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Social Conformity and Response Bias Revisited: The Influence of "Others" on Japanese Respondents This study was undertaken to investigate the impact of other respondents' answers on individual responses in survey studies. The study employed four different conditions and manipulated the direction and the level of social pressure. The results have confirmed that social desirability bias hugely impacts individual answers. It was found that respondents are seven times more likely to choose a socially unacceptable option if majority of the preceding respondents (...) also have chosen the same option. Additionally, the existence of an interviewer during data collection was found to be a factor pressuring respondents to give more socially acceptable responses. (shrink)

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We review the relativistic classical and quantum mechanics of Stueckelberg, and introduce the compensation fields necessary for the gauge covariance of the Stueckelbert–Schrödinger equation. To achieve this, one must introduce a fifth, Lorentz scalar, compensation field, in addition to the four vector fields with compensate the action of the space-time derivatives. A generalized Lorentz force can be derived from the classical Hamilton equations associated with this evolution function. We show that the fifth (scalar) field can be eliminated through the introduction (...) of aconformal metric on the spacetime manifold. The geodesic equation associated with this metric coincides with the Lorentz force, and is therefore dynamically equivalent. Since the generalized Maxwell equations for the five dimensional fields provide an equation relating the fifth field with the spacetime density of events, one can derive the spacetime event density associated with the Friedmann–Robertson–Walker solution of the Einstein equations. The resulting density, in theconformal coordinate space, is isotropic and homogeneous, decreasing as the square of the Robertson–Walker scale factor. Using the Einstein equations, one see that both for the static and matter dominated models, theconformal time slice in which the events which generate the world lines are contained becomes progressively thinner as the inverse square of the scale factor, establishing a simple correspondence between the configurations predicted by the underlying Friedmann–Robertson–Walker dynamical model and the configurations in theconformal coordinates. (shrink)

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ABSTRACTThe psychological and philosophical literature exploring the role of social influence in moral judgments suggests that conformity in moral judgments is common and, in many cases, seems to b...

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Conformal group of Minkowski space-time M is considered as a group of bundle automorphisms of a vector bundle U over M. 4-component spin-vectors (4-spinors) are sections of a subbundle of the tangent bundle over U. Isotropic 4-vectors are images of 4-spinors under projection. This leads to a particularly clear interpretation of the spin properties of Nature.

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A recent paper by Leclerc et al(1) describes how recombinant hamster prion protein can undergo a spontaneous change in conformation to a structure that has features in common with PrPSc. Structural change in the host prion protein, PrPC to an insoluble and aggregated form with increased β‐sheet content (PrPSc) is central to the pathology of prion diseases.(2) A detailed understanding of the nature of these conformational changes will increase our knowledge of the molecular basis of prion pathology. These findings may (...) have implications for how the disease is initiated and provide a format for further investigation. BioEssays 23:772–774, 2001. © 2001 John Wiley & Sons, Inc. (shrink)

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We suggest a new view of secretory and membrane protein folding that emphasizes the role of pathways of biogenesis in generating functional and conformational heterogeneity. In this view, heterogeneity results from action of accessory factors either directly binding specific sequences of the nascent chain, or indirectly, changing the environment in which a particular domain is synthesized. Entrained by signaling pathways, these variables create a combinatorial set of necessary‐but‐not‐sufficient conditions that enhance synthesis and folding of particular alternate, functional, conformational forms. We (...) therefore propose that protein conformation is productively regulated by the cell during translocation across the endoplasmic reticulum (ER), a concept that may account for currently poorly understood aspects of physiological function, natural selection, and disease pathogenesis. BioEssays 24:741–748, 2002. © 2002 Wiley Periodicals, Inc. (shrink)

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In this article we present a brief review of theconformal symmetry and the two-dimensionalconformal quantum field theories. As concrete applications of theconformal theories to the critical phenomena in statistical systems, we calculate the value of central charge and the anomalous scale dimensions of the Z 2 symmetric quantum chain with boundary condition. The results are compatible with the prediction of theconformal field theories.

