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Analysis of the mechanisms underlying sex determination and sex differentiation in Drosophila has provided evidence for a complex but comprehensible regulatory hierarchy governing these developmental decisions. It is suggested here that the pattern of sexual differentiation and dosage compensation characteristic of the male is a default regulatory state. Recent results have provided, in addition, some surprising and intriguing conclusions: (1) that several of the critical controlling genes produce more transcripts than was predicted from the genetic analyses; (2) that setting of (...) the alternative sex‐specific states of the doublesex (dsx) locus involves differential transcript processing; and (3) that some aspects of sexual differentation require the prolonged action of certain elements of the regulatory hierarchy. These findings are discussed in connection with the current model of sex determination in Drosophila. (shrink)

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Increasingly, epistemologists are becoming interested in social structures and their effect on epistemic enterprises, but little attention has been paid to the proper distribution of experimental results among scientists. This paper will analyze a model first suggested by two economists, which nicely captures one type of learning situation faced by scientists. The results of a computer simulation study of this model provide two interesting conclusions. First, in some contexts, a community of scientists is, as a whole, more reliable when its (...) members are less aware of their colleagues' experimental results. Second, there is a robust tradeoff between the reliability of a community and the speed with which it reaches a correct conclusion. ‡The author would like to thank Brian Skyrms, Kyle Stanford, Jeffrey Barrett,Bruce Glymour, and the participants in the Social Dynamics Seminar at University of California–Irvine for their helpful comments. Generous financial support was provided by the School of Social Science and Institute for Mathematical Behavioral Sciences at UCI. †To contact the author, please write to: Department of Philosophy,Baker Hall 135, Carnegie Mellon University, Pittsburgh, PA 15213-3890; e-mail:[email protected]. (shrink)

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A diagram that places two planets in orbit around the sun was inserted into the textual space of a Timaeus manuscript of the late 11th century as well as three more in the 12th century. The diagram derives from a Carolingian tradition of study of Martianus Capella’s astronomy and shows his continued authority into the twelfth century. By way of Capella and through similarly-inspired commentaries on Macrobius’ Commentary on the Dream of Scipio, the idea of circumsolar motion for Mercury and (...) Venus became a well-known and authoritative theme for William of Conches and other scholars in the eleventh and twelfth centuries wo interpreted Plato in terms of current scientific knowledge. (shrink)

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Background: Nurses, social workers, and medical residents are ethically mandated to engage in policy advocacy to promote the health and well-being of patients and increase access to care. Yet, no instrument exists to measure their level of engagement in policy advocacy. Research objective: To describe the development and validation of the Policy Advocacy Engagement Scale, designed to measure frontline healthcare professionals’ engagement in policy advocacy with respect to a broad range of issues, including patients’ ethical rights, quality of care, culturally (...) competent care, preventive care, affordability/accessibility of care, mental healthcare, and community-based care. Research design: Cross-sectional data were gathered to estimate the content and construct validity, internal consistency, and test–retest reliability of the Policy Advocacy Engagement Scale. Participants and context: In all, 97 nurses, 94 social workers, and 104 medical residents (N = 295) were recruited from eight acute-care hospitals in Los Angeles County. Ethical considerations: Informed consent was obtained via Qualtrics and covered purposes, risks and benefits; voluntary participation; confidentiality; and compensation. Institutional Review Board approval was obtained from the University of Southern California and all hospitals. Findings: Results supported the validity of the concept and the instrument. In confirmatory factor analysis, seven items loaded onto one component with indices indicating adequate model fit. A Pearson correlation coefficient of.36 supported the scale’s test–retest stability. Cronbach’s α of.93 indicated strong internal consistency. Discussion: The Policy Advocacy Engagement Scale demonstrated satisfactory psychometric properties in this initial test. Findings should be considered within the context of the study’s limitations, which include a low response rate and limited geographic scope. Conclusion: The Policy Advocacy Engagement Scale appears to be the first validated scale to measure frontline healthcare professionals’ engagement in policy advocacy. With it, researchers can analyze variations in professionals’ levels of policy advocacy engagement, understand what factors are associated with it, and remedy barriers that might exist to their provision of it. (shrink)

