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Smooth muscle cells have developed a contractile machinery that allows them to exert tension on the surrounding extracellular matrix over their entire length. This has been achieved by coupling obliquely organized contractile filaments to a more‐or‐less longitudinal framework of cytoskeletal elements. Earlier structural data suggested that the cytoskeleton was composed primarily of intermediate filaments and played only a passive role. More recent findings highlight the segregation of actin isotypes and of actin‐associated proteins between the contractile and cytoskeletal domains and raise (...) the possibility that the cytoskeleton performs a more active function. Current efforts focus on defining the relative contributions of myosin cross‐bridge cycling and actin‐associated protein interactions to the maintenance of tension in smooth muscle tissue. (shrink)

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After World War II, Japanese intellectuals believed that world history was moving inexorably toward bourgeois democracy and then socialism. But who would be the agents--the active "subjects"--of that revolution in Japan? Intensely debated at the time, this question of active subjectivity influenced popular ideas about nationalism and social change that still affect Japanese political culture today. In a major contribution to modern Japanese intellectual history, J.Victor Koschmann analyzes the debate over subjectivity. He traces the arguments of intellectuals from (...) various disciplines and political viewpoints, and finds that despite their stress on individual autonomy, they all came to define subjectivity in terms of deterministic historical structures, thus ultimately deferring the possibility of radical change in Japan. Establishing a basis for historical dialogue about democratic revolution, this book will interest anyone concerned with issues of nationalism, postcolonialism, and the formation of identities. (shrink)

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La Iglesia de América Latina y el Caribe recibe del Concilio Vaticano II una fuerza crítica y profética, que se evidencia en la Segunda Conferencia del Episcopado, reunida en Medellín, en 1968. A partir de la originalidad propia de nuestra amerindia, este Concilio se asume, integra y traduce para vivir su inspiración y derroteros fundamentales. La iglesia de la que somos testigos hoy, 50 años después de Medellín, se ha entretejido desde allí. Prueba fehaciente de ello, en este continente, son (...) aquellas comunidades que testimonian a una iglesia liberadora y misericordiosa, nazarena y samaritana, una iglesia que es pueblo de Dios y de los pobres, una iglesia comunitaria de comunidades y, siempre, en salida. Comunidades que han trabajado en aras de la paz, la justicia y la dignidad de todos; en una búsqueda y respuesta real de organización, de lucha ante la opresión y explotación de cualquier orden. (shrink)

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It is estimated that 300,000 children 0–14 years of age are diagnosed with cancer worldwide each year. While the absolute risk of cancer in children is low, it is the leading cause of death due to disease in children in high‐income countries. In spite of this, the etiologies of pediatric cancer are largely unknown. Environmental exposures have long been thought to play an etiologic role. However, to date, there are few well‐established environmental risk factors for pediatric malignancies, likely due to (...) technical barriers in collecting biological samples prospectively in pediatric populations for direct measurements. In this review, we propose the use of novel or underutilized biospecimens (dried blood spots and teeth) and molecular approaches for exposure assessment (epigenetics, metabolomics, and somatic mutational profiles). Future epidemiologic studies of pediatric cancer should incorporate novel exposure assessment methodologies, data on molecular features of tumors, and a more complete assessment of gene‐environment interactions. (shrink)

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I show that the latter Wittgenstein's treatment of language and the mind results in a conception of the human subject that goes against the exclusive emphasis on the cognitive that characterizes our modern conception of knowledge and the self. For Wittgenstein, our identification with the cognitive ego is tantamount to a blindness to our own nature — blindness that is entrenched in our present culture. The task of philosophy is thus transformed into a form of cultural therapy that seeks to (...) awaken in us a sensitivity to different modes of awareness than the merely intellectual. Its substance of reflection becomes not only the field of conscious rational thought, but the tension in our nature between reason and vital feeling, that is, between culture and life. (shrink)

