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There is a growing interest in non-invasive stimulation interventions as treatment strategies to improve functional outcomes and recovery after spinal cord injury. Repetitive transcranial magnetic stimulation is a neuromodulatory intervention which has the potential to reinforce the residual spinal and supraspinal pathways and induce plasticity. Recent reviews have highlighted the therapeutic potential and the beneficial effects of rTMS on motor function, spasticity, and corticospinal excitability modulation in SCI individuals. For this scoping review, we focus on the stimulation parameters used in (...) 20 rTMS protocols. We extracted the rTMS parameters from 16 published rTMS studies involving SCI individuals and were able to infer preliminary associations between specific parameters and the effects observed. Future investigations will need to consider timing, intervention duration and dosage that may depend on the stage, the level, and the severity of the injury. There is a need for more real vs. sham rTMS studies, reporting similar designs with sufficient information for replication, to achieve a significant level of evidence regarding the use of rTMS in SCI. (shrink)

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The pandemic of SARS-CoV-2 has led to unprecedented changes to society, causing unique problems that call for extraordinary solutions. We consider one such extraordinary proposal: ‘safer infection sites’ that would offer individuals the opportunity to be intentionally infected with SARS-CoV-2, isolate, and receive medical care until they are no longer infectious. Safer infection could have value for various groups of workers and students. Health professionals place themselves at risk of infection daily and extend this risk to their family members and (...) community. Similarly, other essential workers who face workplace exposure must continue their work, even if have high-risk household members and live in fear of infecting. When schools are kept closed because of the fear that they will be sites of significant transmission, children and their families are harmed in multiple ways and college students who are living on campus, whether or not they are attending classes in person, are contributing to high rates of transmission and experiencing high rates of exposure. We consider whether offering safer infection sites to these groups could be ethically defensible and identify the empirical unknowns that would need to resolve before reaching definitive conclusions. This article is not an endorsement of intentional infection with the coronavirus, but rather is meant to spark conversation on the ethics of out-of-the-box proposals. Perhaps most meaningfully, our paper explores the value of control and peace of mind for those among us most impacted by the pandemic: those essential workers risking the most to keep us safe. (shrink)

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This study investigates whether and how sex and race affect access to and rewards for job authority, using 1980 survey data for 1,216 employed workers. The authors examine whether, net of human-capital characteristics, sex and race affect access to and compensation for job authority. In addition, the authors examine whether the translation of credentials into authority and earnings varies depending on workers' sex or race.

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When there have been substantial failures by institutional leadership in their oversight responsibility to protect research integrity, the public should demand that these be recognized and addressed by the institution itself, or the funding bodies. This commentary discusses a case of research failures in developing genomic predictors for cancer risk assessment and treatment at a leading university. In its review of this case, the Office of Research Integrity, an agency within the US Department of Health and Human Services, focused their (...) report entirely on one individual faculty member and made no comment on the institution’s responsibility and its failure to provide adequate oversight and investigation. These actions missed an important opportunity to emphasize the institution’s critical responsibilities in oversight of research integrity and the importance of institutional transparency and accountability. (shrink)

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An experiment designed to test the highly speculative hypothesis of photon consciousness was executed. It was found that, within the accuracy attainable with the apparatus, there is no empirical justification for the hypothesis.

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Background: The factors influencing parents’ willingness to enroll their children in biobanks are poorly understood. This study sought to assess parents’ willingness to enroll their children, and their perceived benefits, concerns, and information needs under different consent and data-sharing scenarios, and to identify factors associated with willingness. Methods: This large, experimental survey of patients at the 11 eMERGE Network sites used a disproportionate stratified sampling scheme to enrich the sample with historically underrepresented groups. Participants were randomized to receive one of (...) three consent and data-sharing scenarios. Results: In total, 90,000 surveys were mailed and 13,000 individuals responded (15.8% response rate). 5737 respondents were parents of minor children. Overall, 55% (95% confidence interval 50–59%) of parents were willing to enroll their youngest minor child in a hypothetical biobank; willingness did not differ between consent and data-sharing scenarios. Lower educational attainment, higher religiosity, lower trust, worries about privacy, and attitudes about benefits, concerns, and information needs were independently associated with less willingness to allow their child to participate. Of parents who were willing to participate themselves, 25% were not willing to allow their child to participate. Being willing to participate but not willing to allow one’s child to participate was independently associated with multiple factors, including race, lower educational attainment, lower annual household income, public health care insurance, and higher religiosity. Conclusions: Fifty-five percent of parents were willing to allow their youngest minor child to participate in a hypothetical biobank. Building trust, protecting privacy, and addressing attitudes may increase enrollment and diversity in pediatric biobanks. (shrink)

