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The traditional Dung networks depict arguments as atomic and study the relationships of attack between them. This can be generalised in two ways. One is to consider various forms of attack, support, feedback, etc. Another is to add content to nodes and put there not just atomic arguments but more structure, e.g. proofs in some logic or simply just formulas from a richer language. This paper offers to use temporal and modal language formulas to represent arguments in the nodes of (...) a network. The suitable semantics for such networks is Kripke semantics. We also introduce a new key concept of usability of an argument. This is the beginning of a continuing research for adding contents to the nodes of an argumentation network. This research will allow us to address notions like ?what does it exactly mean for a node to attack another? or ?what does it mean for a network to be consistent? or ?can we give proper proof rules to manipulate networks?, and more. (shrink)

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This paper studies general numerical networks with support and attack. Our starting point is argumentation networks with the Caminada labelling of three values 1=in, 0=out and ½=undecided. This is generalised to arbitrary values in [01], which enables us to compare with other numerical networks such as predator–prey ecological networks, flow networks, logical modal networks and more. This new point of view allows us to see the place of argumentation networks in the overall landscape of networks and import and export ideas (...) to and from argumentation networks. We make a special effort to make clear how general concepts in general networks relate to the special case of argumentation networks. We pay special attention to the handling of loops and to the special features of numerical support. We find surprising connections with the Dempster–Shafer rule and with the cross-ratio in projective geometry. This paper is an expansion of our 2005 paper and so we also consider higher level features such as numerical attacks on attacks, and propagation of numerical values.We conclude with a brief view of temporal numerical argumentation and with a detailed comparison with related papers published since 2005. (shrink)

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This chapter considers individual differences associated with alcohol effects. There is wide variability in subjective and other responses to alcohol. The sources of this variability include allelic variation in enzymes responsible for the metabolism of alcoholism, sensitivity, temperament, neurocognitive functioning, and social learning. These sources of heterogeneity in alcohol response appear to be very important not only in understanding the acute effects of alcohol on the individual but also in understanding risk processes underlying the development of alcohol use disorders.

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This chapter begins with a brief overview of the categories of subjective effects of alcohol, then considers the role of subjective effects from the context of prominent contemporary theories of alcohol use and misuse. Building on this conceptual foundation, it discusses important features of beverage and dose and characteristics of the setting that affect the subjective experience of drinking. It then considers what is known based on the various methodological approaches used to investigate subjective effects — including survey research on (...) alcohol expectancies and drinking motives, and ecological momentary assessment — with a particular emphasis on experimental research. (shrink)

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This volume explores how Catholicism began and continues to open its doors to the wider world and to other confessions in embracing ecumenism, thanks to the vision and legacy of the Second Vatican Council. It explores such themes as the twentieth century context preceding the council; parallels between Vatican II and previous councils; its distinctively pastoral character; the legacy of the council in relation to issues such as church-world dynamics, as well as to ethics, social justice, economic activity. Several chapters (...) discuss the role of women in the church before, during, and since the council. Others discern inculturation in relation to Vatican II. The book also contains a wide and original range of ecumenical considerations of the council, including by and in relation to Free Church, Reformed, Orthodox, and Anglican perspectives. Finally, it considers the Council’s ongoing promise and remaining challenges with regard to ecumenical issues, including a groundbreaking essay on the future of ecumenical dialogue by Cardinal Walter Kasper. (shrink)

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The paper examines the structure of the mathematical instrument making trade in London from the mid-sixteenth century to the opening of the Hanoverian era. This analysis of the trade is primarily based on evidence drawn from contemporary advertising. A distinction between informal editorial recommendations and advertising per se is made. It is concluded that up to the mid-seventeenth century mathematical instrument makers worked in eitherwood or metal. After that date a growing number of workshops advertised that they manufactured (...) in all media. Advertising was aimed at informing professional users from whom particular instruments could be purchased, but not on informing customers in specific terms of the range of instruments manufactured. It is concluded that until the early eighteenth century most mathematical instruments were commissioned. Only towards the end of the period is there evidence of over-the-counter sales, and advertising aimed at encouraging the growing consumer market to buy mathematical instruments for the practice of science as a social or recreational activity. (shrink)