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Characterizing the genetic structure of populations is of importance to evolutionary biology, to human disease gene mapping, and to forensic science. Sewall Wright introduced a set of F-statistics to describe population structure in 1951, and he emphasized that these quantities were ratios of variances. Responding to uncertainty over the best way to estimate F-statistics, Weir and Cockerham published a method-of-moments set of estimators in 1984. This paper continues to be widely cited, with over 7,000 citations to date. Some background to (...) the publishing history of the Weir and Cockerham paper is given here, along with subsequent developments and a discussion of current uses of Wright's F-statistics. (shrink)

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Mass literacy, mass communication, and the Internet have all increased the amount of information available. But false knowledge still abounds. Taking cues from Sir Thomas Browne, the English Renaissance skeptic, this title examines a host of contemporary errors in thinking and offers a powerful explanation of why they occur.

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Creativity is a critical 21st‑century skill, encompassing the ability to generate unique, diverse ideas (divergent thinking) and evaluate them to select optimal ones (convergent thinking). Despite attempts to integrate convergent thinking into creativity frameworks, most research focuses on divergent thinking, and studies assessing their association remain inconclusive. We examined the relationship between performance on two widely used measures of divergent and convergent thinking—the Alternate Uses task and the Remote Associations test—in UK adults. Alternate Uses scores of fluency, originality, elaboration, and (...) a composite score were all positively associated with Remote Associations test scores. We also replicated findings that Alternate Uses scores of fluency, originality, and elaboration were intercorrelated. This study reports a direct positive association between these measures, suggesting individuals who generate numerous unique, detailed ideas are also adept at identifying correct solutions. We discuss the implications and the need to integrate convergent thinking into creativity models. (shrink)

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The brain and body need to adapt constantly to changing social and physical environments. A key mechanism for this adaptation is the ‘stress response’, which is necessary and not negative in and of itself. The term ‘stress’, however, is ambiguous and has acquired negative connotations. We argue that the concept of allostasis can be used instead to describe the mechanisms employed to achieve stability of homeostatic systems through active intervention (adaptive plasticity). In the context of allostasis, resilience denotes the ability (...) of an organism to respond to stressors in the environment by means of the appropriate engagement and efficient termination of allostatic responses. In this review, we discuss the neurobiological and organismal factors that modulate resilience, such as growth factors, chaperone molecules and circadian rhythms, and highlight its consequences for cognition and behavior. (shrink)

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The Many-Worlds Interpretation is a theory in physics which proposes that, rather than quantum-level events being resolved randomly as according to the Copenhagen Interpretation, the universe constantly divides into different versions or worlds. All physically possible worlds occur, though some outcomes are more likely than others, and therefore all possible histories exist. This paper explores some implications of this for history, especially concerning causation. Unlike counterfactuals, which concern different starting conditions, MWI concerns different outcomes of the same starting conditions. It (...) is argued that analysis of causation needs to take into account the divergence of outcomes and the possibility that we inhabit a less probable world. Another implication of MWI is convergent history: for any given world there will be similar worlds which are the result of different pasts which are, however, more or less probable. MWI can assist in thinking about historical causation and indicates the importance of probabilistic causation. (shrink)

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This research project investigated the extent to which nurses engage in two important kinds of ethical behaviours: ethical activism (where they try to make hospitals more receptive to nurses’ participation in ethics deliberations) and ethical assertiveness (where they participate in ethics deliberations even when not formally invited). This research probed not only the extent to which nurses engage in these ethical behaviours but also whether this is influenced by professional, training and organizational factors. A random sample of 165 nurses from (...) three major hospitals in Los Angeles provided the data. Regression analyses indicate that both ethical activism and ethical assertiveness are strongly influenced by nurses’ perceptions of the receptivity of hospitals to their inclusion in ethics deliberations. In addition, nurses’ education in ethics is a significant predictor of ethical activism. The findings have important implications for the content of nurses’ ethics training as well as for expanding the boundaries of nurses’ participation in ethics deliberations. The authors define ethics deliberations as specific meetings of a number of people to discuss an ethical issue, such as one regarding the care of a patient. (shrink)

