First Philosophy in the Pragmatic Humanism of F.C.S. Schiller.H. P.McDonald -2003 -International Philosophical Quarterly 43 (4):503-525.detailsDuring his lifetime, F.C.S. Schiller was viewed as a major figure in the pragmatist movement, but his reputation has faded. This article will challenge the view that he was an unoriginal or less important figure. In particular, I will attempt a reconstruction of Schiller’s position on first philosophy, which will examine the differences between Schiller and the other major figures in the pragmatist movement. By using texts from Schiller’s writings, I attempt to create an undistorted reconstruction of what he wrote (...) in order to support this interpretation. I outline the implicit system contained in Schiller’s scattered writings and briefly examine the relation between Schiller’s humanism and other forms of pragmatism. The task seems both justified and worthwhile, since his work has been neglected, despite his prominence in the debates over pragmatism that took place when it emerged at the beginning of the twentieth century. (shrink)
The impact of reporting magnetic resonance imaging incidental findings in the Canadian alliance for healthy hearts and minds cohort.Rhian Touyz,Amy Subar,Ian Janssen,Bob Reid,Eldon Smith,Caroline Wong,Pierre Boyle,Jean Rouleau,F. Henriques,F. Marcotte,K. Bibeau,E. Larose,V. Thayalasuthan,A. Moody,F. Gao,S. Batool,C. Scott,S. E. Black,C. McCreary,E. Smith,M. Friedrich,K. Chan,J. Tu,H. Poiffaut,J. -C. Tardif,J. Hicks,D. Thompson,L. Parker,R. Miller,J. Lebel,H. Shah,D. Kelton,F. Ahmad,A. Dick,L. Reid,G. Paraga,S. Zafar,N. Konyer,R. de Souza,S. Anand,M. Noseworthy,G. Leung,A. Kripalani,R. Sekhon,A. Charlton,R. Frayne,V. de Jong,S. Lear,J. Leipsic,A. -S. Bourlaud,P. Poirier,E. Ramezani,K. Teo,D. Busseuil,S. Rangarajan,H. Whelan,J. Chu,N. Noisel,K.McDonald,N. Tusevljak,H. Truchon,D. Desai,Q. Ibrahim,K. Ramakrishnana,C. Ramasundarahettige,S. Bangdiwala,A. Casanova,L. Dyal,K. Schulze,M. Thomas,S. Nandakumar,B. -M. Knoppers,P. Broet,J. Vena,T. Dummer,P. Awadalla,Matthias G. Friedrich,Douglas S. Lee,Jean-Claude Tardif,Erika Kleiderman & Marcotte -2021 -BMC Medical Ethics 22 (1):1-15.detailsBackgroundIn the Canadian Alliance for Healthy Hearts and Minds (CAHHM) cohort, participants underwent magnetic resonance imaging (MRI) of the brain, heart, and abdomen, that generated incidental findings (IFs). The approach to managing these unexpected results remain a complex issue. Our objectives were to describe the CAHHM policy for the management of IFs, to understand the impact of disclosing IFs to healthy research participants, and to reflect on the ethical obligations of researchers in future MRI studies.MethodsBetween 2013 and 2019, 8252 participants (...) (mean age 58 ± 9 years, 54% women) were recruited with a follow-up questionnaire administered to 909 participants (40% response rate) at 1-year. The CAHHM policy followed a restricted approach, whereby routine feedback on IFs was not provided. Only IFs of severe structural abnormalities were reported.ResultsSevere structural abnormalities occurred in 8.3% (95% confidence interval 7.7–8.9%) of participants, with the highest proportions found in the brain (4.2%) and abdomen (3.1%). The majority of participants (97%) informed of an IF reported no change in quality of life, with 3% of participants reporting that the knowledge of an IF negatively impacted their quality of life. Furthermore, 50% reported increased stress in learning about an IF, and in 95%, the discovery of an IF did not adversely impact his/her life insurance policy. Most participants (90%) would enrol in the study again and perceived the MRI scan to be beneficial, regardless of whether they were informed of IFs. While the implications of a restricted approach to IF management was perceived to be mostly positive, a degree of diagnostic misconception was present amongst participants, indicating the importance of a more thorough consent process to support participant autonomy.ConclusionThe management of IFs from research MRI scans remain a challenging issue, as participants may experience stress and a reduced quality of life when IFs are disclosed. The restricted approach to IF management in CAHHM demonstrated a fair fulfillment of the overarching ethical principles of respect for autonomy, concern for wellbeing, and justice. The approach outlined in the CAHHM policy may serve as a framework for future research studies.Clinical trial registrationhttps://clinicaltrials.gov/ct2/show/nct02220582. (shrink)
