Results for 'Gerard M. Ribbers'
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- Transcranial Direct Current Stimulation Targeting the Entire Motor Network Does Not Increase Corticospinal Excitability.Joris Van der Cruijsen,Zeb D. Jonker,Eleni-Rosalina Andrinopoulou,Jessica E. Wijngaarden,Ditte A. Tangkau,Joke H. M. Tulen,Maarten A. Frens,Gerard M.Ribbers &Ruud W. Selles -2022 -Frontiers in Human Neuroscience 16.Transcranial direct current stimulation over the contralateral primary motor cortex of the target muscle has been described to enhance corticospinal excitability, as measured with transcranial magnetic stimulation. Recently, tDCS targeting the brain regions functionally connected to the contralateral primary motor cortex was reported to enhance corticospinal excitability more than conventional tDCS. We compared the effects of motor network tDCS, 2 mA conventional tDCS, and sham tDCS on corticospinal excitability in 21 healthy participants in a randomized, single-blind within-subject study design. We (...) applied tDCS for 12 min and measured corticospinal excitability with TMS before tDCS and at 0, 15, 30, 45, and 60 min after tDCS. Statistical analysis showed that neither motor network tDCS nor conventional tDCS significantly increased corticospinal excitability relative to sham stimulation. Furthermore, the results did not provide evidence for superiority of motor network tDCS over conventional tDCS. Motor network tDCS seems equally susceptible to the sources of intersubject and intrasubject variability previously observed in response to conventional tDCS. (shrink)
- On the branching factor of the alpha-beta pruning algorithm.Gérard M. Baudet -1978 -Artificial Intelligence 10 (2):173-199.
- The destiny of the universe: in pursuit of the great unknown.Gerard M. Verschuuren -2014 - St. Paul: Paragon House.Using the latest scientific discoveries and theories of astronomy and genetics, the author discusses the nature of life and the universe and asks big questions like, 'Why are we here?' It is both a critique of scientific atheism, and a scientific argument for the "unknown" that people call 'God'.No categories
- English Historical Economics, 1870–1926: The Rise of Economic History and Neomercantilism.Gerard M. Koot -2008 - Cambridge University Press.In the first comprehensive and full-length study of the English historical economists,Gerard Koot traces their revolt against the theory, policy recommendations and academic dominance of classical and neoclassical economics in Britain between 1870 and 1926. English Historical Economics, 1870–1926 shows how these historical critics challenged the deductive method and mechanistic assumptions of the economic orthodoxy, developing an historical and inductive method for economic studies and laying the foundation for the professional study of economic history. The author examines the (...) effect of this new methodology upon English politics, discussing the intellectual framework that the historical economists provided for the conservative attack on laissez-faire philosophy in links between such larger social, economic, political and intellectual controversies and the origin and growth of English historical economics. (shrink)
- Darwin's Philosophical Legacy: The Good and the Not-so-Good.Gerard M. Verschuuren -2012 - Lexington Books.There is hardly any university, college, or even high school left where they do not teach Darwinism—and rightly so. Yet, most of these places do more preaching than teaching. They teach more than they should, and at the same time, they teach less than they should. This book wants to evaluate Darwin’s legacy from a philosophical viewpoint by trying to analyze the strong points as well as the weak points of what came to be known as neo-Darwinism.
