Structure suggests function: the case for synaptic ribbons as exocytotic nanomachines.DavidLenzi &Henrique von Gersdorff -2001 -Bioessays 23 (9):831-840.detailsSynaptic ribbons, the organelles identified in electron micrographs of the sensory synapses involved in vision, hearing, and balance, have long been hypothesized to play an important role in regulating presynaptic function because they associate with synaptic vesicles at the active zone. Their physiology and molecular composition have, however, remained largely unknown. Recently, a series of elegant studies spurred by technical innovation have finally begun to shed light on the ultrastructure and function of ribbon synapses. Electrical capacitance measurements have provided sub‐millisecond (...) resolution of exocytosis, evanescent‐wave microscopy has filmed the fusion of single 30 nm synaptic vesicles, electron tomography has revealed the 3D architecture of the synapse, and molecular cloning has begun to identify the proteins that make up ribbons. These results are consistent with the ribbon serving as a vesicle “conveyor belt” to resupply the active zone, and with the suggestion that ribbon and conventional chemical synapses have much in common. BioEssays 23:831–840, 2001. © 2001 John Wiley & Sons, Inc. (shrink)
The road to character.David Brooks -2015 - New York: Random House.details#1 New York Times bestselling authorDavid Brooks, a controversial and eye-opening look at how our culture has lost sight of the value of humility - defined as the opposite of self-preoccupation - and why only an engaged inner life can yield true meaning and fulfillment.
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Education's Love Triangle.David Aldridge -2019 -Journal of Philosophy of Education 53 (3):531-546.detailsIt has been acknowledged that education includes ‘a love of what one teaches and a love of those whom one teaches’ (Hogan 2010: 81), but two traditions of writing in philosophy of education—concerning love for student and love for subject—have rarely been brought together. This paper considers the extent to which the ‘triangular’ relationship of teacher, student and subject matter runs the risk of the rivalry, jealousy and strife that are characteristic of ‘tragic’ love triangles, or entails undesirable consequences such (...) as transference from one intended object of love to another. It argues that this faultline in the literature of educational love corresponds to education's ‘divided heart’. The implication of this exploration of education's triangular relationship is that we cannot ignore the ‘dark of love’, nor can we address it simply by asserting that educational love must be of a more honourable sort than romantic love. These tensions can be reconciled through the loving recourse of ‘ceasing to strive’ and the possibility of sublimating the two originary loves into a higher ‘love of truth’. (shrink)
Becoming Animal: An Essay on Wonder.David Abram -2010 - Pantheon Books.detailsThe award-winning author of The Spell of the Sensuous presents a cautionary assessment of human involvement in the natural world that celebrates nature's sensuous qualities while revealing how consciousness is a ubiquitous part of the biosphere.
Living together: inventing moral science.David Schmidtz -2023 - New York, NY: Oxford University Press.detailsIs moral philosophy more foundational than political philosophy? In other words, is "how to live?" more fundamental than "how to live together?" We were trained to say yes, but there was never any reason to believe it. Must rigorous reflection on how to live aim to derive necessary truths from timeless axioms, ignoring ephemeral contingencies of time and place? In the 1800s, philosophy left the contingencies to emerging departments of social science. Where did that leave philosophy? Did cutting ties to (...) empirical reality checks leave philosophers with deeper questions? Better answers? Here too, our practices suggest that we assume the answer is yes, but the truth appears to be no. To recover a measure of relevance to questions that truly need answers, theorizing about how to live together might take its cue from philosophy's current renewing of ties with political economy. We can ask which principles have a history of demonstrably being organizing principles of actual thriving communities at their best. (shrink)
Recurrence Theorems: a Unified Account.David Wallace -unknowndetailsI discuss classical and quantum recurrence theorems in a unified manner, treating both as generalisations of the fact that a system with a finite state space only has so many places to go. Along the way I prove versions of the recurrence theorem applicable to dynamics on linear and metric spaces, and make some comments about applications of the classical recurrence theorem in the foundations of statistical mechanics.
