Ethical considerations for involving adolescents in biomedical HIV prevention research.Andrew Mujugira,Kenneth Ngure,Juliet Allen Babirye,Joel Maena,Joselyne Nansimbe,Simon Afrika Akasiima,Hadijah Kalule Nabunya,Florence Biira,Emmie Mulumba,Maria Janine Nambusi,Stella Nanyonga,Sophie C. Nanziri,Doreen Kemigisha,Teopista Nakyanzi,Juliane Etima,Betty Kamira,Monica Nolan,Clemensia Nakabiito,BrendaGati,Carolyne Akello &Rita Nakalega -2021 -BMC Medical Ethics 22 (1):1-7.detailsBackgroundInvolvement of adolescent girls in biomedical HIV research is essential to better understand efficacy and safety of new prevention interventions in this key population at high risk of HIV infection. However, there are many ethical issues to consider prior to engaging them in pivotal biomedical research. In Uganda, 16–17-year-old adolescents can access sexual and reproductive health services including for HIV or other sexually transmitted infections, contraception, and antenatal care without parental consent. In contrast, participation in HIV prevention research involving investigational (...) new drugs requires adolescents to have parental or guardian consent. Thus, privacy and confidentiality concerns may deter adolescent participation. We describe community perspectives on ethical considerations for involving adolescent girls in the MTN 034 study in Uganda.MethodsFrom August 2017 to March 2018, we held five stakeholder engagement meetings in preparation for the MTN 034 study in Kampala, Uganda (NCT03593655): two with 140 community representatives, two with 125 adolescents, and one with 50 adolescents and parents. Discussions were moderated by the study team. Proceedings were documented by notetakers. Summary notes described community perspectives of adolescent participation in HIV research including convergent, divergent or minority views, challenges, and proposed solutions.ResultsMost community members perceived parental or guardian consent as a principal barrier to study participation due to concerns about adolescent disclosure of pre-marital sex, which is a cultural taboo. Of 125 adolescent participants, 119 (95%) feared inadvertent disclosure of sexual activity to their parents. Community stakeholders identified the following critical considerations for ethical involvement of adolescents in HIV biomedical research: (1) involving key stakeholders in recruitment, (2) ensuring confidentiality of sensitive information about adolescent sexual activity, (3) informing adolescents about information to be disclosed to parents or guardians, (4) offering youth friendly services by appropriately trained staff, and (5) partnering with community youth organizations to maximize recruitment and retention.ConclusionsStakeholder engagement with diverse community representatives prior to conducting adolescent HIV prevention research is critical to collectively shaping the research agenda, successfully recruiting and retaining adolescents in HIV clinical trials and identifying practical strategies to ensure high ethical standards during trial implementation. (shrink)
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The Fragmenting Family.Brenda Almond -2008 - Oxford University Press.detailsBrenda Almond throws down a timely challenge to liberal consensus about personal relationships. She maintains that the traditional family is fragmenting in Western societies, causing serious social problems. She urges that we reconsider our attitudes to sex and reproduction in order to strengthen our most important social institution, the family.
Theorica et practica: historická epistemologie a re-vize lékařství třináctého a čtrnáctého století.Brenda S. Gardenour -2012 -Teorie Vědy / Theory of Science 34 (3):83-110.detailsPositivist medical historians, guided by the savoir of modern western biomedicine, have long depicted medieval medicine as an aberration along the continuum of scientific and medical progress. Historical epistemology, founded in the ideas of Cavailles, Foucault, Davidson, and Hacking, however, allows the historian to disrupt this false continuum and to unchain medieval medicine from modern medicine. Postmodernist approaches, such as those sourced in Lyotard, Barthes, and Derrida, allow the historian to further deconstruct medieval and modern medical discourse, revealing a multitude (...) of narrative lenses spinning around biomedical and biocultural strands. In liberating these two medical systems and setting them within the distinct historical and epistemological contexts that both shaped and were shaped by them, the historian can revision the theories, practices, and culture of medieval medicine without having to anachronistically justify them according to modern medical discourse. (shrink)
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Bradley on Disagreements and Diversities In Philosophy.Brenda Jubin -1977 -Idealistic Studies 7 (3):221-238.details§ 1. Apparent philosophical disagreement: a philosophical problem. Philosophers are frequently criticized for their remarkable inability to reach consensus. “‘The same problems,’ we hear it often, ‘the same disputes, the same sheer failure. Why not abandon it and come out? Is there nothing else more worth your labour?’”. In science there are established results and generally accepted theories. Philosophy, by contrast, seems to breed only disagreement and controversy. Unless philosophers are simply a peculiarly argumentative lot, we are told, the fact (...) that philosophy is marked by widespread disagreement must indicate something about the nature of the philosophical enterprise. And the usual conclusion is that either it is intrinsically flawed or it is not as it has appeared to be, a search for truth. (shrink)