- Technology Assessment: a Pocket Version.Gérard M. Fourez -1994 -Bulletin of Science, Technology and Society 14 (3):132-143.No categories
- (1 other version)Training Science Teachers for STS.Gérard M. Fourez -1987 -Bulletin of Science, Technology and Society 7 (5-6):924-929.No categories
- Book notices-life scientists. Their convictions, their activities and their values.Gerard M. Verschuuren -1998 -History and Philosophy of the Life Sciences 20 (1):126-126.Export citation
Bookmark - The perception of repetition rate.Joseph C. Stevens &Gerard M. Shickman -1959 -Journal of Experimental Psychology 58 (6):433.No categories
- Selective citation in the literature on swimming in chlorinated water and childhood asthma: a network analysis.Maurice P. Zeegers,Lex M. Bouter,Gerard M. H. Swaen,Miriam J. E. Urlings &Bram Duyx -2017 -Research Integrity and Peer Review 2 (1).BackgroundKnowledge development depends on an unbiased representation of the available evidence. Selective citation may distort this representation. Recently, some controversy emerged regarding the possible impact of swimming on childhood asthma, raising the question about the role of selective citation in this field. Our objective was to assess the occurrence and determinants of selective citation in scientific publications on the relationship between swimming in chlorinated pools and childhood asthma.MethodsWe identified scientific journal articles on this relationship via a systematic literature search. The (...) following factors were taken into account: study outcome (authors’ conclusion, data-based conclusion), other content-related article characteristics (article type, sample size, research quality, specificity), content-unrelated article characteristics (language, publication title, funding source, number of authors, number of affiliations, number of references, journal impact factor), author characteristics (gender, country, affiliation), and citation characteristics (time to citation, authority, self-citation). To assess the impact of these factors on citation, we performed a series of univariate and adjusted random-effects logistic regressions, with potential citation path as unit of analysis.ResultsThirty-six articles were identified in this network, consisting of 570 potential citation paths of which 191 (34%) were realized. There was strong evidence that articles with at least one author in common, cited each other more often than articles that had no common authors (odds ratio (OR) 5.2, 95% confidence interval (CI) 3.1–8.8). Similarly, the chance of being cited was higher for articles that were empirical rather than narrative (OR 4.2, CI 2.6–6.7), that reported a large sample size (OR 5.8, CI 2.9–11.6), and that were written by authors with a high authority within the network (OR 4.1, CI 2.1–8.0). Further, there was some evidence for citation bias: articles that confirmed the relation between swimming and asthma were cited more often (OR 1.8, CI 1.1–2.9), but this finding was not robust.ConclusionsThere is clear evidence of selective citation in this research field, but the evidence for citation bias is not very strong. (shrink)No categories
- Determinants of Citation in Epidemiological Studies on Phthalates: A Citation Analysis.Miriam J. E. Urlings,Bram Duyx,Gerard M. H. Swaen,Lex M. Bouter &Maurice P. A. Zeegers -2020 -Science and Engineering Ethics 26 (6):3053-3067.Citing of previous publications is an important factor in knowledge development. Because of the great amount of publications available, only a selection of studies gets cited, for varying reasons. If the selection of citations is associated with study outcome this is called citation bias. We will study determinants of citation in a broader sense, including e.g. study design, journal impact factor or the funding source of the publication. As a case study we assess which factors drive citation in the human (...) literature on phthalates, specifically the metabolite mono phthalate. A systematic literature search identified all relevant publications on human health effect of MEHP. Data on potential determinants of citation were extracted in duplo. Specialized software was used to create a citation network, including all potential citation pathways. Random effect logistic regression was used to assess whether these determinants influence the likelihood of citation. 112 Publications on MEHP were identified, with 5684 potential citation pathways of which 551 were actual citations. Reporting of a harmful point estimate, journal impact factor, authority of the author, a male corresponding author, research performed in North America and self-citation were positively associated with the likelihood of being cited. In the literature on MEHP, citation is mostly driven by a number of factors that are not related to study outcome. Although the identified determinants do not necessarily give strong indications of bias, it shows selective use of published literature for a variety of reasons. (shrink)
- Towards a Hierarchical Definition of Life, the Organism, and Death.Gerard A. J. M. Jagers op Akkerhuis -2010 -Foundations of Science 15 (3):245-262.Despite hundreds of definitions, no consensus exists on a definition of life or on the closely related and problematic definitions of the organism and death. These problems retard practical and theoretical development in, for example, exobiology, artificial life, biology and evolution. This paper suggests improving this situation by basing definitions on a theory of a generalized particle hierarchy. This theory uses the common denominator of the “operator” for a unified ranking of both particles and organisms, from elementary particles to animals (...) with brains. Accordingly, this ranking is called “the operator hierarchy”. This hierarchy allows life to be defined as: matter with the configuration of an operator, and that possesses a complexity equal to, or even higher than the cellular operator. Living is then synonymous with the dynamics of such operators and the word organism refers to a select group of operators that fit the definition of life. The minimum condition defining an organism is its existence as an operator, construction thus being more essential than metabolism, growth or reproduction. In the operator hierarchy, every organism is associated with a specific closure, for example, the nucleus in eukaryotes. This allows death to be defined as: the state in which an organism has lost its closure following irreversible deterioration of its organization. The generality of the operator hierarchy also offers a context to discuss “life as we do not know it”. The paper ends with testing the definition’s practical value with a range of examples. (shrink)
- Operators, the Lego-bricks of nature: Evolutionary transitions from fermions to neural networks.Gerard A. J. M. Jagers Op Akkerhuis &Nico van Straalen -1999 -World Futures 53 (4):329-345.
