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Progressive supranuclear palsy is a movement disorder with prominent tau neuropathology. Brain diseases with abnormal tau deposits are called tauopathies, the most common of which is Alzheimer's disease. Environmental causes of tauopathies include repetitive head trauma associated with some sports. To identify common genetic variation contributing to risk for tauopathies, we carried out a genome-wide association study of 1,114 individuals with PSP and 3,247 controls followed by a second stage in which we genotyped 1,051 cases and 3,560 controls for the (...) stage 1 SNPs that yielded P ≤ 10-3. We found significant previously unidentified signals associated with PSP risk at STX6, EIF2AK3 and MOBP. We confirmed two independent variants in MAPT affecting risk for PSP, one of which influences MAPT brain expression. The genes implicated encode proteins for vesicle-membrane fusion at the Golgi-endosomal interface, for the endoplasmic reticulum unfolded protein response and for a myelin structural component. © 2011 Nature America, Inc. All rights reserved. (shrink)

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The editors of the JRE solicited short essays on the COVID‐19 pandemic from a group of scholars of religious ethics that reflected on how the field might help them make sense of the complex religious, cultural, ethical, and political implications of the pandemic, and on how the pandemic might shape the future of religious ethics.

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In Lewin et al. 359–386) the authors proved that certain systems of annotated logics are algebraizable in the sense of Block and Rigozzi 396). Later in Lewin et al. the study of the associated quasi-varieties of annotated algebras is initiated. In this paper we continue the study of the these classes of algebras, in particular, we report some recent results about the free annotated algebras.

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In dieser Schrift begründet Dante die Priorität der Volks- und Muttersprache vor der lateinischen Gelehrtensprache und fordert eine italienische Hochsprache. Er untermauert seine Ausführungen durch eine anthropologische Erörterung der menschlichen Sprachfähigkeit. Dank einer originellen Interpretation des biblischen Mythos vom Turmbau von Babel legt er eine vernünftig begründete Neubewertung der Vielfalt und der historischen Entwicklung der Sprachen vor. Das Problem der Sprache stellt sich im Denken Dantes in zweifacher Weise: als Problem der Sprache der Philosophie und unter dem Gesichtspunkt der Philosophie (...) der Sprache. In "De vulgari eloquentia" bietet Dante ein ganzes Arsenal metaphysischer Paradigmen auf, um der sprachlichen Verständigung der Menschen eine unvordenkliche Dignität zu geben. Er stellt die gesamte Philosophie in den Dienst des Menschen als sprechendes Wesen. Auch wenn Dante die Doppelbestimmung der Sprache als sinnliches Zeichen, das den Gedanken des einen Menschen einem andern zu vermitteln fähig ist, von der Tradition übernimmt, setzt er andere Akzente. Die Sprache der Menschen ist nicht nur eine im Vergleich zur Transparenz der reinen Geister unvollkommenere Form der Kommunikation, sondern sie wird positiv als die dem Menschen gänzlich angemessene und entsprechende Form der Kommunikation interpretiert: Das Sprechen ist der "herausragende Akt des menschlichen Geschlechts". Mit dem Erscheinen von "De vulgari eloquentia" liegt die vierbändige Ausgabe der Philosophischen Werke Dante Alighieris vollständig vor. Bislang erschienen Bd. 1: Das Schreiben an Cangrande (PhB 463) Bd. 2: Disputation über das Wasser und die Erde (PhB 464) Bd. 4: Das Gastmahl I-IV (PhB 466a-d). (shrink)

