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Enhancing research and development and ensuring equitable pricing and access to cutting-edge treatments are both vital to a biopharmaceutical innovation system that works in the public interest. However, despite delivering numerous therapeutic advances, the existing system suffers from major problems: a lack of directionality to meet key needs, inefficient collaboration, high prices that fail to reflect the public contribution, and an overly-financialized business model.

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This study investigated whether and how a person's varied series of lexical categories corresponding to different discriminatory characteristics of the same colors affect his or her perception of colors. In three experiments, Chinese participants were primed to categorize four graduated colors—specifically dark green, light green, light blue, and dark blue—into green and blue; light color and dark color; and dark green, light green, light blue, and dark blue. The participants were then required to complete a visual search task. Reaction times (...) in the visual search task indicated that different lateralized categorical perceptions of color corresponded to the various priming situations. These results suggest that all of the lexical categories corresponding to different discriminatory characteristics of the same colors can influence people's perceptions of colors and that color perceptions can be influenced differently by distinct types of lexical categories depending on the context. (shrink)

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According to the Temporal Focus Hypothesis, people’s sagittal mental space-time mappings are conditioned by their temporal-focus attention. Based on this, it can be predicted that, by virtue of their future-oriented thinking, individuals with high anxiety should be more likely to think about time according to the future-in-front mapping than those with low anxiety. Utilizing a combined correlational and experimental approach, we found converging evidence for this prediction. Studies 1 and 2 found that individuals higher in dispositional anxiety and state anxiety, (...) who characteristically worry about the future, were more likely to conceptualize the future as in front of them and the past as behind than individuals lower in dispositional anxiety and state anxiety. Study 3 showed that participants who were induced with anxiety mood tended to map the future on a frontal position, compared to those in the baseline condition. These findings shed further light on the Temporal Focus Hypothesis, thus providing the first experimental evidence that emotional experience can influence people’s temporal-focus attention in determining their metaphorical sagittal orientation of time. (shrink)

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Previous research suggests that both patterns in orthography and cultural-specific associations of space-time affect how people map space onto time. In the current study, we focused on Chinese Buddhists, an understudied population, investigating how religious experiences influence their mental representations of time. Results showed that Chinese Buddhists could represent time spatially corresponding to left-to-right, right-to-left and top-to-bottom orientations in their religious scripts. Specifically, they associated earlier events with the starting point of the reading and later times with the endpoint. We (...) also found that Chinese Buddhists were more likely to represent time in a clockwise way than Chinese atheists. This is because Buddhism regards time as cyclic and consisting of repeating ages (i.e. Wheel of Time). Taken together, we provide first psychological evidence that Chinese Buddhists’ spatial representations of time are different from atheists’, due to their religious experiences, namely, both the reading direction in Buddhist texts and Buddhist concepts of time. (shrink)

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According to the Temporal Focus Hypothesis (TFH), people’s implicit spatial conceptions are shaped by their temporal focus. Whereas previous studies have demonstrated that people’s cultural or individual differences related to certain temporal focus may influence their spatializations of time, we focus on temporal landmarks as potential additional influences on people’s space-time mappings. In Experiment 1, we investigated how personally-related events influence students’ conceptions of time. The results showed that student examinees were more likely to think about time according to the (...) past-in-front mapping, and student registrants, future-in-front mapping. Experiment 2 explored the influence of calendar markers and found that participants tested on the Chinese Spring Festival, a symbol of a fresh start, tended to conceptualize the future as in front of them, while those tested on the Tomb Sweeping Day, an opportunity to remember the ancestors, showed the reversed pattern. In Experiment 3, two scenarios representing past or future landmarks correspondingly were presented to participants. We found that past-focused/future -focused scenarios caused an increase in the rate of past-in-front/future-in-front responses respectively. Taken together, the results from these three studies suggest that people’s conceptions of time may vary according to temporal landmarks, which can be explained by the TFH. (shrink)

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This paper explores how English language has gradually become a linguistic form of cultural capital in China’s zigzag journey to modernization. It situates English’s status in flux in historical context, with an analysis at both the international and intra-national level. It showcases the necessity to embed cultural capital within Bourdieu’s full framework, and evidences the arbitrary nature of this form of cultural capital for its intimate tie to power and politics. By revealing how English has been officially consecrated as a (...) global lingua franca and then socially recognized for material and symbolic benefits, this paper implicitly problematizes the officially validated cultural hierarchy, argues that the value of a cultural capital is context-dependent, politically and socially constructed, inseparable from the field where it is produced. The present-day English manifests its symbolic power in classification and social stratification, entrenching the already entrenched inequality within and without the national state. (shrink)

