A recurrent 16p12.1 microdeletion supports a two-hit model for severe developmental delay.Santhosh Girirajan,Jill A. Rosenfeld,Gregory M. Cooper,Francesca Antonacci,Priscillia Siswara,Andy Itsara,Laura Vives,Tom Walsh,Shane E. McCarthy,Carl Baker,Heather C. Mefford,Jeffrey M. Kidd,Sharon R. Browning,Brian L. Browning,Diane E. Dickel,Deborah L. Levy,Blake C. Ballif,Kathryn Platky,Darren M. Farber,Gordon C. Gowans,Jessica J. Wetherbee,Alexander Asamoah,David D. Weaver,Paul R. Mark,Jennifer Dickerson,Bhuwan P.Garg,Sara A. Ellingwood,Rosemarie Smith,Valerie C. Banks,Wendy Smith,Marie T. McDonald,Joe J. Hoo,Beatrice N. French,Cindy Hudson,John P. Johnson,Jillian R. Ozmore,John B. Moeschler,Urvashi Surti,Luis F. Escobar,Dima El-Khechen,Jerome L. Gorski,Jennifer Kussmann,Bonnie Salbert,Yves Lacassie,Alisha Biser,Donna M. McDonald-McGinn,Elaine H. Zackai,Matthew A. Deardorff,Tamim H. Shaikh,Eric Haan,Kathryn L. Friend,Marco Fichera,Corrado Romano,Jozef Gécz,Lynn E. DeLisi,Jonathan Sebat,Mary-Claire King,Lisa G. Shaffer & Eic -unknowndetailsWe report the identification of a recurrent, 520-kb 16p12.1 microdeletion associated with childhood developmental delay. The microdeletion was detected in 20 of 11,873 cases compared with 2 of 8,540 controls and replicated in a second series of 22 of 9,254 cases compared with 6 of 6,299 controls. Most deletions were inherited, with carrier parents likely to manifest neuropsychiatric phenotypes compared to non-carrier parents. Probands were more likely to carry an additional large copy-number variant when compared to matched controls. The clinical (...) features of individuals with two mutations were distinct from and/or more severe than those of individuals carrying only the co-occurring mutation. Our data support a two-hit model in which the 16p12.1 microdeletion both predisposes to neuropsychiatric phenotypes as a single event and exacerbates neurodevelopmental phenotypes in association with other large deletions or duplications. Analysis of other microdeletions with variable expressivity indicates that this two-hit model might be more generally applicable to neuropsychiatric disease. © 2010 Nature America, Inc. All rights reserved. (shrink)
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Exploring Innovative Approaches to Managing Cultural Heritage for Economic Benefit.Dr Kajal Chheda,MohanGarg, Monika,Anila Bajpai,Sanjay Bhatnagar,Vidhya Lakshmi &AnveshaGarg -forthcoming -Evolutionary Studies in Imaginative Culture:952-962.detailsCultural heritage management is essential for protecting the historical and cultural significance of sites while contributing to economic growth. This study's objective is to ascertain and evaluate modern management techniques for heritage sites that maximize economic benefits while ensuring sustainable protection. It seeks to discover methods that effectively stabilize heritage conservation with economic development goals. This study investigates the relationship between Economic benefits, Cultural preservation, Public Engagement, Community Impact, Sustainability of Management Practices, and Innovative approaches to managing cultural heritage utilizing (...) Partial Least Squares Structural Equation Modeling (PLS-SEM). A systematic questionnaire with a Likert scale rating was used to collect data from 450 populations. The measurement model assessed the validity and reliability of latent constructs, while the structural model analyzed the relationship between constructs based on the proposed hypotheses. The structural model revealed that EB, CP, and SMP are positively connected to the IMCH, between cultural heritages for economic benefit. (β = 0.55,0.50,and 0.56,p< 0.05), providing well support for hypothesis 1, 2, and 5. The result shows there are no significant changes to managing cultural heritage for economic benefit. (shrink)
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Detailed Study of Cultural Context Effects on Online Shopping Trust and Store Reputation.Arunkumar Devalapura Thimmappa,Anisha Chaudhary,Dr Anil Sharma,PrateekGarg,Dr Rajeev Kumar Sinha,Dr Vinima Gambhir &Shriya Mahajan -forthcoming -Evolutionary Studies in Imaginative Culture:895-903.detailsOnline shopping allows consumers to save anytime, anywhere. However, cultural elements have a profound effect on consumer expectations and perceptions, affecting online shopping trust and in-keep popularity. Understanding these precise cultural factors is crucial to improve e-trade techniques and building consumer consideration. Consumers should buy products online, buying everywhere and anytime. However, purchaser expectancies and impressions are closely influenced by cultural context, affecting online purchasing self-assurance and in-save popularity. Gaining a higher expertise in these particular cultural aspects is critical to (...) improving electronic-trade (e-trade) methods and triumphing over customers. The research looks at exploring