A recurrent 16p12.1 microdeletion supports a two-hit model for severe developmental delay.Santhosh Girirajan,Jill A. Rosenfeld,Gregory M. Cooper,Francesca Antonacci,Priscillia Siswara,Andy Itsara,Laura Vives,Tom Walsh,Shane E. McCarthy,Carl Baker,Heather C. Mefford,Jeffrey M. Kidd,Sharon R. Browning,Brian L. Browning,Diane E. Dickel,Deborah L. Levy,Blake C. Ballif,Kathryn Platky,Darren M. Farber,Gordon C. Gowans,Jessica J. Wetherbee,Alexander Asamoah,David D. Weaver,Paul R. Mark,Jennifer Dickerson,Bhuwan P. Garg,Sara A. Ellingwood,Rosemarie Smith,Valerie C. Banks,Wendy Smith,Marie T.McDonald,Joe J. Hoo,Beatrice N. French,Cindy Hudson,John P. Johnson,Jillian R. Ozmore,John B. Moeschler,Urvashi Surti,Luis F. Escobar,Dima El-Khechen,Jerome L. Gorski,Jennifer Kussmann,Bonnie Salbert,Yves Lacassie,Alisha Biser,Donna M.McDonald-McGinn,Elaine H. Zackai,Matthew A. Deardorff,Tamim H. Shaikh,Eric Haan,Kathryn L. Friend,Marco Fichera,Corrado Romano,Jozef Gécz,Lynn E. DeLisi,Jonathan Sebat,Mary-Claire King,Lisa G. Shaffer & Eic -unknowndetailsWe report the identification of a recurrent, 520-kb 16p12.1 microdeletion associated with childhood developmental delay. The microdeletion was detected in 20 of 11,873 cases compared with 2 of 8,540 controls and replicated in a second series of 22 of 9,254 cases compared with 6 of 6,299 controls. Most deletions were inherited, with carrier parents likely to manifest neuropsychiatric phenotypes compared to non-carrier parents. Probands were more likely to carry an additional large copy-number variant when compared to matched controls. The clinical (...) features of individuals with two mutations were distinct from and/or more severe than those of individuals carrying only the co-occurring mutation. Our data support a two-hit model in which the 16p12.1 microdeletion both predisposes to neuropsychiatric phenotypes as a single event and exacerbates neurodevelopmental phenotypes in association with other large deletions or duplications. Analysis of other microdeletions with variable expressivity indicates that this two-hit model might be more generally applicable to neuropsychiatric disease. © 2010 Nature America, Inc. All rights reserved. (shrink)
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Morality and Christian Theism: H. P. OWEN.H. P. Owen -1984 -Religious Studies 20 (1):5-17.detailsThe relation between morality and religion has often been discussed. However, it is not always recognized that the relation varies greatly according to the variety of religions. I shall here be concerned solely with Christian theism in its traditional form. I take the latter to signify, essentially, belief in a morally perfect Creator who exists in the threefold form of Father, Son and Holy Spirit and who, in the person of the Son, became man in Christ for our salvation. I (...) thus exclude from consideration all non-theistic accounts of God or the Absolute. Also I shall consider, not simply bare theism of the kind that Christians share with Jews and Muslims, but also the distinctively Christian form of theism that is generated by distinctively Christian revelation. Many otherwise sound descriptions of the relation between morality and theism are defective because they fail to consider the distinctively Christian contribution to the theistic concept of God and of his relation to the world. (shrink)
Christian Mysticism: A Study in Walter Hilton's The Ladder of Perfection: H. P. OWEN.H. P. Owen -1971 -Religious Studies 7 (1):31-42.detailsMany writers often generalise about mysticism without a sufficiently close analysis of texts. Consequently the generalisations are often invalid. My present aim is to analyse one text and, in the light of this analysis, to offer some observations concerning mysticism in general and Christian mysticism in particular.