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Why does symbolic communication in humans develop primarily in an oral medium, and how do theories of language origin explain this? Non-human primates, despite their ability to learn and use symbolic signs, do not develop symbols as in oral language. This partly owes to the lack of a direct cortico-motoneuron control of vocalizations in these species compared to humans. Yet such modality-related factors that can impinge on the rise of symbolic language are interpreted differently in two types of evolutionary storylines. (...) 1) Some theories posit that symbolic language originated in a gestural modality, as in “sign languages”. However, this overlooks work on emerging sign and spoken language showing that gestures and speech shape signs differently. 2) In modality-dependent theories, some emphasize the role of iconic sounds, though these lack the efficiency of arbitrary symbols. Other theorists suggest that ontogenesis serves to identify human-specific mechanisms underlying an evolutionary shift from pitch varying to orally-modulated vocalizations (babble). This shift creates numerous oral features that can support efficient symbolic associations. We illustrate this principle using a sound-picture association task with 40 learners who hear words in an unfamiliar language (Mandarin) with and without a filtering of oral features. Symbolic associations arise more rapidly and accurately for sounds containing oral features compared to sounds bearing only pitch features, an effect also reported in experiments with infants. The results imply that, beyond a competence to learn and use symbols, the rise of symbolic language rests on the types of signs that a modality of expression affords. (shrink)

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Two hundred and twenty-six state employees completed a structured questionnaire that investigated their ethical values and training needs. Top management were more likely to have attitudes against cronyism and giving advantage to others. Individuals higher in the organizational hierarchy, and female employees were more likely to believe that discriminatory practices were an ethical concern. In addition, employees with a larger number of clients outside of the organization were more supportive of the need to maintain strict confidentiality in business dealings. Employees'' (...) awareness and use of the organization''s code of conduct generally proved to be poor predictors of ethical values. Other analyses revealed that a variety of sociodemographic factors, job characteristics and ethical values predicted specific areas of training needs in ethics. (shrink)

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By the late nineteenth century, science was well established in the public mind as the primary method by which useful knowledge of the material universe is obtained. Surely, it was thought, if science can discover cathode rays and radio waves, then it should easily authenticate a phenomenon that is far more widely experienced: the supernatural power of the human mind. Non-physical, “psychic” energy appeared to be everywhere, as an integral part of human experience. Indeed, psychic forces are seemingly built into (...) the cores, the souls, of each of us. It should be just a matter of securing the evidence with the hard cement of scientific procedure. At least this was the view of many Victorian scientists, and so was begun a program to verify psychic phenomena scientifically, a task that has continued without success until the current day. By the time the fourth decade of the twentieth century was underway, the search for psychic energy had stalled. The huge database of anecdotal human testimony proved too unreliable, too easy to explain away as subjective desire, fakery, or delusion. Whenever serious attempts were made to gather objective data under controlled conditions, plausible explanations such as trickery or simple coincidence were readily found--if not by the investigators, then by their critics. Although these plausibilities were not always conclusively proven, they were never conclusively ruled out. And, as long as ordinary explanations for reports of suggested psychic phenomena.. (shrink)

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Taking a Harder Line “The New Atheism” is the name that was attached, often pejoratively, to the series of six bestselling books by five authors that appeared in the period 2004-2008.[i] Since then many have joined the movement, with an upsurge in books, freethinker organizations, and an exponential expansion of the blogosphere spreading the word on atheism to thousands. The message of new atheism is that it is time to take a far less accommodating attitude toward religion, including moderate religion, (...) than had been exhibited in previous years by atheist authors and, in particular, non-believing scientists. Science, in the United States, is locked in a battle with conservative Christians over the teaching of evolution and creationism in the schools. While 87 percent of scientists accept evolution by unguided, purely natural processes, only 32 percent of the public does.[ii] Belief in unguided evolution among mainline Protestants and Catholics is about the same as among the general public, while only 10 percent of Evangelicals and 19 percent of Fundamentalist Protestants acknowledge this view. (shrink)

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There has been a longstanding bias in the study of spoken language towards using writing to analyse speech. This approach is problematic in that it assumes language to be derived from an autonomous mental capacity to assemble words into sentences, while failing to acknowledge culture-specific ideas linked to writing. Words and sentences are writing constructs that hardly capture the sound-making actions involved in spoken language. This book brings to light research that has long revealed structures present in all languages but (...) which do not match the writing-induced concepts of traditional linguistic analysis. It demonstrates that language processes are not physiologically autonomous, and that speech structures are structures of spoken language. It then illustrates how speech acts can be studied using instrumental records, and how multisensory experiences in semantic memory couple to these acts, offering a biologically-grounded understanding of how spoken language conveys meaning and why it develops only in humans. (shrink)