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Stone-walling dialogues are exercises in structured non-cooperation. It is true that dialogue participants need to cooperate with one another and in ways sufficient to make possible the very dialogue they are now having. Beyond that there is room for non-cooperation on a scale that gives great offence to what we call the Goody Two-Shoes Model of argument. In this paper, we argue that non-cooperation dialogues have perfectly legitimate objectives and that in relation to those objectives they need not be considered (...) at all subpar to conversations that brim with sunny amity.Two categories of stone-walling non-cooperation dialogues are here examined. They are called MindClosed and NoEngage. They are exemplified by the following cases:1. Hostile Police Interrogation2. Judicial Cross-Examination3. Department Store Complaints Management4. Lakatosian Science5. Gödel's First Incompleteness Proof. (shrink)

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Fluctuating asymmetry (FA) is small deviations from perfect symmetry in normally bilaterally symmetrical traits. We examined the relationship between FA of five body traits (ear height, length of three digits, and ankle circumference) and self-reported scores of physical and verbal aggression in a sample of 90 boys aged 10 to 15 years. The relationships between FA and scores of aggression (particularly physical aggression) were found to be negative; in other words, the most symmetrical boys showed highest aggression. One trait (ankle (...) circumference) showed the characteristics of “ideal” FA—parametric mean of zero and a normal distribution. Mean asymmetries calculated from six repeated measures of ankle FA in 30 subjects taken over a period of five months showed strong negative associations with scores of physical aggression which were independent of age, height, and weight.It is argued that soft tissue “cyclical” FA (as opposed to “fixed” bony FA) is dependent on the secretion of hormones: for example, cortisol. Causal associations between behavioral traits such as aggresion and hormones will lead to similar correlations between FA and behavior. (shrink)

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The purpose of this paper is to communicate some developments in what we call the new logic. In a nutshell the new logic is a model of the behaviour of a logical agent. By these lights, logical theory has two principal tasks. The first is an account of what a logical agent is. The second is a description of how this behaviour is to be modelled. Before getting on with these tasks we offer a disclaimer and a warning. The disclaimer (...) is that although the new logic is significantly different from it, we have no inclination to see the new logic as a rival of mathematical logic. We do not advocate the displacement of, e.g. model theory, but rather its supplementation or adaptation. The warning is that, whereas mathematical logic must eschew psychologism, the new logic cannot do without it. The fuller story of the new logic must eschew psychologism, the new logic cannot do without it. The fuller story of the new logic is part of our book, The Reach of Abduction, scheduled to appear in 2001 or early 2002. (shrink)

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The progression of research and scholarly inquiry does not occur in isolation and is wholly dependent on accurate reporting of methods and results, and successful replication of prior work. Without mechanisms to correct the literature, much time and money is wasted on research based on a crumbling foundation. These guidelines serve to outline the respective responsibilities of researchers, institutions, agencies, and publishers or editors in maintaining the integrity of the research record. Delineating these complementary roles and proposing solutions for common (...) barriers provide a foundation for best practices. (shrink)