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To our knowledge, this is one of the first studies to test different theoretical models of working memory in childhood based on a computerized assessment. We tested this across several countries: Argentina, Brazil, Canada, Italy, and UK. The present study addressed the wider macro-cultural context and how this impacts working memory. We used two economic indices to characterize the participating countries and ranked the countries based on the Global Index of Cognitive Skills and Educational Attainment. Children between 5 and 10 (...) years completed the same set of short-term and working memory tests. There were two main findings. First, there was a similar pattern in verbal working memory across countries, which suggests that this skill may be relatively consistent across different cultural groups. In contrast, the pattern for visuo-spatial working memory was different across countries, which may explained by cultural differences and educational rankings of the countries. The second main finding was that both a domain-general model and a domain-specific model provided a reasonably good fit with the data, there was the high relationship between the verbal and visuo-spatial working memory constructs across the countries in the latter model. Thus, it may be a more parsimonious choice to rely on a three-factor model. The data also suggest culture-similar patterns in a computerized assessment of working memory. (shrink)

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Studies on age-related differences in risk perception in a real-world situation, such as the recent COVID-19 outbreak, showed that the risk perception of getting COVID-19 tends to decrease as age increases. This finding raised the question on what factors could explain risk perception in older adults. The present study examined age-related differences in risk perception in the early stages of COVID-19 lockdown, analyzing variables that can explain the differences in perception of risk at different ages. A total of 1,765 adults (...) aged between 18 and 87 years old completed an online survey assessing perceived risk severity and risk vulnerability of getting COVID-19, sociodemographic status, emotional state, experience relating to COVID-19, and physical health status. Results showed that the older the participants, the lower the perceived vulnerability to getting COVID-19, but the higher the perceived severity. Different predictors explain the perception of risk severity and vulnerability at different ages. Overall, self-reported anxiety over the pandemic is a crucial predictor in explaining risk perceptions in all age groups. Theoretical and practical implications of the empirical findings are discussed. (shrink)

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BackgroundContradictory evidence exists about the emotional burden of participating in qualitative research for palliative care patients and carers and this raises questions about whether this type of research is ethically justified in a vulnerable population. This study aimed to investigate palliative care patients' and carers' perceptions of the benefits and problems associated with open interviews and to understand what causes distress and what is helpful about participation in a research interview.MethodsA descriptive qualitative study. The data were collected in the context (...) of two studies exploring the experiences of care of palliative care patients and carers. The interviews ended with questions about patients' and carers' thoughts on participating in the studies and whether this had been a distressing or helpful event. We used a qualitative descriptive analysis strategy generated from the interviews and the observational and interactional data obtained in the course of the study.ResultsThe interviews were considered helpful: sharing problems was therapeutic and being able to contribute to research was empowering. However, thinking about the future was reported to be the most challenging. Consent forms were sometimes read with apprehension and being physically unable to sign was experienced as upsetting. Interviewing patients and carers separately was sometimes difficult and not always possible.ConclusionThe open interview enables the perspectives of patients and carers to be heard, unfettered from the structure of closed questions. It also enables those patients or carers to take part who would be unable to participate in other study designs. The context is at least as important as the format of the research interview taking into account the relational circumstances with carers and appropriate ways of obtaining informed consent. Retrospective consent could be a solution to enhancing participants control over the interview. (shrink)

