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Our understanding of biological processes in humans is often based on examination of analogous processes in other organisms. The nematode worm Caenorhabditis elegans has been a particularly valuable model, leading to Nobel prize winning discoveries in development and genetics. Until recently, however, the worm has not been widely used as a model to study transcription due to the lack of a comprehensive catalogue of its RNA transcripts. A recent study by Chen et al. uses next‐generation sequencing to address this issue, (...) mapping the transcription initiation sites in C. elegans and finding many unexpected similarities between the transcription of enhancers and promoters in the worm and mammalian genomes. As well as providing a valuable resource for researchers in the C. elegans community, these findings raise the possibility of using the worm as a model to investigate some key, current questions about transcriptional regulation that remain technically challenging in more complex organisms. (shrink)

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In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Spirit Stones of China: The Ian and Susan Wilson Collection of Chinese Stones, Paintings, and Related Scholars' ObjectsGraham ParkesSpirit Stones of China: The Ian and Susan Wilson Collection of Chinese Stones, Paintings, and Related Scholars' Objects. Edited by Stephen Little. Chicago: The Art Institute of Chicago in association with University of California Press, 1999. Pp. 112.Let me introduce Spirit Stones of China: The Ian and Susan Wilson Collection (...) of Chinese Stones, Paintings, and Related Scholars' Objects (edited by Stephen Little) with this quotation:The purest essence of the energy of the heaven-earth world coalesces into rock. It emerges, bearing the soil. Its formations are wonderful and fantastic. Some with cavernous cliffs, revealing their interior; some with peaks and summits in sharp-edged layers.... Within the size of a fist can be assembled the beauty of a thousand cliffs. Rocks large enough to be set up in great courtyards, small enough to be set upon a stand. Like gazing upon the peaks of Song Shan, or facing the entire range of the Meng mountains; sitting quietly, your imagination purified.... The Sage [Confucius] once said, "the humane man loves mountains," and the love of stones has the same meaning. Thus, longevity through quietude is achieved through this love.This passage articulates the very different understanding of stone—as "essential energy" rather than mere matter—that underlies the traditional Chinese passion for rock collecting and appreciating, for which even the terms "petromania" and "litholatry" seem too weak. It comes from the preface to the earliest surviving Chinese manual on the topic, Du Wan's Stone Compendium of Cloudy Forest, compiled in the early twelfth century, and is quoted by Stephen Little in his erudite and informative introduction to this magnificent catalog for a unique collection of "spirit" or "strange stones" (guai shi) and other scholars' articles. This essay nicely complements and amplifies ideas set forth some fifteen years ago by John Hay, in his now classic introduction to the catalog Kernels of Energy, Bones of Earth: The Rock in Chinese Art (New York: China House Gallery, China Institute in America, 1985).Most cultures appear to begin with a natural reverence for stone in its natural state—one thinks of the Druids, the Indian tradition, the Polynesians, Native Americans, and Australian aboriginal culture—and many seem to retain that reverence as they develop. Indeed, when seen in a global perspective, the general lack of interest in (or respect for) rock in its unhewn state that characterizes the European and Anglo-American traditions seems idiosyncratic. But Chinese culture definitely has the longest and most enthusiastic tradition of collecting stones and arranging rocks in gardens: "strange stones" figure among articles of tribute offered to the mythical emperor Yu (mid-second millennium B.C.E.), and the emperor Wu Di (second century B.C.E.) is recorded as having had rocks arranged in the gardens of his palace. [End Page 306]Stephen Little's essay gives an eloquent account of the development of the practice of stone collecting in China, delineating its relationships with poetry and painting and other arts and practices, and containing numerous translations of passages from primary sources otherwise inaccessible to the non-reader of Chinese. Most of the rocks in the catalog are of the well-known Lingbi (sonorous) and Ying types, but other kinds are represented, too. The editor also supplies a context for appreciating the paintings, scrolls, and other articles from scholars' desks that are in the catalog: brush rests, inkstones, brush holders, and so forth. The sixty-six items from the collection are represented in excellent black-and-white photographs.The book is beautifully designed and produced—and is indeed a work of art in itself with its handsome, dark blue Chinese-style case. All in all, this a stylish and informative contribution to the growing literature on a philosophically fascinating topic. [End Page 307]Graham Parkes University of Hawai'iCopyright © 2001 University of Hawai'i Press... (shrink)

