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Literature on maternal exposures and the risk of epigenetic changes or diseases in the offspring is growing. Paternal contributions are often not considered. However, some animal and epidemiologic studies on various contaminants, nutrition, and lifestyle‐related conditions suggest a paternal influence on the offspring's future health. The phenotypic outcomes may have been attributed to DNA damage or mutations, but increasing evidence shows that the inheritance of environmentally induced functional changes of the genome, and related disorders, are (also) driven by epigenetic components. (...) In this essay we suggest the existence of epigenetic windows of susceptibility to environmental insults during sperm development. Changes in DNA methylation, histone modification, and non‐coding RNAs are viable mechanistic candidates for a non‐genetic transfer of paternal environmental information, from maturing germ cell to zygote. Inclusion of paternal factors in future research will ultimately improve the understanding of transgenerational epigenetic plasticity and health‐related effects in future generations. (shrink)

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Drawing on a finance professional’s reflections on his ethical education as an economics undergraduate, Chartered Financial Analyst, and top-tier MBA graduate, this article considers the framing of, and need for philosophy in, ethical training for finance professionals. Role-playing is emphasized as helpful for developing a mature ethical approach, and theory is seen as desirable after the fact, to plan improved future action. The article problematizes an orientation in professional programs that primarily gears the teaching of ethics toward those students perceived (...) to be least ethical. This orientation seems to underlie both the education the financial professional received and current public interest in ‘more ethics’ in professional programming. As an alternative, the article reframes finance students and professionals as ethical actors whose primary dilemma concerns not how to avoid ethical transgressions, but how to better optimize the duty to self in... (shrink)

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IntroductionCardiology is characterized by its state-of-the-art biomedical technology and the predominance of Evidence-Based Medicine. This predominance makes it difficult for healthcare professionals to deal with the ethical dilemmas that emerge in this subspecialty. This paper is a first endeavor to empirically investigate the axiological foundations of the healthcare professionals in a cardiology hospital. Our pilot study selected, as the target population, cardiology personnel not only because of their difficult ethical deliberations but also because of the stringent conditions in which they (...) have to make them. Therefore, there is an urgent need to reconsider clinical ethics and Value-Based Medicine. This study proposes a qualitative analysis of the values and the virtues of healthcare professionals in a cardiology hospital in order to establish how the former impact upon the medical and ethical decisions made by the latter.ResultsWe point out the need for strengthening the roles of healthcare personnel as educators and guidance counselors in order to meet the ends of medicine, as well as the need for an ethical discernment that is compatible with our results, namely, that the ethical values developed by healthcare professionals stem from their life history as well as their professional education.ConclusionWe establish the kind of actions, communication skills and empathy that are required to build a stronger patient-healthcare professional relationship, which at the same time improves prognosis, treatment efficiency and therapeutic adhesion. (shrink)

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Understanding the spread of national public policies to increase the percentage of women on boards is often presented using different types of institutional theory logic. However, the importance of the political games influencing these decisions has not received the same attention. In this article, we look beyond the institutional setting by focusing on the role of actors. We explore processes that include who the critical actors that drive and determine these policies are, and what motivates them to push for change. (...) We employ a processual design approach using a longitudinal country-comparative case study exploring the case of Norway, England, Germany and Italy. We map the political games, both inside and outside legislative areas, including the micro-politics among various actors and groups of actors in the selected countries. Data are collected through participation observations, interviews and text analyses. The study contributes by filling important gaps in the literature by embedding the discussion about women on boards in politicking and national public policies and by introducing dynamic perspectives. Finally, by using a processual design approach, we capture the reality of the women on board debates at different points of time and in different actor and motivational contexts. The study has consequences for how policy-makers and businesses may follow up and act, based on the debates. (shrink)