The New Testament and the Incarnation: A Study in Doctrinal Development: H. P. OWEN.H. P. Owen -1972 -Religious Studies 8 (3):221-232.detailsChristianity affirms, with Judaism and Islam, that God is the omnipotent Creator of all things. But it diverges from them in also affirming that the Creator assumed a human nature in one figure of history, Jesus of Nazareth. Christ thus differs from other men in kind, not merely in degree; he is absolutely, not just relatively, unique. Admittedly many Christian theologians have held that the difference between Christ and other men is only one of degree. Yet the Church's traditional claim, (...) as expressed in the Chalcedonian Definition, is that Jesus was both creature and Creator, both fully man and fully God. (shrink)
“The King of Terrors” Revisited: The Smallpox Vaccination Campaign and its Lessons for Future Biopreparedness.Cynthia P. Schneider &Michael D.McDonald -2003 -Journal of Law, Medicine and Ethics 31 (4):580-589.details“Smallpox was always present, filling the churchyard with corpses, tormenting with constant fear all whom it had not yet stricken, leaving on those whose lives it spared the hideous traces of its power, turning the babe into a changeling at which the mother shuddered, and making the eyes and cheeks of the betrothed maiden objects of horror to the lover.” In 1848, British historian T.B. Macaulay first captured the picture of the devastation smallpox wreaked on its victims, but the “King (...) of Terrors,” as it was dubbed by future president John Adams, had already decimated populations in the ancient world from Greece to Egypt to China. Smallpox had no respect for authority: the earliest identified victim, Pharaoh Ramses V was but the first in a long line of monarchs and rulers who succumbed,. including the Hittite king Suppiluliumas I, Aztec Emperor Cuitlahuac, and Queen Mary II of England. (shrink)
Ethics-committee authorization in Germany.H. P. Graf &D. Cole -1995 -Journal of Medical Ethics 21 (4):229-233.detailsOn 9 August 1994 the German legislature revised the German Drug Law (AMG). Included in the revision is a passage requiring, for the first time, that the sponsors and investigators of clinical studies involving human subjects first obtain the approval of an ethics committee before carrying out such studies. According to the legislation, which takes effect on 17 August 1995, approval is to come from 'an independent ethics committee, set up and administered according to state law [emphasis added]' (1). Although (...) it is clear according to the text that the 16 federal states have been empowered to establish ethics committees within their jurisdictions, this does not mean that the state governments are free to transfer exclusive authority in the matter to their respective medical associations, a step that would effectively abolish Germany's private ethics committees. First, the legislation does not rule out the authorization of private ethics committees. Second, as legal scholars attest, the exclusive control of ethics committees by the medical associations would constitute an illegal monopoly. Third, it is arguable that medical-association ethics committees fail to meet the one prior federal requirement, that of independence. There is a great deal of confusion in Germany today about which kinds of ethics committees (public and/or private) the states will sanction before 17 August 1995. In an attempt to sort things out we present a brief explanation of how ther came to be two kinds of ethics committees in Germany, review the legal battle between the two over the issue of authorization, point out how the German legislature, in passing the recent bill, has missed an opportunity to clarify the issue and, finally suggest why the administration of ethics committees by the medical associations may be incompatible with the requirement that ethics committees be independent. (shrink)