Cell death suffers a TKO.Barbara A.Osborne &Lawrence M. Schwartz -1995 -Bioessays 17 (6):557-559.detailsThe cytokine interferon‐γ (IFN‐γ), initiates both cell cycle arrest and cell death in certain cell lines. Through a novel strategy of cell transfection with episomal vectors expressing antisense cDNAs, Deiss et al.(1.2) have demonstrated that it is possible to isolate genes that are required for the initiation of cell death by the cytokine IFN‐γ. This approach, referred to as TKO, for Technical Knock Out, has identified several genes whose activity appears to be essential for the induction of apoptosis by IFN‐γ (...) in HeLa cells. Interestingly, these genes appear to mediate IFN‐γ‐induced apoptosis in HeLa cells, but their inhibition by antisense does not ameliorate the anti‐proliferative effects of IFN‐γ in these cells. The clever strategy employed by these authors holds promise for others who wish to isolate genes required for other differentiative processes in cultured cell lines. (shrink)
Prolactin and the return of ovulation in breast-feeding women.Barbara A. Gross &Creswell J. Eastman -1985 -Journal of Biosocial Science 17 (S9):25-42.detailsSummaryCross-sectional studies in Australia and the Philippines and a longitudinal prospective study in a selected Australian sample of breast-feeding mothers have shown that basal serum prolactin concentrations are elevated during 15–21 months of lactational amenorrhoea.A predictive model of serum PRL levels and return of cyclic ovarian activity during full breast-feeding, partial breast-feeding and weaning has been developed from the results of breast-feeding behaviour and serum PRL, gonadotrophin and oestradiol measurements in 34 mothers breast-feeding on demand for a mean of 67 (...) weeks.Breast-feeding patterns influence serum PRL levels. Important factors during full breast-feeding are the age of the baby, the longest interval between feeds at night and total 24-hr suckling time, and following the introduction of supplements, the mean interval between feeds, together with the total 24-hr suckling time and the number of solid supplements per day.The precise mechanisms whereby breast-feeding regulates cyclic ovarian activity remain unknown. Gonadotrophin secretion appears to be quantitatively normal, but qualitative changes, secondary to altered hypothalamic activity, may be the most important factor. A direct inhibitory effect of PRL on ovarian follicular development and steroidogenesis remains possible.Ovulation with a normal luteal phase is probable for 30% of breast-feeding mothers before the first menses, but is unlikely before 6 months, provided breast-feeding is frequent day and night.Measurement of serum PRL is a sensitive index of the return of menstruation and fertility during lactation in the population studied. (shrink)
Aesthetics of standstill.Reinhold Görling,Barbara Gronau &Ludger Schwarte (eds.) -2019 - Berlin: Sternberg Press.details'Standstill' could be the name for the exact kind of experience that is the hiatus between social expectations and real possibilities of agency. Standstill may also be the name of an aesthetic strategy to instill a non-linear time of resistance and experience into the political protocol of progress. Finally, standstill can be the name for the temporal fissure in the midst of the subject, for the lapse between the subject of the enunciation and the subject of a statement, the limit (...) that is the border between the inside and the outside. It can be the name for the mode of potentiality, for the moment of gesture, or, with Walter Benjamin, the medium of the dialectical image. The essays of this book transverse these dimensions of standstill as an in-between of time. The book includes essays by Georges Didi-Huberman, David Lapoujade, PeterOsborne, Jacques Rancière, Christine Ross, and others as well as conversations with Via Lewandowsky, Aernout Mik and Marcel Odenbach." -- Provided by publisher. (shrink)
Can Business Ethics be Trained? A Study of the Ethical Decision-making Process in Business Students.Barbara A. Ritter -2006 -Journal of Business Ethics 68 (2):153-164.detailsThe purpose of this paper is to examine the various guidelines presented in the literature for instituting an ethics curriculum and to empirically study their effectiveness. Three questions are addressed concerning the trainability of ethics material and the proper integration and implementation of an ethics curriculum. An empirical study then tested the effect of ethics training on moral awareness and reasoning. The sample consisted of two business classes, one exposed to additional ethics curriculum (experimental), and one not exposed (control). For (...) the experimental group, ethics exercises and discussion relevant to each topic were completed. Findings suggested gender differences such that, relative to other groups, women in the experimental group showed significantly improved moral awareness and decision-making processes. An explanation of the underlying cognitive processes is presented to explain the gender effect. (shrink)
Intellectuals and the Public Good: Creativity and Civil Courage.Barbara A. Misztal -2007 - Cambridge University Press.detailsCreativity and civil courage are major dimensions of an intellectual's authority and contribute towards the enrichment of democracy. This book develops a sociological account of civil courage and creative behaviour in order to enhance our understanding of the nature of intellectuals' involvement in society.Barbara A. Misztal employs both theoretical-analytic and empirical components to develop a typology of intellectuals who have shown civil courage and examines the biographies of twelve Nobel Peace Prize laureates, including Elie Wiesel, Andrei Sakharov and (...) Linus C. Pauling, to illustrate acts of courage which have embodied the values of civil society. She advances our understanding of the nature of intellectuals' public involvement and their contribution to social well-being. In the current climate of fear and insecurity, as governments are forced to deal with issues of increasing complexity, this is a pioneering sociological book with a highly original approach. (shrink)