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In this article, the author discusses the concept of conversion as opposed to conformity to a religious tradition without internal self-assertiveness. A transcendental mission understanding as opposed to an immanent agenda for liberation is proposed as an alternative solution. He analyses the role played and the contributions made by missionary enterprise and the liberation theologies in South Africa as they shaped the path for liberation. The white churches and state theologies sought to produce black conformists to the system; liberation theologies (...) resisted the conformity mentality and fought for an egalitarian and free society. Both movements failed to embrace a transcendental methodology that would go beyond the secular boundaries and bring about transformational and empowering spirituality. This article suggests new spirituality for life and affirmation that would work against self-hate among the previously oppressed and self-guilt among the previously oppressing ruling class. It seeks ways to heal broken relationships through authentic empowerment and transformation. (shrink)

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James S. Coleman was the major proponent of rational choice theory. This article challenges the traditional reading of his work by showing that under the explicit theory of rational choice lay a latent non-rational theory of action. The article shows that instead of rationality, Coleman's psychological starting point was existential insecurity; that instead of the alleged mechanism of the maximization of utility, actors choose to conform to peer values and norms in order to alleviate insecurity; and that the optimal setting (...) for action is provided by intimate and dense communities, rather than unregulated free markets. These three non-rational presuppositions are analyzed and it is suggested that they are crucial for understanding Coleman's assessment of modernity, social change and his call for the rational reconstruction of society. (shrink)

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The proposed European Artificial Intelligence Act (AIA) is the first attempt to elaborate a general legal framework for AI carried out by any major global economy. As such, the AIA is likely to become a point of reference in the larger discourse on how AI systems can (and should) be regulated. In this article, we describe and discuss the two primary enforcement mechanisms proposed in the AIA: the _conformity assessments_ that providers of high-risk AI systems are expected to conduct, and (...) the _post-market monitoring plans_ that providers must establish to document the performance of high-risk AI systems throughout their lifetimes. We argue that the AIA can be interpreted as a proposal to establish a Europe-wide ecosystem for conducting AI auditing, albeit in other words. Our analysis offers two main contributions. First, by describing the enforcement mechanisms included in the AIA in terminology borrowed from existing literature on AI auditing, we help providers of AI systems understand how they can prove adherence to the requirements set out in the AIA in practice. Second, by examining the AIA from an auditing perspective, we seek to provide transferable lessons from previous research about how to refine further the regulatory approach outlined in the AIA. We conclude by highlighting seven aspects of the AIA where amendments (or simply clarifications) would be helpful. These include, above all, the need to translate vague concepts into verifiable criteria and to strengthen the institutional safeguards concerning conformity assessments based on internal checks. (shrink)

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Some arguments, based on the possible spontaneous violation of the cosmological principle (represented by the observed large-scale structures of galaxies), on the Cartan geometry of simple spinors, and on the Fock formulation of hydrogen atom wave equation in momentum space, are presented in favor of the hypothesis that space-time and momentum space should be both conformally compactified and should both originate from the two four-dimensional homogeneous spaces of the conformai group, both isomorphic (S 3 ×S 1)/Z 2 and correlated by (...)conformal inversion, but should not necessarily be identified with them. Within this framework, the possible common origin for the SO(4) symmetry underlying the geometrical structure of the Universe, of Kepler orbits, and of the H atom is discussed. One of the consequences of the proposed hypothesis could be that any quantum field theory should be naturally free from both infrared and ultraviolet divergences. But then physical spaces defined as those where physical phenomena may be best described through some set of fields, could be different from those homogeneous spaces. A simple, exactly soluble, toy model, valid for a two-dimensional spacetime, is presented where the conjectured conformally compactified homogeneous spaces are both isomorphic to (S 1 ×S 1)/Z 2,while the possible physical spaces could be two finite lattices which are dual since Fourier transforms, represented by finite, discrete, sums, may be well defined on them. (shrink)