the effect of cultural context on online popularity and considers the usage of Chi-Square tests, Two-Way Analysis of Variance (ANOVA), and regression analysis to apprehend purchaser behavior and perceptions.Two-way ANOVA results show Hypothesis 1 with the lowest p-value (0.0003) and highest F-value (8.00), representing a significant result. The Chi-square test highlights Hypotheses 2 (X² = 9.87) and H4 (X² = 12.34) as significant, while H1 (X² = 7.12) and H3 (X² = 4.56) are not. Regression analysis shows a strong correlation, especially trust shows a high correlation between attitude (0.828) and behavior (0.719), and attitude shows the strongest relationship with reputation (0.861). Integrating cultural context into online shopping strategies is critical to building trust, enhancing store reputation, and building stronger customer relationships, ultimately leading to global market success. (shrink)
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Comprehensive Evaluation of Imagination's Impact on Psychological Strength in Sports Education.Nitish Vashisht,Dr Nikita Shukla,Dr Sadaf Hashmi,J. Guntaj,M. Sunil Kumar,AnveshaGarg &Dr Shanthanu Chakravarthy -forthcoming -Evolutionary Studies in Imaginative Culture:609-621.detailsIn sports education, psychological strength is considered as an integral component in the performance of any athlete. One of the effective ways to improve many psychological attributes involves training. The sample consisted of 450 athletes divided into an experimental group (EG) (n = 225) that received eight-week imagination training and a control group (CG) (n = 225) that continued with conventional training. Data was examined using the latest version of SPSS 17.0, using descriptive statistics, paired t-tests, and Analysis of covariance (...) (ANCOVA) to control for pre-existing differences. Psychological strength, mental resilience, focus and concentration, confidence, and stress management are important in athletic performance. It is proposed as a method of enhancing these psychological attributes in sports education. There were differences in significance in the EG in psychological strength, focus and concentration, confidence, and stress management compared with the CG. Paired t-tests in these variables reflect p< 0.05. ANCOVA supported the efficiency of imagination training. Imagination training significantly develops psychological strength and other related attributes in athletes. In all the variables studied, the EG performed better compared to the CG, which provided evidence that imagination training is indeed a helpful tool in enhancing psychological strength and performance in sports education. (shrink)
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The Relationship between IT Integration, Organizational Culture, and Supply Chain Performance.Sahil Suri,Nagraj Patil,Prakhar Goyal,AmitaGarg,Lovish Dhingra,Mukul Pandey &Dr Anand Kopare -forthcoming -Evolutionary Studies in Imaginative Culture:904-912.detailsIT integration plays an important role in boosting supply chain performance (SCP) in today’s dynamic organizational environment. It becomes easier for real-time data sharing, collaboration, and communication among supply chain participants. However, the prevailing organizational culture has a considerable impact on how effective IT integration exists, as it can either help or hinder the adoption and exploitation of IT integration. The relationship between SCP, organizational culture, and IT integration is examined in this study. Measurement model assurance and research hypothesis examination (...) are accomplished through the use of structural equation modeling (SEM). 90 manufacturing firms are surveyed for this research online. This analysis employs regression analysis and an ANOVA test that confirms the significant correlation between IT integration, organizational culture, and SCP. The results and findings show that supply chain performance and IT integration are positively correlated, highlighting the fact that the impact of IT integration is increased by an encouraging organizational culture that values adaptability, teamwork, and continuous learning. (β=0.50,0.45,0.35,and 0.30,p<0.001) provide strong evidence in favor of hypotheses 1–4. The study finds that SCP is greatly improved by successful IT integration, but the effectiveness of the integration is heavily dependent on an organizational culture that encourages flexibility and teamwork. (shrink)
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Downward Causation.P. B. Andersen,Claus Emmeche,N. O. Finnemann &P. V. Christiansen (eds.) -2000 - Aarhus, Denmark: University of Aarhus Press.detailsThe book deals with the notion of Downward Causation from a wide array of perspectives, including physics, biology, psychology, social science, communication studies, text theory, and philosophy. The book includes proponents as well as opponents discussing the validity of the notion.