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According to the Body‐Specificity Hypothesis (BSH), people implicitly associate positive ideas with the side of space on which they are able to act more fluently with their dominant hand. Though this hypothesis has been rigorously tested across a variety of populations and tasks, the studies thus far have only been conducted in linguistic and cultural communities which favor the right over the left. Here, we tested the effect of handedness on implicit space‐valence mappings in Tibetan practitioners of Bön who show (...) a strong religious preference for the left, in comparison to an English group. Results showed that Bön right‐handers tended to implicitly associate positive valence more strongly with their dominant side of space despite strong explicit associations between the left and goodness in their religion. This pattern of results found in Bön participants was indistinguishable from that found in English speakers. The findings of the present study support the BSH, demonstrating that space‐valence mappings in people's minds are shaped by their bodily experience, which appears to be independent of space‐valence mappings enshrined in cultural conventions. (shrink)

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People implicitly associate the “past” and “future” with “front” and “back” in their minds according to their cultural attitudes toward time. As the temporal focus hypothesis proposes, future-oriented people tend to think about time according to the future-in-front mapping, whereas past-oriented people tend to think about time according to the past-in-front mapping. Whereas previous studies have demonstrated that culture exerts an important influence on people's implicit spatializations of time, we focus specifically on religion, a prominent layer of culture, as potential (...) additional influence on space-time mappings. In Experiment 1 and 2, we observed a difference between the two religious groups, with Buddhists being more past-focused and more frequently conceptualizing the past as ahead of them and the future as behind them, and Taoists more future-focused and exhibiting the opposite space-time mapping. In Experiment 3, we administered a religion prime, in which Buddhists were randomly assigned to visualize the picture of the Buddhas of the Past or the Future. Results showed that the pictorial icon of Dipamkara increased participants' tendency to conceptualize the past as in front of them. In contrast, the pictorial icon of Maitreya caused a dramatic increase in the rate of future-in-front responses. In Experiment 4, the causal effect of religion on implicit space-time mappings was replicated in atheists. Taken together, these findings provide converging evidence for the hypothesized causal role of religion for temporal focus in determining space-time mappings. (shrink)

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Schizophrenia is a serious mental illness characterized by a disconnection between brain regions. Transcranial magnetic stimulation is a non-invasive brain intervention technique that can be used as a new and safe treatment option for patients with schizophrenia with drug-refractory symptoms, such as negative symptoms and cognitive impairment. However, the therapeutic effects of transcranial magnetic stimulation remain unclear and would be investigated using non-invasive tools, such as functional connectivity. A longitudinal design was adopted to investigate the alteration in FC dynamics using (...) a dynamic functional connectivity approach in patients with schizophrenia following high-frequency repeated transcranial magnetic stimulation with the target at the left dorsolateral prefrontal cortex. Two groups of schizophrenia inpatients were recruited. One group received a 4-week high-frequency rTMS together with antipsychotic drugs, while the other group only received antipsychotic drugs. Resting-state functional magnetic resonance imaging and psychiatric symptoms were obtained from the patients with schizophrenia twice at baseline and after 4-week treatment. The dynamics was evaluated using voxel- and region-wise FC temporal variability resulting from fMRI data. The pattern classification technique was used to verify the clinical application value of FC temporal variability. For the voxel-wise FC temporary variability, the repeated measures ANCOVA analysis showed significant treatment × time interaction effects on the FC temporary variability between the left DLPFC and several regions, including the thalamus, cerebellum, precuneus, and precentral gyrus, which are mainly located within the cortico-thalamo-cerebellar circuit. For the ROI-wise FC temporary variability, our results found a significant interaction effect on the FC among CTCC. rTMS intervention led to a reduced FC temporary variability. In addition, higher alteration in FC temporal variability between left DLPFC and right posterior parietal thalamus predicted a higher remission ratio of negative symptom scores, indicating that the decrease of FC temporal variability between the brain regions was associated with the remission of schizophrenia severity. The support vector regression results suggested that the baseline pattern of FC temporary variability between the regions in CTCC could predict the efficacy of high-frequency rTMS intervention on negative symptoms in schizophrenia. These findings confirm the potential relationship between the reduction in whole-brain functional dynamics induced by high-frequency rTMS and the improvement in psychiatric scores, suggesting that high-frequency rTMS affects psychiatric symptoms by coordinating the heterogeneity of activity between the brain regions. Future studies would examine the clinical utility of using functional dynamics patterns between specific brain regions as a biomarker to predict the treatment response of high-frequency rTMS. (shrink)

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In Freedom of the Will and the Concept of a Person, Harry Frankfurt put forward a theory that what is essential to be a person is second-order volition. The notion of second-order volition can be used as a key conceptual tool in understanding the conflict between desires. By means of the notion, this paper argues that the conflict between desires in our minds lies in the conflict between second-order volitions, other than the conflict between first-order desires. Based on this claim, (...) this paper suggests that, due to the misunderstanding of the nature of the conflict between desires, the analysis of unwilling addict and wanton addict given by Frankfurt is thus wrong, and in his follow-up articles he made wrong description of the phenomenon concerning the conflict between desires. (shrink)

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Neuro-philosophy and the Healthy Mind (2016) is an intriguing book. The neuroscientist, psychiatrist, and philosopher Georg Northoff offers a careful and alluring investigation of brain-environment...

