kitab about the principles, such as the abolition of other religious rules constituting the basis of Muhammad's legitimacy and establishment of Islam instead, and him being a universal prophet. An important privilege of Samarqandi is that he not only grounds his claims on a theoretical scale but also engages in debates with the leaders of the Ahl al-Kitab. Although Samarqandi exhibits a satisfactory analytical attitude in most of his claims, he displays a sophisticated approach based on the method of coercion (ilzām) in some of his claims. Although he adheres to the tradition of beshair al-nubuwwah in general, he gives a different perspective and strong reasoning to the same evidence within the tradition with the effect of his identity as a verifier (muhaqqik). (shrink)

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The persistent gender inequalities in higher education are an ongoing concern among academics. This paper investigates how male and female academics perceive the need for gender-related changes to support academic women’s career advancement in China. Drawing on 40 interviews with male and female academics at a leading Chinese research university, this paper finds that attitudes among male academics were overwhelmingly negative toward the necessity for gender-related changes, whereas the female academics’ responses varied. Two underlying issues cause the relatively similar degrees (...) of unwillingness of men and women to make gender-related policy changes at universities. First, these academics had a strong belief in merit-based rules for promotion, which embedded gender blindness in the name of ‘fairness’. Second, the power of individual choice was the determining factor for women’s career progression, although both men and women acknowledged that their traditional cultural beliefs were rooted in processes and practices that systematically disadvantaged women. The findings expose academics’ low expectations for the successful creation or implementation of institutional policies that support academic women’s career development, considering that male academics did not support gender-related changes, and female academics were not united in their perspectives. In addition, socio-cultural norms were a critical obstacle. The findings suggest that the successful implementation of any gender policies must meet two conditions: they should stress equal opportunities for both sexes and should not jeopardize the perceived ‘fair’ meritocracy in academia. (shrink)

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Mei di li cheng -- Huaxia mei xue -- Mei xue si jiang.

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In late autumn of the year 1995, trudging alone over ice- and snow-covered hills and plains, I walked into the Crow Valley in mountainous western Colorado and examined the sites of ancient American Indian tribes. Local archaeologists had told me the Indians living here had migrated from North China and Northeast China nine thousand years ago. I returned from the mountains that evening and made my way to a wooden cabin for archaeologists, built in a col. I planned to have (...) supper there. To my surprise the little dining room, which normally was occupied only by myself and two undergraduate archaeologists, was packed with youngsters. (shrink)

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One of the problems regarding one of the breaking points in the history of Islamic thought is the presidency. Muslims did not only fall into a theoretical conflict on this issue, but unfortunately, they also engaged in actual battles. The disagreement among Muslims has retained its influence to the present day and has shaped both the religious and worldly views of Muslims. The debate on the identity of the candidate who will assume the role of Muhammad and organize the religious (...) and worldly affairs of Muslims has set the scene of historical conflicts that manifest themselves in the theoretical and practical fields. The religious references made in order to legitimize the political theses caused the said theses to be institutionalized, and matters basically of a political character were associated with religion. Among the Islamic sects, especially Shia, attributed an existential meaning to the problem of the presidency and shaped all their religious and worldly views on this axis. The Shia, who considered the presidency almost a basis of faith, assigned a rank close to prophethood to the heads of state. Zaydiyya stands out as the closest branch of the Shia to the Ahl al-Sunnah in terms of politics. They think more moderately about the characteristics of the head of state, heads of state other than Ali, and the Companions. Ahl as-Sunnah considers the presidency essentially as a juristically -political issue. Bringing this discussion into the field of belief, even with the aim of objecting to Shia, who sees the presidency as a problem of faith and systematizes this problem, shows the first effects of Shia on Sunni political thought. In order to defend Ali's presidency and to question the legitimacy of others, Shia brought the issue into the field of belief, and sought to prove that Ali was superior in the sight of Allah, and therefore, more worthy of the presidency, by referring to various religious texts. Shia examined the issue in a dogmatic way in order to prove his political theses strongly and establish absolute authority. As an inevitable consequence of this method, the institution of the presidency is endowed with divine powers. The theses that the heads of state are appointed with religious references and have the quality of ismah (infallibility) are the most concrete reflections of this approach. Ahl as-Sunnah tried to justify Abu Bakr's legitimacy by defending his superiority against Shia, who defended Ali's superiority. This approach reveals the methodical interaction as well as taking on the mission of responding to Shia effectively in its own way. Shamsaddin as-Samarqandī, whose political imagination we have examined, is a Sunni scholar belonging to the Hanafi - Maturidite kalam tradition. Due to his political views and style, he is also described as a Shiite by some. By examining Samarqandī's concept of politics in the context of his ideas on the general philosophy of theology, we can have clearer information about his sectarian belonging and political stance. He adopted the analytical method in politics, as in other issues, and revealed his own unique style and views, while adhering to the main vein of Ahl as-Sunnah. He adopted the analytical method in politics, as in other issues, and revealed his own unique style and views, while adhering to the main street of Ahl al-Sunnah. (shrink)

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