The Making of a Pan(en)demic.Brenda Seals &Greg Seals -2021 -Philosophy of Education 77 (2):118-136.detailsThis comparative case analysis contrasts two nations – Viet Nam and The United States of America (U.S.) – in terms of processes each employed and results each achieved in respective response to the COVID-19 pandemic. We use a general theory of teaching to contrast the countries in terms of their approaches to COVID public health education. Viet Nam followed the recommendations of the theory. The U.S. did not. While our analysis does not and cannot prove educational theory acted as the (...) sole causal factor in realization of the disparate results in the countries, our case study does illustrate that the different approaches to public health education used by the countries may be counted among factors contributing to wide differences in the contrasting cases. The argument proceeds by 1) describing differences in relevant statistics between Viet Nam and the U.S., 2) outlining the theory of teaching we use to analyze differences in public health education in the two contexts, and 3) discussing successful implementation of the theory in Viet Nam and failure to implement in the U.S. Finally, we 4) dismiss competing explanations of differences between the countries and 5) offer considerations about how the U.S. may educate citizens away from turning the pandemic into a pan(en)demic. (shrink)
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Improving our Practice of Sentencing:Brenda M. Baker.Brenda M. Baker -1997 -Utilitas 9 (1):99-114.detailsRestorative justice should have greater weight as a criterion in criminal justice sentencing practice. It permits a realistic recognition of the kinds of harm and damage caused by offences, and encourages individualized non-custodial sentencing options as ways of addressing these harms. Non-custodial sentences have proven more effective than incarceration in securing social reconciliation and preventing recidivism, and they avoid the serious social and personal costs of imprisonment. This paper argues in support of restorative justice as a guiding idea in sentencing. (...) As part of this defence, it considers whether the use of the idea of restorative justice will conflate criminal law with civil law or displace the authority of the criminal courts, and whether the sentences it recommends are best thought of as punishments or alternatives to punishment. (shrink)
The Handbook of Cognitive Neuropsychology: What Deficits Reveal About the Human Mind.Brenda Rapp (ed.) -2001 - Psychology Press/Taylor & Francis.detailsIndeed, data from impaired performance have often played a central role in our understanding of the skills and abilities of the human mind/brain This volume ...
Money Talks: In Therapy, Society, and Life.Brenda Berger &Stephanie Newman (eds.) -2011 - Routledge.detailsSometimes referred to as "the last taboo," money has remained something of a secret within psychoanalysis. Ironically, while it is an ingredient in almost every encounter between analyst and patient, the analyst's personal feelings about money are rarely discussed openly or in any great depth. So what is it about money that relegates it to the background, both on the couch and off? In _Money Talks_,Brenda Berger, Stephanie Newman, and their excellent cast of contributors address this and other (...) questions surrounding the tender topic of money, how we talk about it, and how it talks to us. Its multiple meanings are explored in the contexts of patients and analysts and the ways in which they relate, in the training and practice of the analysts themselves, as well as the psychological and cultural consequences of having too much or too little in both flush and tight economic times. Throughout, a clinical sensibility is brought to bear on money's softly spoken place in therapy and life. _Money Talks_ paves the way for an open discourse into the psychology of money and its pervasive influence on the psyche of both patient and analyst. (shrink)
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Character-Infused Ethical Decision Making.Brenda Nguyen &Mary Crossan -2022 -Journal of Business Ethics 178 (1):171-191.detailsDespite a growing body of research by management scholars to understand and explain failures in ethical decision making (EDM), misconduct prevails. Scholars have identified character, founded in virtue ethics, as an important perspective that can help to address the gap in organizational misconduct. While character has been offered as a valid perspective in EDM, current theorizing on how it applies to EDM has not been well developed. We thus integrate character, founded in virtue ethics, into Rest’s (1986) EDM model to (...) reveal how shifting attention to the nature of the moral agent provides critical insights into decision making more broadly and EDM specifically. Virtue ethics provides a perspective on EDM that acknowledges and anticipates uncertainties, considers its contextual constraints, and contemplates the development of the moral agent. We thus answer the call by many scholars to integrate character in EDM in order to advance the understanding of the field and suggest propositions for how to move forward. We conclude with implications of a character-infused approach to EDM for future research. (shrink)
The Legitimate corporation: essential readings in business ethics and corporate governance.Brenda Sutton (ed.) -1993 - Cambridge: Blackwell Business.detailsThis is an important collection of works, from an international team of authors, on corporate power and its justification and authority. It highlights the growing importance of corporate governance issues, an area which now has unprecedented coverage by the media in the commercial sector and is increasingly important in business schools.