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This work seeks to take seriously the common philosophical claim that individual subjects are constituted by their social world. A detailed understanding this claim requires an analysis of what is involved in being a subject, of the nature of 'the social', and of the possible constitutive relationships between these. I begin with a critical history of the idea that subjects are norm-followers, and that social groups constitute individuals by demanding their conformity to norms. I trace this 'conformity theory' through the (...) thought of Rousseau, Hegel, Mead, and Althusser, to its manifestation in contemporary continental and Anglo-American philosophy. I criticize this theory for being unable to sufficiently accommodate creativity and social resistance. I go on to develop an account of subjects as not only norm-followers but also sense-makers, who have identities in virtue of their engagement in narrative dramas. Such subjects are socially constituted in at least two ways: through their 'dialogical' interactions with particular others , and through their position in a public culture which determines what counts as a meaningful possibility for action. This understanding of subjectivity allows me to develop a new account of the nature of social groups--such as groups based on gender, class and nationality--which provides an alternative to the conformity theory. Social groups contribute to individual identities not only by imposing norms, but also by providing sense-making resources, in the form of literary and artistic traditions as well as the actual lives and dramas of members. My account allows us to understand creativity and social resistance as enabled by subjects' membership in social groups, and it reveals how the internal diversity of a group can strengthen rather than compromise its role in individual identities. I end with a discussion of the political implications of my work. (shrink)

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The Einstein-conformally coupled scalar field system is studied in the presence of a cosmological constant. We consider a massless or massive scalar field with no additional self-interaction, and spherically symmetric black hole geometries. When the cosmological constant is positive, no scalar hair can exist and the only solution is the Schwarzschild–de Sitter black hole. When the cosmological constant is negative, stable scalar field hair exists provided the mass of the scalar field is not too large.

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The unique discourse of Confucian ritual practice encompasses a powerful and sophisticated way of talking about individual fulfillment within the context of more substantive or universal conceptions of the good life. To make this case, I will consider both the text of the "Analects" and the influential readings of the "Analects" offered by Fingarette in "Confucius: The Secular as Sacred" and by Hall and Ames in "Thinking through Confucius". Though the two interpretive works are helpful in articulating the classical Confucian (...) contribution to the problem of balancing conformity and individuality, I will argue that an alternative reading is required to appreciate fully how values thought to embody and express the fullest humanity might be inculcated in ethical agents without undoing their individuality. Such an alternative is developed here. (shrink)

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This paper investigates the behavior ofconformal fluctuations of space-time geometry that are admissible under the quantized version of Einstein's general relativity. The approach to quantum gravity is via path integrals. It is shown that considerable simplification results when only theconformal degrees of freedom are considered under this scheme, so much so that it is possible to write down a formal kernel in the most general case where the space-time contains arbitrary distributions of particles with no other (...) interaction except gravity. The behavior of this kernel near the classical space-time singularity then shows that quantum fluctuations inevitably diverge near the singularity. It is shown further that the root cause of this divergence lies in the fact that the Green's function for the conformally invariant scalar wave equation diverges at the singularity. The limitations on the validity of classical general relativity near the space-time singularity are discussed and it is argued that the notion of singularity itself needs to be radically modified once the quantum effects are taken into account. (shrink)

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Scientists are generally subject to social pressures, including pressures to conform with others in their communities, that affect achievement of their epistemic goals. Here we analyze a network epistemology model in which agents, all else being equal, prefer to take actions that conform with those of their neighbors. This preference for conformity interacts with the agents’ beliefs about which of two possible actions yields the better result. We find a range of possible outcomes, including stable polarization in belief and action. (...) The model results are sensitive to network structure. In general, though, conformity has a negative effect on a community’s ability to reach accurate consensus about the world. (shrink)

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We discuss the concepts of Weyl and Riemann frames in the context of metric theories of gravity and state the fact that they are completely equivalent as far as geodesic motion is concerned. We apply this result to conformally flat spacetimes and show that a new picture arises when a Riemannian spacetime is taken by means of geometrical gauge transformations into a Minkowskian flat spacetime. We find out that in the Weyl frame gravity is described by a scalar field. We (...) give some examples of how conformally flat spacetime configurations look when viewed from the standpoint of a Weyl frame. We show that in the non-relativistic and weak field regime the Weyl scalar field may be identified with the Newtonian gravitational potential. We suggest an equation for the scalar field by varying the Einstein-Hilbert action restricted to the class of conformally-flat spacetimes. We revisit Einstein and Fokker’s interpretation of Nordström scalar gravity theory and draw an analogy between this approach and the Weyl gauge formalism. We briefly take a look at two-dimensional gravity as viewed in the Weyl frame and address the question of quantizing a conformally flat spacetime by going to the Weyl frame. (shrink)