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In contrast to many aspects of the social responsibility of business, CSR scholarship has been largely silent on the issue of the payment of corporate tax. This is curious because such tax payments are often considered a fundamental and easily measured example of a company’s citizenship behavior. However, because the payment of corporate tax can often be legally avoided, this activity represents a boundary condition for CSR. If the law and CSR suggest that a company should pay its fair share (...) of tax, yet many successful companies actively avoid this social obligation, should they be considered socially irresponsible. This paper explores the issue of tax avoidance and the implications it has for any credible definition and measure of CSR. It also highlights an aspect of corporate practice that is deliberately hidden from public view. (shrink)

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The aim of this article is to examine some of the consequences of the recent advances in neurobiology in terms of the ability of drugs to manipulate the mind. Most laymen are totally ignorant of the general mechanism underlying the brain-mind relationship and therefore of the action of mind-altering drugs. ProfessorGrahame-Smith considers that one of the intrinsic evils of man's neurobiological make up is that a prime motive of the brain seems to be to bring comfort, security and (...) pleasure for itself. Therefore it is not surprising that drugs - notably the barbiturates and more recently the benzodiazepines (tranquilizers) - have been prescribed to give to the brain that peace of mind that it seeks. However, it can be argued that such drugs cannot replace anxiety with peace of mind or unhappiness or depression with happiness. The action of such drugs upon the molecules of the brain is negative - a placebo effect. (shrink)

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This essay describes institutional ethnography as a method of inquiry pioneered by Dorothy E. Smith, and introduces a collection of papers which make distinctive contributions to the development of this novel form of investigation. Institutional ethnography is presented as a research strategy which emerges from Smith's wide-ranging explorations of the problematic of the everyday world. Smith's conception of the everyday world as problematic involves a critical departure from the concepts and procedures of more conventional sociologies. She argues for an alternative (...) sociology which begins with the standpoint of the actor in everyday life, rather than from within a professional sociological discourse aligned with the society's ruling institutions. The familiar sociologies of everyday life do not suffice for this purpose, since they deal with local settings and social worlds, but stop short of examining how these are knitted into broader forms of social organization. In contrast, institutional ethnography examines how the scenes of everyday life are shaped by forms of social organization which cannot be fully grasped from within those scenes. The principal tasks of institutional ethnography include describing the coordination of activities in the everyday world, discovering how ideological accounts define those activities in relation to institutional imperatives, and examining the broader social relations in which local sites of activity are embedded. The four papers which follow demonstrate that specific contributions to institutional ethnography can be made in relation to a wide array of topics, methods, and interests. (shrink)

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The first objective of this paper is to recognize the role of emotion and feeling in Ricœur’s “little ethics” and what they can further add to it, then to explore in more detail how solicitude as a virtue, and affective disposition more broadly, can contribute to a modern ethics of technology. Ultimately, emotions help us to understand technologies and technological ways of being today; Ricœur’s “little ethics”, along with his narrative theory, provide a framework for understanding the ethically salient aspects (...) of technical practice, especially through the openness to the other demanded by solicitude, and essentially by emphasising emotion or feeling as a way of being in the world, and a mode of existence: one which is done with, if not sometimes because of, technology and technical practice. (shrink)

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This article draws on Alasdair MacIntyre’s influential theory of practice and employs it as a framework to analyze community organizing, focusing on the organizing tradition of Saul Alinsky. As a practice in MacIntyre’s sense, it argues, community organizing constitutes a teleological form of social activity that is oriented toward distinctive kinds of “internal goods” and that functions to develop new capacities within its practitioners to recognize, desire, and attain those goods, relying on standards of excellence, characteristic institutions, and its own (...) “tradition” of practice. Such a MacIntyrean analysis of organizing foregrounds its ethical character as a practice and tradition of practice, informed by larger moral-cultural traditions. It also shows how organizing embodies, in practice, the core principles of the Catholic social tradition. Thus, it enables a clearer articulation of the conceptual and historical relationship between community organizing and the Catholic social tradition, and lays a theoretical foundation for further dialogue. (shrink)