The defense of atheism.Brenda Watson -2014 -Think 13 (37):19-22.detailsReginald Williams in (Think Autumn 2011) argued that the psychological need offers for endorsing atheism over theism. My article outlines six objections to his thesis, questioning how empirically verifiable the evidence he adduces is, and pointing out various logical fallacies such as illicit use of generalizations and begging the question. It concludes that atheism needs defending on stronger grounds.
Bioethics and the use of social media for medical crowdfunding.Brenda Zanele Kubheka -2020 -BMC Medical Ethics 21 (1):1-5.detailsBackgroundSocial media has globalised compassion enabling requests for donations to spread beyond geographical boundaries. The use of social media for medical crowdfunding links people with unmet healthcare needs to charitable donors. There is no doubt that fundraising campaigns using such platforms facilitates access to financial resources to the benefit of patients and their caregivers.Main textThis paper reports on a critical review of the published literature and information from other online resources discussing medical crowdfunding and the related ethical questions. The review (...) highlighted the benefits of crowdfunding as well as the under-exploration of the risk of having patients’ desires and human rights undermined during online fundraising campaigns. Majority of these campaigns get initiated on behalf of the patients, especially the very sick and dependant. The ethical questions raised relate to the voluntariness of informed consent and the possibility of patients being used as a means to an end. Vulnerability of patients may expose them to coercion, undue influence, manipulation, and violation of their human rights. The success of these campaigns is influenced by the digital skills, pre-existing social networks and, the emotional potency. Healthcare is a public good, and online market forces should not determine access to essential health services. The benefits of crowdfunding cannot be subverted, but it can perpetuate unintended injustices, especially those arising from socio-economic factors.ConclusionsPolicymakers ought to monitor the utilisation of crowdfunding sites to identify policy failures and unmet essential health care needs responsible for driving individuals to use these platforms. The upholding of human rights and the fundamental respect of the individual’s wishes is a moral imperative. The need for an ethics framework to guide different stakeholders during medical crowdfunding needs further examination. (shrink)
Interest Groups and Pro-Animal Rights Legislation.Brenda J. Lutz &James M. Lutz -2011 -Society and Animals 19 (3):261-277.detailsThe American states have demonstrated varying levels of support for animal rights legislation. The activities of interest groups, including pressures from competing groups, help to explain the presence or absence of ten pro-animal regulations and laws. This article analyzes and ranks each of the fifty states with regard to ten key areas of animal protection and welfare legislation. The analysis reveals that states with a more agricultural economic base are less likely to provide protection to animals. In addition, states with (...) a more traditional political culture are less likely to have pro-animal legislation in place. (shrink)
Informed consent in paediatric critical care research – a South African perspective.Brenda M. Morrow,Andrew C. Argent &Sharon Kling -2015 -BMC Medical Ethics 16 (1):62.detailsMedical care of critically ill and injured infants and children globally should be based on best research evidence to ensure safe, efficacious treatment. In South Africa and other low and middle-income countries, research is needed to optimise care and ensure rational, equitable allocation of scare paediatric critical care resources.
Dismantling our own foundations: A German perspective on contemporary philosophy of education.Brenda Almond -1992 -Journal of Philosophy of Education 26 (2):265–269.detailsBrenda Almond; Dismantling Our Own Foundations: a German perspective on contemporary philosophy of education, Journal of Philosophy of Education, Volume 26, Iss.
IV*—Principles and Situations: The Liberal Dilemma and Moral Education.Brenda Cohen -1976 -Proceedings of the Aristotelian Society 76 (1):75-88.detailsBrenda Cohen; IV*—Principles and Situations: The Liberal Dilemma and Moral Education, Proceedings of the Aristotelian Society, Volume 76, Issue 1, 1 June 1976.