- Epistemic Logic and the Theory of Games and Decisions.M. Bacharach,Louis AndréGerard-Varet,Philippe Mongin &H. S. Shin (eds.) -1997 - Dordrecht: Springer.This collection of papers in epistemic logic is oriented towards applications to game theory and individual decision theory. Most of these papers were presented at the inaugural conference of the LOFT (Logic for the Theory and Games and Decisions) conference series, which took place in 1994 in Marseille. Among the notions dealt with are those of common knowledge and common belief, infinite hierarchies of beliefs and belief spaces, logical omniscience, positive and negative introspection, backward induction and rationalizable equilibria in game (...) theory. (shrink)
- Books briefly noted.Gerard Casey,Deirdre Carabine,Attracta Ingram,Aidan Moran,M. V. Rainwater,Alan P. F. Sell,Ciaran McGlynn &Patrick Gorevan -1993 -Humana Mente 1 (1):163-171.No categories
- Ethiek redt beschaving!Gerard J. H. M. Pijnenburg -1946 - Heide-Kalmthout,: Dienen.No categories
- From Management Systems to Corporate Social Responsibility.Gerard I. J. M. Zwetsloot -2003 -Journal of Business Ethics 44 (2-3):201-208.At the start of the 21st century, Corporate Social Responsibility (CSR) seems to have great potential for innovating business practices with a positive impact on People, Planet and Profit. In this article the differences between the management systems approach of the nineties, and Corporate Social Responsibility are analysed.An analysis is structured around three business principles that are relevant for CSR and management systems: (1) doing things right the first time, (2) doing the right things, and (3) continuous improvement and innovation. (...) Basically CSR is focussing on the second principle, and management systems focus on the first. However, CSR is very likely to build on the management systems as well.From a CSR point of view, the existing generation of management systems with their focus on rational control (= doing things right) can only be of limited use in the development of CSR. However, the preventive rationalities of management systems are important. Values and the principle doing the right things is extremely relevant for CSR. This goes far beyond the present generation of ISO type management systems; opportunities stem from building on TQM approaches like the EFQM Business Excellence model. Continuous improvement and innovation is a permanent challenge underlying the two other business principles, and requires both individual and organisational learning processes. In the present generation of management systems, continuous improvement mainly addresses rational prevention, barely the value aspects of business.For the further development and implementation of CSR, each of the three business management principles are vital. There is a need for a new generation of management systems that addresses the values at stake in strategic decision-making, both at company level and in the behaviour of individuals, while the rationalities of prevention and anticipation are still relevant. In both directions more emphasis for continuous learning and innovation will be needed.CSR is likely to trigger the development of management systems in the directions mentioned. This will support companies to be credible and transparent in improving the performance with respect to people, planet and profit. (shrink)
- The usefulness of lean six sigma to the development of a clinical pathway for hip fractures.Gerard C. Niemeijer,Elvira Flikweert,Albert Trip,Ronald J. M. M. Does,Kees T. B. Ahaus,Anja F. Boot &Klaus W. Wendt -2013 -Journal of Evaluation in Clinical Practice 19 (5):909-914.
- Making Sense of Knowing‐How and Knowing‐That.L. U. M.Gerard -2017 -Journal of Philosophy of Education 51 (3):655-672.