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When Thomas of Celano wrote these words in his first hagiography of the poverello, his intention, quite naturally, was to focus attention on Francis. But it is notable that Celano wrote that Francis conformed himself to the poor. Francis learned how to be Christian and how to live out his faith by modeling his life on the anonymous poor who surrounded him. But when looking at histories of the various Franciscan orders—including the Third Order and Order of Poor Clare sisters—the (...) role of the laity, especially the anonymous poor is ignored.2 The role of the anonymous laity has been largely forgotten with the possible exception of frequent mention of lepers whose encounter with Francis marked a significant turning... (shrink)

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The two-point correlation functions of classical electromagnetic zero-point radiation fields are evaluated in four-vector notation. The manifestly Lorentz-covariant expressions are then shown to be invariant under scale transformations and under theconformal transformations of Bateman and Cunningham. As a preliminary to the electromagnetic work, analogous results are obtained for a scalar Gaussian random classical field with a Lorentz-invariant spectrum.

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Mind has played the starring role in the West's arts, humanities, and sciences, while an embodied notion of oneself, others, and the physical world has been customarily pushed under the rug. In view of radical new theories, methods and techniques that have emerged during the past century and a half, the notion of complementary, sympathetic co-participation, and its accompanying re-enchantment, merits attention. C. S. Peirce is at the crossroads between modernism, enchantment, and misplaced concreteness, on the one hand, and postmodernism (...) and its attendant poststructuralism, on the other. His categories of feeling, sensation, and thought, and his triadic, all-encompassing concept of the sign, can help bring all facets of human creativity, concrete living, and understanding into a proper balance. Three coined terms — homogeny, hierogeny, and heterogeny — serve to elucidate how Peirce's triadic vision can offer a middle path, a way of mediating between antagonistic modes of sensing, living, and thinking. This middle path follows traditional tenets of logic and reason — identity, non-contradiction, and excluded-middle — while at its fringes, it allows deviation — by way of process, inconsistency, and incompleteness — from the rigidity that lies therein. Studies of feminist postures and various cultural processes in Latin America bear out the premise that a dose of conformity accompanying a tendency toward resistance can synethnically help keep broad cultural processes on an even keel, balancing mind and body, conflicting theories and methods and modes of living, and styles of reason and unreason in equilibrium. (shrink)

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Previous simulation models have found positive effects of cognitive diversity on group performance, but have not explored effects of diversity in demographics (e.g., gender, ethnicity). In this paper, we present an agent-based model that captures two empirically supported hypotheses about how demographic diversity can improve group performance. The results of our simulations suggest that, even when social identities are not associated with distinctive task-related cognitive resources, demographic diversity can, in certain circumstances, benefit collective performance by counteracting two types of conformity (...) that can arise in homogeneous groups: those relating to group-based trust and those connected to normative expectations towards in-groups. (shrink)

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Conformity is a large topic and its causes are undoubtedly heterogenous. Of the various mechanisms that contribute to conformity, I will comment on two: coordination and esteem. Game theorists have given coordination significant attention. Lewis first posited that social conventions are, roughly, particular equilibrium outcomes to recurrent coordination problems. Once the equilibrium occurs, it is, by definition, in everyone’s interest to conform. Evolutionary game theorists have explored the conditions that make a certain equilibrium likely to emerge and persist when more (...) than one equilibrium is possible. In the first section below, I set forth one point about the nature of conformity in such settings—that there can be a strong stability to conventions in which the required behavior varies by the observable physical differences among human beings, such as sex and those that come to be associated with race. In a certain class of important games, observable personal differences work to “break symmetry,” which significantly changes the possible outcomes to the game. My aim is not to provide a particular model of conformity involving sex and race, but to illustrate the usefulness of a particular approach to model-building. (shrink)

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It is well-known that theconformal structure of a relativistic spacetime is of profound physical and conceptual interest. In this note, we consider the analogous structure for Newtonian theories. We show that the Newtonian Weyl tensor is an invariant of this structure.