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Covenantal Rights: A Study in Jewish Political Theory.David Novak -2009 - Princeton University Press.detailsCovenantal Rights is a groundbreaking work of political theory: a comprehensive, philosophically sophisticated attempt to bring insights from the Jewish political tradition into current political and legal debates about rights and to bring rights discourse more fully into Jewish thought.David Novak pursues these aims by presenting a theory of rights founded on the covenant between God and the Jewish people as that covenant is constituted by Scripture and the rabbinic tradition. In doing so, he presents a powerful challenge (...) to prevailing liberal and conservative positions on rights and duties and opens a new chapter in contemporary Jewish political thinking.For Novak, "covenantal rights" are rooted in God's primary rights as creator of the universe and as the elector of a particular community whose members relate to this God as their sovereign. The subsequent rights of individuals and communities flow from God's covenantal promises, which function as irrevocable entitlements. This presents a sharp contrast to the liberal tradition, in which rights flow above all from individuals. It also challenges the conservative idea that duties can take precedence over rights, since Novak argues that there are no covenantal duties that are not backed by correlative rights. Novak explains carefully and clearly how this theory of covenantal rights fits into Jewish tradition and applies to the relationships among God, the covenanted community, and individuals. This work is a profound and provocative contribution to contemporary religious and political theory. (shrink)
Moral Rights and Their Grounds.David Alm -2018 - New York, USA: Routledge.detailsMoral Rights and Their Grounds offers a novel theory of rights based on two distinct views. The first--the value view of rights--argues that for a person to have a right is to be valuable in a certain way, or to have a value property. This special type of value is in turn identified by the reasons that others have for treating the right holder in certain ways, and that correlate with the value in question.David Alm then argues that (...) the familiar agency view of rights should be replaced with a different version according to which persons' rights, and thus at least in part their value, are based on their actions rather than their mere agency. This view, which Alm calls exercise-based rights, retains some of the most valuable features of the agency view while also defending it against common objections concerning right loss. This book presents a unique conception of exercise-based rights that will be of keen interest to ethicists, legal philosophers, and political philosophers interested in rights theory. (shrink)
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Fields as Bodies: a unified presentation of spacetime and internal gauge symmetry.David Wallace -unknowndetailsUsing the parametrised representation of field theory I demonstrate that in both local and global cases, internal and spacetime symmetries can be treated precisely on a par, so that gravitational theories may be regarded as gauge theories in a completely standard sense.
The Growth of the Liberal Soul.David Walsh -1997 - University of Missouri.detailsIn The Growth of the Liberal Soul,David Walsh confronts a core difficulty of the liberal democratic tradition in explaining and justifying itself.
Truth or beauty: science and the quest for order.David Orrell -2012 - New Haven [Conn.]: Yale University Press.detailsInfatuation -- Complication -- Maturation.
Tradition and Imagination: Revelation and Change.David Brown -1999 - Oxford University Press UK.detailsTradition and revelation are often seen as opposites: tradition is viewed as being secondary and reactionary to revelation which is a one-off gift from God. Drawing on examples from Christian history, Judaism, Islam, and the classical world, this book challenges these definitions and presents a controversial examination of the effect history and cultural development has on religious belief: its narratives and art.David Brown pays close attention to the nature of the relationship between historical and imaginative truth, and focuses (...) on the way stories from the Bible have not stood still but are subject to imaginative 'rewriting'. This rewriting is explained as a natural consequence of the interaction between religion and history: God speaks to humanity through the imagination, and human imagination is influenced by historical context. It is the imagination that ensures that religion continues to develop in new and challenging ways. (shrink)