- Targeting vulnerable populations: The ethical implications of data mining, automated prediction, and focused marketing.Gerard A. Callanan,David F. Perri &Sandra M. Tomkowicz -2021 -Business and Society Review 126 (2):155-167.No categories
- Psychoanalysis and Trauma: September 11 Revisited.M.Gerard Fromm -2004 -Diogenes 51 (3):3-14.On November 9, 2002, a few hundred people, mostly mental health clinicians, gathered at the New York University Medical Center for two days of discussions on the theme, September 11th: Psychoanalytic Reflections in the Second Year. The conference was sponsored by the five New York Societies of the International Psychoanalytical Association. The presentations described various bits of learning that seemed to be emerging from the crisis clinical work with so many traumatized people since the attack on the World Trade Center. (...) This paper discusses three of those presentations in the context of the author’s reflections based on his psychotherapeutic work with very troubled patients in a therapeutic community setting. He emphasizes the effect of trauma, not only on individuals, but on the holding environments and symbolic order on which human beings depend for their psychic survival. (shrink)
- Josephson, B. 84.R.Gerard,W. Gibbs,A. Gierer,S. Greenfield,G. Groddeck,M. Guarini,V. Guillemin,S. Hameroff,N. R. Hanson &D. Hebb -2004 - In Gordon G. Globus, Karl H. Pribram & Giuseppe Vitiello,Brain and Being: At the Boundary Between Science, Philosophy, Language and Arts. John Benjamins.No categoriesExport citation Bookmark
- Bradley Conditionals and Dynamic Choice.Simon M. Huttegger &Gerard J. Rothfus -2021 -Synthese 199 (3-4):6585-6599.One of the main contributions of Richard Bradley’s book is an elegant extension of Jeffrey’s Logic of Decision that countenances the evaluation of conditional prospects. This extension offers a promising new setting in which to model dynamic choice. In Bradley’s framework, plans can be understood as conditionals of an appropriate sort, while dynamic consistency can be viewed as providing a constraint on the evaluation of conditionals across time. In this paper, we study connections between planning conditionals and dynamic consistency.No categories
- Balancing Change and Tradition in Global Education Reform.Gérard Bonnet,Mary Canning,Kai-Ming Cheng,Terry J. Crooks,Luis Crouch,Ori Eyal,Eva Forsberg,Phyllis Ghim-Lian Chew,Ratna Ghosh,Martin Gustafsson,Batia P. Horsky,Dan Inbar,Barbara M. Kehm,Stephen T. Kerr,Allan Luke,Ulf P. Lundgren,Robert W. McMeekin,Adam Nir,Peter Schrag,Hasan Simsek,Ryo Watanabe,Alison Wolf &Ali Yildirim (eds.) -2010 - R&L Education.Balancing Change and Tradition in Global Education Reform is an invaluable resource for policymakers, faculty, students, and anyone interested in how decisions made about the education system ultimately affect the quality of education, educational access, and social justice.
- Poems ofGerard Manley HopkinsGerard Manley Hopkins ; A Study of Poetic Idiosyncrasy in Relation to Poetic TraditionGerard Manley Hopkins; A Critical Essay towards the Understanding of His PoetryImmortal Diamond: Studies inGerard Manley Hopkins.Craig la Driere,W. H. Gardner,Gerard Manley Hopkins,W. A. M. Peters &Norman Weyand -1950 -Journal of Aesthetics and Art Criticism 9 (2):153.
- Boekbesprekingen.J. -M. Tison,W. Beuken,Th de Kruijf,P. G. van Breemen,Ben Hemelsoet,P. Smulders,B. Van Dorpe,Bernard Van Dorpe,P. Fransen,S. Trooster,E. Kerckhof,F. Malmberg,G. De Schrijver,W. G. Tillmans,Jos Vercruysse,C. Verhaak,A. J. Leijen,Robert Ceusters,Frank De Graeve,G. Wilkens &Gerard Hommels -1970 -Bijdragen 31 (1):89-110.No categories
- A corporate approach to healthcare ethics.Elizabeth M. Whitley &Gerard F. Heeley -1995 -HEC Forum 7 (5):296-301.
- Ethical Considerations of Whole-Eye Transplantation.Kia M. Washington,Gerard Magill,Mario G. Solari,Joel S. Schuman,Maxine R. Miller,Yang Li,Chiaki Komatsu,Edward H. Davidson &Wesley N. Sivak -2016 -Journal of Clinical Ethics 27 (1):64-67.Whole eye transplantation (WET) remains experimental. Long presumed impossible, recent scientific advances regarding WET suggest that it may become a clinical reality. However, the ethical implications of WET as an experimental therapeutic strategy remain largely unexplored. This article evaluates the ethical considerations surrounding WET as an emerging experimental treatment for vision loss. A thorough review of published literature pertaining to WET was performed; ethical issues were identified during review of the articles.No categories