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This research aims to identify and elaborate on the philosophical issues inherent in the concept of the Profil Pelajar Pancasila (Pancasila Student Profile) as the epitome of human idealism in Pancasila intended for implementation through educational means in Indonesia. This matter holds significance for examination due to the Pancasila Student Profile serving as the ultimate destination or objective of the complete educational system in Indonesia. Philosophical scrutiny of this concept is imperative to ensure alignment between the Pancasila Student Profile and (...) the notion of the Indonesian ideal individual in line with Pancasila’s principles. This investigation adopts a qualitative method to delve into philosophical quandaries within this domain. The data utilized in this research comprises literary works addressing the Pancasila Student Profile, which are then philosophically scrutinized based on four key attributes: radical, critical, systematic, and comprehensive. The findings of this study reveal a philosophical dilemma within the Pancasila Student concept, specifically the underrepresentation of two vital dimensions of human nature in Pancasila, namely materiality and individuality. Consequently, it is recommended that a reassessment and restructuring of the Pancasila Student Profile concept be undertaken to ensure the realization of the ideal human archetype of Pancasila without straying from the educational objectives outlined in Law No. 20 of 2003 regarding the National Education System. (shrink)

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"Dieser Beitrag fasst den aktuellen Stand der rechtlichen Herausforderungen der Blockchain-Technologie kurz und prägnant zusammen. Blockchain stellt, ähnlich dem World Wide Web, eine Art Grundlagentechnologie dar, auf deren Basis neue Plattformen und Geschäftsmodelle geschaffen werden können. Es stellt sich jedoch die Frage, ob das deutsche Rechtssystem grundsätzlich in der Lage ist, die Herausforderungen, die eine solch dezentrale Technologie mit sich bringt, zu bewältigen. Insbesondere hinsichtlich strafbarer Handlungen oder der neuen Datenschutzgrundverordnung. Fraglich ist dabei, wie sich die derzeitigen Negativschlagzeilen (beispielsweise Silk (...) Road) langfristig auf Kryptowährungen und infolgedessen wo- möglich auch auf die Blockchain-Technologie, nicht nur im Hinblick auf die rechtswidrigen Inhalte wie Kinderpornographie, auswirken. This article summarizes the current status of the legal challenges of blockchain technology. Similar to the World Wide Web, Blockchain represents a kind of basic technology on the basis of which new platforms and business models can be created. However, the question arises as to whether the German legal system is fundamentally capable of mastering the challenges posed by such a decentralized technology. In particular with regard to criminal offences or the new Basic Data Protection Ordinance. The question is how the current negative headlines (e. g. Silk Road) will affect crypto currencies in the long term and, as a result, blockchain technology, not only with regard to illegal content such as child pornography. ". (shrink)

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Das Kernanliegen Eugen Finks gilt dem Weltverhältnis des Menschen. Obgleich für ihn zunächst die Ansätze von Husserl und Heidegger richtungsweisend sind, legt Fink bereits in seiner bei Husserl angefertigten Dissertation den Grund zu seiner eigenständigen philosophischen Position. Sein späteres "kosmologisches" Denken erschließt dem Weltbegriff durch Rückgriff auf die philosophische Tradition neue Dimensionen und konkretisiert ihn zugleich im Rahmen einer Philosophischen Anthropologie, Sozialphilosophie und einer Philosophie des Pädagogischen. Mit dieser Verschränkung von Mensch und Kosmos bietet Finks Werk bedeutsame Ansatzpunkte für die (...) interdisziplinäre geistes- und naturwissenschaftliche Forschung. Der erste Teil des Buches verortet Finks kosmologisches Denken im Kontext der philosophischen Tradition. Im zweiten Teil wird Finks Konzept sowohl bezüglich seines Gesamtentwurfs wie seiner philosophisch-anthropologischen, sozialtheoretischen und religionsphilosophischen Implikationen befragt. Der Band wird durch Finks Studie "Nietzsches Metaphysik des Spiels" eröffnet. Diese aus dem Jahr 1946 stammende und bislang unveröffentlichte Arbeit belegt die wichtige Rolle, die Nietzsche bei der Ausbildung von Finks Denken von Welt gespielt hat. (shrink)