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Compactified Minkowski spacetime is suggested byconformal covariance of Maxwell equations, while E. Cartan's definition of simple spinors leads to the idea of compactified momentum space. Assuming both diffeomorphic to (S 3 × S 1 )/Z 2 , one may obtain in the conformally flat stereographic projection field theories both infrared and ultraviolet regularized. On the compact manifold themselves instead, Fourier integrals of wave-field oscillations would have to be replaced by Fourier series summed over indices of spherical eigenfunctions: n, (...) l, m, m′. Tentatively identifying those wave structures with spacetime itself (in the frame of Big-Bang) and/or with matter and radiation distribution, some large-scale (hydrogenic) and small-scale (lattice) space structures are conjectured. (shrink)

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Research on gender inequality within different-sex marriages shows that women do more unpaid labor than men, and that the perception of inequality influences perceptions of marital quality. Yet research on same-sex couples suggests the importance of considering how gender is relational. Past studies show that same-sex partners share unpaid labor more equally and perceive greater equity than do different-sex partners, and that lesbian, gay, and bisexual people are less gender conforming than heterosexuals. However, studies have not considered how gender conformity (...) might shape inequalities and marital quality within same- and different-sex unions. In this study, we analyze dyadic data from both spouses in same- and different-sex marriages to explore how sex of spouse and gender conformity influence perceptions of shared power within the relationship, which, in turn, influences marital quality. Results show that greater gender conformity is related to stronger perceptions of shared power in different-sex and male same-sex couples but not in female same-sex couples. Perceptions of shared power are positively associated with marital quality in all union types. Our findings suggest that maintaining hegemonic masculinity and power inequalities may be salient to marriages with men. In female same-sex couples, gender and its relation to power inequalities may carry less meaning. (shrink)

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Contesting Conformity investigates the writings of Tocqueville, Mill, and Nietzsche in order to examine the relationship between non-conformity and modern democracy. Jennie Ikuta argues that non-conformity is an intractable issue for democracy while non-conformity is often important for cultivating a just polity, non-conformity can also undermine democracy. Democracy therefore needs non-conformity, but not in an unconditional way. This book examines this intractable relationship, and offers resources for navigating the relationship in contemporary democracies in ways that promote justice and freedom.

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Penrose'sconformal cyclic cosmology describes the cosmos as a collection of successive universes, the so-called aeons. The beginning and ending of our universe are directly connected to two other, anterior and posterior, universes. Penrose considers but rules out a different interpretation ofconformal cyclic cosmology: that the beginning of our universe is connected to its own end in a cosmic loop. The paper argues that the view, aeon monism, should be regarded as a natural interpretation ofconformal (...) cyclic cosmology and discusses its implications for the concept of eternal return in light of the most popular metaphysics of time. (shrink)

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We review some recent developments in theconformal gravity theory that has been advanced as a candidate alternative to standard Einstein gravity. As a quantum theory theconformal theory is both renormalizable and unitary, with unitarity being obtained because the theory is a PT symmetric rather than a Hermitian theory. We show that in the theory there can be no a priori classical curvature, with all curvature having to result from quantization. In theconformal theory gravity requires (...) no independent quantization of its own, with it being quantized solely by virtue of its being coupled to a quantized matter source. Moreover, because it is this very coupling that fixes the strength of the gravitational field commutators, the gravity sector zero-point energy density and pressure fluctuations are then able to identically cancel the zero-point fluctuations associated with the matter sector. In addition, we show that when theconformal symmetry is spontaneously broken, the zero-point structure automatically readjusts so as to identically cancel the cosmological constant term that dynamical mass generation induces. We show that the macroscopic classical theory that results from the quantumconformal theory incorporates global physics effects that provide for a detailed accounting of a comprehensive set of 138 galactic rotation curves with no adjustable parameters other than the galactic mass to light ratios, and with the need for no dark matter whatsoever. With these global effects eliminating the need for dark matter, we see that invoking dark matter in galaxies could potentially be nothing more than an attempt to describe global physics effects in purely local galactic terms. Finally, we review some recent work by ’t Hooft in which a connection betweenconformal gravity and Einstein gravity has been found. (shrink)