- A diagnosis of conflict: theoretical barriers to integration in mental health services & their philosophical undercurrents. [REVIEW]Nathan M.Gerard -2010 -Philosophy, Ethics, and Humanities in Medicine 5:4.This paper examines the philosophical substructure to the theoretical conflicts that permeate contemporary mental health care in the UK. Theoretical conflicts are treated here as those that arise among practitioners holding divergent theoretical orientations towards the phenomena being treated. Such conflicts, although steeped in history, have become revitalized by recent attempts at integrating mental health services that have forced diversely trained practitioners to work collaboratively together, often under one roof. Part I of this paper examines how the history of these (...) conflicts can be understood as a tension between, on the one hand, the medical model and its use by the dominant profession of psychiatry, and on the other, those alternative models and practitioners in some way differentiated from the medical model camp. Examples will be given from recent policy and research to highlight the prevalence of this tension in contemporary practice. Part II of this paper explores the deeper commonalities that lay beneath the theoretical conflict outlined in Part I. These commonalities will be shown to be apart of a captivating framework that has continued to grip the conflict since its inception. By exposing this underlying framework--and the motivations inherent therein--the topic of integration appears in wholly different light, allowing a renewed philosophical basis for integration to emerge. (shrink)
- Matière et conscience, coll. « Milieux ».Paul M. Churchland &Gérard Chazal -2001 -Revue Philosophique de la France Et de l'Etranger 191 (3):409-409.Export citation Bookmark
- Catholicism Engaging Other Faiths: Vatican Ii and its Impact.Vladimir Latinovic,Gerard Mannion &O. F. M. Welle (eds.) -2018 - Springer Verlag.This book assesses how Vatican II opened up the Catholic Church to encounter, dialogue, and engagement with other world religions. Opening with a contribution from the President of the Pontifical Council for Interreligious Dialogue, Cardinal Jean-Louis Tauran, it next explores the impact, relevance, and promise of the Declaration Nostra Aetate before turning to consider how Vatican II in general has influenced interfaith dialogue and the intellectual and comparative study of world religions in the postconciliar decades, as well as the contribution (...) of particular past and present thinkers to the formation of current interreligious and comparative theological methods. Additionally, chapters consider interreligious dialogue vis-à-vis theological anthropology in conciliar documents; openness to the spiritual practices of other faith traditions as a way of encouraging positive interreligious encounter; the role of lay and new ecclesial movements in interreligious dialogue; and the development of Monastic Interreligious Dialogue. Finally, it includes a range of perspectives on the fruits and future of Vatican’s II’s opening to particular faiths such as Judaism, Islam, Hinduism, and Buddhism. (shrink)No categories
- Catholicism Opening to the World and Other Confessions: Vatican Ii and its Impact.Vladimir Latinovic,Gerard Mannion &O. F. M. Jason Welle (eds.) -2018 - Springer Verlag.This volume explores how Catholicism began and continues to open its doors to the wider world and to other confessions in embracing ecumenism, thanks to the vision and legacy of the Second Vatican Council. It explores such themes as the twentieth century context preceding the council; parallels between Vatican II and previous councils; its distinctively pastoral character; the legacy of the council in relation to issues such as church-world dynamics, as well as to ethics, social justice, economic activity. Several chapters (...) discuss the role of women in the church before, during, and since the council. Others discern inculturation in relation to Vatican II. The book also contains a wide and original range of ecumenical considerations of the council, including by and in relation to Free Church, Reformed, Orthodox, and Anglican perspectives. Finally, it considers the Council’s ongoing promise and remaining challenges with regard to ecumenical issues, including a groundbreaking essay on the future of ecumenical dialogue by Cardinal Walter Kasper. (shrink)No categories