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Will robots ever be able to learn like humans? To answer that question, one first needs to ask: what is learning? Hubert and Stuart Dreyfus had a point when they claimed that computers and robots would never be able to learn like humans because human learning, after an initial phase of rule-based learning, is uncertain, context sensitive and intuitive under contract F49620-C-0063 with the University of California) Berkeley, February 1980.. Washington, DC: Storming Media. https://www.stormingmedia.us/15/1554/A155480.html. Accessed 10 Oct 2017, 1980). I (...) would add that learning also builds on prior learning, and that from the outset, human learning is a socio-cultural materially grounded collective epistemology. This posthuman acknowledgement shifts the focus from the individual learner to learning within collective phenomena. Dreyfus and Dreyfus do not seem to emphasise the essentially social and cultural nature of the human condition. Learning theory, new materialism and postphenomenology have emphasised in different ways the materially based socio-cultural nature of human learning. They thereby point towards a ‘posthuman’ learning that is far from the machine-like or enhanced creature envisioned by singularists. Until robots are essentially social and ground their epistemologies in socio-cultural materiality, I suggest that human-like AI is not possible. (shrink)

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What is the relation between material hermeneutics, bodies, perception and materials? In this article, I shall argue cultural learning processes tie them together. Three aspects of learning can be identified in cultural learning processes. First, all learning is tied to cultural practices. Second, all learning in cultural practice entangle humans’ ability to recognize a material world conceptually, and finally the boundaries of objects, the object we perceive, are set by shifting material-conceptual entanglements. All these aspects are important for material hermeneutics (...) in a technoculture. Postphenomenology has expanded the connection between hermeneutics and phenomenology by focusing on studies of how perception, bodies, materials, the sensual realm and hermeneutics are entwined when we perceive the world through technologies. Following Don Ihde, hermeneutics expands beyond interpretation of texts in the humanities. We can interpret materials as for instance animal bones to make new sense of the Bible. New technologies have expanded material hermeneutics, when we can ‘look’ into bodies and ‘perceive’ below surfaces. Interpretation via such tools in a technoculture, both limit and extend our hermeneutic horizons in the humanities as well as in the natural sciences. Furthermore, from the perspective of cultural learning processes, material hermeneutics in the human and natural sciences depend on more than mediating instruments. Material hermeneutics also involve the material cultural environments of scientific apparatuses and the scientists’ processes of learning in cultural practice. This changes the focus from relations in postphenomenology to processes of relations. (shrink)

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Kap. Rhythmus Ce texte est une section du livre de C. Nielsen, Zeitatomistik und “Wille zur Macht”. Annäherungen an Nietzsche, Tübingen, Attempto, 2014, 134 S. Nous remercions chaleureusement Cathrin Nielsen de nous avoir autorisé à le reproduire ici. Das griechische Wort rhythmos bedeutet zunächst, ähnlich wie schema und tropos, lediglich das Moment der Distinktion und impliziert darin so etwas wie die Abstandnahme einer einförmigen Bewegung von sich selbst. Erst Platon verbindet ihn mit - Philosophie.

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Robots are simultaneously real machines and technical images that challenge our sense of self. I discuss the movie Ex Machina by director Alex Garland. The robot Ava, played by Alicia Vikander, is a rare portrait of what could be interpreted as a feminist robot. Though she apparently is created as the dream of the ‘perfect woman’, sexy and beautiful, she also develops and urges to free herself from the slavery of her creator, Nathan Bateman. She is a robot created along (...) the perfect dimensions as a Vitruvian robot but is also a creature which could be interpreted as a human being. However, the point I want to raise is not whether Ava’s reaction to robot slavery is justified or not but how her portrait raises questions about the blurred lines between reality and fiction when we discuss our robotic future. A real version of Ava would not last long in a human world because she is basically a solipsist, who does not really care about humans. She cannot co-create the line humans walk along. The robots created as ‘perfect women’ today are very far from the ideal image of Ava. They are sexist, primitively normative and clearly ‘wax-doll machines’. So though Ava’s dimensions are perfect she, like the Vitruvian Man, remains a fiction. In real life, however, we may have to deal with an increasing solipsism stemming from people engaging with machines like sex robots. In this case, it is human and not robotic solipsism we need to worry about. (shrink)