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Biological evolution provides a creative fount of complex and subtle adaptations, often surprising the scientists who discover them. However, because evolution is an algorithmic process that transcends the substrate in which it occurs, evolution’s creativity is not limited to nature. Indeed, many researchers in the field of digital evolution have observed their evolving algorithms and organisms subverting their intentions, exposing unrecognized bugs in their code, producing unexpected adaptations, or exhibiting outcomes uncannily convergent with ones in nature. Such stories routinely reveal (...) creativity by evolution in these digital worlds, but they rarely fit into the standard scientific narrative. Instead they are often treated as mere obstacles to be overcome, rather than results that warrant study in their own right. The stories themselves are traded among researchers through oral tradition, but that mode of information transmission is inefficient and prone to error and outright loss. Moreover, the fact that these stories tend to be shared only among practitioners means that many natural scientists do not realize how interesting and lifelike digital organisms are and how natural their evolution can be. To our knowledge, no collection of such anecdotes has been published before. This paper is the crowd-sourced product of researchers in the fields of artificial life and evolutionary computation who have provided first-hand accounts of such cases. It thus serves as a written, fact-checked collection of scientifically important and even entertaining stories. In doing so we also present here substantial evidence that the existence and importance of evolutionary surprises extends beyond the natural world, and may indeed be a universal property of all complex evolving systems. (shrink)

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Cytokines are polypeptides released by activated vertebrate blood cells which have profound effects on other blood cells and which have hormone‐like properties affecting other organ systems as well. In recent years a wide variety of these mediators has been isolated and characterized. Many of these molecules have subsequently been cloned and expressed in E. coli. The tremendous importance of these proteins to host immune and non‐specific defense systems along with the striking similarities of their properties among different species suggested to (...) us that cytokines may have been proteins that have been conserved through evolution. Investigations of the evolution of cytokines will help us decipher the complex cellular, humoral and molecular interactions that regulate host defenses. Studies of the invertebrates will shed light on the phylogenetic emergence of these molecules as well. (shrink)

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Responding to a major pandemic and planning for allocation of scarce resources under crisis standards of care requires coordination and cooperation across federal, state and local governments in tandem with the larger societal infrastructure. Maryland remains one of the few states with no state-endorsed ASR plan, despite having a plan published in 2017 that was informed by public forums across the state. In this article, we review strengths and weaknesses of Maryland’s response to COVID-19 and the role of the Maryland (...) Healthcare Ethics Committee Network in bridging gaps in the state’s response to prepare health care facilities for potential implementation of ASR plans. Identified “lessons learned” include: Deliberative Democracy Provided a Strong Foundation for Maryland’s ASR Framework; Community Consensus is Informative, Not Normative; Hearing Community Voices Has Inherent Value; Lack of Transparency & Political Leadership Gaps Generate a Fragmented Response; Pandemic Politics Requires Diplomacy & Persistence; Strong Leadership is Needed to Avoid Implementing ASR … And to Plan for ASR; An Effective Pandemic Response Requires Coordination and Information-Sharing Beyond the Acute Care Hospital; and The Ability to Correct Course is Crucial: Reconsidering No-visitor Policies. (shrink)

