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Since the growth cone was first described a century ago by Cajal, considerable effort has been directed towards understanding the mechanisms responsible for its guidance. Traditionally, attention has focussed on the role of adhesive molecules in determining neural development. Recently, it has become apparent that inhibitory interactions may play a crucial part in axonal navigation. A common feature of inhibition seen in three model systems (peripheral nerve segmentation, retinotectal mapping and CNS/PNS segregation) is a collapse of the motile structures of (...) the growth cone. It is increasingly clear that the identification of molecular mechanisms of inhibition, as well as those of adhesion, will be of fundamental importance to understanding neural development. (shrink)

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The task of the historian is not one of tracing a series of links in a temporal chain; rather, it is his task to analyze a complex pattern of change into the factors which served to make it precisely what it was. The relationship which I therefore take to be fundamental to historiography is ... a relationship of part to whole, not a relationship of antecedent to consequent.Mandelbaum's historian relates the part to the whole, leaving it for the sociologist to (...) relate the antecedent to the consequence.If that is so, then Maigret is first an historian ascertaining and accumulating the subjective meanings that individuals use to produce the facticity of their own lives. And in the course of so doing he discovers the nature of the reality in which the crime occurred. Once he finds his way into the realities of the crime there is time and need for the sociological analysis of antecedent and consequent. To suggest a comparison, Maigret practices in miniature the method of Norbert Elias in that he tries to understand his subjects as they understand themselves. Maigret's is an idiographic science and not a nomethetic one. For this reason Maigret, unlike Holmes, almost never refers to previous cases in the effort to understand the matter at hand.The temptation is to conclude that Maigret is a little like Fernand Braudel in combining history and sociology by turns. But I wonder if there is not a more profound sense in which Maigret, if not all sociologists, is an historian. If we have any knowledge it is of the past, not of the present or the future. Minerva's owl does indeed take wing only at dusk, as Hegel wrote. By the time we have understood the present, it is the past.If Maigret's aim is not the unvarnished truth, that is not because of the constraints of police work but because of the constraints of the world. The irony of Maigret's ethnomethodology is this. Simenon's style is rightly celebrated for its evocation of atmosphere. The apposite analogy occasionally offered is between Simenon's spare and laconic style and Impressionist painting. Simenon does not describe people and places in the Maigret stories but suggests them with a sentence or two. The style is not realism, whatever the effect. As Rafael Koskimies has written, Simenon selects and simplifies. Impressionism is the style of painting that accepts the surface as reality. The play of light and color on the surface of objects is suggested on the surface of the canvas with the texture and color of the paint. If Simenon is an impressionist in his art, Maigret cannot be in his. He does not settle for the surface, but goes inside of it. Once there he learns all he needs to know and all that he can know. The confessions that so frequently occur in the Maigret stories do not confirm his suppositions, but release the tensions of the drama in a catharsis. Finally, if Maigret's Maigret must admit in his Memoirs that he could not in fact go into the detail of every reality personally in the manner described above, it only proves how terribly taxing the method called Verstehen is.To conclude, Maigret has a method, but it is not a recipe that others can follow step-by-step. His method is an orientation to reality and a commitment to understanding in a certain way. To call Maigret's procedure a method requires the definition of “method” to include more thancook books, however brilliant thecook books are. Maigret's method is a part of the context of discovery. Naive realists like Méchin imagine that they live only in the context of justification.Of course, no one's understanding is perfect. Maigret makes mistakes. There are times when an explanation based on behavior would be more accurate and economical. If Simenon does not dwell on Maigret's failures it is clear that Maigret uses other methods, too. The triangulation of a variety of methods is what in fact most of us practice whatever we preach. (shrink)

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Critics of evolutionary psychology and sociobiology have advanced an adaptationists-as-right-wing-conspirators (ARC) hypothesis, suggesting that adaptationists use their research to support a right-wing political agenda. We report the first quantitative test of the ARC hypothesis based on an online survey of political and scientific attitudes among 168 US psychology Ph.D. students, 31 of whom self-identified as adaptationists and 137 others who identified with another non-adaptationist meta-theory. Results indicate that adaptationists are much less politically conservative than typical US citizens and no more (...) politically conservative than non-adaptationist graduate students. Also, contrary to the “adaptationists-as-pseudo-scientists” stereotype, adaptationists endorse more rigorous, progressive, quantitative scientific methods in the study of human behavior than non-adaptationists. (shrink)

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While rooted in careful study of Mead’s original writings and transcribed lectures and the historical context in which that work was carried out, the papers in this volume have brought Mead’s work to bear on contemporary issues in metaphysics, epistemology, cognitive science, and social and political philosophy.