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This paper examines the attempts of one mainstream women''s organization to organize and include women of color. Using the approach to social organization developed in the work of Dorothy Smith, I aim to make visible the complex of relations within which the work of this organization is embedded. In mapping the institutional relations structuring the activities in a local setting, the concern is to articulate how activities in the local setting are organized by and in relation to others. My analysis (...) takes as its point of departure my work involvements with this organization over a period of two years. Beginning with my own activities and others'' within the setting, the analysis problematizes the concepts of "organizing women of color" and "inclusion/exclusion." What comes into view are the ways in which "organizing" and "inclusion" are ideological constructs brought into service to account for the practices in which various members of the organization were engaged. Their ideological character came to be unveiled in the "troubles" the organization encountered in its attempts to "organize" women of color. The inquiry shows that those troubles arose out of the organization''s location at the juncture between private foundations, grassroots women, and the state. On the one hand, the activities of the organization are articulated to an understanding of what funders might be willing to support, and on the other hand the organization''s activities have to be seen as serving women of color by both women of color and others. Displayed through the mapping of institutional relations is the deep mismatch between the institutional characterization of what it means to be "organized" and the actual activities women of color were engaged in. I argue that the activities and practices of the mainstream organization embedded in a complex of relations with funding agencies, public policy makers and so on actually produce the definition of women of color as "unorganized.". (shrink)

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As a classical liberal, or libertarian, I am concerned to advance liberty and minimize coercion. Indeed on this view liberty just is the absence of coercion or costs imposed on others. In order to better understand the notion of coercion I discuss Robert Nozick's classic essay on the subject as well as more recent contributions. I then address the question of whether law is coercive, and respond to Edmundson and others who think that it isn't. Assuming that the law is (...) in fact coercive, there is still a question,as with all coercive acts, as to whether that coercion is justified. Edmundson thinks that this places a special burden on the state of justifying its existence, whereas it simply places the same burden on the state as anyone else. What I reject is the longstanding doctrine of Staatsrason, namely that the state is not subject to the same moral rules as its subjects. With respect to the relation of morality to law, Edmundson thought that another of the fallacies of which philosophical anarchists were guilty was that of assuming that there was a sphere of morality where law had no business. On the contrary, our concern is with spheres of law which appear to have little to do with morality, which is to say laws against wrongs of the malum prohibitum variety, as opposed to wrongs which are malum in se. I then turn to a matter with which Edmundson begins his study, namely how it is that states acquire the authority to do what they do, namely coerce their subjects. While the fact that the philosopher's stone of political obligation has proved rather elusive may mean that a legitimate state lacks the authority to demand obedience pure and simple, Edmundson contends that it can at the very least demand that we do not interfere in the administration of justice. I argue that this attempt to sidestep the justification of the authority of the state fails and that we seem in the end to be having to take the state's word for it that we must do X on pain of penalty P. Nor, as I go on to argue, is it any help to appeal to democracy to remedy a failed justification of the authority of the state. There either is a moral justification of state coercion in order to prevent harm to innocent subjects, or there isn't, and this holds,if it does, not only at the level of individuals, but also at the level of the state, regardless of its constitutional form. After concluding that the attempts of Edmundson and others to refute the anarchic turn in recent political philosophy have failed, it would seem that the withering away of the state foreseen in Marx's eschatology is not as improbable as maybe it once appeared. (shrink)

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The eighth book of Aristotle's Physics is the culmination of his theory of nature. He discusses not just physics, but the origins of the universe and the metaphysical foundations of cosmology and physical science. He moves from the discussion of motion in the cosmos to the identification of a single source and regulating principle of all motion, and so argues for the existence of a first `unmoved mover'. Daniel Graham offers a clear, accurate new translation of this key text in (...) the history of Western thought, and accompanies the translation with a careful philosophical commentary to guide the reader towards an understanding of the wealth of important and influential arguments and ideas that Aristotle puts forward. (shrink)

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In traditional ethnographies, it is customarily assumed that the field researcher is an outsider who seeks to acquire an insider’s understanding of the social world being investigated. While conducting field research projects on education and tourism in Trinidad (West Indies) we found that the standard distinction between insider and outsider became problematic for us. Our experiences can be understood in terms of two competing conceptions of fieldwork. One, rooted in classical ethnography, views fieldwork as a process whereby the researcher learns (...) to translate the cultural practices of a little-known or misunderstood group into terms understandable to the ethnographic audience. The other, growing out of the institutional ethnography approach pioneered by Dorothy E. Smith, views fieldwork as a process of mapping the relations that govern an institutional complex. In the latter approach, local experiences provide the point of departure for exploring a wider set of social arrangements. In this article, we treat our own fieldwork experiences as points of departure for a reflexive examination of this alternative ethnographic strategy. (shrink)