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What can well-meaning people do about terror and genocide? The more we fight against systems of violence, the further we seem to sink into them. This book explores the lives and letters of ordinary and intellectual Germans who faced the ethical challenges of the Third Reich. Trained in history, literary criticism, philosophy, and theology, its four authors look at the role of myths, lies, non-conformity, irony, and modeling in cultivating a self. They explain how we might use these ordinary strategies (...) of selfhood to bear the burden of historical responsibility and be happy doing so.". (shrink)

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Late in 1990, the Center for the Study of Ethics in the Professions at Illinois Institute of Technology (lIT) received a grant of more than $200,000 from the National Science Foundation to try a campus-wide approach to integrating professional ethics into its technical curriculum.! Enough has now been accomplished to draw some tentative conclusions. I am the grant's principal investigator. In this paper, I shall describe what we at lIT did, what we learned, and what others, especially philosophers, can learn (...) from us. We set out to develop an approach that others could profitably adopt. I believe that we succeeded. (shrink)

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This study investigates financial correlates of corporate philanthropy in Fortune 1000 companies using structural equation modeling. The results suggest that cash flow (one of the most discretionary types of organizational slack) has a significant impact on a firm’s cash donations to charitable causes, but monetary donations do not affect firm financial performance. These findings support the accepted view of corporate philanthropy as a discretionary social responsibility and the traditional thinking about firm giving in the business and society literature—that doing well (...) enables doing good. Contrary to some contemporary thinking, the findings imply no significant effect on profits from corporate generosity. (shrink)

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We identify two aspects of the problem of maintaining perceptual stability despite an observer's eye movements. The first, visual direction constancy, is the (egocentric) stability of apparent positions of objects in the visual world relative to the perceiver. The second, visual position constancy, is the (exocentric) stability of positions of objects relative to each other. We analyze the constancy of visual direction despite saccadic eye movements.Three information sources have been proposed to enable the visual system to achieve stability: the structure (...) of the visual field, proprioceptive inflow, and a copy of neural efference or outflow to the extraocular muscles. None of these sources by itself provides adequate information to achieve visual direction constancy; present evidence indicates that all three are used.Our final question concerns how information processing operations result in a stable world. The three traditionally suggested means have been elimination, translation, or evaluation. All are rejected. From a review of the physiological and psychological evidence we conclude that no subtraction, compensation, or evaluation need take place. The problem for which these solutions were developed turns out to be a false one. We propose a “calibration” solution: correct spatiotopic positions are calculated anew for each fixation. Inflow, outflow, and retinal sources are used in this calculation: saccadic suppression of displacement bridges the errors between these sources and the actual extent of movement. (shrink)

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This collection brings together previously unpublished works by well-known philosophers on the philosophy of action, the metaphysics of causality, and the philosophy of psychology. Nine of the essays directly discuss Donald Davidson's work on these topics, while three others challenge a Davidsonian approach through discussion of independent but related issues. These essays are followed by replies from Davidson, including a previously unpublished essay, "Adverbs of Action.".