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An article by F. Ochieng'-Odhiambo asserted that Prof. H. Odera Oruka's work on "philosophic sagacity" in Kenya could be divided into three periods, beginning with an early period denouncing ethnophilosophy and ending with a later period which embraced and engaged in ethnophilosophy. This article says that such a characterization is inaccurate, because Odera Oruka continued to distinguish sage philosophy from ethnophilosophy in several key ways, even in his later work. While pointing out Odera Oruka's changing positions is a service to (...) scholars, Ochieng'-Odhiambo implicitly champions the early work at the expense of the latter. This article argues that folk sages were added to the later stages of the sage philosophy project with good reason, and that the project as it developed provided insights on ethical and socio-political issues as well as identity issues facing Kenyans. (shrink)

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This anthology of readings in the survey of Western philosophy--from the Ancient Greeks to the 20th Century--is designed to be accessible to today's readers. Striking a balance between major and minor figures, it features the best available translations of texts--complete works or complete selections of works-- which are both central to each philosopher's thought and are widely accepted as part of the canon. The selections are readable and accessible, while still being faithful to the original. Includes Introductions to each historical (...) period and to each philosopher, and an abundance of drawings, diagrams, photographs, and a timeline. This Combined Volume contains the most important works from Baird's Philosophic Classics, Volumes I-V. ANCIENT GREEK PHILOSOPHY. Plato. Aristotle. HELLENISTIC PHILOSOPHY. Epicurus. Epictetus. Plotinus. MEDIEVAL PHILOSOPHY. Augustine. Boethius. Anselm (and Guanilo). Moses Maimonides. Thomas Aquinas. William of Ockham. Pico Della Mirandola. MODERN PHILOSOPHY. Ren Descartes. Thomas Hobbes. Blaise Pascal. Baruch Spinoza. John Locke. Gottfried Leibniz. George Berkeley. David Hume. Immanuel Kant. NINETEENTH-CENTURY PHILOSOPHY. G.W.F. Hegel. John Stuart Mill. Soren Kierkegaard. Karl Marx. Friedrich Nietzsche. TWENTIETH-CENTURY PHILOSOPHY. Edmund Husserl. Bertrand Russell. Martin Heidegger. Ludwig Wittgenstein. A.J. Ayer. Jean-Paul Sartre. Willard Van Orman Quine. Jacques Derrida. For anyone interested in Philosophy, History of Philosophy, or History of Intellectual Thought. (shrink)

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"M. F. Simone Roberts's A Poetics of Being-Two is animated by a lively and engaging voice, drawing readers in with a sense of serious purpose working (delightfully) in tandem with a sense of humor. Roberts's aesthetics and her close readings of Yves Bonnefoy, St-John Perse, and Jorie Graham clearly demonstrate the literary effectiveness of Irigarayan sexual difference as an analytic trope, even as they emphasize the philosophical and political possibilities sexual difference opens up for feminism, environmentalism, and all levels of (...) contemporary cultural critique and activism."—Gail M. Schwab, Hofstra University -/- In An Ethics of Sexual Difference, Irigaray calls for a new poetics in the sense of both art and life. Rather than a critique from within philosophy, A Poetics of Being-Two tests Irigaray's ethics by extending it to other sites of cultural production. Where Irigaray's method finds stirrings and repressions of sexual difference in philosophy, this project explores that tension in poetics. Building from Irigaray's ethics, the book describes a poetics of being-two as concerns gendered subjectivity in literary poetics and then traces the on-going emergence of a poetics of being-two in the post-symbolist poetic tradition. Irigaray scholars will be interested in the sustained interpolation of Irigaray's ethical concepts as principles for a critical aesthetics and in their hermeneutic application in reading a literary tradition. Readers in comparative literature will find the first sustained feminist engagements with the major French poets Bonnefoy and Perse and an elucidation of their influence on the Pulitzer Prize winning poet Jorie Graham. (shrink)

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Between 1860-1920 a number of distinguished Scottish theologians grappled with the problems of reconciling a biblical faith with current philosophical and theological trends. Alan Sell has selected eight of these: John Kennedy of Dingwall ; Robert Flint ; John Caird ; A. B. Bruce ; James Iverach ; James Orr ; D. W.Forrest ; and James Denney. The book is not only of historical interest; many of the issues confronted by these scholars are also of contemporary interest. Professor (...) James Torrance comments: 'This study is invaluable in keeping alive the authentic tradition that Scotland has produced great theologians,... but perhaps supremely in the period covered by this eminently readable book.'. (shrink)