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The problem of threat to international politics and global peace has undermined the effectiveness of the power of dialogue. The world seems to be in the condition of will to power derivable from the mutually assured destructive tendencies. Is it possible to extend global peace? How can this be achieved? In this paper, we posit that dialogue is a fundamental medium for conflict resolution and peaceful coexistence in a diverse world. We contend that monologue in international politics understood in terms (...) of might is right undermines the effectiveness of dialogue and often leads to violent conflicts within and between countries. Our world today is at a crossroads. Dialogue, however, foregrounds the medium of conflict resolution and the social consciousness of human communication. We present a hermeneutic understanding of dialogue that follows from relevant works of Hans Georg Gadamer and Jűrgen Habermas. This paper espouses the power of dialogue as a basis for the normative foundation of an emancipated social global order. The dialogical sequence has a cobweb of social interconnectedness and the ethics of global peace. We present a literal and philosophical understanding of dialogue and a contextual understanding of dialogue within the hermeneutic tradition. (shrink)

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Studies of individuals under conditions of confinement or severe social and physical restrictions have consistently shown deleterious mental health effects but also high levels of adaptability when dealing with such conditions. Considering the role of physical activity and sport in psychological adaptation, this paper describes a longitudinal study to explore to what extent the imposed restrictions due to the outbreak of SARS-CoV-2 may have affected athletes’ mental health outcomes and how far the process of adaptation to confinement conditions is differentially (...) affected depending on whether the sports activity was practiced individually or in a group, and outdoors, indoors, or both. Two hundred and seventy-four athletes were assessed over 7 weeks using the GHQ-28 and an ad hoc survey exploring the practice of physical activity. A mixed-model fixed effects ANCOVA was used to analyze the effects of time, place, and company in which the sport was practiced, with an index of the amount of physical activity expended as a covariate. Results show a significant effect of time in three out of four of the GHQ-28 subscales, in all cases showing a consistent adaptation to conditions over time. Results also show that playing sport indoors, outdoors, or both, and practicing alone vs. with others differentially affect the somatic symptoms exhibited during confinement: Athletes who practiced sport with others showed higher levels of somatic symptoms at the beginning of the set of data but a quicker rate of adaptation. Differences arising from practicing sport alone or with others were more pronounced in the case of indoor sports, which could be related to the fact that physical activity that can be practiced during confinement is more similar to that practiced indoors alone. Implications relating to what sport psychologists and other health professionals may offer to athletes in stressful situations are discussed. (shrink)

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In this fascinating and accessible book, physicistVictor J. Stenger guides the lay reader through the key developments of quantum mechanics and the debate over its apparent paradoxes. In the process, he critically appraises recent metaphysical fads. Dr. Stenger's knack for elucidating scientific ideas and controversies in language that the nonspecialist can comprehend opens up to the widest possible audience a wealth of information on the most important findings of contemporary physics.

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Le présent article offre une nouvelle interprétation du concept aristotélicien d' « imagination » ou phantasia par les moyens d'une lecture attentive du Traité de l'âme, III, 3, tout particulièrement de son début. Aristote soutient que ses prédécesseurs ne peuvent expliquer comment l'erreur se produit. Mais c'est également une difficulté pour sa propre explication des formes de base de la perception et de la pensée, et Aristote introduit la phantasia précisément pour répondre à cette question. Il soutient qu'elle ne peut (...) être réduite aux autres états mentaux et offre donc une nouvelle explication causale du contenu, laquelle explique comment un état mental peut être aussi bien vrai que faux. The present article offers a new interpretation of Aristotle's concept of « imagination » or phantasia through a close reading of On the Soul, 3. 3, with special attention to the chapter's opening. Aristotle argues that his predecessors cannot explain how error can ever occur. But it is equally a difficulty for his own account of the most basic types of perception and thought, and Aristotle introduces phantasia precisely to answer this problem. He argues that it cannot be reduced to other mental states and then offers a new causal account of content which explains how a mental state can be either true or false. (shrink)

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While belief in gods was almost universal in the ancient world, Thales of Miletus introduced the notion that observed phenomena could be explained in natural terms without invoking imagined spirits. Leucippus and Democritus, and later Epicurus and Lucretius, proposed that everything was composed of particulate atoms in an otherwise empty void. Any gods that existed played no role in the human world. The universe was infinite, eternal, uncreated, and included many worlds besides our own. These ideas conflicted with the other (...) philosophical schools of the time and were suppressed by the Church during the Dark Ages. Atomism reappeared during the Renaissance and became a crucial ingredient in the scientific revolution that followed. The atomic picture of matter has now been solidly confirmed. Furthermore, the notion of an infinite, eternal, and uncreated ‘multiverse’ is strongly suggested by modern cosmology. (shrink)