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This book is about the mind and its connection to the brain. The first two chapters discuss the basic characteristics of the mind, and places it in historical context by noting trends in popular culture, and various people's ideas about the mind. This discussion ends by concluding that the most fruitful approach to studying the mind is a scientific approach that looks for connections between the mind and the brain. The last four chapters focus on the following specific principles: The (...) operation of the mind is hidden; Prediction is an important function of the mind; and Connectivity and communication between different areas of the mind are crucial for the mind's operation. An important feature of this discussion is that it is supported by empirical research, by briefly describing experiments. This book therefore goes beyond simply presenting conclusions, by elucidating the procedures and reasoning that led to those conclusions. The intent of the book is to give readers a feel for the latest scientific thinking about the mind, by focusing on basic principles that hold across many different functions of the mind. One key to marketing the book is to emphasize the fact that the writing makes a fascinating, but complex, subject accessible to the general reader. (shrink)

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The current paradigm in medicine generally distinguishes between genetic and environmental causes of disease. Although the word paradigm has become a commonplace, the theories of Thomas Kuhn have not received much attention in the journals of medicine. Kuhn's structuralist method differs radically from the daily activities of the scientific method itself. Using linguistic theory, this essay offers a structuralist reading of Thomas Kuhn's The Structure of Scientific Revolutions. Our purpose is to highlight the similarities between these structuralist models of science (...) and language. In part, we focus on the logic that enables Kuhn to assert the priority of perception over interpretation in the history of science. To illustrate some of these issues, we refer to the distinction between environmental and genetic causes of disease. While the activity of scientific research results in the revision of concepts in science, the production of significant differences that shape our knowledge is in part a social and linguistic process. (shrink)

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The brain is an ever‐changing organ that encodes memories and directs behavior. Neuroanatomical studies have revealed structural plasticity of neural architecture, and advances in gene expression technology and epigenetics have demonstrated new mechanisms underlying the brain's dynamic nature. Stressful experiences challenge the plasticity of the brain, and prolonged exposure to environmental stress redefines the normative transcriptional profile of both neurons and glia, and can lead to the onset of mental illness. A more thorough understanding of normal and abnormal gene expression (...) is needed to define the diseased brain and improve current treatments for psychiatric disorders. The efforts to describe gene expression networks have been bolstered by microarray and RNA‐sequencing technologies. The heterogeneity of neural cell populations and their unique microenvironments, coupled with broad ranging interconnectivity, makes resolving this complexity exceedingly challenging and requires the combined efforts of single cell and systems level expression profiling to identify targets for therapeutic intervention. (shrink)

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One of America's foremost philosophers reflects on the discipline and its relation to everyday life.

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[first paragraph]: Robert Forman's theory outlined in `Mysticism, language and the via negativa' reacts against an earlier account of mysticism which he calls constructivism'. Constructivism grew from a book of collected papers, Mysticism and philosophical analysis , contributed to and edited by Steven Katz. According to Forman, `the constructivist approach is, roughly, that of the historian [of ideas]' . But this characterization is much too generous.

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Solidarity corresponds to virtuous social behavior, including personal freedom and responsibility, civic friendship, benevolence, reciprocity, and cooperation. These attributes are fundamentally good for individual persons and communities of work. Solidarity is therefore vitally important to the practice of humanistic management. This paper aims to provide management insights into the cultivation of solidarity. The paper begins by developing a theoretical framework to understand solidarity in business context, with attention to philosophical and theological connotations. An empirical research model is presented in the (...) form of a survey instrument to test for indications of solidarity in the workplace, and this measure is used to test several hypotheses regarding the positive associations of solidarity with validated measures of workplace engagement. Research results show that it is possible to identify and analyze workplace behaviors associated with solidarity. Data analysis confirms the validity of the model and demonstrates the positive associations of the hypotheses, based on empirical study of 40 workplaces and 399 employees. Moreover, the condition of whether the workplace was a public or private organization was found to affect the main relationship between solidarity and workplace engagement. The paper concludes with suggestions for practicable, tangible workplace behaviors based on the model, offering guidance in the pursuit of humanistic management. (shrink)