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Ronald Preston defended the middle axiom approach to doing Christian social ethics developed by J. H. Oldham for the 1937 ‘Life and Work’ conference. Preston argued that middle axioms continue to offer the churches a relevant ecumenical method. Middle axions has since been subject to fundamental criticism by ethicists such as Duncan Forrester. It will be argued that a case study of the Church of Scotland's contribution to the devolution debate, as part of Scottish civil society, supports Preston's defence of (...) the middle axiom approach as a relevant form of political engagement in the new context of local-global politics. (shrink)

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“Resistir significa en primer lugar rechazar. Hoy, la insurgencia consiste en ese rechazo que no tiene nada de negativo, que es un acto indispensable, vital “ V. F.Hace ya seis años, en 1997, dos importantes editoriales publicaron en Barcelona, México y Buenos Aires, una traducción al español de El horror económico, y tres años después apareció en nuestra lengua Una extraña dictadura, ambos de la destacada ensayista y novelista francesa Vivianne Forrester. Estas obras se convirtieron en éxit..

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In "How Do We Know It Is Now Now?" David Braddon-Mitchell (Analysis 2004) develops an objection to the thesis that the past is real but the future is not. He notes my response to this, namely that the past, although real, is lifeless and (a fortiori?) lacking in sentience. He argues, however, that this response, which I call 'the past is dead hypothesis', is not tenable if combined with 'special relativity'. My purpose in this reply is to argue that, on (...) the contrary, 'special relativity' supports the thesis that the future is unreal. (shrink)

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The book comprises an enquiry into what quantum theory shows us about the world. Its aim is to sort out which metaphysical speculations are tenable and which are not. After an initial discussion of realism, the author provides a non-technical exposition of quantum theory and a criticism of the proposal that quantum theory should make us revise our beliefs about logic. He then discusses the various problems and puzzles which make quantum theory both interesting and perplexing. The text defends three (...) markedly different speculations. The first of them, the "determinate particle speculation", is shown to involve both a view which proposes determinate locations and velocities for particles and the opposite. With the "wave speculation" particles are seen as different again: here the professor proposes a radically original view of particles as polywaves. In the final chapter, he compares the competing particle theories and shows that two ostensibly opposing views are in fact compatible. He goes on to discuss the implications of quantum theory for our understanding of persons. The work assumes no prior knowledge of quantum theory and confines the necessary mathematical details to end-notes. (shrink)

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In this paper I present the Discrete Space-Time Thesis, in a way which enables me to defend it against various well-known objections, and which extends to the discrete versions of Special and General Relativity with only minor difficulties. The point of this presentation is not to convince readers that space-time really is discrete but rather to convince them that we do not yet know whether or not it is. Having argued that it is an open question whether or not space-time (...) is discrete, I then turn to some possible empirical evidence, which we do not yet have. This evidence is based on some slight differences between commonly occurring differential equations and their discrete analogs. (shrink)

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Introduction -- Overview -- Theism, simplicity, and properly anthropocentric metaphysics -- Materialism and dualism -- The power, knowledge, and motives of the primordial God -- The existence of the primordial God -- God changes -- Understanding evil -- The Trinity -- The Incarnation -- Concluding remarks.

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This paper concerns the structure of appearances. I argue that to be appeared to in a certain way is to be aware of one or more universals. Universals therefore function like the sense‐data, once highly favoured but now out of fashion. For instance, to be appeared to treely, in a visual way, is to be aware of the complex relation, being tree‐shaped and tree‐coloured and being in front of, a relation of a kind which could be instantiated by a material (...) object and a perceiver, which is thus instantiated in the veridical case but not in the non‐veridical. (shrink)