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BackgroundKinarm Standard Tests is a suite of upper limb tasks to assess sensory, motor, and cognitive functions, which produces granular performance data that reflect spatial and temporal aspects of behavior. We have previously used principal component analysis to reduce the dimensionality of multivariate data using the Kinarm End-Point Lab. Here, we performed PCA using data from the Kinarm Exoskeleton Lab, and determined agreement of PCA results across EP and EXO platforms in healthy participants. We additionally examined whether further dimensionality reduction (...) was possible by using PCA across behavioral tasks.MethodsHealthy participants were assessed using the Kinarm EXO and EP. Four behavioral tasks were performed that quantified arm sensory and motor function, including position sense [Arm Position Matching ] and three motor tasks [Visually Guided Reaching, Object Hit, and Object Hit and Avoid ]. The number of components to include per task was determined from scree plots and parallel analysis, and rotation type was decided on a per-task basis. To assess agreement, we compared principal components across platforms using distance correlation. We additionally considered inter-task interactions in EXO data by performing PCA across all six behavioral assessments.ResultsBy applying PCA on a per task basis to data collected using the EXO, the number of behavioral parameters were substantially reduced by 58–75% while accounting for 76–87% of the variance. These results compared well to the EP analysis, and we found good-to-excellent agreement values between PCs from the EXO and those from the EP. Finally, we were able to reduce the dimensionality of the EXO data across tasks down to 16 components out of a total of 76 behavioral parameters, which represents a reduction of 79% while accounting for 73% of the total variance.ConclusionPCA of Kinarm robotic assessment appears to capture similar relationships between kinematic features in healthy individuals and is agnostic to the robotic platform used for collection. Further work is needed to investigate the use of PCA-based data reduction for the characterization of neurological deficits in clinical populations. (shrink)

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of (from Oxford Uehiro Centre for Practical Ethics).

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The recently uncovered role of Fukutin‐related protein (FKRP) in fibronectin glycosylation has challenged our understanding of the basis of disease pathogenesis in the muscular dystrophies. FKRP is a Golgi‐resident glycosyltransferase implicated in a broad spectrum of muscular dystrophy (MD) pathologies that are not fully attributable to the well‐described α‐Dystroglycan hypoglycosylation. By revealing a new role for FKRP in the glycosylation of fibronectin, a modification critical for the development of the muscle basement membrane (MBM) and its associated muscle linkages, new possibilities (...) for understanding clinical phenotype arise. This modification involves an interaction between FKRP and myosin‐10, a protein involved in the Golgi organization and function. These observations suggest a FKRP nexus exists that controls two critical aspects to muscle fibre integrity, both fibre stability at the MBM and its elastic properties. This review explores the new potential disease axis in the context of our current knowledge of muscular dystrophies. (shrink)

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The complexity of biobank research raises concerns about individuals’ understanding of the information conveyed in the consent process for such research.. We report the results of a qualitative, cognitive interview study with an ethnically, linguistically, and educationally diverse sample of 43 respondents to assess the clarity and utility of a multimedia tool developed for a biobank. Using weighted randomization, respondents were assigned to either view the multimedia tool or read a written consent document . The study illustrates the utility of (...) cognitive interviews for gaining insights from prospective research participants about the clarity of informed consent tools. Findings suggest that a multimedia tool is useful for communicating key messages but should be combined with a written consent document and personal interaction with the study staff. We recommend that the potential value of multimedia tools should be more rigorously tested in a randomized controlled trial. (shrink)

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RNA localization is a powerful strategy used by cells to localize proteins to subcellular domains and to control protein synthesis regionally. In germ cells, RNA targeting has profound implications for development, setting up polarities in genetic information that drive cell fate during embryogenesis. The frog oocyte offers a useful system for studying the mechanism of RNA localization. Here, we discuss critically the process of RNA localization during frog oogenesis. Three major pathways have been identified that are temporally and spatially separated (...) in oogenesis. Each pathway uses a different mechanism to effect RNA localization. In some cases, localization elements within the 3' untranslated region have been identified and have provided unique insights into the localization process. This important field is still in its infancy, however, and much remains to be learned. BioEssays 21:546–557, 1999. © 1999 John Wiley & Sons, Inc. (shrink)

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Preparing the Next Generation of Oral Historians is an invaluable resource to educators seeking to bring history alive for students at all levels. Filled with insightful reflections on teaching oral history, it offers practical suggestions for educators seeking to create curricula, engage students, gather community support, and meet educational standards. By the close of the book, readers will be able to successfully incorporate oral history projects in their own classrooms.

