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Here I discuss findings that suggest a universal mechanism for proteins (and RNA) to recognize and interact with various binding partners by selectively binding to different conformations that pre‐exist in the free protein's conformational ensemble. The tandem RNA recognition motif domains of splicing factor U2AF65 fluctuate in solution between a predominately closed conformation in which the RNA binding site of one of the domains is blocked, and a lowly populated open conformation in which both RNA binding pockets are accessible. RNA (...) binding to U2AF65 may thus occur through the weakly populated open conformation, and the binding interaction stabilizes the open conformation. The conformational diversity observed in U2AF65 might also facilitate binding to diverse RNA sequences as found in the polypyrimidine tracts that help define 3′ splice sites. Similar binding pathways in other systems have important consequences in biological regulation, molecular evolution, and information storage. (shrink)

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A general framework by which dynamic interactions within a protein will promote the necessary series of structural changes, or “conformational cycle,” required for function is proposed. It is suggested that the free‐energy landscape of a protein is biased toward this conformational cycle. Fluctuations into higher energy, although thermally accessible, conformations drive the conformational cycle forward. The amino acid interaction network is defined as those intraprotein interactions that contribute most to the free‐energy landscape. Some network connections are consistent in every structural (...) state, while others periodically change their interaction strength according to the conformational cycle. It is reviewed here that structural transitions change these periodic network connections, which then predisposes the protein toward the next set of network changes, and hence the next structural change. These concepts are illustrated by recent work on tryptophan synthase. Disruption of these dynamic connections may lead to aberrant protein function and disease states. (shrink)

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Hannah Arendt's work inspires many to stand in solidarity against authoritarianism, racial or gender-based violence, climate change, and right-wing populism. But what if a careful analysis of her oeuvre reveals a darker side to this intellectual legacy? What if solidarity, as she conceives of it, is not oriented toward equality, freedom, or justice for all, but creates a barrier to intersectional coalition building? In Arendt's Solidarity,David D. Kim illuminates Arendt's lifelong struggle with this deceptively straightforward yet divisive concept. (...) Drawing upon her publications, unpublished documents, private letters, radio and television interviews, newspaper clippings, and archival marginalia, Kim examines how Arendt refutes solidarity as an effective political force against anti-Semitism, racial injustice, or social inequality. As Kim reveals, this conceptual conundrum follows the arc of Arendt's forced migration across the Atlantic and is directly related to every major concern of hers: Christian neighborly love, friendship, Jewish assimilation, Zionism, National Socialism, the American republic, Black Power, revolution, violence, and the human world. Kim places these thoughts in dialogue with dissenting voices, such as Thomas Mann, Gershom Scholem, Jean-Paul Sartre, James Baldwin, Frantz Fanon, James Forman, and Ralph Ellison. The result is a full-scale reinterpretation of Arendt's oeuvre. (shrink)

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Constructivism is based on the principle that our personalities, behavior, and society are organized by the ways in which we attribute meanings to events, and act upon those meanings. It provides a philosophy, an epistemology, and methods that are especially congruent with the central values of social work, particularly client self-determination. In this volume, Dr.David D.V. Fisher introduces social workers to constructivism, a perspective which is becoming increasingly popular in the social sciences, and which has already been embraced (...) by clinical psychologists, communication researchers, and cyberneticians. Fisher explains constructivism as an epistemology, shows the consequences of adopting a constructivist epistemology in contrast to operating from within the traditional objectivist epistemology, demonstrates the ethical appropriateness and practicality of constructivism for social work, and explicates a number of specific applications of constructivism to social work. The book is divided into two parts. The first part consists of an introduction and then explains and expands the theory of constructivism and its relationship to social work. The second part shows how constructivist principles may be applied in social work practices. Constructivist principles are applied to selected aspects of assessment, intervention, and interviewing--using immediate experience as a guide to action and the creation of professional responsibility. An Introduction to Constructivism for Social Workers will be of particular interest to social workers and psychologists involved in theory and research. (shrink)

