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Results for 'Bijoy Prasad Das'

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  1.  13
    Aurobindo's philosophy of nationalism: a review in the 21st century.BijoyPrasad Das (ed.) -2017 - [Kolkata]: Avenel Press in association with Durgapur Women's College.
    Contributed articles presented at the National Seminar on Aurobindo's Philosophy of Nationalism--a Review in the 21st Century on 15th and 16th September, 2016 at Durgapur, India sponsored by UGC.
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  2.  24
    Valuing 'Self' in the Corporate Sector.GaneshPrasad Das -2001 -Journal of Human Values 7 (2):159-169.
    This paper deals with issues related to character building and human values, both in personal and work life. The focus of the author is value-centred management, which has been discussed along two aspects of the human self, that is, the micro self and macro self. Here, the author tries to highlight the importance of both 'selves' in the organizational context. In the concluding part of the paper the author presents the authenticity of Kautilya's views on the macro self in the (...) context of the present business scenario. The author attempts to portray the transition created by the market economy, which cannot provide an exclusively painless solution. Moreover, he advocates culturing of self-discipline in corporate life, which can bring about qualitative improvement, both in work and personal life. 'Work with integrity and serve with love' is the philosophy the author presents in this paper. (shrink)
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  3. Cloning Humans: Philosophical Dimensions.GaneshPrasad Das -2007 - In Manjulika Ghosh,Musings on philosophy: perennial and modern. New Delhi: Sundeep Prakashan.
     
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  4. Value Education must be Ingrained.GaneshPrasad Das -2002 - In P. George Victor,Social relevance of philosophy: essays on applied philosophy. New Delhi: D.K. Printworld. pp. 31.
     
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  5.  45
    The Jaina philosophy of non-absolutism: a critical study of Anekāntavāda.Satkari Mookerjee -1978 - Delhi: Motilal Banarsidass.
    These are the Mahavira Extension Lectures 12 (2nd Series), delivered by Dr. Mookerjee, under the patronage of Sri SantiPrasad Jain, Jainism reveals an ideology entirely different from the Vedic. The study of Jainism in its earlier aspects suggests some kind of animistic philosophy of the people,and especially its literature, having been written in Prakrit, shows a definitive trend towards a sort of folk-philosophy interested in overstraining the moral aspects without any theistic bias. This folk-philosophy reveals elements developed into (...) logical doctrines remarkable for their originality, acuteness and subtlety. Dr. Mookerjee lays bare the fundamentals of the Jaina doctrine, Syadvada of Anekantavada, with all the relevant problems to the benefit of the reader. With a rich background in other darsanas both East and West the author has endeavoured to give a thorough and powerful exposition of Jaina Thought, which could be done only by an adherent of Jaina faith. (shrink)
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  6.  30
    Prudence, Identity, and Value.Ramon Das -2003 - In Heather Dyke,Time and Ethics: Essays at the Intersection. Kluwer Academic Publishers. pp. 27--39.
  7.  51
    Advaita Epistemology and Metaphysics: An Outline of Indian Non-Realism (review). [REVIEW]Sukharanjan Saha -2004 -Philosophy East and West 54 (2):264-268.