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This paper presents a cognitive model of the planning process. The model generalizes the theoretical architecture of the Hearsay‐ll system. Thus, it assumes that planning comprises the activities of a variety of cognitive “specialists.” Each specialist can suggest certain kinds of decisions for incorporation into the plan in progress. These include decisions about: (a) how to approach the planning problem; (b) what knowledge bears on the problem; (c) what kinds of actions to try to plan; (d) what specific actions to (...) plan; and (e) how to allocate cognitive resources during planning. Within each of these categories, different specialists suggest decisions at different levels of abstraction. The activities of the various specialists are not coordinated in any systematic way. Instead, the specialists operate opportunistically, suggesting decisions whenever promising opportunities arise. The paper presents a detailed account of the model and illustrates its assumptions with a “thinking aloud” protocol. It also describes the performance of a computer simulation of the model. The paper contrasts the proposed model with successive refinement models and attempts to resolve apparent differences between the two points of view. (shrink)

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This introduction explores the relationship between Europe and its Christianities. It analyses different diagnostic and evaluative approaches to Europe's Christian or post-Christian identity. These are grouped around the concepts of diverse traditional, and, on the other hand, post-Enlightenment Christianities. While the first revolves around a liturgical and mystical account of the church, a Christ-centred humanism, an emphasis on man's future life, noetic theology and a foundationalist claim to universal truth, the second endorses a moralization of the “Christian message,” political implementation (...) of “Christian goals,” rationalism, a this-worldly humanism, and tolerance for religious diversity. Since even the concepts of “traditional” and “post-Enlightenment” Christianity turn out to be deeply ambiguous, the essay concludes with exploring the different ways in which the Christianity of the Apostolic Church, the Enlightenment (along with the “Western” Christianities it shaped), and contemporary liberalism each conceive of their respective endorsements of human freedom as either normative, that is obligatory, value-laden, or contingent, and arbitrary. In each case, a different notion of “tradition” (as well as familial and church authority) is placed either in harmony or in opposition to such freedom. As a result of this conceptual analysis, the deeply fractured identity of Europe, as exemplified by the diverse bioethical positions adopted by the authors in this issue, becomes visible. (shrink)

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This article presents a conceptual investigation into the value impacts and relations of algorithms in the domain of justice and security. As a conceptual investigation, it represents one step in a value sensitive design based methodology. Here, we explicate and analyse the expression of values of accuracy, privacy, fairness and equality, property and ownership, and accountability and transparency in this context. We find that values are sensitive to disvalue if algorithms are designed, implemented or deployed inappropriately or without sufficient consideration (...) for their value impacts, potentially resulting in problems including discrimination and constrained autonomy. Furthermore, we outline a framework of conceptual relations of values indicated by our analysis, and potential value tensions in their implementation and deployment with a view towards supporting future research, and supporting the value sensitive design of algorithms in justice and security. (shrink)

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Rewilding is often promoted and defended with eudaimonistic reasons, by appeals to living better, happier lives. It has long been argued eudaimonistic reasoning is hopelessly self-interested and, in an environmental context, anthropocentric. Holmes Rolston’s classic critique of environmental virtue ethics stands to challenge the rewilding movement’s increasing focus on happier lives, rather than intrinsic natural value. This critique misses the mark, however, by insisting on an impressively longstanding, yet unhelpfully rigid distinction between egoistic and altruistic ethical reasoning. In this way, (...) Rolston’s critique serves as an example of some much older and larger tensions which haunt everyday ethical thinking, tensions between desiring the good and doing what’s right, between self-love and selfishness. This paper embraces Rolston’s lifelong love of our living world, while nuancing what it means to hope for a Good Life within it. (shrink)

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Bitcoin, cryptocurrencies, and blockchains have become buzzwords in the media and are attracting increasing academic interest, mainly from the fields of computer science and financial economics. In...