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Book Reviewed in this article: Israel's Prophetic Tradition: Essays in honour of Peter R. Ackroyd. Edited by Richard Coggins, Anthony Phillips and Michael Knibb, Pp.xxi, 272. Cambridge University Press, 1982, £21.00. Essays on John. By C.K. Barrett. Pp.viii, 167, London, SPCK, 1982, £10.50. The Letter to the Colossians. By Eduard Schweizer, translated by Andrew Chester. Pp.319, London, SPCK, 1982, £12.50. Foundational Theology: Jesus and the Church. By Francis Schüssler Fiorenza. Pp.xix, 326, New York Crossroad, 1984, $22.50. The Darkness of God: (...) Theology after Hiroshima. By Jim Garrison. Pp.x, 238, London, SCM Press, 1982, £5.95. Discerning the Mystery, An Essay on the Nature of neology. By Andrew Louth. Pp.xiv, 150, Oxford, Clarendon Press, 1983, £12.50. The Tao and the Daimon: Segments of a Religious Inquiry. By Robert C. Neville. Pp.xv, 281, Albany, New York, State University of New York Press, 1982, $34.50 ), $11.95. Person and Myth: Maurice Leenhardt in the Melanesian World. By James Clifford. Pp.xi, 270, Berkeley, University of California Press, 1982, £21.50. Transcendence and the Sacred. Edited by A.M. Olson and L.S. Rouner. Pp.xv, 230, University of Notre Dame Press, 1981, £10.75. A History of Religious Ideas. Vol. 2: From Gautama Buddha to the Triumph of Christianity. By Mircea Eliade. Translated by William R. Trask. Pp.xi, 565, Chicago, University of Chicago Press, 1982, £17.50. Ordeal by Labyrinth: Conversations with Claude‐Henri Racquet. By Mircea Eliade. Translated by Derek Coltman. Pp.ix, 225, Chicago, University of Chicago Press, 1982, £12.55. Religious Philosophy of Prince‐Bishop Njegosh of Montenegro. By Zika Rad. Prvulovich. Pp.xviii, 273, Birmingham, The Author, 1984, £12.50, £10.50. The Home of Meaning: The Hermeneutics of the Subject of Paul Ricoeur. By John W. Van Dengel. Pp.xxi, 333, Washington, D.C., University Press of America, 1982, $24.50, $13.25. Life Forms and Meaning Stucture. By Alfred Schutz, translated, introduced and annotated by Helmut Wagner. Pp.vi, 217, London, Routledge & Kegan Paul, 1982, £11.95. The Shaping of Man: Philosophical Aspects of Sociobiology. By Roger Trigg. Pp.xx, 186. Oxford, Basil Blackwell, 1982, £12.50, £5.95. Marx and Marxisms: Royal Institute of Philosophy Lecture Series, 14. Edited by G.H.R. Parkinson. Pp.vi, 268, Cambridge University Press, 1982, £9.95. Marx and Justice: The Radical Critique of Liberalism. By Allen E. Buchanan. Pp.xiv, 206, London, Methuen, 1982, £12.95. Israel Satanter: Text, Structure, Idea. By Hillel Goldberg. Pp.xvii, 358, New York, Ktav, 1981, $17.50. Freud on Femininity and Faith. By Judith Van Herik. Pp.xiii, 216, Berkeley, University of California Press, 1982, £17.50. Women, Reason and Nature. By Carol McMillan. Pp.x, 165, Oxford, Basil Blackwell, 1982, £12.50. Supererogation: Its Status in Ethical Theory. By David Heyd. Pp.vii, 191, Cambridge University Press, 1982, £14.00. The Cambridge History of Later Medieval Philosophy. Edited by Norman Kretzmann, Anthony Kenny and Jan Finborg. Pp.xi, 1035, Cambridge, Cambridge University Press, 1982, £40.00. St Thomas Aquinas. By Ralph McInerny. Pp.197, Notre Dame, University of Notre Dame Press, 1982, £4.50. Yves de Vallone: The Making of an Esprit‐Fort. By James O'Higgins, S.J. Pp.viii, 248, The Hague, Martinus Nijhoff, 1982, $35.00. Religion and National Identity. Edited by Stuart Mews. Pp.xvi, 618, Oxford, Basil Blackwell, 1982, £19.50. Mortmain Legislation and the English Church, 1279–1500. By Sandra Raban. Pp.xii, 215,, Cambridge University Press, 1982, £25.00. John XXIII, Pope of the Council. By Peter Hebblethwaite. Pp.viii, 550, London,Geoffrey Chapman, 1984, £14.95.iCompiled by J.F. Púglisi and S.J. Voicu. Pp.260, Rome, Centro Pro Unione, 1984, $20.00. Ireland: A Bibliography of Material held at St Deiniol's Library. Compiled by Helen C. Price. Pp.iv, 136, Hawarden, St Deiniol's, 1984, £2.50. The Later Poems, 1972–1982. By R.S. Thomas. Pp.224, London, Macmillan, 1984, £4.95. (shrink)