Basic Hoops: an Algebraic Study of Continuous t-norms.P. Aglianò,I. M. A. Ferreirim &F. Montagna -2007 -Studia Logica 87 (1):73-98.detailsA continuoxis t- norm is a continuous map * from [0, 1]² into [0,1] such that is a commutative totally ordered monoid. Since the natural ordering on [0,1] is a complete lattice ordering, each continuous t-norm induces naturally a residuation → and becomes a commutative naturally ordered residuated monoid, also called a hoop. The variety of basic hoops is precisely the variety generated by all algebras, where * is a continuous t-norm. In this paper we investigate the structure of the (...) variety of basic hoops and some of its subvarieties. In particular we provide a complete description of the finite subdirectly irreducible basic hoops, and we show that the variety of basic hoops is generated as a quasivariety by its finite algebras. We extend these results to Hájek's BL-algebras, and we give an alternative proof of the fact that the variety of BL-algebras is generated by all algebras arising from continuous t-norms on [ 0,1] and their residua. The last part of the paper is devoted to the investigation of the subreducts of BL- algebras, of Gödel algebras and of product algebras. (shrink)
Children’s consent and the zone of parental discretion.P. Alderson -2017 -Clinical Ethics 12 (2):55-62.detailsThis paper briefly reviews highlights from decades of debates in medicine, law, bioethics, psychology and social research about children’s and parents’ views and consent to medical treatment and research. There appears to have been a rise and later a fall in respect for children’s views, illustrated among many examples by a recent book on the zone of parental discretion, which is reviewed. A return to greater respect for children’s views and consent is advocated.
Christian Mysticism: A Study in Walter Hilton's The Ladder of Perfection: H. P. OWEN.H. P. Owen -1971 -Religious Studies 7 (1):31-42.detailsMany writers often generalise about mysticism without a sufficiently close analysis of texts. Consequently the generalisations are often invalid. My present aim is to analyse one text and, in the light of this analysis, to offer some observations concerning mysticism in general and Christian mysticism in particular.
Commentary on the "Family Rule".P. Alderson -1999 -Journal of Medical Ethics 25 (6):497-498.detailsThe “family rule” paper by Dr Foreman proposes a way of resolving the present uncertainty about medical law on children's consent and refusal. This commentary reviews how doctors' decisions are already well protected by English law and respected by the courts. The “family rule” appears to be likely only to complicate the already diffuse law on parental consent, and to weaken further the competent minor's position in cases of uncertainty and disagreement. It leaves the difficult questions about defining and assessing (...) children's competence unanswered. This commentary suggests that these questions would be better resolved through professionally determined standards of good practice that respect children and parents, rather than through rules or laws. (shrink)
Opus Epistolarum Des. Erasmi Roterodami: Volume Xi: 1534-1536.P. S. Allen,H. M. Allen &H. W. Garrod (eds.) -1992 - Clarendon Press.detailsAn edition of the letters of Erasmus, regarded as one of the greatest humanist writers. All 12 volumes of this work have been reissued, complete with their scholarly apparatus of commentary and notes, as well as plates.