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Despite suggestions that the end of metaphysics leaves us with nothing but history, essential questions about the place of history in a post-metaphysical culture have been neglected. In one sense history "weakens" as the scope for "realism" or a teleological master narrative fall away. But it invites overreaction to suggest that history becomes a "process of weakening" insofar as things have come to be as they are not as the resultants of full, meaningful origins, but only through the "dread accident" (...) of the historical process. The world that has resulted from history is the only one we have, and it weighs on us; in that sense history does not weaken but strengthens. Still, the historical process enveloping us is not Hegelian and necessary but weak and contingent, its outcomes subject to further contest. Conversely, although truth is weak, finite, and provisional, it is not merely consensual or relative precisely because it is historical. To grasp the sense it which history both weakens and strengthens enables us to grasp the scope for learning more deeply from our historical experience. A fuller range of historical questions about modernity would enable us better to understand the ongoing dangers and possibilities of modern politics. (shrink)

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Sie halten stolz Ihre neue digitale Kamera in den Händen und würden damit gerne alles übertreffen, was Sie jemals an Fotos geschossen haben? Mit Digitale Fotografie für Dummies XXL-Edition ist das kein Problem!David D. Busch gibt Ihnen nicht nur einen Überblick über die Möglichkeiten der neuen Kameratechnik, sondern steigt mit Ihnen tief und Schritt für Schritt in alle Bereiche ein, die für ein gutes Foto wichtig sind. Angefangen vom Equipment über die richtige Aufnahmetechnik bis hin zur Bearbeitung am (...) Computer und der Ausgabe im Druck oder Internet bleiben keine Fragen offen. Machen Sie die digitale Fotografie zu Ihrem Lieblingshobby und genießen Sie nachher die beeindruckenden, professionellen Ergebnisse! (shrink)

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No writer or public intellectual of our era has been as sensitive to the role of faith in the lives of ordinary Americans as Robert Coles. Though not religious in the conventional sense, Coles is unparalleled in his astute understanding and respect for the relationship between secular life and sacredness, which cuts across his large body of work. Drawing inspiration from figures like Dietrich Bonhoeffer, Dorothy Day, and Simone Weil, Coles’s extensive writings explore the tug of war between faith and (...) doubt. As Coles himself admits, the “back-and-forthness between faith and doubt is the story of my life.” These thirty-one thought-provoking essays are drawn from Coles’s weekly column in the Catholic publication _America_. In them, he turns his inquisitive lens on a range of subjects and issues, from writers and painters to his recent reading and film viewing, contemporary events and lingering controversies, recollections of past and present mentors, events of his own daily life, and ordinary encounters with students, patients, neighbors, and friends. Addressing moral questions openly and honestly with a rare combination of rectitude and authorial modesty, these essays position Coles as a preeminent, durable, and trusted voice in the continuing national conversation over religion, civic life, and moral purpose. (shrink)

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A fascinating collection of revealing memoirs by sixty-four philosophers discussing how they fell in love with philosophy, their calling to this life in pursuit of wisdom, and how they eventually or suddenly became philosophers.

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Having trouble putting down your Nikon D80 long enough to read the manual? Slip this convenient, full-color guide into your camera bag instead. You'll find big, clear color photos to help you identify the camera's many controls, complete information on using each button and dial, and breathtaking examples of the results. Then discover step-by-step recipes for shooting terrific photos in more than 15 specific situations. This indispensable guide is like having a personal photographic assistant. Test-drive your Nikon D80 with a (...) Quick Tour. Learn to efficiently operate all your camera's controls. Review photographic basics like exposure, lighting, and composition. Explore different types of lenses. Discover the appropriate lens, ISO setting, aperture or mode, shutter speed, and lighting for a variety of subjects and situations. Get expert tips on downloading and editing your photos. Order today so you'll have this go-anywhere guide along wherever you go. (shrink)

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Describes the features of the Sony Alpha DSLR-A100 camera, with information on such topics as exposure, lighting, lenses, composition, landscape photography, panoramic photography, and editing pictures.