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BACKGROUND: Hallucinations and delusions that complicate Parkinson’s disease could lead to nursing home placement and are linked to increased mortality. Cognitive impairments are typically associated with the presence of hallucinations but there are no data regarding whether such a relationship exists with delusions. OBJECTIVE: We hypothesized that hallucinations would be associated with executive and visuospatial disturbance. An exploratory examination of cognitive correlates of delusions was also completed to address the question of whether they differ from hallucinations. METHODS: 144 PD subjects (...) completed a neuropsychological battery to assess cognition and the SAPS to examine psychosis. Correlational analyses assessed associations between hallucinations and delusions with cognitive domains. RESULTS: 48 subjects reported psychotic symptoms: 25 experienced hallucinations without delusions, 23 had symptoms dominated by delusions. Severity and/or number of hallucination subtypes were significantly correlated with lower scores in language, memory, attention, executive functioning, and visuospatial ability. Correlations with delusions were non-significant. Tests of differences in the size of the correlations between groups revealed a significant relationship between language and visuospatial performance with hallucinations. CONCLUSIONS: Cognitive correlates of hallucinations and delusions appear to be different in PD, suggesting distinct pathogenic mechanisms and possibly anatomical substrates. Hence, delusions may not share the same associations with dementia as hallucinations. Since this is a new finding, further studies will be needed to confirm our results. (shrink)

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While outcomes for children with T-cell acute lymphoblastic leukemia have improved dramatically, survival rates for patients with relapsed/refractory disease remain dismal. Prior studies indicate that glucocorticoid resistance is more common than resistance to other chemotherapies at relapse. In addition, failure to clear peripheral blasts during a prednisone prophase correlates with an elevated risk of relapse in newly diagnosed patients. Here we show that intrinsic GC resistance is present at diagnosis in early thymic precursor T-ALLs as well as in a subset (...) of non-ETP T-ALLs. GC-resistant non-ETP T-ALLs are characterized by strong induction of JAK/STAT signaling in response to interleukin-7 stimulation. Removing IL7 or inhibiting JAK/STAT signaling sensitizes these T-ALLs, and a subset of ETP T-ALLs, to GCs. The combination of the GC dexamethasone and the JAK1/2 inhibitor ruxolitinib altered the balance between pro- and anti-apoptotic factors in samples with IL7-dependent GC resistance, but not in samples with IL7-independent GC resistance. Together, these data suggest that the addition of ruxolitinib or other inhibitors of IL7 receptor/JAK/STAT signaling may enhance the efficacy of GCs in a biologically defined subset of T-ALL.Leukemia advance online publication, 30 May 2017; doi:10.1038/leu.2017.136. (shrink)