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Ce livre a pour seule ambition de faire comprendre quelque chose de la pensée de Ludwig Wittgenstein et de sa conception de tâche de la philosophie conçue comme une " thérapie " censée guérir certaines " maladies de l'esprit ". Le fait que Wittgenstein soit venu à la philosophie par le biais de réflexions sur la logique et les mathématiques est important à cet égard. Mais ce même Wittgenstein, ami de Bertrand Russell et de John Maynard Keynes, professeurs à l'Université (...) de Cambridge, ne fut pourtant jamais un universitaire typique. Qui plus est, sa pensée ne cadre point avec les théories et les problématiques caractéristiques de la philosophie contemporaine. Cela n'aurait d'ailleurs guère étonné Wittgenstein lui-même, qui se moquait des modes et des vogues intellectuelles, qui tenait notre siècle de progrès pour un âge de l'Unkultur et qui ne rédigeait ses pensées que " pour quelques amis dispersés aux quatre coins du monde ". (shrink)

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(2005). Between Morality and Repentance: Recapturing “Sin” for Bioethics. Christian Bioethics: Vol. 11, No. 2, pp. 93-132.

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Leading ‘agonist’ theorist Chantal Mouffe has attracted controversy by founding her democratic theory, as well as her Left populist politics, upon Carl Schmitt’s account of the friend/enemy distinction. Adopting Schmitt’s premises while rejecting his reactionary politics, Mouffe contends that liberal democratic politics can transform destructive ‘antagonism’ into constructive ‘agonism’ by converting ‘enemies’ into ‘adversaries’. Mouffe’s critics charge that Schmitt’s friend/enemy politics are ultimately irreconcilable with liberal democracy, rendering her agonism untenable. In this article, I offer a qualified defense of Mouffe’s (...) agonism by drawing a new voice into the debate: Saul Alinsky, the ‘dean of community organizing’. Because of its deep affinities with Mouffe’s agonism, Alinsky’s democratic organizing shows how her theory might plausibly be put into practice, enabling a more cogent response to Mouffe’s critics than her own work provides. Simultaneously, Alinsky’s organizing offers new insights and raises fresh questions about the role of enmity in democratic politics. (shrink)

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Schmidt and Egler's critique of Christianity's exclusivist claim to truth rests on two suppositions: (a) that inter-religious pastoral care for dying patients requires a respect for their cultural backgrounds which necessitates accepting the equal validity of their respective (non-Christian) religions, and (b) that exclusivism is incompatible with the Christian love-of-neighbor commandment. In opposition to this critique, (a) the authors' own “pluralist” understanding of Christianity is refuted on two levels. First, it leads to inconsistencies in the authors' own (and very adequate) (...) understanding of pastoral care, especially with regard to their notion of intolerance, and second, it is irreconcilable with explicit New and Old Testament claims to absoluteness. In addition, (b) the authors' understanding of the way in which “exclusivism” justifies intolerance and missionary violence is shown to rest, first, on a secularized reduction of Christianity, i.e., of Christians' own “religious identity” as well as of the Christian way of “helping those in need,” and second, on a merely theoretical (rather than also practical) view of Christians' commitment to God. As a corollary to that refutation, a reconsideration of the truly Christian sources of obedience and charity is recommended. (shrink)

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Like most religions, the Buddhist tradition is rich in stories that are designed to illustrate key principles and values. Stories of the Buddha himself offer a verbal portrait of an ideal human being that followers of the tradition can aspire to emulate; his story offers a picture of a person with a perfectly healthy mind. Stories of other people (and of gods, ghosts and ghouls) portray a wide range of beings from the nearly perfect to the dreadfully imperfect, all presented (...) as models of what one could eventually become oneself through gradual transformations from one’s present mentality. In what follows, I shall first tell a brief story about myself and will then recount the stories of two men who were cousins with similar but importantly different mentalities. And I shall conclude with a few observations about what I see as the significance of the difference between these two cousins. (shrink)

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Welfare internalism holds that "for any intrinsic good φ for a person p, it must be the case that φ 'fits' p, resonates with p, fails to alienate p, and so forth." This "resonance constraint" is often employed in arguments against objectivist theories of well-being. Many philosophers argue that, because objectivist theories ground a person's good in sources other than that person's subjective attitudes, such theories fail to satisfy the resonance constraint. And because welfare internalism and the resonance constraint seem (...) so plausible—at least to these philosophers—they therefore reject objectivist theories. A person's welfare or well-being is, they claim, subjective. I push back against such arguments. I argue that many objectivist theories can (and do) adopt the resonance constraint. Looking to a historical example—Thomas Aquinas—I argue that an objectivist can put forward a theory of value that preserves an affective/motivational link between a person and his good, without sacrificing the objectivity of value. I therefore claim that the argument from internalism, when waged against objectivist theories of well-being, generally fails. Moreover, I argue that this sort of internalist-objectivism can explain things that subjectivism cannot; for example, why we claim that φ is good for p despite p 's beliefs and actions suggesting the opposite, or why valuing is important for humans in the first place. In short, certain objective approaches to welfare—such as Thomas Aquinas'—are more plausible than their subjective counterparts. (shrink)