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Wittgenstein's later philosophy is usually characterized as pragmatist, his account of linguistic meaning as conventionalist, and his methodology as naturalistic. Wittgenstein is said to have renounced in the later work his early concern with the Unsayable, and to have relocated philosophy within the realm of discourse. I argue against that picture of Wittgenstein's later philosophy in this dissertation. ;The central insight of Wittgenstein's discussion of rules and language in the Investigations is that meaning is not the result of a cognitive (...) achievement, but that it is grounded in precognitive natural reactions common to all human beings. I show that the appeal to the precognitive is transcendental, for it involves reference to a synthesis that is prior to discursive articulation and presupposed as a necessary condition of meaning. ;I argue against the conventionalist reading of Wittgenstein that the transcendental appeal to precognitive reactions in the discussion of rules is distinct from the appeal to a social context in the Private Language Argument, and that the relation between those two discussions is analogous to that between Kant's Transcendental Deduction and the Refutation of Idealism. ;The parallel with Kant helps to show how the failure to distinguish the empirical and transcendental levels in Wittgenstein's discussion leads to the conventionalist readings of his account of language . . It also shows that Wittgenstein is not subject to the charge of relativism commonly levelled against him . ;The distinction between empirical and transcendental levels, as it appears in the pivotal notion of Form of Life, reveals that Wittgenstein's methodology is not naturalistic but instead depends on a non-discursive mode of awareness. . I argue on this basis that Wittgenstein is closer to intuitive-realists than to pragmatists . ;Wittgenstein's Transcendentalism thus shows a deep continuity between the motivations behind his early and his later thought. In fact, the Unsayable plays a central role in the later work, for it is through non-discursive insight into the Unsayable that philosophy fulfills the therapeutic task that Wittgenstein assigns to it in the Investigations. (shrink)

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This paper focuses on the uses of Dewey’s ideas in Mexico before his appropriation by the Mexican revolutionary government in 1923. During the early 20th century, anarchists, socialists, and teacher advocates of progressive education in Mexico invoked the name of John Dewey as an important pillar for a vision of a modern Mexico. Deweyan ideas circulated among these radical pedagogues, sprouting in urban centers such as Mérida in Yucatán province, or in poor barrios of México City, where pockets of urban (...) radicalism emerged concurrently without the necessity of concerted action. Subsequently, self-professed disciples of Dewey founded the journal Educación identifying Dewey as a member of the journal’s board of .. (shrink)

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For years theists have claimed that the constants of physics had to be finely tuned by God to the values that have for life in the universe to be possible. In my column of June, 2009 I showed that many of these claims are based on an improper analysis of the data. Even some of the competent scientists who write on this subject commit the fallacy of holding all the parameters constant and varying just one. When you allow all to (...) vary, you find that changes to one parameter can be easily compensated for by changes to another, leaving the ingredients for life in place. This point is also made nicely in a recent Scientific American cover story by Alejandro Jenkins and Gilad Perez. In this column I will discuss perhaps the most cited example of claimed fine-tuning, the Hoyle resonance. In 1953 the famous astronomer Fred Hoyle calculated that the production of carbon would not occur with sufficient probability unless that probability was boosted by the presence of an excited nuclear state of C12 at a very specific energy. In what appeared to be a remarkable victory for anthropic reasoning, Hoyle proposed that this previously unknown state must exist at about 7.7 MeV. (shrink)

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The story of a triumphant idea from Democritus to the Higgs boson, one of the most successful scientific hypotheses ever devised is chronicled in this history of atomism. Stenger makes the case that in the final analysis atoms and the void are all that exists.