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hoc est, Capitolium’. This sentence comes in a passage based on a portion of the Historia Regum Britanniae ofGeoffrey of Monmouth , but is not itself to be found inGeoffrey. Since Luard was unable to find the words attributed to him ‘in Lucan’, he concluded that the chronicler who was responsible for their inclusion had made a mistake. He offers no suggestions about the origins of the quotation. In a posthumous work of G. Gundermann's edited by (...) G. Goetz, Trogtis und Gellius bei Radulfus de Diceto, we find the quotation described as ‘einen angeblichen Lucanvers'. W. Morel learned of its existence from this reference and printed it as fr. 12 of Lucan. (shrink)

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BackgroundPromoting the social value of global health research undertaken in resource poor settings has become a key concern in global research ethics. The consideration for benefit sharing, which concerns the elucidation of what if anything, is owed to participants, their communities and host nations that take part in such research, and the obligations of researchers involved, is one of the main strategies used for promoting social value of research. In the last decade however, there has been intense debate within academic (...) bioethics literature seeking to define the benefits, the beneficiaries, and the scope of obligations for providing these benefits. Although this debate may be indicative of willingness at the international level to engage with the responsibilities of researchers involved in global health research, it remains unclear which forms of benefits or beneficiaries should be considered. International and local research ethics guidelines are reviewed here to delineate the guidance they provide.MethodsWe reviewed documents selected from the international compilation of research ethics guidelines by the Office for Human Research Protections under the US Department of Health and Human Services.ResultsAccess to interventions being researched, the provision of unavailable health care, capacity building for individuals and institutions, support to health care systems and access to medical and public health interventions proven effective, are the commonly recommended forms of benefits. The beneficiaries are volunteers, disease or illness affected communities and the population in general. Interestingly however, there is a divide between "global opinion" and the views of particular countries within resource poor settings as made explicit by differences in emphasis regarding the potential benefits and the beneficiaries.ConclusionAlthough in theory benefit sharing is widely accepted as one of the means for promoting the social value of international collaborative health research, there is less agreement amongst major guidelines on the specific responsibilities of researchers over what is ethical in promoting the social value of research. Lack of consensus might have practical implications for efforts aimed at enhancing the social value of global health research undertaken in resource poor settings. Further developments in global research ethics require more reflection, paying attention to the practical realities of implementing the ethical principles in real world context. (shrink)

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hoc est, Capitolium’. This sentence comes in a passage based on a portion of the Historia Regum Britanniae ofGeoffrey of Monmouth, but is not itself to be found inGeoffrey. Since Luard was unable to find the words attributed to him ‘in Lucan’, he concluded that the chronicler who was responsible for their inclusion had made a mistake. He offers no suggestions about the origins of the quotation. In a posthumous work of G. Gundermann's edited by G. (...) Goetz, Trogtis und Gellius bei Radulfus de Diceto, we find the quotation described as ‘einen angeblichen Lucanvers'. W. Morel learned of its existence from this reference and printed it as fr. 12 of Lucan. (shrink)