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By a simple revision of Newton's diagram for Proposition 6 of the third edition of the Principia, one can see directly how the mathematics of uniform circular motion have been employed to solve the Kepler problem of elliptical planetary motion in Proposition 11. Newton strove initially to build his dynamics on the linear kinematics of Galileo; and, in this utilization of uniformly accelerated linear motion to solve more complicated problems, he can be seen as revolutionary. But he could not escape (...) completely from the coils of celestial circularity, and in his utilization of uniform circular motion to solve problems of elliptical motion, he can be seen as reactionary. The key to understanding Newton's mature dynamics resides in the discussion of the alternate dynamics ratio, as presented here in section six. (shrink)

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Kids in the Middle: The Micro-Politics of Special Education takes the reader on a fascinating journey through special education in the past, present, and future. On this journey, the micro-politics of special education are seen through the eyes and experiences of children with disabilities, their parents and advocates, adult educators, and school administrators. Supplementing these perspectives to develop an understanding of special education that goes beyond its administrative and political aspects, such as the Individuals with Disabilities Education Act , are (...) scholars with expertise in special education law, administration, severe and profound disabilities, ethics, finance, teaching, and disability rights. Together, these voices explain the micro-political issues that affect how children with disabilities are educated. Kids in the Middle promotes a new model of special education to help transform special education. Instead of perpetuating a system grounded in the concepts of promises, privilege, and power, this book considers how to build a system based on caring, compassion, and the common good, a system that will elevate the status of special education children who are lost in the middle. (shrink)

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Psychology can be based on plans, internally held images of achievement that organize the stimulus-response links of traditional psychology. The hierarchical structure of plans must be produced, held, assigned priorities, and monitored. Consciousness is the operation of the plan-executing mechanism, enabling behavior to be driven by plans rather than immediate environmental contingencies. The mechanism unpacks a single internally held idea into a series of actions. New in this paper is the proposal that language uses this mechanism for communication, unpacking an (...) idea into a series of articulatory acts. Language comprehension uses the plan-monitoring mechanism to pack a series of linguistic events into an idea. Recursive processing results from monitoring one's own speech. Neurophysiologically, the planning mechanism is identified with higher-order motor control. (shrink)

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Jacob Klapwijk’s book Purpose in the Living World? (Cambridge 2998) is examined with special attention given to the scholarly background from out of which it emerges as a significant contribution to reformational philosophical reflection. As an initial step to clarify some important issues raised by Klapwijk’s critical comments about Dooyeweerd’s “essentialist” concept of species, the article probes facets of the way Jan Lever incorporated reformational philosophical concepts into his biological theory and considers the 1959 review written by Herman Dooyeweerd of (...) Lever’s Creation and Evolution. The analysis focuses specifically upon the social responsibilities of these two scholars and the confrontation of their respective views. With the work of Lever and Dooyeweerd we sense something of the ambiguities when reformational philosophy confronts an evangelical scholasticism. This confrontation is an important facet of the context in which Klapwijk has set forth his discussion of creation and emergent evolution. Purpose is also the fruit of scholarly collaboration across disciplines, providing a welcome stimulus for a deepened understanding of the corporate character of the student vocation. (shrink)

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Karl Popper, in "The Logic of Scientific Discovery" Section *vii, argues that if you find that some objecta a,b, c ... have a specific property P, then this discovery by itself does not increase the probability that some other object also has P. He concludes that there can be no effective principle of induction. My paper disproves Popper's claim, using very elementary considerations..

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Boehm's model conceptualizes a common ancestor to humans, chimpanzees, and bonobos at several million years B.P., followed by a model of prehistoric foragers at 25,000-50,000 B.P. based on ethnographic data from twentieth-century hunters and gatherers. By putting processes of complex communication into the picture, we can refine Boehm's model considerably by filling in significant scenarios for humans beginning at perhaps 2 million years ago. These include a suite of features that include constraints on sexual behaviour, a rudimentary division of labour, (...) the gendering of morality, socialized control over junior males, increased group size, increased home range size, the reduction of bullying behaviour, and a reverse dominance hierarchy that promotes egalitarianism among fully adult males. Boehm's model emphasizes the last two of these, but it is consistent with the others as well. Cultural or proto-cultural elaboration of beliefs and associated practices is the symbolic dimension of morality and is an important component of human evolution. Boehm's model is extremely important for outlining socio-political mechanisms and concomitants in the formation of adult male egalitarian groups, and, in the process, identifying a key element in the evolution of human morality. (shrink)