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En este ensayo se examina de manera crítica el desarrollo de la filosofía analítica y, en particular, de la filosofía analítica latinoamericana. Se propone que esta última adopte un giro político y uno pedagógico con el fin de recuperar su espíritu original y reconectarse con la tradición intelectual latinoamericana. This essay is a critical examination of the development of analytic philosophy and, in particular, of Latin American analytic philosophy. It is argued that the latter ought to adopt a political and (...) pedagogical turn in order to recover its original spirit and to be reconnected to Latin American intelectual tradition. (shrink)

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The article probes into tensions following in the wake of feminism’s mappings of itself as a landscape that ‘is not there’, so to speak, but which is constituted and reconstituted discursively and affectively. The author discusses these tensions in relation to the notion of feminist genealogy. The discussion is elaborated with reference to a concrete, past and perhaps disturbing political and theoretical landscape: the official, state-sanctioned ‘women’s studies’ in the GDR during the Cold War. The author argues that efforts at (...) mappings and fillings of historical gaps in the production of women’s studies knowledge with reference to inclusion and recognition of ‘women’s experiences’ and ‘women’s voices’ may render feminists unable to trace and question the political operations that have produced and reproduce ‘woman’ and ‘women’ as the significant subject of feminism. The first part of the article illustrates the challenging complexity of feminist projects of inclusion and recognition by discussing some of the feminist critiques of the so-called ‘women’s studies’ in the GDR during the Cold War. The second part locates this complexity within feminist political and theoretical landscapes and cartographies by discussing it in relation to feminist genealogy. (shrink)

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This paper argues that slips present a problem for reductive intellectualism. Reductive intellectualists (e.g., Stanley and Williamson 2001; Stanley 2011, 2013; Brogaard 2011) argue that knowledge how is a form of knowledge that. Consequently, knowledge how must have the same epistemic properties as knowledge that. Slips show how knowledge how has epistemic properties not present in knowledge that. When an agent slips, she does something different from what she intended; nonetheless, the performance is guided by her knowledge how. This reveals (...) a divide between the knowledge that actively guides behaviour: the knowledge how that the agent applies sub-consciously; and the knowledge how she intends to guide her behaviour in the first place, which she is under the illusion of acting on even as she slips. I argue that this divide between two levels of knowledge how operative in the slip case has no parallel when it comes to knowledge that. Therefore, knowledge how cannot be reduced to knowledge that. (shrink)

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The PRDM family has recently spawned considerable interest as it has been implicated in fundamental aspects of cellular differentiation and exhibits expanding ties to human diseases. The PRDMs belong to the SET domain family of histone methyltransferases, however, enzymatic activity has been determined for only few PRDMs suggesting that they act by recruiting co‐factors or, more speculatively, confer methylation of non‐histone targets. Several PRDM family members are deregulated in human diseases, most prominently in hematological malignancies and solid cancers, where they (...) can act as both tumor suppressors or drivers of oncogenic processes. The molecular mechanisms have been delineated for only few PRDMs and little is known about functional redundancy within the family. Future studies should identify target genes of PRDM proteins and the protein complexes in which PRDM proteins reside to provide a more comprehensive understanding of the biological and biochemical functions of this important protein family. (shrink)

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Es un panorama, como dice el título, de la Filosofía del Derecho, escrito de manera clara, pedagógica, profunda bien fundamentado, con reflexiones permanentes sobre las distintas instituciones y conceptos del Derecho como tal, su evolución con el transcurso del tiempo, y referencias a citas de los más prestigiosos autores en la materia, de las distintas épocas. Está dividida la obra en veintidós capítulos.