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PurposeThis study investigated the impact of age and myopia on visual form perception among Chinese school-age children.MethodsThis cross-sectional study included 1,074 students with a mean age of 12.1 ± 4.7 years. The mean spherical equivalence refraction of the participants was −1.45 ± 2.07 D. All participants underwent distance visual acuity, refraction measurement and local and global visual form perception test including orientation, parallelism, collinearity, holes and color discrimination tasks.ResultsThe reaction times of emmetropes were slower than those of myopic and high (...) myopic groups on both local and global discrimination tasks. A reduction in reaction times was found with increasing age on both local and global discrimination tasks. Age was significantly associated with both local and global visual perception performance after adjusting for gender, visual acuity and SER.ConclusionsThis study revealed that both local and global visual perception improve with age among Chinese children and that myopes seem to have better visual perception than emmetropes. (shrink)

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We examine the influence of face-based judgments of CFO and CEO honesty on earnings management for the largest publicly traded companies in America. After controlling for incentives and opportunities to manage earnings, CFOs perceived to be less honest engage in higher levels of accruals earnings management and real earnings management. The beneficial impact of perceived honesty on earnings quality is most pronounced when both the CFO and the CEO are perceived to be more honest. Findings are consistent with our conjecture (...) that both the CFO and CEO contribute to a firm’s financial reporting environment. (shrink)

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According to the Temporal Focus Hypothesis, space–time mappings in people’s minds are shaped by their attentional focus. Previous research has shown that numerous cultural and individual factors underpinning temporal focus may contribute to the direction of space–time mappings in people’s mental models. However, the role of time of day in shaping spatial conceptions of time has not been investigated. In a series of three experiments, Chinese participants, who were more likely to be future-focused in the morning than afternoon, were also (...) more likely to produce a future-in-front mapping. However, this morning future-minded effect can only be found in morning people, suggesting a mediating role of chronotype processes. Taken together, the findings across studies suggest that people’s representations of time may arise from an interaction between a person’s chronotype and time-of-day, a phenomenon that we refer to as the chronotype future-minded effect. (shrink)

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Journal Name: Cognitive Linguistics Issue: Ahead of print.

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Across many languages and cultures, people tend to explicitly and implicitly associate brightness with God and darkness with the Devil. In the current research, we used an explicit Brightness-Godas...

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ABSTRACTThe Moving Time metaphor and the Moving Ego metaphor are common in English speakers’ conceptualization of time. Previous research has suggested a broad range of factors influencing people’s...

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Volume 34, Issue 4, October-December 2019, Page 258-261.

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国家哲学社会科学创新基地浙江大学语言与认知研究中心研究成果本书为浙江省哲学社会科学规划课题成果.

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In a congested large-scale subway network, the distribution of passenger flow in space-time dimension is very complex. Accurate estimation of passenger path choice is very important to understand the passenger flow distribution and even improve the operation service level. The availability of automated fare collection data, timetable, and network topology data opens up a new opportunity to study this topic based on multisource data. A probability model is proposed in this study to calculate the individual passenger’s path choice with multisource (...) data, in which the impact of the network time-varying state on passenger path choice is fully considered. First, according to the number and characteristics of OD candidate paths, the AFC data among special kinds of OD are selected to estimate the distribution of passengers’ walking time and waiting time of each platform. Then, based on the composition of path travel time, its real-time probability distribution is formulated with the distribution of walking time, waiting time, and in-vehicle time as parameters. Finally, a membership function is introduced to evaluate the dependence between passenger’s travel time and the real-time travel time distribution of each candidate path and take the path with the largest membership degree as passenger’s choice. Finally, a case study with Beijing Subway data is applied to verify the effectiveness of the model presented in this study. We have compared and analysed the path calculation results in which the time-varying characteristics of network state are considered or not. The results indicate that a passenger’s path choice behavior is affected by the network time-varying state, and our model can quantify the time-varying state and its impact on passenger path choice. (shrink)

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Abduction and metaphor are two significant concepts in cognitive science. It is found that the both mental processes are on the basis of certain similarity. The similarity inspires us to seek the answers to the following two questions: (1) Whether there is a common cognitive mechanism behind abduction and metaphor? And (2) if there is, whether this common mechanism could be interpreted within the unified frame of modern intelligence theory? Centering on these two issues, the paper attempts to characterize and (...) interpret the generation and evolution of scientific metaphors from the perspective of the cognitive mechanism of abductive inference. Then it interprets the common cognitive mechanism behind abduction and metaphor within Hawkins’ frame of intelligence theory. The commonality between abduction and metaphor indicates the potential to further explore human intelligence. (shrink)

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