    In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Advaita Epistemology and Metaphysics: An Outline of Indian Non-RealismS. R. SahaAdvaita Epistemology and Metaphysics: An Outline of Indian Non-Realism. By Chakravarthi Ram-Prasad. London: RoutledgeCurzon, 2002. Pp. xii + 274. Hardcover $75.00.Chakrabarthi Ram-Prasad deserves praise for Advaita Epistemology and Metaphysics: An Outline of Indian Non-Realism, a book on the core area of Advaita Vedānta philosophy, written in an analytical and comparative style, choosing contemporary Western philosophy as (...) his canvas. George Thibaut's translations of Vedānta commentaries were supplemented by the writings of Sarvepalli Radhakrishnan and others, who followed the style of history of philosophy in their works. But the brand of Western philosophy that served as the background for them was perhaps limited to Hegelian and Neo-Hegelian philosophy. Many later philosophers, notably Krish-nachandra Bhattacharya, Rashbihary Das, G. R. Malkani, T.R.V. Murti, and T.M.P. Mahadevan, followed an interpretive style in their writings on Vedānta, mostly confining themselves to systems of Indian philosophy. After India achieved independence, a new era began for analytical research in Indian philosophy, led by Daniel Ingalls, J. N. Mohanty, Bimal Krishna Matilal, and Arindam Chakrabarti, although their work is mostly confined to Nyāya, Buddhism, and Vedānta. Following their model many others in India and abroad have been doing important work mainly in the areas of Nyāya and Buddhism but rarely in Vedānta. The credit goes to Chakra-barthi Ram-Prasad to have been able to produce a full-length book on Advaita Vedānta written in a thoroughly analytical style that transcends geographical barriers in philosophy.The book contains an Introduction and four sections. In the Introduction we get an idea of the project Ram-Prasad has undertaken. By "Advaita" he means the philosophy that Ś an.kara argues for in his commentaries on various Upaniṣads and on Bādarāyaṇa's Vedāntasūtras. It is not Ram-Prasad's aim to give an exposition of this philosophy in the style of historicist-philological exegesis, but rather to give an innovative reconstruction of Advaita on the basis of the views of three philosophers of the school interpreted in the light of the views of prominent philosophers of the West, although the book is firmly anchored in the Indian tradition. A distinction is made in Advaita between soteriology and philosophy. The Upaniṣads declare that brahman is the ultimate reality. Brahman is, however, identical with ātman, and ātman is again identical with ji¯va. That there is a self cannot be denied, for one who denies is the self itself. This self is undeniable because it is reflexive in nature. Self, understood in this sense, is identical with brahman. ji¯va, which is conceived as suffering consciousness, is only a particular exemplification of this brahman-ātman. Every ji¯va is thus individuated ātman. The goal of liberation for an individual is nothing other than the attainment of the de-individuated state. Not only ji¯va but also the [End Page 264] world, according to Advaita, is ultimately brahman, although the world is independent of ji¯va and its cognitional states. The de-individuation of ji¯va and the reducibility of the world to brahman do not get ready acceptance in human consciousness. On the matter of such a realization, s´ravaṇa or teachings from the texts stand in need of aid from manana or philosophical reflection. Ram-Prasad has argued for a philosophy of Advaita that is not incompatible with its soteriological goal, although his interest in developing this philosophy is autonomous in character.Ram-Prasad calls the brand of philosophy that he develops in this book "non-realism." It holds that the object of experience is not what it appears to be. The object appears in experience as an "other" to cognition. According to realism, the object is really so and is elementary to reality. But according to anti-realism the object is not elementary and is reducible to cognition and hence is only a construct. Advaita metaphysics is neither realistic nor anti-realistic. Ram-Prasad argues for this philosophical position on the basis of his interpretation of some leading philosophers of... (shrink)
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  8. 100 F. Merrell knowing full well that talk, well, it's just talk. In the United States, talk is more often than in Brazil meant to be taken quite seriously, and customary naivete waxes indignantly outraged when it is paid little heed; yet talk invariably becomes cloudy, for, after all, if it were perfectly.A. Assinatura das Coisas -1996 -Semiotica 108 (1/2):99-127.
     
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  9.  14
    Justification Of Rules In Quantification Logic.K. Das -2001 -Indian Philosophical Quarterly 28 (2):119-138.
  10.  10
    Textures of the ordinary: doing anthropology after Wittgenstein.Veena Das -2020 - New York: Fordham University Press.
    Textures of the Ordinary shows how anthropology finds a companionship with philosophy in the exploration of everyday life. Based on two decades of ethnographic work among low-income urban families in India, Das shows how the notion of texture aligns ethnography with the anthropological tone in Wittgenstein and Cavell, as well as in literary texts. The book shows different routes of return to the everyday as it is corroded not only by catastrophic events but also by repetitive and routine violence within (...) everyday life itself. As an alternative to normative ethics, this book develops ordinary ethics as attentiveness to the other and as the ability of small acts of care to stand up to horrific violence. Textures of the Ordinary offers a model of thinking in which concepts and experience are shown to be mutually vulnerable. The book is an intellectually intimate invitation into the ordinary, that which is most simple yet most difficult to perceive in our lives. (shrink)
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  11.  30
    Actual and Possible Worlds: An Intuitionistic Approach.Kantilal Das -1998 -Indian Philosophical Quarterly 25 (1):133-150.