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In his recent writings, Jürgen Habermas asks how the liberal constitutional principle of separation between church and state, religion and politics, should be understood. The problem, he holds, is that a liberal state guarantees equal freedom for religious communities to practise their faith, while at the same time shielding the political bodies that take collectively binding decisions from religious influences. This means that religious citizens are asked to justify their political statements independently of their religious views, resulting in a burden (...) that secular citizens do not experience. To compensate, Habermas demands from secular citizens that they open their minds to the possible truth content of religion, enter into dialog and contribute to the translation of religious reasons into generally acceptable reasons. This article focuses on Habermas’s assumption that religious citizens suffer an asymmetrical cognitive burden that should be compensated, and his claim that his approach to religion in the public sphere is less restrictive than that of John Rawls. (shrink)

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Theory‐of‐mind (ToM) is an integral part of social cognition, but how it develops remains a critical question. There is evidence that children can gain insight into ToM through experience, including language training and explanatory interactions. But this still leaves open the question of how children gain these insights—what processes drive this learning? We propose that analogical comparison is a key mechanism in the development of ToM. In Experiment 1, children were shown true‐ and false‐belief scenarios and prompted to engage in (...) multiple comparisons (e.g., belief vs. world). In Experiments 2a, 2b, and 3, children saw a series of true‐ and false‐belief events, varying in order and in their alignability. Across these experiments, we found that providing support for comparing true‐ and false‐belief scenarios led to increased performance on false‐belief tests. These findings show that analogical comparison can support ToM learning. (shrink)

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Cet article a déjà paru dans Beiträge zur geistigen Situation der Gegenwart Jg. 8, Heft 3. Nous remercions Cathrin Nielsen de nous voir permis de la reproduire ici. Im Oktober 1887, also knapp zwei Jahre vor seinem geistigen Zusammenbruch, schreibt Nietzsche an Hermann Levi in München : „Vielleicht hat es nie einen Philosophen gegeben, der in dem Grade im Grund so sehr Musiker war, wie ich es bin“. Wenig später vertraut er seinem engen Freund Heinrich Köselitz alias Peter Gast an (...) : es - XIXe siècle – Nouvel article. (shrink)

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The increasing need for innovative research driven by rapid global changes gives doctoral supervisors of early-stage researchers a significant role in facilitating the ethical conduct of qualitative research. In the context of European Commission funding, the demands of research ethics and integrity place a tremendous responsibility on the supervisors of early-stage researchers involved in cross-national projects. This document study seeks to illuminate the role of the supervisors in facilitating research ethics in these projects. Specifically, we describe and discuss the supervisor (...) role associated with five approaches to doctoral supervision of qualitative research, namely those described as ‘Functional’, ‘Enculturation’, ‘Critical thinking’, ‘Emancipation’ and ‘Developing a quality relationship’. The main challenges for supervisors of cross-national research projects are the cultural and linguistic mobilisation of ethical principles in qualitative research processes and the management of the future use of open data. The results from this study have implications for planning and conducting cross-national studies within research involving human participants. These results can guide supervisors in the codification and mobilisation of ethical qualitative research in practice. (shrink)

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For quite some time, cognitive science has offered philosophy an opportunity to address central problems with an arsenal of relevant theories and empirical data. However, even among those naturalistically inclined, it has been hard to find a universally accepted way to do so. In this article, we offer a case study of how cognitive-science input can elucidate an epistemological issue that has caused extensive debate. We explore Jason Stanley’s idea of the practical grasp of a propositional truth and present naturalistic (...) arguments against his reductive approach to knowledge. We argue that a plausible interpretation of cognitive-science input concerning knowledge—even if one accepts that knowledge how is partly propositional—must involve an element of knowing how to act correctly upon the proposition; and this element of knowing how to act correctly cannot itself be propositional. (shrink)

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Esta obra congrega a un grupo de reconocidos filósofos alemanes, argentinos, españoles, venezolanos y colombianos, en torno a la figura del Profesor Dr. Guillermo Hoyos Vásquez. Con aportes en los ámbitos de la fenomenología, la filosofía política y la ética se ofrece al lector especializado, pero también al estudiante de filosofía y al lector interesado en la reflexión filosófica, una serie de escritos de primer orden y de máxima actualidad.