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El Foro Global de Bioética en Investigación (GFBR por sus siglas en inglés) se reunió el 3 y 4 de noviembre en Buenos Aires, Argentina, con el objetivo de discutir la ética de la investigación con mujeres embarazadas. El GFBR es una plataforma mundial que congrega a actores clave con el objetivo de promover la investigación realizada de manera ética, fortalecer la ética de la investigación en salud, particularmente en países de ingresos bajos y medios, y promover colaboración entre países (...) del norte y del sur.a Los participantes en el GFBR provenientes de Latinoamérica incluyeron a eticistas, investigadores, miembros de comités de ética y representantes de autoridades sanitarias provenientes de Argentina, Brasil, Chile, Colombia, Ecuador, El Salvador, Guatemala, Honduras, Panamá, Perú, Nicaragua y la República Dominicana. Una legítima preocupación por la protección de las mujeres embarazadas y sus embriones o fetos ha llevado a la mayoría de los países de la Región de las Américas a limitar la realización de estudios con mujeres embarazadas exclusivamente a aquellos estudios específicos sobre el embarazo, y a requerir la exclusión sistemática de las mujeres embarazadas o de las mujeres que quedan embarazadas en el curso del estudio. Ciertamente, a lo largo de la historia de la ética de la investigación, se ha creído erróneamente que proteger a una población es sinónimo de excluirla de los estudios. Se sabe ahora que proceder así implica exponer a riesgos mucho mayores a la población que se busca proteger. El embarazo implica cambios fisiológicos sustantivos e impacta profundamente la manera como el cuerpo metaboliza los medicamentos. Sin embargo, por evitar hacer investigación con mujeres embarazadas, no se ha producido la evidencia científica necesaria para tomar decisiones sobre tratamientos e intervenciones preventivas con dosis eficaces y seguras para ellas y sus embriones o fetos. A manera de ilustración, en el 2001 había en los Estados Unidos apenas más de una docena de medicamentos aprobados para uso en el embarazo (1) y en el 2011 la Food and Drug Administration (FDA) aprobó por primera vez en 15 años un medicamento para su uso en el embarazo (2). Como consecuencia de no haber producido la evidencia necesaria, se pone en riesgo la salud de las mujeres embarazadas cada vez que se les da atención médica. Las mujeres embarazadas se enferman y las mujeres enfermas se embarazan, y no se sabe si los medicamentos que se les da son eficaces o siquiera seguros para ellas y sus embriones o fetos. (shrink)

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Mathematical correspondence offers a rich heritage for the history of mathematics and science, as well as cultural history and other areas. It naturally covers a vast range of topics, and not only of a scientific nature; it includes letters between mathematicians, but also between mathematicians and politicians, publishers, and men or women of culture. Wallis, Leibniz, the Bernoullis, D'Alembert, Condorcet, Lagrange, Gauss, Hermite, Betti, Cremona, Poincaré and van der Waerden are undoubtedly authors of great interest and their letters are valuable (...) documents, but the correspondence of less well-known authors, too, can often make an equally important contribution to our understanding of developments in the history of science. Mathematical correspondences also play an important role in the editions of collected works, contributing to the reconstruction of scientific biographies, as well as the genesis of scientific ideas, and in the correct dating and interpretation of scientific writings. This volume is based on the symposium “Mathematical Correspondences and Critical Editions,” held at the 6th International Conference of the ESHS in Lisbon, Portugal in 2014. In the context of the more than fifteen major and minor editions of mathematical correspondences and collected works presented in detail, the volume discusses issues such as • History and prospects of past and ongoing edition projects, • Critical aspects of past editions, • The complementary role of printed and digital editions, • Integral and partial editions of correspondence, • Reproduction techniques for manuscripts, images and formulae, and the editorial challenges and opportunities presented by digital technology. (shrink)

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This paper addresses a variant of the job shop scheduling problem with total tardiness minimization where task durations and due dates are uncertain. This uncertainty is modelled with intervals. Different ranking methods for intervals are considered and embedded into a genetic algorithm. A new robustness measure is proposed to compare the different ranking methods and assess their capacity to predict ‘expected delays’ of jobs. Experimental results show that dealing with uncertainty during the optimization process yields more robust solutions. A sensitivity (...) analysis also shows that the robustness of the solutions given by the solving method increases when the uncertainty grows. (shrink)

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Written by two of the leading figures in the field, this is a lucid and systematic introduction to semantics as applied to transformational grammars of the ...

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This article uses a conversation analytic framework to describe a type of wh-question used to challenge a prior utterance, specifically to challenge the basis for or right to do an action done by the prior utterance. These wh-questions are able to do challenging because, rather than asking for new information, they are used to convey a strong epistemic stance of the questioner, a negative assertion. The utterances are designed as requests for an account for a prior claim or action, but (...) by conveying a negative assertion, they suggest that there is no adequate account available and, thus, that there are no grounds for the prior claim or action. The use of these questions in institutional settings can display participants' orientation to institutional goals, norms and roles, showing that institutional roles can thus be enacted, and goals accomplished, by means of practices of talk which are not, themselves, institutionally specific. (shrink)