How Ought Decisions That Weigh on Life and Death Be Justly Informed and Governed to Benefit More than the Privileged Few with Access to a Trusted Clinician?Barbara A. Koenig &Julia E. H. Brown -2022 -American Journal of Bioethics 22 (2):1-3.detailsThe two target articles in this issue bring into focus the struggle for governance over biomedical interventions that may offer some families more agency—the capacity to act—in the context of many...
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Have We Asked Too Much of Consent?Barbara A. Koenig -2014 -Hastings Center Report 44 (4):33-34.detailsPaul Appelbaum and colleagues propose four models of informed consent to research that deploys whole genome sequencing and may generate incidental findings. They base their analysis on empirical data that suggests that research participants want to be offered incidental findings and on a normative consensus that researchers incur a duty to offer them. Their models will contribute to the heated policy debate about return of incidental findings. But in my view, they do not ask the foundational question, In the context (...) of genome sequencing, how much work can consent be asked to do? (shrink)
Interactional Reconstruction in Real‐Time Language Processing.Barbara A. Fox -1987 -Cognitive Science 11 (3):365-387.detailsThis study documents and characterizes a phenomenon in naturally‐occurring conversation which I have termed interactional reconstruction. Interactional reconstruction involves retroactive reinterpretation of an earlier utterance (or set of utterances) on the basis of a more recent utterance (or set of utterances). This work is meant to serve two functions: first, to enrich our theories of human communication; and second, to explore directions and implications for theories of meaning and discourse modeling within cognitive science.
Exploring risk in professional nursing practice: an analysis of work refusal and professional risk.Barbara A. Beardwood &Jan M. Kainer -2015 -Nursing Inquiry 22 (1):50-63.detailsThis article explores risk in professional nursing practice. Professional risk refers to the threat of professional discipline if it is found that a registered nurse has violated professional nursing practice standards. We argue professional risk is socially constructed and understood differently by nurse regulatory bodies, unions, professional associations and frontline nurses. Regulatory bodies emphasize professional accountability of nurses; professional associations focus on system problems in health‐care; unions undertake protecting nurses' right to health and safety; and frontline nurses experience fear and (...) uncertainty in their attempt to interpret practice standards to avoid professional discipline. Perspectives of professional risk are investigated by analyzing three professional nursing bodies' views of professional codes governing the right of nurses to refuse unsafe work assignments. The workplace dynamics surrounding work refusal experienced by frontline nurses are illustrated primarily through the lens of the 2003 SARS influenza outbreak in Ontario, Canada. We conclude that frontline nurses in Ontario are required to manage risk by following professional protocols prioritizing patient care and professional accountability which disregard the systemic, unpredictable and hazardous circumstances in their everyday practice. Moreover, we argue professional protocols cannot anticipate every eventuality in clinical practice creating the fear of professional discipline for nurses. (shrink)
Self-insight, other-insight, and their relation to interpersonal conflict.Barbara A. Reilly -1996 -Thinking and Reasoning 2 (2 & 3):213 – 224.detailsThe pessimistic conclusion that people have relatively poor insight into the weighting schemes they use when they make holistic judgements has been generally accepted among judgement researchers. The empirical research that supported this generalisation rested on indices of self-insight that were produced directly by the subjects. It was often the case that subjects were unable to correctly name even the single most important factor influencing their decisions, as indicated by a mathematical model of their judgement schemes. Using an alternate method (...) of assessing self-insight, however, Reilly and Doherty found that subjects have far better self-insight than previously believed possible. The present paper employed the same methodology to investigate insight into the policy of another person as well as into oneself, and examined the relation of self-insight and other-insight to interpersonal conflict. Subjects were 50 dyads of university students. The results showed that: subjects exhibited the expected high levels of self-insight via the recognition procedure; subjects were able to identify the statistically generated policy of their roommate, thus exhibiting other-insight; the ability to identify one's own policy is somewhat related to the ability to articulate one's own policy that is, roommates with insight via recognition had higher indices of self-insight as measured by the traditional correlation method; subjects who were able to identify their own policy were more likely to identify their roommate's policy and individuals who possess self- and other-insight had less conflict in their roommate relationships. (shrink)
On the relation between counterfactual and causal reasoning.Barbara A. Spellman &Dieynaba G. Ndiaye -2007 -Behavioral and Brain Sciences 30 (5-6):466-467.detailsWe critique the distinction Byrne makes between strong causes and enabling conditions, and its implications, on both theoretical and empirical grounds. First, we believe that the difference is psychological, not logical. Second, we disagree that there is a strict Third, we disagree that it is easier for people to generate causes than counterfactuals.