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Objectives To conduct an independent evaluation of the first phase of the Health Foundation’s Safer Patients Initiative (SPI), and to identify the net additional effect of SPI and any differences in changes in participating and non-participating NHS hospitals. Design Mixed method evaluation involving five substudies, before and after design. Setting NHS hospitals in the United Kingdom. Participants Four hospitals (one in each country in the UK) participating in the first phase of the SPI (SPI1); 18 control hospitals. Intervention The SPI1 (...) was a compound (multi-component) organisational intervention delivered over 18 months that focused on improving the reliability of specific frontline care processes in designated clinical specialties and promoting organisational and cultural change. Results Senior staff members were knowledgeable and enthusiastic about SPI1. There was a small (0.08 points on a 5 point scale) but significant (P<0.01) effect in favour of the SPI1 hospitals in one of 11 dimensions of the staff questionnaire (organisational climate). Qualitative evidence showed only modest penetration of SPI1 at medical ward level. Although SPI1 was designed to engage staff from the bottom up, it did not usually feel like this to those working on the wards, and questions about legitimacy of some aspects of SPI1 were raised. Of the five components to identify patients at risk of deterioration—monitoring of vital signs (14 items); routine tests (three items); evidence based standards specific to certain diseases (three items); prescribing errors (multiple items from the British National Formulary); and medical history taking (11 items)—there was little net difference between control and SPI1 hospitals, except in relation to quality of monitoring of acute medical patients, which improved on average over time across all hospitals. Recording of respiratory rate increased to a greater degree in SPI1 than in control hospitals; in the second six hours after admission recording increased from 40% (93) to 69% (165) in control hospitals and from 37% (141) to 78% (296) in SPI1 hospitals (odds ratio for “difference in difference” 2.1, 99% confidence interval 1.0 to 4.3; P=0.008). Use of a formal scoring system for patients with pneumonia also increased over time (from 2% (102) to 23% (111) in control hospitals and from 2% (170) to 9% (189) in SPI1 hospitals), which favoured controls and was not significant (0.3, 0.02 to 3.4; P=0.173). There were no improvements in the proportion of prescription errors and no effects that could be attributed to SPI1 in non-targeted generic areas (such as enhanced safety culture). On some measures, the lack of effect could be because compliance was already high at baseline (such as use of steroids in over 85% of cases where indicated), but even when there was more room for improvement (such as in quality of medical history taking), there was no significant additional net effect of SPI1. There were no changes over time or between control and SPI1 hospitals in errors or rates of adverse events in patients in medical wards. Mortality increased from 11% (27) to 16% (39) among controls and decreased from 17% (63) to 13% (49) among SPI1 hospitals, but the risk adjusted difference was not significant (0.5, 0.2 to 1.4; P=0.085). Poor care was a contributing factor in four of the 178 deaths identified by review of case notes. The survey of patients showed no significant differences apart from an increase in perception of cleanliness in favour of SPI1 hospitals. Conclusions The introduction of SPI1 was associated with improvements in one of the types of clinical process studied (monitoring of vital signs) and one measure of staff perceptions of organisational climate. There was no additional effect of SPI1 on other targeted issues nor on other measures of generic organisational strengthening. (shrink)

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Wood's book argues for the integral place of the "moral arguments"--the arguments for freedom, immortality, and the existence of God--in Kant's total philosophical work. These arguments have always been the object of some suspicion not only as regards their internal plausibility but also because it has been maintained that they constitute a surreptitious reintroduction of the speculative way of arguing clearly banned by the first Critique. This suspicion was reinforced by Adickes' edition of the Opus Postumum in which the (...) editor contended that Kant had therein repudiated the moral arguments in favor of a personal experience of God through the Categorical Imperative.Wood's argument to the contrary is vigorous and extremely interesting. He holds that Kant's notion of "rational faith" is a profound religious insight, one whose importanceWood does not hesitate to say is directly proportionate to that of the critical theory itself.--J. D. C. (shrink)

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In contrast to the introspective doubts of nineteenth century agnosticism comes a synthetic survey of the Age of Faith through the sharp eyes of a candid believer. Professor Warrington translates with care and grace the third of a herculean series of five Church history volumes, which have been widely successful in the original French edition. It is economically understandable but unfortunate that the bibliography of its rich French and German sources is omitted as well as the cross-references to its two (...) predecessors, although a useful twenty-five page index is provided. In an age of specialists who find the humane sharing of discovery increasingly difficult, M. Daniel-Rops is a publicist-prodigy—a practised littérateur with a comprehensive grasp of ideas, events and writings, sacred and profane, which he diffuses widely in works properly described as being de haute vulgarisation. This vivid view of the medieval Church as a whole—spiritually, politically and culturally—is personally rethought as a live unity, and should benefit both the exacting specialist in constant danger of failing to see thewood for his pet trees and the serious beginner trying to recapture the events and mentality of a remote past. Nor should one cavil at the author’s presentation in terms of his own unconcealed belief in its value. A definitive history, in which the observer conceals his own viewpoint and muffles his personal conviction, is an artificial ideal healthily rejected nowadays, as at best producing a stale record of uninspiring fact. This personal testament frankly judges the interaction of Christian belief and institution in the High Middle Ages, which saw the Christianisation of the whole continent, its cultural manifestation in cathedral and university and its militant challenge in the wars of Investiture and crusade. (shrink)

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