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This paper explores whether MacIntyrean virtue ethics concepts are applicable in non-Western business contexts, specifically in SMEs in Taiwan, a country strongly influenced by the Confucian tradition. It also explores what differences exist between different polities in this respect, and specifically interprets observed differences between the Taiwanese study and previous studies conducted in Europe and Asia. Based on case study research, the findings support the generalizability of the MacIntyrean framework. Drawing on the institutional logics perspective and synthesizing this with MacIntyrean (...) concepts, the paper explains the differences between the studies largely by reference to the Confucian tradition operating at both the micro-level within firms and at the macro-level as a means of harmonizing the potentially competing institutional logics to which firms are subject. The recent weakening of this tradition, however, suggests that increased conflict may characterize the future. (shrink)

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Plato and the Metaphysical Feminine offers a new interpretation of the role of the female and the feminine in Plato's political dialogues--the Republic, Laws, and Timaeus--informed by Deleuze's film theory and Irigaray's psychoanalytic feminism.Irene Han reads Plato against the grain in order to close the gap between the vitalists and Plato, instead of magnifying their differences. Han explores the ambivalence that the vitalist tradition, Irigaray, and Derrida have towards Platonism. The application of Deleuzian and Irigarayan concepts to the (...) ancient texts produces a new reading of Plato, focusing on the centrality and importance of motion, change, sensuality, and becoming to Platonic philosophy and, thereby, reinterprets Platonic philosophy in the direction of Heraclitus rather than Parmenides: as feminist rather than masculinist, and as mimetic. It therefore prioritizes Heraclitean principles of movement and flux over Form, the feminine over masculine, and materiality, feeling, or sensation over abstraction and universal essence. Han's exploration illustrates how, in Plato's thought, the feminine maps itself onto the plane of phenomena--a plane associated with vitalist themes such as motion, tactility, and change (metabolē). Platonic metaphysics is recontextualized by illustrating how Being expresses itself through processes of (feminine) becoming. With this reformulation, the resulting account of Platonic Being destabilizes any purported Platonic dualism. (shrink)

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The overall goal of speech perception research is to explain how spoken language is recognized and understood. In the current research framework it is assumed that the key to achieving this overall goal is to solve the lack of invariance problem. But nearly half a century of sustained effort in a variety of theoretical perspectives has failed to solve this problem. Indeed, not only has the problem not been solved, virtually no empirical candidates for solving the problem have been produced. (...) One explanation for this lack of progress is simply that no theory has yet hit upon the correct set of invariant properties. Another explanation is that the goal of solving the lack of invariance problem is itself misguided. The most basic claim of this dissertation is that the latter explanation is correct. ;The lack of progress in explaining speech perception exhibited by the current research framework, I argue, is not, in the first instance, due to the failure of individual theories to solve the lack of invariance problem, but rather to the common background assumption that doing so is in fact the key to explaining speech perception. ;My overall argument in support of this basic claim has three main components: criticism of the empirical results of research in the current framework; criticism of the formulation of theories generated in the current research framework; and the availability of an alternative account of phonetic structure. ;The heart of my argument is an analysis of the character of the theoretical weaknesses of three theories of speech perception: the motor theory of speech perception, the ecological theory of speech perception, and the theory of acoustic invariance. I show that, in each case, the particular theoretical problems result from trying to satisfy the common goal of identifying invariant properties of phonetic percepts. ;I analyze the methodological error embodied in the current approach to explaining speech perception as, in general, one of abstracting the wrong kinds of properties from the detail of the speech event, and, in particular, of abstracting away from dynamic and context-dependent properties. (shrink)

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This book offers a major reassessment of Peter Abelard's modal logic and theory of modalities, presenting them as far more uniform and consistent than was until now recognized.Irene Binini offers new ways of connecting Abelard's modal views with other parts of his logic, semantics, metaphysics and theology. Further, the work also provides a comprehensive study of the logical context in which Abelard's theories originated and developed, by presenting fresh evidence about many 11th- and 12th-century sources that are still (...) unpublished. This analysis sheds new light on the relations between Abelard and ancient authors such as Aristotle, Boethius, and Priscian, as well as between Abelard and his contemporaries, such as Anselm of Canterbury, William of Champeaux, Joscelin of Soissons, and Alberic of Paris. (shrink)

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Journal Name: Semiotica Issue: Ahead of print.