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  12. Ātma darśana.Lakshmidhar Das -1962
     
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  13. (1 other version)A handbook to Kant's Critique of pure reason.Rashvihari Das -1949 - Bombay,: Hind Kitabs.
     
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  14.  13
    Buddha evaṃ Bauddha śāsana.Sanjib Kumar Das -2022 - Delhi: Buddhist World Press.
    On Buddhism, and on the life and philosophy of Gautama Buddha; includes contributed articles.
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  15. (1 other version)Christian ethics and Indian ethos.Somen Das -1989 - Delhi: Published by the Indian Society for Promoting Christian Knowledge for the Bishop's College, Calcutta.
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  16. Hare on Moral Universalizability: A Critical Survey.K. Das -2001 -Indian Philosophical Quarterly 28 (3):297-314.
     
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  17.  4
    Introduction to Shankara.Rashvihari Das -1968 - Calcutta,: Firma K. L. Mukhopadhyay. Edited by Śaṅkarācārya.
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  18. Negative Fact, Negation and Truth.Adhar Chandra Das -1944 -Philosophical Review 53:603.
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  19.  102
    Similarities in Eastern and Western Philosophy.A. C. Das -1952 -Review of Metaphysics 5 (4):631 - 638.
    We are told that some of the most important points discussed at the recent conference of East-West philosophers were the following.
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  20. The Metaphysical Basis of Environmental Ethics: A Spinozistic Approach.K. L. Das -2006 -Indian Philosophical Quarterly 33 (3/4):263.
     
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  21. The Ritual Kinship and the Traditional Political System of the Ao Nagas'.N. K. Das -1983 -Social Research: An International Quarterly 1:40-44.
     
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  22.  2
    The self and the ideal.Rashvihari Das -1935 - [Calcutta]: Calcutta university press.
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  23. Udayana Ācārya's The Flower-Offering of Reason.Nilanjan Das -2020 - In Malcolm Keating,Controversial Reasoning in Indian Philosophy: Major Texts and Arguments on Arthâpatti. London: Bloomsbury Academic Publishing.
     
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  24.  27
    The Political Theology of Kierkegaard.Saitya Brata Das -2020 - Edinburgh University Press.
    Saitya Brata Das argues that in Kierkegaard's work we find a radical eschatological critique, not only of the liberal-humanist pathos of modernity but also the political theology of Carl Schmitt, that seeks to legitimise the sovereign power of the state by an appeal to a divine or theological foundation. Relating Kierkegaard's notion of 'Christianity without Christendom' to the Schellingian eschatological critique of sovereignty, he shows how Schelling's insistence on the eschatological difference between religion and politics is transformed and further intensified (...) in Kierkegaard's critique of historical reason. Such an exception without sovereignty, Das argues, is the very task of our contemporary time. (shrink)
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  25.  99
    Managing Ethically Cultural Diversity: Learning from Thomas Aquinas.João César das Neves &Domènec Melé -2013 -Journal of Business Ethics 116 (4):769-780.
    Cultural diversity is an inescapable reality and a concern in many businesses where it can often raise ethical questions and dilemmas. This paper aims to offer suggestions to certain problems facing managers in dealing with cultural diversity through the inspiration of Thomas Aquinas. Although he may be perceived as a voice from the distant past, we can still find in his writings helpful and original ideas and criteria. He welcomes cultural differences as a part of the perfection of the universe. (...) His systemic approach leads one to place the problem in its proper context, and to reflect on it from the perspective of virtue ethics, with a central role for practical wisdom and giving primacy to neighborly love and natural moral law. Rather than a set of rigid standards with no consideration of diversity Aquinas focuses on the common human ground, which allows for the indispensable dialogue between different positions. When dealing with practical questions, the problem is one of finding the right balance between general principle and cultural specifics, tolerance, and dialogue, always guided by practical wisdom. In this way, Aquinas’ approach is neither rigid ethical universalism with no consideration for diversity nor moral relativism with no place for any transcultural and absolute morals. (shrink)
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  26.  428
    Externalism and exploitability.Nilanjan Das -2020 -Philosophy and Phenomenological Research 104 (1):101-128.