Effect of ethnicity, gender and drug use history on achieving high rates of affirmative informed consent for genetics research: impact of sharing with a national repository.Brenda Ray,Colin Jackson,Elizabeth Ducat,Ann Ho,Sara Hamon &Mary Jeanne Kreek -2011 -Journal of Medical Ethics 37 (6):374-379.detailsAim Genetic research representative of the population is crucial to understanding the underlying causes of many diseases. In a prospective evaluation of informed consent we assessed the willingness of individuals of different ethnicities, gender and drug dependence history to participate in genetic studies in which their genetic sample could be shared with a repository at the National Institutes of Health. Methods Potential subjects were recruited from the general population through the use of flyers and referrals from previous participants and clinicians (...) with knowledge of our study. They could consent to 11 separate choices so that they could specify how and with whom their genetic sample could be shared. Rates of affirmative consent were then analysed by gender, ethnicity and drug dependence history. Results Of 1416 volunteers enrolled, 99.7% gave affirmative informed consent for studies of addiction conducted in our laboratory. No significant difference was found for participation in genetic studies conducted in our laboratory by gender, ethnicity or drug dependence history. Over all 11 questions, individuals with a history of drug use were more likely to agree to consent to participate in our study than were healthy volunteers. Conclusion A high percentage of each category of gender, ethnicity and drug history, gave affirmative consent at all levels. The level of detail in and the amount of time spent reviewing the informed consent, and a relationship of trust with the clinical investigator may contribute to this outcome. (shrink)
On the Foundation of the Actian Games.Brenda M. Tidman -1950 -Classical Quarterly 44 (3-4):123-.detailsIt has usually been assumed that the Actian Games at Nicopolis were founded in 28 B.C. . In Mélanges d'Arch. et d'Hist., 1936, pp. 94 ff., J. Gagé argues also for 28 B.C., his principal grounds being as follows: ‘Comme Auguste leur conféra en même temps le rang isolympique et que le calcul du temps par Actiades fut admis çá et lá á remplacer celui des Olympiades, il est logique de penser que ces deux computs coïncidaient. Or, la première célébration (...) olympique après Actium est celle de l'an 28 av. J-C.; c'est done presque sûrement en 28 que commence en fait la première Actiade.’. (shrink)
What have tissue culture studies told us about the development of oligodendrocytes?Brenda P. Williams &Jack Price -1992 -Bioessays 14 (10):693-698.detailsOne major success of studying neural cell development in tissue culture has been the discovery of the O‐2A cell. This bipotential cell generates oligodendrocytes or, under certain conditions, a type of astrocyte. This essay considers the evidence that the characteristic properties demonstrated by the O‐2A cells in vitro are an accurate reflection of oligodendrocyte development in vivo.
Untangling fear and eudaimonia in the healthcare provider-patient relationship.Brenda Bogaert -2020 -Medicine, Health Care and Philosophy 23 (3):457-469.detailsEnsuring patient participation in healthcare decision making remains a difficult task. Factors such as a lack of time in the consultation, medical objectivation, or the difficulties of translating individual patient experience into the treatment plan have been shown to limit patient contributions. Little research attention has focused however on how emotions experienced by both the patient and the healthcare provider may affect the ability of the patient to participate. In this research, patient’s and healthcare provider’s emotions were identified and analysed. (...) The research method showed fear as a prominent emotion experienced. This included patient’s fears both inside and outside the consultation, as well as the healthcare provider’s fears in their professional practice. Using Martha Nussbaum’s cognitive-evaluative theory of emotions as an additional means of analysis, the research looked at what this emotion could show about the importance of the object of this fear to the person’s eudaimonia (flourishing). At the end of the article, several solutions were proposed to help mitigate this fear to keep it from becoming a destructive force in the healthcare provider—patient relationship. (shrink)
Equality, freedom and independent schools.Brenda Cohen -1978 -Journal of Philosophy of Education 12 (1):121–128.detailsBrenda Cohen; Equality, Freedom and Independent Schools, Journal of Philosophy of Education, Volume 12, Issue 1, 30 May 2006, Pages 121–128, https://doi.org/10.
The Second Somatic Revolution1.Brenda Farnell &Charles R. Varela -2008 -Journal for the Theory of Social Behaviour 38 (3):215-240.detailsThis paper proposes a dynamic theory of embodiment that aims to get beyond the absent moving body in embodied social theory. The first somatic revolution, inspired by Merleau Ponty, provided theories based on the feeling and experience of the body. The theory of dynamic embodiment focuses instead on the doing itself as embodied social action, in which the embodied person is fore-grounded as a complex resource for meaning making. This represents a theoretical enrichment of the earlier turn to the body (...) in social theory, which tended to separate the semiotic, as necessarily representational and/or linguistic, from the somatic as a wide range of corporeal processes and practices assumed to be separated from mind, language and/or conscious thought. We argue that overcoming this persistent Cartesianism requires a New Realist approach to the proper location of human agency as a causal power, one that promotes a bio-psycho-social concept of personhood. Part one of the paper presents a general framework for this perspective, while part two applies this paradigm ethnographically to illustrate how bringing semiosis and somatics together requires a robust conception of multi-sensory modalities. (shrink)