Opting Out: Conscience and Cooperation in a Pluralistic Society.David S. Oderberg -2018 - London, UK: Institute of Economic Affairs.detailsWe live in a liberal, pluralistic, largely secular society where, in theory, there is fundamental protection for freedom of conscience generally and freedom of religion in particular. There is, however, both in statute and common law, increasing pressure on religious believers and conscientious objectors (outside wartime) to act in ways that violate their sincere, deeply held beliefs. This is particularly so in health care, where conscientious objection is coming under extreme pressure. I argue that freedom of religion and conscience need (...) to be put on a sounder footing both legislatively and by the courts, particularly in health care. I examine a number of important legal cases in the UK and US, where freedom of religion and conscience have come into conflict with government mandates or equality and anti-discrimination law. In these and other cases we find one of two results: either the conscientious objector loses out against competing rights, or the conscientious objector succeeds, but due to what I consider unsound judicial reasoning. In particular, cases involving cooperation in what the objector considers morally impermissible according to their beliefs have been wrongly understood by some American courts. I argue that a reasonable theory of cooperation incorporated into judicial thinking would enable more acceptable results that gave sufficient protection to conscientious objectors without risking a judicial backlash against objectors who wanted to take their freedoms too far. -/- I also venture into broader, more controversial waters concerning what I call freedom of dissociation – the fundamental right to withdraw from associating with people, groups, and activities. It is no more than the converse of freedom of association, which all free societies recognise as a basic right. How far should freedom of dissociation go? What might society be like if freedom of dissociation were given more protection in law than it currently has? It would certainly give freedom of religion and conscience a substantial foundation, but it could also lead to discriminatory behaviour to which many people would object. I explore some of these issues, before going back to the narrower area of freedom of conscience and religion in health care, making some proposals about how the law could strengthen these basic pillars of a liberal, free society. (shrink)
(1 other version)Oxford Studies in Ancient Philosophy Volume Xxii: Summer 2002.David Sedley (ed.) -2002 - Oxford University Press.detailsOxford Studies in Ancient Philosophy is a volume of original articles on all aspects of ancient philosophy. The articles may be of substantial length, and include critical notices of major books. Plato, Aristotle, and the Stoics are the focuses of discussion in this volume. -/- Editor:David Sedley, Laurence Professor of Ancient Philosophy, University of Cambridge. -/- 'standard reading among specialists in ancient philosophy' Brad Inwood, Bryn Mawr Classical Review.
The Old New Logic: Essays on the Philosophy of Fred Sommers.David S. Oderberg (ed.) -2005 - Bradford/MIT Press.detailsOver the course of a career that has spanned more than fifty years, philosopher Fred Sommers has taken on the monumental task of reviving the development of Aristotelian (syllogistic) logic after it was supplanted by the predicate logic of Gottlob Frege and Bertrand Russell. The enormousness of Sommers's undertaking can be gauged by the fact that most philosophers had come to believe - asDavid S. Oderberg writes in his preface - that "Aristotelian logic was good but is now (...) as good as dead." A revival of traditional syllogistic logic would involve not only its restatement but its refashioning into a system that could rival the elegance and deductive power of predicate logic. Building on work by medieval scholastic logicians, Leibniz, and nineteenth-century algebraic logicians, Sommers accomplished this renovation and rehabilitation of syllogistic logic with his magnum opus The Logic of Natural Language, published in 1982. In The Old New Logic, essays by a diverse group of contributors show how widely influential Sommers's work has been-not only in logic, but in category theory and other areas. Scholars in psychology, linguistics, and computer science join philosophers and logicians in discussing aspects of Sommers's contributions to philosophy. Sommers himself provides an intellectual autobiography at the beginning and in the final chapter offers comments on the contributions. This collection should help bring to Sommers's work the attention it deserves from the wider philosophical and intellectual community. (shrink)
Teaching Language to a Boy Born Deaf: The Popham Notebook and Associated Texts.David Cram &Jaap Maat (eds.) -2017 - Oxford University Press.detailsAn edition of the recently discovered notebook used in the seventeenth-century by John Wallis to teach language to the 'deaf mute' Alexander Popham, who could not inherit unless he could speak - one of the most famous cases in the history of deaf education.David Cram and Jaap Maat place the work in its personal, social, and scientific contexts.