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Business ethics education aims to enable students to become conscious of their own values and develop the capacity to voice such values and make value-consistent decisions. However, a student’s personal values and the capacity to act on them tend to change after graduation. In this study, we discuss how moral learning is different in real work life compared to a business school setting, and we explain why graduates may downplay or abandon their values after graduation. We launch the concept of (...) dynamic moral capacity (DMC), defined as the metacognitive routines for processing moral decision outcomes, motivated by humility goals. We suggest that future courses in business ethics develop DMC to avoid value drift and negative moral learning over time after graduation. Finally, we discuss how DMC can be included in the instructional framework of giving voice to values and thus increase its impact on moral learning after graduation. (shrink)

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In the Letter of Humanism, Heidegger reinterprets the Greek notion of ethos as designating the way in which human beings dwell in the world through a “unifying” language. Through various down strokes in the autobiographical and psychopathological literature on schizophrenia as well as in literary texts and literary criticism, this paper, experimental in its effort, argues that the language productions of schizophrenia and poetry, each in its own way, seem to fall outside this unification of a language in common. Furthermore, (...) it argues that this “falling outside” is related to radical experiences of “alienation” and “otherness,” which call for an alteration of conventional language. However, whereas poetry appears to open new linguistic possibilities, schizophrenia runs the risk of reducing language to the silence of incomprehensible “nonsense.” The paper ends with the suggestion that a poetic employment of language may hold a double potential with regard to the understanding and possible treatment of schizophrenia spectrum disorders. (shrink)

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The paper reconstructs the “speculative exposition” of the correlative distinction between being and cognition called for by Fink in Husserl’s intentional analytics on the basis of his discussion of Hegel’s Phenomenology of Spirit. In this context, for Fink the chapter “Force and the Understanding, Appearance and the Supersensible World” is key in the Phenomenology asa whole. There, not only the transition fromobject-consciousness to self-consciousness is accomplished but also the question of the basic structure of thinghood in general is raised: From (...) where does being as such and as a whole make itself appear? The paper traces Fink’s reading step by step, which is guided by a radicalisation of “ontological experience” – ontology as an “Er-fahrung (ex-perience)”, which sounds out itself in view of its presuppositions. “Radicalisation”, according to Fink, is the “transition from operative use to the subject”: the living, performative reference itself moves to the abysmal centre of an “inverted world”, which at the same time can be read as an introduction to Fink’s own thinking of a “cosmological difference”. (shrink)

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This article discusses the notion of justice from a capabilities approach. We undertake an empirical analysis of the concepts of justice held by healthcare personnel, gleaned from a qualitative analysis of interviews on the subject of ethical dilemmas in everyday practice. The article states that Justice undoubtedly presents a work in progress, which implicates the link between justice as capability and human dignity.We empirically found a contrast between the views of justice based on the patient's own perceptions and those based (...) on the perceptions of healthcare personnel. We establish the kind of actions, communication skills and justice required to build a stronger relationship between patients and healthcare professionals, which would improve prognosis, treatment efficiency and therapeutic adhesion. (shrink)

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Editorial for issue 29 of Scandinavian Jewish Studies, 'The Problem of Evil and Images of Humanity'.

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Name der Zeitschrift: Kierkegaard Studies Yearbook Jahrgang: 19 Heft: 1 Seiten: 255-284.

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Name der Zeitschrift: Nietzscheforschung Jahrgang: 24 Heft: 1 Seiten: 193-210.

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