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This paper explores the mereology of structural universals, using the structural richness of a non-classical mereology without unique fusions. The paper focuses on a problem posed by David Lewis, who using the example of methane, and assuming classical mereology, argues against any purely mereological theory of structural universals. The problem is that being a methane molecule would have to contain being a hydrogen atom four times over, but mereology does not have the concept of the same part occurring several times. (...) This paper takes up the challenge by providing mereological analysis of three operations sufficient for a theory of structural universals: Reflexive binding, i.e. identifying two of the places of a universal; Existential binding, i.e. the language-independent correlate of an existential quantification; and Conjunction. (shrink)

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According to a number of popular intentionalist theories in philosophy of mind, phenomenology is essentially and intrinsically intentional: phenomenal properties are identical to intentional properties of a certain type, or at least, the phenomenal character of an experience necessarily fixes a type of intentional content. These views are attractive, but it is questionable whether the reasons for accepting them generalize from sensory-perceptual experience to other kinds of experience: for example, agentive, moral, aesthetic, or cognitive experience. Meanwhile, a number of philosophers (...) have argued for the existence of a proprietary phenomenology of thought, so-called cognitive phenomenology. There are different ways of understanding the relevant sense of “proprietary,” but on one natural interpretation, phenomenology is proprietary to thought just in case enjoying an experience with that phenomenal character is inseparable from thinking an occurrent, conscious thought. While one may have instances of thought without CP experience, one will never find CP independent of thought. So the former justifiably can be said to “belong to” the latter. The purpose of this paper is to argue that these intentionalist and cognitive phenomenology views make surprisingly uncomfortable bedfellows. I contend that the combination of the two views is incompatible with our best theories of how our concepts are structured. So cognitive phenomenology cannot determine the contents of our thoughts. (shrink)

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This paper concerns the structure of any spatially extended things, including regions of space or spacetime. I shall use intuitions about the quantity of extended things to argue for a dichotomy: either a given finite extended thing is point-free gunk, that is, it has no points as parts, or it is made of grit, that is there are only finitely many points.

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Typical structural universals are not just the mereological sum of their constituents. Hence, there is the Structure Problem of explaining this non-mereological structure. The Instantiation Problem is that the predicate "U is instantiated by x, y, etc., in that order" is ill-suited to be a primitive, unanalyzed predicate. The proposed solution to these problems is based on the observation that if universal U is said to supervene upon universals V, W, etc., then it is the instantiation of U that supervenes (...) on the instantiation of V, W, etc. Assuming there are few subvenient universals, which is admittedly a speculation, their instantiation may be explained in ways that would be uneconomic if there were too many. (shrink)

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In this paper, I present a piece of natural theology, whose pro tanto conclusion is the existence of god-the-artist, that is a lower case “g” god, a creator who creates for the sake of beauty, but who is not worthy of worship, a god who can be admired but should not be loved. I then consider some only partially successful responses to this dismal conclusion. Finally, I show to reconcile the idea of a god motivated by love of beauty with (...) the religious tradition of an upper case “G” God, who is not merely to be worshiped but loves us and invites a loving response. (shrink)

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As part of his Constructive Empiricism, Van Fraassen commends agnosticism about the existence of the unobservable entities posited by the physical sciences. This position of Scientific Agnosticism is compatible with the acceptance, in his sense, of Science. For to accept Science is, he says, to accept it as empirically adequate, but to refrain from deciding between the realistically interpreted theory and the as-if variant, according to which the observations are as if the theory is correct but the theory is not (...) correct. My purpose in this paper is to argue, against van Fraassen, that we—or at least most of us—should embrace Scientific Realism not Scientific Agnosticism. (shrink)

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My enquiry will be within the scope of two suppositions. The first is that Space is continuous, not discrete. The second is that we are to adopt realism about either points or regions or both. That does not, however, preclude a choice of categories—substance or property—for these entities. Thus we could think of either regions or points as properties of the things in those regions or at those points. Alternatively, we could think of regions or points as substances which themselves (...) have properties. (shrink)