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Physicians and other healthcare professionals are increasingly finding ways to use artificial intelligent decision support systems in their work. IBM Watson Health, for example, is a commercially available technology that is providing AI-DDS services in genomics, oncology, healthcare management and more.1 AI’s ability to scan massive amounts of data, detect patterns, and derive solutions from data is vastly more superior than that of humans. AI technology is undeniably integral to the future of healthcare and public health, and thoughtful consideration of (...) the legal, ethical and moral issues surrounding this technology is a must. The authors of the article, Responsibility, Second Opinions, and Peer-Disagreement—Ethical and Epistemological Challenges of Using AI in Clinical Diagnostic Contexts, provide an informed discussion of how AI-DSS may be used, both practically and ethically, to assist healthcare professionals in cooperative diagnostic processes2. The authors propose a process, whereby AI-DSS would provide a physician a second opinion, and when there is a mismatch between opinions, another physician would provide a third opinion. This approach maintains a ‘physician-in-charge’ perspective, and suggests that decision-making must ultimately be made by a person. This approach is also consistent with the ‘physician in-the-loop’ concept, such that even when increasingly autonomous AI-DSSs are put to use, physicians will still be providing checks and overseeing clinical decisions. The authors conceptualise AI as a replacement of human cognitive labour. That is, AI is used to supplant a human professional in particular functions …. (shrink)

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Controversy has long surrounded the complex relationship between King Victor Emmanuel III and the dictator Benito Mussolini in Fascist Italy. It is clear that the king played decisive roles in bringing Mussolini to power in 1922 and in removing him in 1943. In between, the two coexisted as Italy became a ‘dyarchy’, with two foci of power. The presence of the monarchy at once checked Fascist radicalism and persuaded many conservatives to adhere to the regime. Thanks especially to the monarchy, (...) the innovative thrust of Fascism was channelled in certain delimited directions, toward a statist economy, for example. Still, the relationship between the crown and Mussolini was often rocky, though the king’s reluctance did not prevent alliance with Nazi Germany, anti-Semitism, and war. Tensions were largely papered over by rhetoric and myth-making, as if the elements of Fascism fit together neatly. Despite his opposition to certain particulars, Victor Emmanuel identified with the overall Fascist project to some extent, and he worried that outright opposition to the regime would jeopardize the monarchy. But as the Second World War went badly for Italy, the king finally deposed Mussolini. Nevertheless, Italy soon voted to eliminate the monarchy, discredited by its association with fascism. (shrink)

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_Draws out numerous affinities between the sophists and Socrates in Plato's dialogues._.

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his volume investigates Proclus' own thought and his wide-ranging influence within late Neoplatonic, Alexandrine and Byzantinian philosophy and theology. It further explores how Procline metaphysics and doctrines of causality influence and transition into Arabic and Islamic thought, up until Richard Hooker in England, Spinoza in Holland and Pico in Italy. John Dillon provides a helpful overview of Proclus' thought, Harold Tarrant discusses Proclus' influence within Alexandrian philosophy and Tzvi Langermann presents ground breaking work on the Jewish reception of Proclus, focusing (...) on the work of Joseph Solomon Delmedigo (1591-1655), while Stephen Gersh presents a comprehensive synopsis of Proclus' reception throughout Christendom. The volume also presents works from notable scholars like Helen Lang, Sarah Wear and Crystal Addey and has a considerable strength in its presentation of Pseudo-Dionysius, Proclus' transmission and development in Arabic philosophy and the problem of the eternity of the world. It will be important for anyone interested in the development and transition of ideas from the late ancient world onwards. (shrink)

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Perhaps the best way to understand Harold Bloom's enigmatic theory of "poetic misprision" is to avoid the immanent critique altogether. It is best described, rather , as a synthesis. Bloom seems to have taken Aristotle's mimesis and linked it to Freud's concept of sublimation,1 with particular emphasis on the role that sublimation plays in "the family romance." Even if one were to hedge a bit and take into account the fact that neo-Freudian re-evaluations of orthodox psychoanalysis have succeeded in extracting (...) the purely sexual component out of the psychodynamics of sublimation, one is still left with the notion of sublimation as anxiety producing. Thus it is that, according to Bloom, the modern poet, in particular, sublimates his imitation of a strong precursor poet. Since the emphasis today is on desexualizing libido, Freud's original sexual vocabulary seems to have survived for its metaphorical value alone; the "unconscious fear of castration," for example, is simply a metaphor for "the poet's fear of ceasing to be a poet," a man's fear of ceasing to be a man. No matter how much we "modernize" Freud, the fact will always remain that the psychoanalytic context is the context of psychopathology: "a variety of the uncanny." · 1. See Sigmund Freud, Three Contributions to the Theory of Sex, in The Basic Writings of Sigmund Freud, ed. and trans. A. A. Brill , pp. 625-26.David D. Cooper is an associate in the department of English at the University of California, Santa Barbara. Using the critical paradigm developed in the present essay, he has written a book on Thomas Merton's poetry. See also: "Poetry, Revisionism, Repression" by Harold Boom in Vol. 2, No. 2; "Formalism, Savagery, and Care; or, The Function of Criticism Once Again" by Jerome J. McGann in Vol. 2, No. 3. (shrink)