- Gutsy Moves: The Amygdala as a Critical Node in Microbiota to Brain Signaling.Caitlin S. M. Cowan,Alan E. Hoban,Ana Paula Ventura-Silva,Timothy G. Dinan,Gerard Clarke &John F. Cryan -2018 -Bioessays 40 (1):1700172.The amygdala is a key brain area regulating responses to stress and emotional stimuli, so improving our understanding of how it is regulated could offer novel strategies for treating disturbances in emotion regulation. As we review here, a growing body of evidence indicates that the gut microbiota may contribute to a range of amygdala-dependent brain functions from pain sensitivity to social behavior, emotion regulation, and therefore, psychiatric health. In addition, it appears that the microbiota is necessary for normal development of (...) the amygdala at both the structural and functional levels. While further investigations are needed to elucidate the exact mechanisms of microbiota-to-amygdala communication, ultimately, this work raises the intriguing possibility that the gut microbiota may become a viable treatment target in disorders associated with amygdala dysregulation, including visceral pain, post-traumatic stress disorder, and beyond. Also see the video abstract here: https://youtu.be/O5gvxVJjX18 The amygdala plays a central role in regulating many aspects of behavior in rodents and humans, from pain responding to social interaction and psychiatric function. Accumulating evidence suggests microbiota-to-amygdala communication along the gut-brain axis is a key modulator of these amygdala-dependent behaviors, with critical implications for health and disease. (shrink)
- The IARC Monographs: Updated procedures for modern and transparent evidence synthesis in cancer hazard identification.Jonathan M. Samet,Weihsueh A. Chiu,Vincent Cogliano,Jennifer Jinot,David Kriebel,Ruth M. Lunn,Frederick A. Beland,Lisa Bero,Patience Browne,Lin Fritschi,Jun Kanno,Dirk W. Lachenmeier,Qing Lan,Gérard Lasfargues,Frank Le Curieux,Susan Peters,Pamela Shubat,Hideko Sone,Mary C. White,Jon Williamson,Marianna Yakubovskaya,Jack Siemiatycki,Paul A. White,Kathryn Z. Guyton,Mary K. Schubauer-Berigan,Amy L. Hall,Yann Grosse,Véronique Bouvard,Lamia Benbrahim-Tallaa,Fatiha El Ghissassi,Béatrice Lauby-Secretan,Bruce Armstrong,Rodolfo Saracci,Jiri Zavadil,Kurt Straif &Christopher P. Wild -unknownThe Monographs produced by the International Agency for Research on Cancer (IARC) apply rigorous procedures for the scientific review and evaluation of carcinogenic hazards by independent experts. The Preamble to the IARC Monographs, which outlines these procedures, was updated in 2019, following recommendations of a 2018 expert Advisory Group. This article presents the key features of the updated Preamble, a major milestone that will enable IARC to take advantage of recent scientific and procedural advances made during the 12 years since (...) the last Preamble amendments. The updated Preamble formalizes important developments already being pioneered in the Monographs Programme. These developments were taken forward in a clarified and strengthened process for identifying, reviewing, evaluating and integrating evidence to identify causes of human cancer. The advancements adopted include strengthening of systematic review methodologies; greater emphasis on mechanistic evidence, based on key characteristics of carcinogens; greater consideration of quality and informativeness in the critical evaluation of epidemiological studies, including their exposure assessment methods; improved harmonization of evaluation criteria for the different evidence streams; and a single-step process of integrating evidence on cancer in humans, cancer in experimental animals and mechanisms for reaching overall evaluations. In all, the updated Preamble underpins a stronger and more transparent method for the identification of carcinogenic hazards, the essential first step in cancer prevention. (shrink)No categories
- Making productive use of students' initial conceptions in developing the concept of force.Peter J. J. M. Dekkers &Gerard D. Thijs -1998 -Science Education 82 (1):31-51.Export citation Bookmark
- The Epistemic Revolution Induced by Microbiome Studies: An Interdisciplinary View.Eric Bapteste,PhilippeGerard,Catherine Larose,Manuel Blouin,Fabrice Not,Liliane Campos,Géraldine Aïdan,M. André Selosse,M. Sarah Adénis,Frédéric Bouchard,Sébastien Dutreuil,Eduardo Corel,Chloé Vigliotti,Philippe Huneman,F. Joseph Lapointe &Philippe Lopez -2021 -Biology 10.No categories
- Society and Ideology: An Inquiry into the Sociology of Knowledge.Henry M. Magid &Gerard L. DeGre -1943 -Journal of Philosophy 40 (26):723.
- Boekbesprekingen.H. W. M. van Grol,Bart J. Koet,Theo de Kruijf,Martin Parmentier,Martien Parmentier,Gerard Rouwhorst,H. Rikhof,Paul van Geest,A. H. C. van Eijk,Ton Meijers,Veerle Fraeters,Walter Van Herck,Carlo Leget,Paul Favraux &Annemie Dillen -2003 -Bijdragen 64 (1):97-122.No categories
- Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis.David C. Whitcomb,Jessica LaRusch,Alyssa M. Krasinskas,Lambertus Klei,Jill P. Smith,Randall E. Brand,John P. Neoptolemos,Markus M. Lerch,Matt Tector,Bimaljit S. Sandhu,Nalini M. Guda,Lidiya Orlichenko,Samer Alkaade,Stephen T. Amann,Michelle A. Anderson,John Baillie,Peter A. Banks,Darwin Conwell,Gregory A. Coté,Peter B. Cotton,James DiSario,Lindsay A. Farrer,Chris E. Forsmark,Marianne Johnstone,Timothy B. Gardner,Andres Gelrud,William Greenhalf,Jonathan L. Haines,Douglas J. Hartman,Robert A. Hawes,Christopher Lawrence,Michele Lewis,Julia Mayerle,Richard Mayeux,Nadine M. Melhem,Mary E. Money,Thiruvengadam Muniraj,Georgios I. Papachristou,Margaret A. Pericak-Vance,Joseph Romagnuolo,Gerard D. Schellenberg,Stuart Sherman,Peter Simon,Vijay P. Singh,Adam Slivka,Donna Stolz,Robert Sutton,Frank Ulrich Weiss,C. Mel Wilcox,Narcis Octavian Zarnescu,Stephen R. Wisniewski,Michael R. O'Connell,Michelle L. Kienholz,Kathryn Roeder &M. Micha Barmada -unknownPancreatitis is a complex, progressively destructive inflammatory disorder. Alcohol was long thought to be the primary causative agent, but genetic contributions have been of interest since the discovery that rare PRSS1, CFTR and SPINK1 variants were associated with pancreatitis risk. We now report two associations at genome-wide significance identified and replicated at PRSS1-PRSS2 and X-linked CLDN2 through a two-stage genome-wide study. The PRSS1 variant likely affects disease susceptibility by altering expression of the primary trypsinogen gene. The CLDN2 risk allele is (...) associated with atypical localization of claudin-2 in pancreatic acinar cells. The homozygous CLDN2 genotype confers the greatest risk, and its alleles interact with alcohol consumption to amplify risk. These results could partially explain the high frequency of alcohol-related pancreatitis in men. © 2012 Nature America, Inc. All rights reserved. (shrink)No categories
- Prescriptivism in theory and in practice: The moral philosophy of R. M. Hare.Gerard J. Hughes &J. S. -1973 -Heythrop Journal 14 (2):136–146.
- Josep M. COLL, Filosofía de la relación interpersonal.Gerard Vilar -1993 -Enrahonar: Quaderns de Filosofía 21:96.No categories
- Philosophy of Communication Ethics: Alterity and the Other.Brenda Allen,Austin S. Babrow,Isaac E. Catt,Andreea Deciu Ritivoi,Gina Ercolini,Janie Harden Fritz,Pat Gehrke,John Hatch,Gerard A. Hauser,Alain Létourneau,Lisbeth Lipari,Annette Holba,Lester C. Olson &Lindsey M. Rose (eds.) -2014 - Madison: Fairleigh Dickinson University Press.Philosophy of Communication Ethics is a unique and timely volume that creatively examines communication ethics, philosophy of communication, and "the other.".
- Design Principles for Promoting Students’ Social Scientific Reasoning About Social Problems.Thomas Klijnstra,Gerhard L. Stoel,Gerard J. F. Ruijs,Geerte M. Savenije &Carla A. M. van Boxtel -2024 -Journal of Social Studies Research 48 (3):204-217.Social scientific reasoning (SSR) is essential to social science education and to a democratic society as a whole. Students are challenged to analyze and reason about social problems such as social inequality, crime, and poverty. However, students experience difficulties with SSR. This study addresses the research question: Which design principles can guide teachers in designing lessons that promote social scientific reasoning? In this design-based research, four social science teachers employed a conceptualization of SSR and its levels together with three initial (...) design principles to develop curriculum materials and activities. These design principles and curriculum materials were piloted in two secondary education classes (9th and 10th grades) and evaluated by four social science teachers, four social science teacher educators and 90 students. The study produced six design principles that can promote students’ SSR. In combination with the curriculum materials, those design principles can help develop teachers’ pedagogical content knowledge and guide the design of tasks and units that develop SSR. (shrink)
- Opening the Black Box of CSR Decision Making: A Policy-Capturing Study of Charitable Donation Decisions in China.Shuo Wang,Yuhui Gao,Gerard P. Hodgkinson,Denise M. Rousseau &Patrick C. Flood -2015 -Journal of Business Ethics 128 (3):665-683.This policy-capturing study, conducted in China, investigated the cognitive basis of managerial decisions to make a corporate charitable donation, a global issue in the context of corporate social responsibility research and practice. Participants responded to a series of scenarios manipulating pressure from the five stakeholders most commonly addressed by CSR research. The independent variables examined included organizational factors and the participants’ personal values. Results indicate a large positive effect of shareholder and governmental pressure on the decision with lesser positive effects (...) from customers and competitors. Surprisingly, employee pressure had a negative effect on the decision to make a charitable donation. Further, personal values and perceived CEO attitudes toward charity were significantly related to the decisions participants made. In line with our theorizing, the findings indicate that a combination of personal, organizational, and institutional factors was salient in the minds of decision makers. (shrink)