Supercoiled loops and the organization of replication and transcription in eukaryotes.Barbara A. Zehnbauer &Bert Vogelstein -1985 -Bioessays 2 (2):52-54.detailsThe nuclear DNA of eukaryotes is organized into a series of loops each topologically anchored by elements of the nuclear matrix. Evidence is reviewed which indicates that the anchorage points of the loops are formed by transcriptionally active genes and that individual loops function as replicons. The data suggests a specific model for coupling of DNA replication and transcription in eukaryotes.
Hypothesis testing: Strategy selection for generalising versus limiting hypotheses.Barbara A. Spellman -1999 -Thinking and Reasoning 5 (1):67 – 92.detailsHumans appear to follow normative rules of inductive reasoning in "premise diversity tasks" that is, they know that dissimilar rather than similar evidence is better for generalising hypotheses. In three experiments, we use a "hypothesis limitation task" to compare a related inductive reasoning skill knowing how to limit hypotheses by using a negative test strategy. Participants are told that one category member has some property (e.g. Dogs have a merocrine gland) and are asked what evidence they would test to ensure (...) that either all (generalisation) or only (limitation) category members have that property (e.g. All/Only mammals have merocrine glands; tests: wolf, bull, crocodile). Despite participants' reluctance to use negative tests in the Wason 2-4-6 task and other reasoning tasks, participants do use normatively correct negative tests in the hypothesis limitation task as often as they use diverse positive tests in the premise diversity task. Moreover, when given a hypothesis limitation task before a rule evaluation task (similar to the 2-4-6 task), the use of negative tests increases. Thus, when testing hypotheses, people can and do use the right kind of test strategy for the task. (shrink)
Kultura polityczna: czy tego można się nauczyć?Barbara A. Markiewicz -2020 -Civitas. Studia Z Filozofii Polityki 18:53-74.detailsIn this paper, the concept of political culture is considered in reference to the notions of G.A. Almond, S. Verba and J. Rawls. It is defined as a specific educational project, which is linked to the idea of a fair, democratic and constitutional system. The author also points to potential contemporary obstacles to implementation of this project. Deepening inequalities arising from personal culture are the first threat to liberal civic education. The second threat is associated with the development of new (...) media and the related changes in the public sphere, including various forms of political and civic activity. (shrink)
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From General History to Philosophy: Black Lives Matter, Late Neoliberal Molecular Biopolitics, and Rhetoric.Barbara A. Biesecker -2017 -Philosophy and Rhetoric 50 (4):409-430.detailsOn the fiftieth anniversary of Philosophy and Rhetoric I hope a future for the journal that not only continues to publish scholarship that reflects seriously on the productive possibilities of putting the unique understandings of the human condition delivered by philosophy into contact with the singular insights into the power and perils of speech, writing, and gesture offered up by rhetoric. I also wish for it printed pages on which scholars engage thoughtfully the challenges posed by worlds and loss of (...) worlds. Never before in my lifetime has this task seemed so urgent and so necessary. This article is delivered in that spirit.On 13 July 2013 a jury of six women in Sanford, Florida, returned a verdict of not... (shrink)
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