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Philosophers of language have drawn on metamathematical results in varied ways. Extensionalist philosophers have been particularly impressed with two, not unrelated, facts: the existence, due to Frege/Tarski, of a certain sort of semantics, and the seeming absence of intensional contexts from mathematical discourse. The philosophical import of these facts is at best murky. Extensionalists will emphasize the success and clarity of the model theoretic semantics; others will emphasize the relative poverty of the mathematical idiom; still others will question the aptness (...) of the standard extensional semantics for mathematics. In this paper I investigate some implications of the Gödel Second Incompleteness Theorem for these positions. I argue that the realm of mathematics, proof theory in particular, has been a breeding ground for intensionality and that satisfactory intensional semantic theories are implicit in certain rigorous technical accounts. (shrink)

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When The Absurd Hero in American Fiction was first released in 1966, Granville Hicks praised it in a lead article for the Saturday Review as a sensitive and definitive study of a new trend in postwar American literature. In the years that followed,David Galloway’s analysis of the writings of John Updike, William Styron, Saul Bellow, and J. D. Salinger became a standard critical work, an indispensable tool for readers concerned with contemporary American literature. The New York Times described (...) the book as “a seminal study of the modern literary imagination."David Galloway, himself an established novelist, later extensively revised The Absurd Hero to include authoritative discussions of more than a dozen novels which had appeared since the first revised edition was released in 1970. Among them are John Updike’s Couples, Rabbit Redux, and The Coup; William Styron’s The Confessions of Nat Turner and Sophie’s Choice; and Saul Bellow’s Mr. Sammler’s Planet and Humboldt’s Gift. Through detailed analyses of these works, Galloway demonstrates the continuing relevance of his own provocative concept of the absurd hero and provides important insights into the literary achievements of four of America’s most influential postwar novelists. (shrink)

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Following other contributions about the MAX accidents to this journal, this paper explores the role of betrayal and moral injury in safety engineering related to the U.S. federal regulator’s role in approving the Boeing 737MAX—a plane involved in two crashes that together killed 346 people. It discusses the tension between humility and hubris when engineers are faced with complex systems that create ambiguity, uncertain judgements, and equivocal test results from unstructured situations. It considers the relationship between moral injury, principled outrage (...) and rebuke when the technology ends up involved in disasters. It examines the corporate backdrop against which calls for enhanced employee voice are typically made, and argues that when engineers need to rely on various protections and moral inducements to ‘speak up,’ then the ethical essence of engineering—skepticism, testing, checking, and questioning—has already failed. (shrink)

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When considering submissions ethics committees should be consistent in all aspects of their review. A wide variation in performance is likely to result in the unfair dismissal of good research on the one hand with inadequate ethical review on the other, neither of which is acceptable. The recent annual reports for UK MRECs suggest that the level of unfavourable opinion ranges from 6.9% to 24.2% Although a certain level of inconsistency is inherent in the system of ethical review there is (...) little research to determine how much of that inconsistency in inevitable and how much of it is the result of poor process. The time has come for high quality research to be done to assess the consistency and hence the validity of ethical review. (shrink)

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Political science faces a challenge from a “Mr. Perestroika,” who decries the hegemony of formal and statistical analysis in the discipline. Although not connected with this movement, Bent Flyvbjerg makes the best case for a renewed dominance for qualitative and case study work throughout the social sciences. This article challenges Flyvbjerg’s call for a phronetic as opposed to an epistemic discipline. It challenges as well the unqualified call for pluralism advocated by many in the perestroika movement. It offers instead an (...) integrated tripartite method in which narrative, statistics, and formal modeling fill in a scientific frame. (shrink)

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Explains how to set up a digital photography studio, improve picture-taking techniques, edit images, use Photoshop and Photoshop Elements, restore photographs, and print and distribute digital images.