- Catholicism Engaging Other Faiths: Vatican Ii and its Impact.Michael Amaladoss S. J.,Roberto Catalano,Francis X. Clooney S. J.,Archbishop Michael L. Fitzgerald,Richard Girardin,Roger Haight S. J.,Sallie B. King,Vladimir Latinovic,Leo D. Lefebure,Archbishop Felix Machado,Gerard Mannion,Alexander E. Massad,Sandra Mazzolini,Dawn M. Nothwehr O. S. F.,John T. Pawlikowski O. S. M.,Peter C. Phan,Jonathan Ray,William Skudlarek O. S. B.,Cardinal Jean-Louis Tauran,Jason Welle O. F. M. &Taraneh R. Wilkinson (eds.) -2018 - Springer Verlag.This book assesses how Vatican II opened up the Catholic Church to encounter, dialogue, and engagement with other world religions. Opening with a contribution from the President of the Pontifical Council for Interreligious Dialogue, Cardinal Jean-Louis Tauran, it next explores the impact, relevance, and promise of the Declaration Nostra Aetate before turning to consider how Vatican II in general has influenced interfaith dialogue and the intellectual and comparative study of world religions in the postconciliar decades, as well as the contribution (...) of particular past and present thinkers to the formation of current interreligious and comparative theological methods. Additionally, chapters consider interreligious dialogue vis-à-vis theological anthropology in conciliar documents; openness to the spiritual practices of other faith traditions as a way of encouraging positive interreligious encounter; the role of lay and new ecclesial movements in interreligious dialogue; and the development of Monastic Interreligious Dialogue. Finally, it includes a range of perspectives on the fruits and future of Vatican’s II’s opening to particular faiths such as Judaism, Islam, Hinduism, and Buddhism. (shrink)No categories
- Ludwig Von Mises, the Man and His Economics - Israel M. Kirzner.Gérard Bramoullé -2002 -Journal des Economistes Et des Etudes Humaines 12 (2).
- Apropos de l'ouvrage de M.P. DUCLOS : La réforme du conseil de l'Europe.Gérard Deleixhe -1960 -Res Publica 2 (1):74-76.
- A propos du livre "Le conflit sarrois 1945-1955" de M.J. Freymond.Gérard Deleixhe -1961 -Res Publica 3 (2):176-180.
- Aquinas and Modern Science: A New Synthesis of Faith and Reason. ByGerard M. Verschuuren. [REVIEW]James M. Jacobs -2017 -International Philosophical Quarterly 57 (4):473-475.No categories
- Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy.Günter U. Höglinger,Nadine M. Melhem,Dennis W. Dickson,Patrick M. A. Sleiman,Li-San Wang,Lambertus Klei,Rosa Rademakers,Rohan de Silva,Irene Litvan,David E. Riley,John C. van Swieten,Peter Heutink,Zbigniew K. Wszolek,Ryan J. Uitti,Jana Vandrovcova,Howard I. Hurtig,Rachel G. Gross,Walter Maetzler,Stefano Goldwurm,Eduardo Tolosa,Barbara Borroni,Pau Pastor,P. S. P. Genetics Study Group,Laura B. Cantwell,Mi Ryung Han,Allissa Dillman,Marcel P. van der Brug,J. Raphael Gibbs,Mark R. Cookson,Dena G. Hernandez,Andrew B. Singleton,Matthew J. Farrer,Chang-En Yu,Lawrence I. Golbe,Tamas Revesz,John Hardy,Andrew J. Lees,Bernie Devlin,Hakon Hakonarson,Ulrich Müller &Gerard D. Schellenberg -unknownProgressive supranuclear palsy is a movement disorder with prominent tau neuropathology. Brain diseases with abnormal tau deposits are called tauopathies, the most common of which is Alzheimer's disease. Environmental causes of tauopathies include repetitive head trauma associated with some sports. To identify common genetic variation contributing to risk for tauopathies, we carried out a genome-wide association study of 1,114 individuals with PSP and 3,247 controls followed by a second stage in which we genotyped 1,051 cases and 3,560 controls for the (...) stage 1 SNPs that yielded P ≤ 10-3. We found significant previously unidentified signals associated with PSP risk at STX6, EIF2AK3 and MOBP. We confirmed two independent variants in MAPT affecting risk for PSP, one of which influences MAPT brain expression. The genes implicated encode proteins for vesicle-membrane fusion at the Golgi-endosomal interface, for the endoplasmic reticulum unfolded protein response and for a myelin structural component. © 2011 Nature America, Inc. All rights reserved. (shrink)
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Area Editors:
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Jack Alan Reynolds
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