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BackgroundThe concept of benefit sharing to enhance the social value of global health research in resource poor settings is now a key strategy for addressing moral issues of relevance to individuals, communities and host countries in resource poor settings when they participate in international collaborative health research.The influence of benefit sharing framework on the conduct of collaborative health research is for instance evidenced by the number of publications and research ethics guidelines that require prior engagement between stakeholders to determine the (...) social value of research to the host communities. While such efforts as the production of international guidance on how to promote the social value of research through such strategies as benefit sharing have been made, the extent to which these ideas and guidelines have been absorbed by those engaged in global health research especially in resource poor settings remains unclear. We examine this awareness among stakeholders involved in health related research in Kenya.MethodsWe conducted in-depth interviews with key informants drawn from within the broader health research system in Kenya including researchers from the mainstream health research institutions, networks and universities, teaching hospitals, policy makers, institutional review boards, civil society organisations and community representative groups.ResultsOur study suggests that although people have a sense of justice and the moral aspects of research, this was not articulated in terms used in the literature and the guidelines on the ethics of global health research.ConclusionThis study demonstrates that while in theory several efforts can be made to address the moral issues of concern to research participants and their communities in resource poor settings, quick fixes such as benefit sharing are not going to be straightforward. We suggest a need to pay closer attention to the processes through which ethical principles are enacted in practice and distil lessons on how best to involve individuals and communities in promoting ethical conduct of global health research in resource poor settings. (shrink)

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The Judeo-Christian creation myth has a lot to answer for even in our supposedly secular age. In and after the European Enlightenment, the deity who had made heaven and earth became the prototype of impersonal forces—notably Universal Reason, Progress, and History—then believed to be at work in the world. These apparent secularizations of the Word of God, each of which failed in its own way, were expressions of a collective fear of the unintelligible, that is, of the very idea that (...) the world might just be without reason or purpose. What follows is an attempt to explore the forms and origins of this fear, which perhaps remains unresolved in our culture to this day. It begins outside the Judeo-Christian tradition with the world view implied, on one interpretation, in a famous haiku by the seventeenth-century Japanese poet Bashō. The essay ends by suggesting that secular society will achieve a completely honest accommodation with the world only when it comes to terms with the reality of the creation, namely.. (shrink)

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Are humans at their core seekers of their own pleasure or cooperative members of society? Paradoxically, they are both. Pleasure-seeking can take place only within the context of what works within a defined community, and central to any community are the evolved codes and principles guiding appropriate behavior, or morality. The complex interaction of morality and self-interest is at the heart ofGeoffrey M. Hodgson’s approach to evolutionary economics, which is designed to bring about a better understanding of human (...) behavior. In From Pleasure Machines to Moral Communities, Hodgson casts a critical eye on neoclassical individualism, its foundations and flaws, and turns to recent insights from research on the evolutionary bases of human behavior. He focuses his attention on the evolution of morality, its meaning, why it came about, and how it influences human attitudes and behavior. This more nuanced understanding sets the stage for a fascinating investigation of its implications on a range of pressing issues drawn from diverse environments, including the business world and crucial policy realms like health care and ecology. This book provides a valuable complement to Hodgson’s earlier work with Thorbjørn Knudsen on evolutionary economics in Darwin’s Conjecture, extending the evolutionary outlook to include moral and policy-related issues. (shrink)

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I have been writing and publishing in economics for 50 years and much of my work has been debated and criticised. But I think that this is the first time that someone has honoured me by a full-scale article criticising an unpublished working paper. I am very grateful to Lynne Chester for bringing the questions I raise to a wider audience. The working paper that she criticizes went through several versions, of which the 12 July 2017 draft that Lynne downloaded (...) from the World Interdisciplinary Network for Institutional Research (WINIR) website is not the final version. In addition, the working paper has now expanded into a book entitled Is There a Future for Heterodox Economics? (Hodgson, 2019). Lynne's criticisms help me to attempt to make the text clearer and deal with some misunderstandings that have arisen... (shrink)

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For Herbert Gintis, the “rational actor,” or “beliefs, preferences, and constraints (BPC),” model is central to his unifying framework for the behavioral sciences. It is not argued here that this model is refuted by evidence. Instead, this model relies ubiquitously on auxiliary assumptions, and is evacuated of much meaning when applied to both human and nonhuman organisms. An alternative perspective of “program-based behavior” is more consistent with evolutionary principles. (Published Online April 27 2007).