    According to Bayesian orthodoxy, an agent should update---or at least should plan to update---her credences by conditionalization. Some have defended this claim by means of a diachronic Dutch book argument. They say: an agent who does not plan to update her credences by conditionalization is vulnerable (by her own lights) to a diachronic Dutch book, i.e., a sequence of bets which, when accepted, guarantee loss of utility. Here, I show that this argument is in tension with evidence externalism, i.e., the (...) view that an agent's evidence can entail non-trivial propositions about the external world. I argue that this tension casts doubt on the idea that diachronic Dutch books can be used to justify or vindicate updating plans. (shrink)
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  27.  25
    Paketisierung~ PAD.Pl Bezeichnung fUr das Kommunikationsprotokoll -1990 -Idee 10:3.
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  28.  84
    How Strong are the Ethical Preferences of Senior Business Executives?T. K. Das -2005 -Journal of Business Ethics 56 (1):69-80.
    How do senior business executives rank their preferences for various ethical principles? And how strongly do the executives believe in these principles? Also, how do these preference rankings relate to the way the executives see the future (wherein business decisions play out)? Research on these questions may provide us with an appreciation of the complexities of ethical behavior in management beyond the traditional issues concerning ethical decision-making in business. Based on a survey of 585 vice presidents of U.S. businesses it (...) was found that: (1) there is a distinct set of principles of ethical conduct that is considered favorable as opposed to another set considered unfavorable among a comprehensive list of 14 ethical principles; (2) the executives believed overwhelmingly that their own individual ethical preferences are better than those of other executives; (3) the strength of their preferences for ethical principles is associated with whether the executives are relatively near-future oriented or more distant-future oriented; and (4), there are very few significant differences in terms of gender, age, education level, private/public education, prestigious/other schools, business/non-business academic backgrounds, and length of job experience. Implications of these findings are discussed. (shrink)
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  29.  287
    Evolutionary debunking of morality: epistemological or metaphysical?Ramon Das -2016 -Philosophical Studies 173 (2):417-435.
    It is widely supposed that evolutionary debunking arguments against morality constitute a type of epistemological objection to our moral beliefs. In particular, the debunking force of such arguments is not supposed to depend on the metaphysical claim that moral facts do not exist. In this paper I argue that this standard epistemological construal of EDAs is highly misleading, if not mistaken. Specifically, I argue that the most widely discussed EDAs all make key and controversial metaphysical claims about the nature of (...) morality or the possibility of moral truth that belie their apparently epistemological character. I show that the debunking force of these EDAs derives largely from metaphysical claims about morality and their implications for the possibility of moral reduction, rather than from epistemological worries associated with the existence of an causal/non-moral explanation of our moral judgments. The paper briefly concludes with a dilemma that I believe confronts all EDAs such as those discussed in this paper: either such arguments are unsound, or else they prove too much, debunking our knowledge of science and the external world, as well as morality. (shrink)
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  30.  170
    Bad News for Moral Error Theorists: There Is No Master Argument Against Companions in Guilt Strategies.Ramon Das -2017 -Australasian Journal of Philosophy 95 (1):58-69.