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A general framework by which dynamic interactions within a protein will promote the necessary series of structural changes, or “conformational cycle,” required for function is proposed. It is suggested that the free‐energy landscape of a protein is biased toward this conformational cycle. Fluctuations into higher energy, although thermally accessible, conformations drive the conformational cycle forward. The amino acid interaction network is defined as those intraprotein interactions that contribute most to the free‐energy landscape. Some network connections are consistent in every structural (...) state, while others periodically change their interaction strength according to the conformational cycle. It is reviewed here that structural transitions change these periodic network connections, which then predisposes the protein toward the next set of network changes, and hence the next structural change. These concepts are illustrated by recent work on tryptophan synthase. Disruption of these dynamic connections may lead to aberrant protein function and disease states. (shrink)

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We provide a canonical construction ofconformal covers for finite hypergraphs and present two immediate applications to the finite model theory of relational structures. In the setting of relational structures,conformal covers serve to construct guarded bisimilar companion structures that avoid all incidental Gaifman cliques-thus serving as a partial analogue in finite model theory for the usually infinite guarded unravellings. In hypergraph theoretic terms, we show that every finite hypergraph admits a bisimilar cover by a finiteconformal (...) hypergraph. In terms of relational structures, we show that every finite relational structure admits a guarded bisimilar cover by a finite structure whose Gaifman cliques are guarded. One of our applications answers an open question about a clique constrained strengthening of the extension property for partial automorphisms (EPPA) of Hrushovski, Herwig and Lascar. A second application provides an alternative proof of the finite model property (FMP) for the clique guarded fragment of first-order logic CGF, by reducing (finite) satisfiability in CGF to (finite) satisfiability in the guarded fragment, GF. (shrink)

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We present some interesting connections between PT symmetry andconformal symmetry. We use them to develop a metricated theory of electromagnetism in which the electromagnetic field is present in the geometric connection. However, unlike Weyl who first advanced this possibility, we do not take the connection to be real but to instead be PT symmetric, with it being \ rather than \ itself that then appears in the connection. With this modification the standard minimal coupling of electromagnetism to fermions (...) is obtained. Through the use of torsion we obtain a metricated theory of electromagnetism that treats its electric and magnetic sectors symmetrically, with aconformal invariant theory of gravity being found to emerge. An extension to the non-Abelian case is provided. (shrink)

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On the basis of the Woodhouse causal axiomatics, we show thatconformal proper times and an extra variable in addition to those of space and time, together give a physical justification for the ‘chronometric hypothesis’ of general relativity. Indeed, we show that, with a lack of these latter two ingredients and of this hypothesis, clock paradoxes exist for which the unparadoxical asymmetry cannot be recovered when using the ‘clock and message functions’ only. These proper times originate from a given (...)conformal structure of the spacetime when ascribing different compatible projective structures to each Woodhouse particle, and then, each defines a specific Weylian ‘sheaf structure’. In addition, the proper time parameterizations are defined via path-dependentconformal scale factors, which act like sockets for any kind of physical interaction and also represent the values of the variable associated with the extra dimension. (shrink)

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The mathematical and physical aspects of theconformal symmetry of space-time and of physical laws are analyzed. In particular, the group classification of conformally flat space-times, theconformal compactifications of space-time, and the problem of imbedding of the flat space-time in global four-dimensional curved spaces with non-trivial topological and geometrical structure are discussed in detail. The wave equations on the compactified space-times are analyzed also, and the set of their elementary solutions constructed. Finally, the implications of global compactified (...) space-times for cosmology are discussed. It is argued that the recent discovery of periodic structure of matter distribution on large distances strongly suggests that the global cosmological space-time should be close. Next we analyze the inflation scalar field in the inflationary model of universe evolution considered on the spatially compact Robertson-Walker space-time. It is shown that the energy distribution in this model is periodic and the periods and density decrease with increasing distance, in striking agreement with experimental data. Our model of the universe also provides a definite predictions for the energy distribution, polar and azimuthal, considered as a function of angles θ and φ. These predictions should be tested with the new astronomical data. (shrink)