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Life, death, and meaning: key philosophical readings on the big questions.David Benatar (ed.) -2016 - Lanham, Md: Rowman & Littlefield.detailsDo our lives have meaning? Should we create more people? Is death bad? Should we commit suicide? Would it be better to be immortal? Should we be optimistic or pessimistic? Since Life, Death, and Meaning: Key Philosophical Readings on the Big Questions first appeared,David Benatar’s distinctive anthology designed to introduce students to the key existential questions of philosophy has won a devoted following among users in a variety of upper-level and even introductory courses. While many philosophers in the (...) "continental tradition"—those known as "existentialists"—have engaged these issues at length and often with great popular appeal, English-speaking philosophers have had relatively little to say on these important questions. Yet, the methodology they bring to philosophical questions can, and occasionally has, been applied usefully to "existential" questions. This volume draws together a representative sample of primarily English-speaking philosophers' reflections on life's big questions, divided into six sections, covering (1) the meaning of life, (2) creating people, (3) death, (4) suicide, (5) immortality, and (6) optimism and pessimism. These key readings are supplemented with helpful introductions, study questions, and suggestions for further reading, making the material accessible and interesting for students. In short, the book provides a singular introduction to the way that philosophy has dealt with the big questions of life that we are all tempted to ask. (shrink)
Privacy in the Age of Neuroscience: Reimagining Law, State and Market.David Grant -2021 - Cambridge University Press.detailsNeuroscience has begun to intrude deeply into what it means to be human, an intrusion that offers profound benefits but will demolish our present understanding of privacy. In Privacy in the Age of Neuroscience,David Grant argues that we need to reconceptualize privacy in a manner that will allow us to reap the rewards of neuroscience while still protecting our privacy and, ultimately, our humanity. Grant delves into our relationship with technology, the latest in what he describes as a (...) historical series of 'magnitudes', following Deity, the State and the Market, proposing the idea that, for this new magnitude, we must control rather than be subjected to it. In this provocative work, Grant unveils a radical account of privacy and an equally radical proposal to create the social infrastructure we need to support it. (shrink)
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Why Žižek?...Why online?David Gunkel -2007 -International Journal of Žižek Studies 1 (1).detailsIn "Why Žižek? - Why Online?"David J. Gunkel addresses head-on the complexly related issues Žižek's intellectual appeal and the suitability or otherwise of this Journal's online format. The essay not only demonstrates the way that Žižek's materialist philosophy complicates decisions about the material of publication but illustrates how these questions materialize in recent debates about scholarship and why they should matter for us.
American underdog: historic outsider upset: ethics and economics matter in Washington, DC.David Alan Brat -2016 - New York: Center Street.detailsFromDavid Brat, the college professor who made political headlines when he unseated Majority Leader Eric Cantor, comes his plan for restoring fiscal liberty for America. CongressmanDavid Brat's odds-defying win against Eric Cantor--a triumph of a modest $200,000 campaign fund against a $5 million war chest--immediately broughtDavid Brat, heretofore a liberal arts college economics professor, into the political limelight. Now, in his first book, AMERICAN UNDERDOG, Brat examines how we brought down the status quo by (...) tapping into moral and economic lessons as old as our civilization and discusses how Washington can learn from history instead of ignoring it. A fighter for children, he illuminates how our current fiscal policies are selling their future, and outlines new ways to move forward with a conservative agenda that provides fairer treatment for all. (shrink)
Talking with Doctors.David Newman -2005 - Routledge.detailsWithout any warning, in September 1999,David Newman was told he had a rare and life-threatening tumor in the base of his skull. In the compressed space of five weeks, he consulted with leading physicians and surgeons at four major medical centers. The doctors offered drastically differing opinions; several pronounced the tumor inoperable and voiced skepticism about the effectiveness of any nonsurgical treatment. _Talking with Doctors_ is the story of Newman's efforts, at a time of great stress and even (...) impending death, to wend his way through the dense thicket of medical consultations in search of a physician and a treatment that offered the possibility of survival. It is the story, especially, of the harrowing process of assessing conflicting "expert" opinions and, in so doing, of making sense of the priorities, personalities, and vulnerabilities of different doctors. All too often, he found, the leading specialists to whom he was sent were strangers in the consulting room-and strangers who became stranger still, both cognitively and emotionally, when ambiguous findings pushed them to the outer limits of their training and experience. Newman writes poignantly of his sense of powerlessness and desperation, of the painstaking means by which he ascertained what could be known about his tumor, and of the fortuitous events that finally led him to life-saving help. _Talking with Doctors_ is a compelling, absorbing, unsettling story that touches a collective raw nerve about the experience of doctors and medical care when life-threatening illness leads us to subspecialists at major medical centers. Probing the nature of medical authority and the grounds of a trusting doctor-patient relationship, Newman illuminates with grace and power what it now means for a patient to participate in life-and-death medical decisions. (shrink)