    A ‘companions in guilt’ strategy against moral error theory aims to show that the latter proves too much: if sound, it supports an implausible error-theoretic conclusion in other areas such as epistemic or practical reasoning. Christopher Cowie [2016 Cowie, C. 2016. Good News for Moral Error Theorists: A Master Argument Against Companions in Guilt Strategies, Australasian Journal of Philosophy 94/1: 115–30.[Taylor & Francis Online], [Web of Science ®] [Google Scholar]] has recently produced what he claims is a ‘master argument’ against (...) all such strategies. The essence of his argument is that CG arguments cannot work because they are afflicted by internal incoherence or inconsistency. I argue, first, that Cowie's master argument does not succeed. Beyond this, I argue that there is no good reason to think that any such argument—one that purports to identify an internal incoherence in CG arguments—can succeed. Second, I argue that the main substantive area of disagreement between error theorists and CG theorists essentially concerns the conceptual profile of epistemic reasons—specifically, whether they are strongly categorical—not the ontological question of whether such reasons exist. I then develop an argument in favour of the CG theorist's position by considering the moral error theorist's arguments in support of the conceptual claim that moral reasons are strongly categorical. These include, notably, criticisms made by Joyce [2011] and Olson [2014] of Finlay's [2008] ‘end relational’ view of morality, according to which moral reasons are relative to some end or standard, hence not strongly categorical. Examining these criticisms, I argue that, based on what moral error theorists have said regarding the conceptual profile of moral reasons, there is a strong case to be made that moral reasons are strongly categorical if and only if epistemic reasons are. (shrink)
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  31.  205
    Accuracy and ur-prior conditionalization.Nilanjan Das -2019 -Review of Symbolic Logic 12 (1):62-96.
    Recently, several epistemologists have defended an attractive principle of epistemic rationality, which we shall call Ur-Prior Conditionalization. In this essay, I ask whether we can justify this principle by appealing to the epistemic goal of accuracy. I argue that any such accuracy-based argument will be in tension with Evidence Externalism, i.e., the view that agent's evidence may entail non-trivial propositions about the external world. This is because any such argument will crucially require the assumption that, independently of all empirical evidence, (...) it is rational for an agent to be certain that her evidence will always include truths, and that she will always have perfect introspective access to her own evidence. This assumption is in tension with Evidence Externalism. I go on to suggest that even if we don't accept Evidence Externalism, the prospects for any accuracy-based justification for Ur-Prior Conditionalization are bleak. (shrink)
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  32. Raghunātha on Arthâpatti.Nilanjan Das -2020 - In Malcolm Keating,Controversial Reasoning in Indian Philosophy: Major Texts and Arguments on Arthâpatti. London: Bloomsbury Academic Publishing.
     
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  33.  22
    An ethical analysis of clinical triage protocols and decision-making frameworks: what do the principles of justice, freedom, and a disability rights approach demand of us?Sunit Das,Chloë G. K. Atkins,Liam G. McCoy,Connor T. A. Brenna &Jane Zhu -2022 -BMC Medical Ethics 23 (1):1-9.
    BackgroundThe expectation of pandemic-induced severe resource shortages has prompted authorities to draft and update frameworks to guide clinical decision-making and patient triage. While these documents differ in scope, they share a utilitarian focus on the maximization of benefit. This utilitarian view necessarily marginalizes certain groups, in particular individuals with increased medical needs.Main bodyHere, we posit that engagement with the disability critique demands that we broaden our understandings of justice and fairness in clinical decision-making and patient triage. We propose the capabilities (...) theory, which recognizes that justice requires a range of positive capabilities/freedoms conducive to the achievement of meaningful life goals, as a means to do so. Informed by a disability rights critique of the clinical response to the pandemic, we offer direction for the construction of future clinical triage protocols which will avoid ableist biases by incorporating a broader apprehension of what it means to be human.ConclusionThe clinical pandemic response, codified across triage protocols, should embrace a form of justice which incorporates a vision of pluralistic human capabilities and a valuing of positive freedoms. (shrink)
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  34.  62
    The Boundaries of the “We:” Cruelty, Responsibility and Forms of Life.Veena Das -2016 -Critical Horizons 17 (2):168-185.
    This paper establishes a dialogue between the later works of Wittgenstein, those of Cavell and the novels of J. M. Coetzee concerning the problem of violence, authority and the authoritative voice. By drawing on J. M. Coetzee's Waiting for the Barbarians and Diary of a Bad Year, the paper discusses lessons and insights on the nature of violence and the ways in which it can be accepted as “normal.” The term “normalization” is used in order to show how violence and (...) cruelty can become a “form of life” that develops according to its own actors, cultural practices and legitimacies. (shrink)
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  35.  146
    Factors Impacting Ethical Behavior in Hospitals.Satish P. Deshpande,Jacob Joseph &RashmiPrasad -2006 -Journal of Business Ethics 69 (2):207-216.