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In the svārthānumāna chapter of his Pramāṇavārttika, the Buddhist philosopher Dharmakīrti presented a defense of his claim that legitimate inference must rest on a metaphysical basis if it is to be immune from the risks ordinarily involved in inducing general principles from a finite number of observations. Even if one repeatedly observes that x occurs with y and never observes y in the absence of x, there is no guarantee, on the basis of observation alone, that one will never observe (...) y in the absence of x at some point in the future. To provide such a guarantee, claims Dharmakīrti, one must know that there is a causal connection between x and y such that there is no possibility of y occurring in the absence of x. In the course of defending this central claim, Dharmakīrti ponders how one can know that there is a causal relationship of the kind necessary to guarantee a proposition of the form “Every y occurs with an x.” He also dismisses an interpretation of his predecessor Dignāga whereby Dignāga would be claiming non-observation of y in the absence of x is sufficient to warrant to the claim that no y occurs without x. The present article consists of a translation of kārikās 11–38 of Pramānavārttikam, svārthānumānaparicchedaḥ along with Dharmakīrti’s own prose commentary. The translators have also provided an English commentary, which includes a detailed introduction to the central issues in the translated text and their history in the literature before Dharmakīrti. (shrink)

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The article by Barbey & Sloman (B&S) provides a valuable framework for integrating research on base-rate neglect and respect. The theoretical arguments and data supporting the nested set model are persuasive. But we found the dual-process account to be under-specified and less compelling. Our concerns are based on (a) inconsistencies within the literature cited by B&S, and (b) studies of base-rate neglect in categorization.

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The U.S. Food and Drug Administration's drug advisory committees provide expert assessments of the safety and efficacy of new therapies considered for approval. A committee hears from a variety of speakers, from six groups, including voting members of the committee, FDA staff members, employees of the pharmaceutical company seeking approval of a therapy, patient and consumer representatives, expert speakers invited by the company, and public participants. The committees convene at the request of the FDA when the risks and harms of (...) novel products are not immediately clear, and their final decisions carry significant weight, as most therapies that receive advisory committee approval are subsequently approved by the FDA. In recent years, across a series of diverse publications, the financial conflicts of interest of each category of participants in the meetings have been investigated. Here, we summarize these findings and their ethical implications, focusing on the FDA Oncologic Drugs Advisory Committee, and we suggest ways to move toward more transparent and impartial advisory committee meetings. (shrink)

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Trust is essential in human relationships including those within healthcare. Recent studies have raised concerns about patients’ declining levels of trust. This article will explore the role of trust in decision-making about cardiopulmonary resuscitation (CPR). In this research thirty-three senior doctors, junior doctors and division 1 nurses were interviewed about how decisions are made about providing CPR. Analysis of these interviews identified lack of trust as one cause for poor understanding of treatment decisions and lack of acceptance of medical judgement. (...) Two key implications emerged from the analysis. First, before embarking on a discussion about CPR it is essential to establish trust between the doctor and the patient/family. Secondly, it is essential that the CPR discussion itself does not undermine trust and cause harm to the patient. (shrink)

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The Madhyamaka school of Buddhism, the followers of which are called Mādhyamikas, was one of the two principal schools of Mahāyāna Buddhism in India, the other school being the Yogācāra. The name of the school is a reference to the claim made of Buddhism in general that it is a middle path (madhyamā pratipad) that avoids the two extremes of eternalism—the doctrine that all things exist because of an eternal essence—and annihilationism—the doctrine that things have essences while they exist but (...) that these essences are annihilated just when the things themselves go out of existence. The conviction of the Madhyamaka school, which can be called the Centrist school in English, is that this middle path is best achieved by a denial that things have any inherent natures at all. All things are, in other words, empty of inherent natures. This doctrine of universal emptiness of inherent natures (svabhāva-śūnyatā) is the hallmark of the school, which places the school solidly in the tradition associated with the Perfection of Wisdom (prajñāpāramitā) literature of Mahāyāna Buddhism. (shrink)

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