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This study investigates the malleability of the eyewitness memory by analyzing the effects of Memory Conformity and Cross-Race Effect (CRE) among Asian ethnic groups. A live crime enactment (snatch theft) was initiated in order to assess both variables. Two experiments were conducted using a questionnaire with a total of 36 participants in a private university. Experiment 1 examined the effects of group conformity. After the live enactment and the filler task, participants were randomly assigned to one of two conditions: discussed (...) and no discussed groups. All participants were given a questionnaire and was informed to complete it individually. Experiment 2 examined the cross-race effect. Participants were informed to answer the questionnaire individually and the results were analyzed based on the racial identity. No difference in memory accuracy was found between discussed and no discussed conditions in the experiment 1. However, in experiment 2, a disparate racial identity effect was found opposing the past literature. (shrink)

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Diffusion in social networks is a result of agents’ natural desires to conform to the behavioral patterns of their peers. In this article we show that the recently proposed “propositional opinion diffusion model” could be used to model an agent’s conformity to different social groups that the same agent might belong to, rather than conformity to the society as whole. The main technical contribution of this article is a sound and complete logical system describing the properties of the influence relation (...) in this model. The logical system is an extension of Armstrong’s axioms from database theory by one new axiom that captures the topological structure of the network. (shrink)

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G protein‐coupled receptors (GPCRs) constitute the largest family of transmembrane proteins and play a crucial role in regulating diverse cellular functions. They transmit their signaling via binding to intracellular signal transducers and effectors, such as G proteins, GPCR kinases, and β‐arrestins. To influence specific GPCR signaling behaviors, β‐arrestins recruit effectors to form larger signaling complexes. Intriguingly, they facilitate divergent functions for the binding to different receptors. Recent studies relying on advanced structural approaches, novel biosensors and interactome analyses bring us closer (...) to understanding how this specificity is achieved. In this article, we share our hypothesis of how active GPCRs induce specific conformational rearrangements within β‐arrestins to reveal distinct binding interfaces, enabling the recruitment of a subset of effectors to foster specialized signaling complexes. Furthermore, we discuss methods of how to comprehensively assess β‐arrestin conformational states and present the current state of research regarding the functionality of these multifaceted scaffolding proteins. (shrink)

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Einstein's conform-invariant light metrics g'ik=(WiklmWiklm)1/2 glk imply a Machian cosmology and exclude conformally flat space-times.

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Kant discovered a philosophical problem with mathematical proof. Despite being a priori , its methodology involves more than analytic truth. But what else is involved? This problem is widely taken to have been solved by Frege’s extension of logic beyond its restricted (and largely Aristotelian) form. Nevertheless, a successor problem remains: both traditional and contemporary (classical) mathematical proofs, although conforming to the norms of contemporary (classical) logic, never were, and still aren’t, executed by mathematicians in a way that transparently reveals (...) why these proofs—written in the vernacular to this very day—succeed in conforming to those norms. (shrink)

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It is plausible that we have moral reasons to become better at conforming to our moral reasons. However, it is not always clear what means to greater moral conformity we should adopt. John Harris has recently argued that we have reason to adopt traditional, deliberative means in preference to means that alter our affective or conative states directly—that is, without engaging our deliberative faculties. One of Harris’ concerns about direct means is that they would produce only a superficial kind of (...) moral improvement. Though they might increase our moral conformity, there is some deeper kind of moral improvement that they would fail to produce, or would produce to a lesser degree than more traditional means. I consider whether this concern might be justified by appeal to the concept of moral worth. I assess three attempts to show that, even where they were equally effective at increasing one’s moral conformity, direct interventions would be less conducive to moral worth than typical deliberative alternatives. Each of these attempts is inspired by Kant’s views on moral worth. Each, I argue, fails. (shrink)

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