    This study examines factors impacting ethical behavior of 203 hospital employees in Midwestern and Northwestern United States. Ethical behavior of peers had the most significant impact on ethical behavior. Ethical behavior of successful managers, professional education in ethics and sex of the respondents also significantly impacted ethical behavior. Nurses were significantly more ethical than other employees. Race of the respondent did not impact ethical behavior. Overclaiming scales indicated that social desirability bias did not significantly impact the results of our study. (...) Implications of this study for researchers and practitioners are discussed. (shrink)
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  36.  30
    The Divided Principle of Justice: Ethical Decision-Making at Surge Capacity.Sunit Das &Connor T. A. Brenna -2021 -American Journal of Bioethics 21 (8):37-39.
    As Alfandre and colleagues describe in “Between Usual and Crisis Phases of a Public Health Emergency: The Mediating Role of Contingency Measures”, efforts to maintain standards of care durin...
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  37.  39
    Interpretations for a class on minority assessment.J. P. Das -1985 -Behavioral and Brain Sciences 8 (2):228-228.
  38. El dios del sistema frente al Dios de la sociedad alternativa.R. M. Gracio das Neves -1989 -Ciencia Tomista 116 (3):457-494.
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  39.  30
    The Ethics of the Reuse of Disposable Medical Supplies.Anjan Kumar Das,Taketoshi Okita,Aya Enzo &Atsushi Asai -2020 -Asian Bioethics Review 12 (2):103-116.
    The use of single-use items is now ubiquitous in medical practice. Because of the high costs of these items, the practice of reusing them after sterilisation is also widespread especially in resource-poor economies. However, the ethics of reusing disposable items remain unclear. There are several analogous conditions, which could shed light on the ethics of reuse of disposables. These include the use of restored kidney transplantation and the use of generic drugs etc. The ethical issues include the question of patient (...) safety and the possibility of infection. It is also important to understand the role of informed consent before reuse of disposables. The widespread practice of reuse may bring down high healthcare costs and also reduce the huge amount of hospital waste that is generated. The reuse of disposables can be justified on various grounds including the safety and the cost effectiveness of this practice. (shrink)
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  40.  13
    Galen and the Arabic Reception of Plato's Timaeus.Aileen R. Das -2020 - New York: Cambridge University Press.
    This first full-length study of the Arabic reception of Plato's Timaeus considers the role of Galen of Pergamum in shaping medieval perceptions of the text as transgressing disciplinary norms. It argues that Galen appealed to the entangled cosmological scheme of the dialogue, where different relations connect the body, soul, and cosmos, to expand the boundaries of medicine in his pursuit for epistemic authority – the right to define and explain natural reality. Aileen Das situates Galen's work on disciplinary boundaries in (...) the context of medicine's ancient rivalry with philosophy, whose professionals were long seen as superior knowers of the cosmos vis-à-vis doctors. Her case studies show how Galen and four of the most important Christian, Muslim, and Jewish thinkers in the Arabic Middle Ages creatively interpreted key doctrines from the Timaeus to reimagine medicine and philosophy as well as their own intellectual identities. (shrink)
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  41. The Value of Biased Information.Nilanjan Das -2023 -British Journal for the Philosophy of Science 74 (1):25-55.
    In this article, I cast doubt on an apparent truism, namely, that if evidence is available for gathering and use at a negligible cost, then it’s always instrumentally rational for us to gather that evidence and use it for making decisions. Call this ‘value of information’ (VOI). I show that VOI conflicts with two other plausible theses. The first is the view that an agent’s evidence can entail non-trivial propositions about the external world. The second is the view that epistemic (...) rationality requires us to update our credences by conditionalization. These two theses, given some plausible assumptions, make room for rationally biased inquiries where VOI fails. I go on to argue that this is bad news for defenders of VOI. (shrink)
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  42.  23
    Unravelling Discourses on COVID-19, South Asians and Punjabi Canadians.Tania Das Gupta &Sugandha Nagpal -2022 -Studies in Social Justice 16 (1):103-122.