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The interweavement of philosophy and literature allows to gain a new sense from the own, lived experiences and to express them through narrations, as the paradigmatic works of Nietzsche, Deleuze and Borges show. They all deal with the inexorability of time and the fact of being at the mercy of the unwanted aspects of Being-in-the-world, the detailed reading of which allows us to assert that the event of the emergence of a new sense lies in the experience of the creative (...) power of the instant, wherein the difference is introduced as the first principle through a Copernican turn and where the eternity expresses itself. In fact, the instant in its repetition results from a strike of chance, an assumption which leads to a new understanding not only of time as a network of destinies, but of eternity as extensive, intensive or ecstatic eternity. Being involved in this experience means to undergo an existential experience of time which produces an irrevocable change of the self. (shrink)

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ABSTRACT The purpose of this paper is to study the idea of black visual intonation in the video-essay Love Is the Message, the Message Is Death (2016) by visual artist Arthur Jafa. With the aim at discovering the singularity of black cinema in filmic composition, the artist carried out an experiment to examine how embodied memories emerge in the form of songs and dances, recovering traditional cultural features that the Afro-Atlantic diaspora dissipated. We find that the aesthetic-political singularity of black (...) cinema emerges in the black verbal-vocal-visual intonation, which externalizes interactive inner energies and organizes a critical-discursive space in which black people can talk about themselves, their desires, dreams and sorrows. (shrink)

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Resumo Como se organizam os meios para que seus produtos sejam oferecidos a seus usuários como produtos de comunicação? Esta é a pergunta que sustenta e justifica o estudo da gramática dos meios, segundo a articulação de códigos eletrônicos geradores das linguagens icônicas em processos perceptuais e cognitivos. Orienta-se pelas explorações que M.McLuhan formulou em suas análises e exercícios de seu projeto pedagógico e também na metodologia semiótica dos processos de articulação sintática, semântica e pragmática.

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In this paper I provide a metatheoretical analysis of speech perception research. I argue that the central turning point in the history of speech perception research has not been well understood. While it is widely thought to mark a decisive break with what I call "the alphabetic conception of speech," I argue that it instead marks the entrenchment of this conception of speech. In addition, I argue that the alphabetic conception of speech continues to underwrite speech perception research today and (...) moreover that it functions as a dogma which ought to be rejected. (shrink)

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The commentaries on the Ethica nova and the Ethica vetus written by some masters of the arts – presumably operating in the Paris faculty – in the first half of the thirteenth century expound in an original way the doctrine of the virtutes consuetudinales which Aristotle, at the end of the first book of his Ethica (I 13), distinguishes into the two main classes of the “moral virtues” and the “intellectual virtues”. The present paper aims at highlighting the particularly important (...) task which is assigned to the intellectual virtues in these early commentaries: joining man to God directly, through a contemplation which becomes love. The masters of the arts maintain that the moral virtues, in spite of the definition given by Aristotle (habitus a quo quis bonus est et opus eius bene reddit), are not sufficient alone to bring man to perfection, but that other more perfect virtues, namely the intellectual ones, are needed in order to make him know and love the supreme good. Having no knowledge of the sixth book of the Ethica, in which Aristotle deals in particular with the intellectual virtues, our masters know only their general description and are concerned with clarifying their relationships with the moral virtues, compared to which they appear to be sometimes really distinct and sometimes united to them in sharing the recta ratio, so much that they may constitute a double virtue. Although the masters of the arts seem to be well-informed about the teaching of the theologians – which they often cite without opposing to it, albeit stressing their own philosophical point of view –, it is significant that no reference whatsoever is made by them to the theological virtues and that they have recourse to the themes of Avicennian mysticism such as the doctrine of the two faces of the soul. Besides presenting the commentaries on the Ethica vetus from a general point of view, I will focus on the Paris commentary in Ethicam veterem (Paris BN lat. 3804A, ff. 152ra-159vb, 241ra-247vb; Paris BN lat. 3572, ff. 226ra-235ra), of which I am preparing a critical edition. The Paris commentary contains in fact a special and original discussion of the doctrine of the virtutes intellectuales. (shrink)