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Without embracing Reformed Epistemology (advocated by Plantinga and others), I argue against two claims: (1) A person S is epistemically justified in believing that God exists only if S has a good argument for the existence of God. (2) There are no professional philosophers in our culture today who are justified in believing that God exists even though they do not have, and have never had, a good argument for the existence of God. Likely evidentialist objections are discussed at length.

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Recently Terrance McConnell has attempted to show that not only does psychological egoism lend no support to ethical egoism but is even incompatible with it. 1 McConneU's attempt has been vitiated by Paul Simpson's critique of the version of psychological egoism that McConnell offered) In this discussion I will consider McConnell's and Simpson's arguments and then offer a version of psychological egoism that avoids Simpson's objections. After showing that one version of ethical egoism is incompatible with that version of psychological (...) egoism, I will consider other versions of ethical egoism in an attempt to find the best version of that moral doctrine. It will turn out that even the best version of ethical egoism is incompatible with the version of psychological egoism that avoids Simpson's criticisms. However, another version of psychological egoism will be offered that is compatible with all versions of ethical egoism and that is also not open to Simpson's objections. An argument will be offered, and then criticized, that seems to lend support to ethical egoism and that rests, in part, on this other version of psychological egoism. (shrink)

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Ruth Millikan and Alvin Plantinga claim, roughly, that knowledge is true belief produced by processes in circumstances for which they are designed to yield truth. Neither offers the account as a conceptual analysis of knowledge. Instead, for Plantinga it represents the core concept of knowledge characterizing central cases, and for Millikan an empirically warranted theoretical definition of knowledge as a natural phenomenon. Counterexamples are then dismissed as appropriately called "knowledge" only in some analogically extended sense. I argue instead that a (...) definition of knowledge is better thought of, like an account of justice, as an explication, or a decision about what normative constraints to adopt. It reflects trade-offs in intuitive judgements and pragmatic concerns. and perhaps background theories, for the sake of some overall coherence. However the contentious scientific and historical claims that underwritetheir views gives us reason not to accept the design account's norms for knowledge. Further, the controversial character of these claims gives us reason not to rest an interpersonally acceptable account of knowledge on them. (shrink)

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It is tempting, in remembering Jacques Derrida=s death on October 8, 2004, in Paris, to focus on the controversy surrounding the obituaries already written. Derrida was, after all, the theorist of text, and responding to the proliferation of texts at this moment seems almost too enticing to pass up. I can almost hear a playful reversal in the making, a deflection and deferral of both the critical and the fawning accounts of his life. And yet, I can also hear disappointment. (...) He was the one, after all, who spoke against speaking too soon after a death, particularly the death of a friend, in case the academic impulse turned mourning into analysis: What I thought impossible, indecent, and unjustifiable, what long ago and more or less secretly and resolutely I had promised myself never to do (out of a concern for rigor or fidelity, if you will, and because it is in this case too serious) was to write following the death, not after, not long after the death by returning to it, but just following the death, upon or on the occasion of the death, at the commemorative gatherings and tributes, in the writings Ain memory@ of those who while living would have been my friends, still present enough to me that some Adeclaration,@ indeed some analysis or Astudy,@ would seem at that moment completely unbearable.i That many of those friends, and enemies, have spoken, is inevitable and understandable.ii More texts about Derrida=s life, influence, and death are inevitable, especially for a philosopher who was so preoccupied with death in his later years. But even though I never knew him, it seems a bit odd writing about him at this time, in this place. It is as if his death can be used to make points, even if those points are only to establish his relevance within Africana philosophy. (shrink)

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