    This article uses critical discourse analysis to examine how the higher COVID-19 infection rates among South Asians in general, and Punjabis more specifically, have been represented by conservative politicians and their representatives as a consequence of cultural and religious practices. Two counter-narratives are discussed. The first substitutes the negative image of the Sikh Punjabi Canadian community with a celebratory and positive view of Sikh humanitarianism and community service. The second attributes the high numbers to class attributes such as precarious jobs, (...) poverty-level wages, employment insecurity, lack of sick days, over-crowded housing, racism and lack of access to healthcare. We argue that the conservative explanation as well as the first counter-narrative reveal continuities in culturalist understandings of South Asian immigrants, albeit in slightly different ways. The second counter-narrative represents a discursive resistance by advancing a structural analysis of health and disease in immigrant communities. (shrink)
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  43.  36
    Proteoglycan 4: From Mere Lubricant to Regulator of Tissue Homeostasis and Inflammation.Nabangshu Das,Tannin A. Schmidt,Roman J. Krawetz &Antoine Dufour -2019 -Bioessays 41 (1):1800166.
    Proteoglycan 4 (PRG4), first identified in synovial fluid, is an extracellular matrix structural protein in the joint implicated in reducing shear at the cartilage surface as well as controlling adhesion‐dependent synovial growth and regulating bulk protein deposition onto the cartilage. However, recent evidence suggests that it can bind to and effect downstream signaling of a number of cell surface receptors implicated in regulating the inflammatory response. Therefore, we pose the hypothesis: Does PRG4 regulate the inflammatory response and maintain tissue homeostasis? (...) Based on these novel findings implicating PRG4 as an inflammatory signaling molecule, we will present and discuss several hypotheses regarding potential mechanisms by which PRG4 may be able to regulate inflammation. If future studies can demonstrate that PRG4 is a potent inflammatory mediator, this will change current paradigms in the musculoskeletal and ophthalmological fields regarding the how the inflammatory microenvironment is regulated in these tissues and potentially others. (shrink)
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  44.  88
    Advaita vedānta and liberation in bodily existence.A. C. Das -1954 -Philosophy East and West 4 (2):113-123.
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  45.  195
    Vātsyāyana’s Guide to Liberation.Nilanjan Das -2020 -Journal of Indian Philosophy 48 (5):791-825.
    In this essay, my aim is to explain Vātsyāyana’s solution to a problem that arises for his theory of liberation. For him and most Nyāya philosophers after him, liberation consists in the absolute cessation of pain. Since this requires freedom from embodied existence, it also results in the absolute cessation of pleasure. How, then, can agents like us be rationally motivated to seek liberation? Vātsyāyana’s solution depends on what I will call the Pain Principle, i.e., the principle that we should (...) treat all aspects of our embodied existence as pain. If we were to follow this advice, we would come to apply the label of pain to all aspects of our embodied existence, including pleasure. This would undermine our attachment to our own embodied existence. I show that this fits with Vātsyāyana’s general theory of motivation. According to this theory, by manipulating the labels using which we think about the world and ourselves, we can induce radical shifts in our patterns of motivation. (shrink)
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  46.  17
    Samarasya: studies in Indian arts, philosophy, and interreligious dialogue: in honour of Bettina Bäumer.Bettina Bäumer,Sadananda Das &Ernst Fürlinger (eds.) -2005 - New Delhi: D.K. Printworld.
    This Inspirational Guide To An Open, Critical Exchange Between India And The West Is Framed As A Tribute To Dr. Bettina Baumer, An Eminent Scholar Of Indology. Comprising 32 Essays, Segregated Into Three Sections Indian Philosophy And Spirituality, Indian Arts And Aesthetics, And Interreligious And Intercultural Dialogue.