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In Monetary Evolution, Free Banking, and Economic Order, Stephen Horwitz has provided an excellent review of the profound problems in the neoclassical theory of money and an important statement of the alternative Austrian?school approach. However, Horwitz's ?free banking? perspective rests on a false dichotomy between intervention and spontaneous order. In using the extreme case of an entirely undesigned evolutionary process to counter the equally extreme proposition that social order can be wholly designed, Horwitz loses sight of the messy world of (...) intermediate realities and possibilities. Even if money has strong spontaneous qualities, the state may play a vital role in the evolution of the financial system. (shrink)

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Deliberative democracy is a noble project: an attempt to make citizens philosophize. Critics of deliberative democracy usually claim either that the proposed deliberation threatens an existing moral consensus or, instead, that deliberation is impossible amid power imbalances that oppress the weak. But another problem is that combining democracy and deliberation is inherently an attempt to engage publicly in a private activity—where sensitivity to each interlocutor may require a special form of address. Can this be done? Yes, in some contexts. The (...) tradition of esoteric writing has demonstrated that it is possible to layer one's discourse in such a way that all citizens can partake at a level that suits them. But writing for a public is not really deliberation among equals; it is leadership by the writer of the readers. Genuine dialogue among equals that takes account of their differences is, in contrast, inherently a private affair. (shrink)

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The established definition of replication in terms of the conditions of causality, similarity and information transfer is very broad. We draw inspiration from the literature on self-reproducing automata to strengthen the notion of information transfer in replication processes. To the triple conditions of causality, similarity and information transfer, we add a fourth condition that defines a “generative replicator” as a conditional generative mechanism, which can turn input signals from an environment into developmental instructions. Generative replication must have the potential to (...) enhance complexity, which in turn requires that developmental instructions are part of the information that is transmitted in replication. Demonstrating the usefulness of the generative replicator concept in the social domain, we identify social generative replicators that satisfy all of the four proposed conditions. (shrink)

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Did Hobbes's political philosophy have practical intentions? There exists no "Hobbist" school of thought; no new political order was inspired by Hobbesian precepts. Yet in Behemoth Teaches LeviathanGeoffrey M. Vaughan revisits Behemoth to reveal hitherto unexplored pedagogic purpose to Hobbes's political philosophy.

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Introduction, W G Runciman Social Evolution in Primates: The Role of Ecological Factors and Male Behaviour, Carel P van Schaik Determinants of Group Size in Primates: A General Model, R I M Dunbar Function and Intention in the Calls of Non-Human Primates, Dorothy L Cheney & Robert M Seyfarth Why Culture is Common, but Cultural Evolution is Rare, Robert Boyd & Peter J Richerson An Evolutionary and Chronological Framework for Human Social Behaviour, Robert A Foley Friendship and the Banker?s Paradox: (...) Other Pathways to the Evolution of Adaptations for Altruism, John Tooby & Leda Cosmides The Early Prehistory of Human Social Behaviour: Issues of Archaeological Inference and Cognitive Evolution, Steven Mithen The Emergence of Biologically Modern Populations in Europe: A Social and Cognitive ?Revolution??, Paul Mellars Responses to Environmental Novelty: Changes in Men?s Marriage Strategies in a Rural Kenyan Community, Monique Borgerhoff Mulder Genetic Language Impairment: Unruly Grammars, M Gopnik, J Dalalakis, S E Fukuda, S Fukuda & E Kehayia The Emergence of Cultures among Wild Chimpanzees, Christophe Boesch Terrestriality, Bipedalism and the Origin of Language, Leslie C Aiello Conclusions, John Maynard Smith. (shrink)

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