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THE ARTICLE IS AN ATTACK ON THE MYSTERY OR REDUCTION DILEMMA FOR SUPERVENIENCE. THIS IS THE DILEMMA THAT EITHER SUPERVENIENCE IS MYSTERIOUS OR THE SUPERVENIENT IS REDUCIBLE TO THE SUBVENIENT. A NONMYSTERIOUS, NONREDUCTIVE ACCOUNT OF SUPERVENIENCE IS PROPOSED, BASED ON THE METAPHYSICAL SPECULATION THAT SUPERVENIENT TERMS AND PHRASES APPLY TO OBJECTS WHOSE INTRINSIC NATURES THEMSELVES HAVE AN APPROPRIATE PROPERTY. SINCE THIS IS A PROPERTY OF A NATURE IT IS A PROPERTY OF A PROPERTY, THAT IS, A GRAND-PROPERTY. SUPERVENIENCE FOLLOWS FROM (...) THIS HYPOTHESIS QUITE NONMYSTERIOUSLY, BY APPEAL TO THE INDISCERNIBILITY OF IDENTICALS. THE METAPHYSICAL SPECULATIONS REQUIRED MIGHT SEEM EXTRAVAGANT. A LARGE PART OF THE PAPER IS DESIGNED TO SHOW THAT THEY ARE NOT EXTRAVAGANT. (shrink)

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Several authors, including Stephen Law in this journal, have argued that the case for an evil God is (about) as strong as for a good God. In this article I take up the challenge on behalf of theists who, like Richard Swinburne, argue for an agent of unrestricted power and knowledge as the ultimate explanation of all contingent truths. I shall argue that an evil God is much less probable than a good one. I do so by (1) distinguishing the (...) analogical predication of 'good' or 'evil' of God from the literal predication, (2) interpreting 'acting in a morally good way' to mean 'acting like a good consequentialist', and (3) relying on an axiarchist thesis about agency that is congenial to theists and perhaps even presupposed by theism. (shrink)

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In this chapter I assume that we accept, perhaps reluctantly, general facts, that is states of affairs corresponding to universal generalizations. I then argue that, without any addition, this ontology provides us with physical necessities, and moreover with various grades of physical necessity, including the strongest grade, which I call absolute physical necessity. In addition there are consequences for our understanding of time. For this account, which I call the Mortmain Theory, provides a defence of No Futurism against an otherwise (...) serious objection due to David Armstrong. In addition the Mortmain theory enables me to argue against the ‘‘Parmenidean’’ or Block Universe position that future and past are both real. (shrink)

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Intelligent design creationism (ID) is a religious belief requiring a supernatural creator's interventions in the natural order. ID thus brings with it, as does supernatural theism by its nature, intractable epistemological difficulties. Despite these difficulties and despite ID's defeat in Kitzmiller v. Dover Area School District (2005), ID creationists' continuing efforts to promote the teaching of ID in public school science classrooms threaten both science education and the separation of church and state guaranteed by the U. S. Constitution. I examine (...) the ID movement's failure to provide either a methodology or a functional epistemology to support their supernaturalism, a deficiency that consequently leaves them without epistemic support for their creationist claims. My examination focuses primarily on ID supporter Francis Beckwith, whose published defenses of teaching ID, as well as his other relevant publications concerning education, law, and public policy, have been largely exempt from critical scrutiny. Beckwith's work exhibits the epistemological deficiencies of the supernaturally grounded views of his ID associates and of supernaturalists in general. I preface my examination of Beckwith's arguments with (1) philosopher of science Susan Haack's clarification of the established naturalistic methodology and epistemology of science and (2) discussions of the views of Beckwith's ID associates Phillip Johnson and William Dembski. Finally, I critique the religious exclusionism that Beckwith shares with his ID associates and the implications of his exclusionism for public policy. (shrink)

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The concept ‘silence’ has diametrically opposed meanings; it connotes peace and contemplation as well as death and oblivion. Silence can also be considered a practice. There is keeping the rule of silence to still the mind and find inner truth, as well as forcibly silencing in the sense of subjugating another to one's own purposes. The concept of teaching runs the gamut between these extremes, from respectfully leading students to search and discover, to relentlessly bending them to one's own will. (...) This article examines contradictory connotations and practices of silence and teachers’ ambivalent perceptions of it in order to conceptualize a positive practice of silence for teacher education. (shrink)

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