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  47.  33
    University-age vaccine mandates: reply to Lam and Nichols.Tracy Beth Høeg,Allison Krug,Stefan Baral,Euzebiusz Jamrozik,Salmaan Keshavjee,Trudo Lemmens,VinayPrasad,Martin A. Makary &Kevin Bardosh -2024 -Journal of Medical Ethics 50 (2):143-145.
    We thank Leo Lam and Taylor Nichols for their response1 to our paper ‘COVID-19 vaccine boosters for young adults: a risk–benefit assessment and ethical analysis of mandate policies at universities’.2 In our paper, we demonstrate that the risk–benefit calculus to mandate boosters for young adults aged 18–29 is a net risk intervention. The authors assert that we have made three inappropriate comparisons of benefits versus risks of the mRNA vaccine booster dose in this age group. We provide our response to (...) each below. We erred on the side of overestimating benefits of the booster dose against severe COVID-19 in this age group and still found net harms to outweigh net benefits. The conclusion of our paper holds, and university booster mandates for young people were—and remain—unethical. For the first comparison, we weighed predicted hospitalisations prevented by one booster dose of BNT162b2 with vaccine-associated SAEs from the manufacturer’s randomised trial (3/5055).3 We found that the rate of expected SAEs would outweigh the benefits of the booster against hospitalisation by at least 18-fold. Lam and Nichols suggest that this was an inappropriate comparison, as not all SAEs result in hospitalisation. However, the definition of SAE as used in the trial included death, hospitalisation, disability, permanent damage, life-threatening event or condition, which required medical or surgical intervention to prevent a serious outcome.4 While all comparisons include some degree of incommensurability, comparing these SAEs with hospitalisations prevented by the booster is more reasonable than Lam and Nichols’ suggestion of comparing SAEs to infections prevented. The COVID-19 infection hospitalisation risk in this age group was<0.5% (or<1/200)5 even prior to widespread immunity, thus comparing SAEs to infection risk is entirely inappropriate. Furthermore, a booster dose will only offer transient (if any) protection against infection6 and cumulative infection rates …. (shrink)
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  48.  4
    Lessons from COVID-19 patient visitation restrictions: six considerations to help develop ethical patient visitor policies.Tracy Beth Høeg,Benjamin Knudsen &VinayPrasad -forthcoming -Monash Bioethics Review:1-12.
    Patient visitor restrictions were implemented in unprecedented ways during the COVID-19 pandemic and included bans on any visitors to dying patients and bans separating mothers from infants. These were implemented without high quality evidence they would be beneficial and the harms to patients, families and medical personnel were often immediately clear. Evidence has also accumulated finding strict visitor restrictions were accompanied by long-term individual and societal consequences. We highlight numerous examples of restrictions that were enacted during the COVID-19 pandemic, including (...) some that continue to be in place today. We outline six specific concerns about the nature and effects of the visitor restrictions seen during the COVID-19 pandemic. These considerations may help provide both an ethical and science-based framework, through which healthcare workers, families and government entities can work towards safeguarding patient and family rights and well-being. (shrink)
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  49.  33
    Commentary: Trauma and Testimony: Between Law and Discipline.Veena Das -2007 -Ethos: Journal of the Society for Psychological Anthropology 35 (3):330-335.
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  50.  33
    How and why multiple MCMs are loaded at origins of DNA replication.Shankar P. Das &Nicholas Rhind -2016 -Bioessays 38 (7):613-617.
    Recent work suggests that DNA replication origins are regulated by the number of multiple mini‐chromosome maintenance (MCM) complexes loaded. Origins are defined by the loading of MCM – the replicative helicase which initiates DNA replication and replication kinetics determined by origin's location and firing times. However, activation of MCM is heterogeneous; different origins firing at different times in different cells. Also, more MCMs are loaded in G1 than are used in S phase. These aspects of MCM biology are explained by (...) the observation that multiple MCMs are loaded at origins. Having more MCMs at early origins makes them more likely to fire, effecting differences in origin efficiency that define replication timing. Nonetheless, multiple MCM loading raises new questions, such as how they are loaded, where these MCMs reside at origins, and how their presence affects replication timing. In this review, we address these questions and discuss future avenues of research. (shrink)
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