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TThis paper aims to evidence the inherently metonymic nature of co-speech gestures. Arguing that motivation in gesture involves iconicity (similarity), indexicality (contiguity), and habit (conventionality) to varying degrees, it demonstrates how a set of metonymic principles may lend a certain systematicity to experientially grounded processes of gestural abstraction and enaction. Introducing visuo-kinetic signs as an umbrella term for co-speech gestures and signed languages, the paper shows how a frame-based approach to gesture may integrate different cognitive/functional linguistic and semiotic accounts of (...) metonymy (e.g., experiential domains, frame metonymy, contiguity, and pragmatic inferencing). The guiding assumption is that gestures metonymically profile deeply embodied, routinized aspects of familiar scenes, that is, the motivating context of frames. The discussion shows how gestures may evoke frame structures exhibiting varying degrees of groundedness, complexity, and schematicity: basic physical action and object frames; more complex frames; and highly abstract, complex frame structures. It thereby provides gestural evidence for the idea that metonymy is more basic and more directly experientially grounded than metaphor and thus often feeds into correlated metaphoric processes. Furthermore, the paper offers some initial insights into how metonymy also seems to induce the emergence of schematic patterns in gesture which may result from action-based and discourse-driven processes of habituation and conventionalization. It exemplifies how these forces may engender grammaticalization of a basic physical action into a gestural marker that shows strong metonymic form reduction, decreased transitivity, and interacting pragmatic functions. Finally, addressing basic metonymic operations in signed lexemes elucidates certain similarities regarding sign constitution in gesture and sign. English and German multimodal discourse data as well as German Sign Language (DGS) are drawn upon to illustrate the theoretical points of the paper. Overall, this paper presents a unified account of metonymy’s role in underpinning forms, functions, and patterns in visuo-kinetic signs. (shrink)

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This study investigates the performance measurement systems adopted by companies to manage their social responsibility activities, a theme that remains under-researched despite the important role that these mechanisms may play in helping firms control and improve their social performance. An integrative model is developed to examine how the three fundamental drivers of corporate social strategies, i.e., business motivations, perceived stakeholder pressures, and top management’s social commitment, influence the use of social performance indicators for internal decision-making and control and how such (...) use impacts companies’ social and economic performance. The results from a survey of 97 Italian companies suggest that economic motivations and top management’s commitment are associated with a more intensive use of social performance indicators for decision-making and control, whereas perceived pressures from stakeholders do not represent a significant determinant of such use. The use of social performance indicators, in turn, is found to directly influence a firm’s social performance and, indirectly, its bottom line. (shrink)

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This essay is a critical review of two recent collections, Feminism and Foucault: Reflections on Resistance, edited byIrene Diamond and Lee Quinby and Feminism as Critique: On the Politics of Gender, edited by Seyla Benhabib and Drucilla Cornell. While the collections differ in their manner of addressing the critical sources that have inspired them-the former relying upon a single theorist, the latter attempting to move through some of the philosophical history that constitutes our present theoretical terrain-both attempt to (...) think through and thus revisualize some of the categories of difference which we have inherited. Though the best essays from these collections are celebrated for demonstrating how "feminism as critique" can work to move us toward a clearer and more inclusive feminist theory, questions are raised about what the inattention to race in these volumes suggests about our own role in the construction of power and knowledge, and the erasures that help to secure them both. (shrink)

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