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As the latest tool for disseminated information and editorial comment shaping public opinion, blogging is quickly gaining popularity, prominence, and power. One major controversy for the new medium of circulating news and commentary is to what extent or even whether blogs should have codes of ethics. We examined 30 politically-oriented weblogs. Of these, only a few had a code of ethics, stated or implied. Little cohesion existed between the codes of ethics, but a few themes emerged. Qualitative analysis of the (...) codes of ethics shows that what bloggers valued most included accuracy, credibility, and etiquette. We further provide evidence to support the prevailing thought that, while appearing to be "ethical" seems important to bloggers, blogging ethics and credibility are difficult to operationalize. (shrink)

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Nikon D40/D40x Digital Field Guide is filled with everything you need to know in order to take amazing photographs using your Nikon D40 or Nikon D40x. This full-color portable guide walks you through the essential controls, features, and functions of your Nikon D40 or D40x digital SLR using step-by-step instructions and full-color images of each menu screen. This robust guide not only shows you how to adjust white balance, autofocus, exposure, and choose lenses, it also teaches you when and why (...) you should adjust each of these key settings. The Nikon D40/D40x Digital Field Guide goes beyond camera settings to offer you a refresher guide to the principles of digital photography, covering the essentials of lighting, composition, and exposure. Filled with amazing examples, this book also presents you with a variety of tips and tricks to capturing portraits, candids, sports, travel, macro photography, and much more. (shrink)

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Provides information on using digital SLR cameras, covering such topics as memory cards, choosing exposure, lenses, using RAW files, using the flash, composing a photograph, and image editing.

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The history of the book is everywhere, so widely diffused that it merits comparison with the famously elusive Scarlet Pimpernel, whose pursuers sought him without success. Like that figure, book history passes among us in disguise, reluctant to reveal its presence even as it gains ever-greater recognition. In some quarters, it lurks within the domain of bibliography, a field of scholarship dedicated to describing the histories of printed texts and, in the service of this enterprise, concerned with the details of (...) book-making. Elsewhere, book history installs itself within descriptions of libraries and education, sharing, with the first of these, a concern for how old books were accumulated and classified and, with the second, for the many ramifications of literacy and the fashioning of schoolbooks. Together with the history of journalism it studies how news was disseminated and ponders the significance of periodicals, be these newspapers or magazines. Political history has been another convenient site of disguise in the wake of efforts to connect the public sphere and concepts of nation with the emergence of print culture. And, of course, book history has enjoyed a long and fruitful kinship with literary history, a relationship freshly energized in recent decades as literary historians turned to describing the rise and remaking of a canon and to emphasizing the mediations that all texts undergosociology of texts,” to borrow a phrase made famous by D. F. McKenzie. To this list we can add the version of intellectual history that reconstructs the reading of a person or group and employs this data to generalize about the coming of the Enlightenment and similar formations. (shrink)

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Your digital camera is the perfect travel companion. You don't need to pack extra film, worry about airport scanners, budget for processing costs, or wait until you get home to learn whether you got that once-in-a-lifetime shot. Tuck this book in beside your Frommer's travel guide and you'll have everything you need for fantastic photos-how to watch for the right opportunity, compose the picture, work with lighting-even how to edit and upload from the road. * Learn what you must take (...) along and which accessories are nice to have * Capture the soul of a city, its people, and its sights * Include fellow travelers without shooting stereotypes * Take great shots even where flash is prohibited or your light sources are limited * Explore scenarios and expert tips for photographing scenery, wildlife, events, exhibits, and much more * Post your photos on the Web before you get home. (shrink)

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Christian Exegesis of the Qurʾān: A Critical Analysis of the Apologetic Use of the Qurʾān in Select Medieval and Contemporary Arabic Texts. By J. Scott Bridger. American Society of Missiology Monograph Series, vol. 23. Eugene, OR: Wipf and Stock, 2015. Pp. xii + 188. $25.

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