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The claim that certain fundamental constants of nature are fine tuned for life and that this provides strong evidence for supernatural design is perhaps the best scientific argument for the existence of God since Paley’s watch. Even atheist physicists find these so called “anthropic coincidences” difficult to explain and need to invoke the Weak Anthropic Principle and multiple universes to do so. Certainly if there are many universes, fine tuning is simple. Our form of life was fined tuned to our (...) universe by evolution. While multiple universes are expected from modern cosmological theories, theists and some scientists object that invoking the unobservable is not science. Of course, God is unobservable too, so the best theists can claim is a standoff. This is the first in a series of columns based on a book in the works that attempts to show that the apparent fine tuning of fundamental constants can be understood from basic physics without invoking multiple universes. In some cases the explanation is provable. In other cases, it is not provable but plausible. Fine tuning by design is a God of the Gaps argument. The proponent has the burden if proving that no possible natural explanation can be found. Thus a plausible natural explanation is sufficient to defeat the argument. A list of thirty four parameters that seem to be fine tuned has been assembled by Rich Deem on the God and Science website. Several of Deem’s constants, such as the speed of light in a vacuum, c, Newton’s constant of gravity, G, and Planck’s constant, h, are just arbitrary numbers that are determined simply by the unit system you are using. They can be set equal to any number you want, except zero, with no impact on the physics. So no fine tuning can possibly be involved, just as the number p is not fine tuned. I will focus first on the five parameters that have the most significance because, if interpreted correctly, they seem to pretty much rule out almost any conceivable kind of life without fine tuning: · Ratio of electrons to protons · Ratio of electromagnetic force to gravity Expansion rate of the universe · Mass density of the universe · Cosmological constant I will admit that the features a universe would have for slightly different values of these parameters, all other parameters remaining the same, would render unlikely any form of life even remotely like ours, that is, one that is based on a lengthy process, chemical or otherwise, by which complex matter evolved from simpler matter. Let me discuss each in turn, with the last, the most difficult, reserved for a future column.. (shrink)

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part self-help guide, part college lecture, part confessional, part time travel adventure, On Purpose" uses a beautiful fantasy-filled graphic novel format to tell a story of self- discovery and personal growth that you'll never forget.

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Over-flexibility in the definition of Friston blankets obscures a key distinction between observational and interventional inference. The latter requires cognizers form not just a causal representation of the world but also of their own boundary and relationship with it, in order to diagnose the consequences of their actions. We suggest this locates the blanket in the eye of the beholder.

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All editors and translators of Propertius seem convinced that the Roman poet has endowed the horse Arion with the power of speech. I present a few sample translations of the two lines.

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Many theists regard the claim that certain fundamental constants of nature are fine-tuned for life as the best scientific argument for the existence of God since Paley’s watch. Even atheist physicists find these so-called “anthropic coincidences” difficult to explain naturally and many think they need to invoke multiple universes and the so-called “anthropic principle” to do so. Certainly if there are many universes, fine-tuning is simple. Our universe is not fine-tuned for life. Life is fine-tuned to our universe. While multiple (...) universes are expected from modern cosmological theories, theists and some scientists object that invoking the unobservable is not science. Of course, God is unobservable too, so the best theists can claim is a standoff. (shrink)

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This paper provides a philosophical analysis of the Price equation and its role in evolutionary theory. Traditional models in population genetics postulate simplifying assumptions in order to make the models mathematically tractable. On the contrary, the Price equation implies a very specific way of theorizing, starting with assumptions that we think are true and then deriving from them the mathematical rules of the system. I argue that the Price equation is a generalization-sketch, whose main purpose is to provide a unifying (...) framework for researchers, helping them to develop specific models. The Price equation plays this role because, like other scientific principles, shows features as abstractness, unification and invariance. By underwriting this special role for the Price equation some recent disputes about it could be diverted. (shrink)

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Due to its high degree of complexity and its historical nature, evolutionary biology has been traditionally portrayed as a messy science. According to the supporters of such a view, evolutionary biology would be unable to formulate laws and robust theories, instead just delivering coherent narratives and local models. In this article, our aim is to challenge this view by showing how the Price equation can work as the core of a general theoretical framework for evolutionary phenomena. To support this claim, (...) we outline some unnoticed structural similarities between physical theories and evolutionary biology. More specifically, we shall argue that the Price equation, in the same way as fundamental formalisms in physics, can serve as a heuristic principle to formulate and systematise different theories and models in evolutionary biology. (shrink)

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This paper analyses the structure of evolutionary theory as a quasi-Newtonian theory and the need to establish a Zero-Cause Law. Several authors have postulated that the special character of drift is because it is the default behaviour or Zero-Cause Law of evolutionary systems, where change and not stasis is the normal state of them. For these authors, drift would be a Zero-Cause Law, the default behaviour and therefore a constituent assumption impossible to change without changing the system. I defend that (...) drift's causal and explanatory power prevents it from being considered as a Zero-Cause Law. Instead, I propose that the default behaviour of evolutionary systems is what I call the Principle of Stasis, which posits that an evolutionary system where there is no selection, drift, mutation, migration, etc., and therefore no difference-maker, will not undergo any change (it will remain in stasis). (shrink)

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This chapter contains sections titled: Notes.

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