Romanticism and the Re-Invention of Modern Religion: The Reconciliation of German Idealism and Platonic Realism.Alexander J. B. Hampton -2019 - Cambridge University Press.detailsEarly German Romanticism sought to respond to a comprehensive sense of spiritual crisis that characterised the late eighteenth century. The study demonstrates how the Romantics sought to bring together the new post-Kantian idealist philosophy with the inheritance of the realist Platonic-Christian tradition. With idealism they continued to champion the individual, while from Platonism they took the notion that all reality, including the self, participated in absolute being. This insight was expressed, not in the language of theology or philosophy, but through (...) aesthetics, which recognised the potentiality of all creation, including artistic creation, to disclose the divine. In explicating the religious vision of Romanticism, this study offers a new historical appreciation of the movement, and furthermore demonstrates its importance for our understanding of religion today. (shrink)
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Human enhancement making use of technological incorporations in their biology - Ethical perspective.FreddyAlexanderDiaz,Katherin Salazar &Oscar Herrera -2020 -Revista de Filosofia Aurora 32 (57).detailsIs it ethical or not to enhance the characteristics and capacities of human beings, making use of technological incorporations in their biology? This article presents arguments from both position pros and cons, about technological incorporations in human bodies. The denaturalization of technologically enhanced humans is discussed; A discussion is raised about the impact of these technologies on the population inequality; We present a contrast between whether the research is for treatment or enhancement purposes. Some of the repercussions on a society (...) of humans are analyzed, both hyper connected and technologically enhanced. Some of the future challenges that societies with technologically enhanced humans must face are presented. In conclusion, the development of technologies, within a regulatory and normative framework, to enhancing the characteristics and capacities of human beings is ethical. Because technologically enhanced humans are part of the NBIC convergence, and the NBIC convergence will generate new knowledge that will surely be used to develop clean and safe energy sources, preventive medical treatments that will eliminate diseases such as cancer and HIV, and design strategies to the conservation and decontamination of the planet. (shrink)
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Friedrich Jacobi and the end of the enlightenment: religion, philosophy, and reason at the crux of modernity.Alexander J. B. Hampton (ed.) -2023 - New York, NY: Cambridge University Press.detailsJacobi held a position of unparalleled importance in late eighteenth and early nineteenth century intellectual history. This includes his role in bringing about the close of the Enlightenment, his central part in shaping the reception of Kant's philosophy and German idealism, and his influence on the development of Romanticism and existentialism.
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The Mnemonic Consequences of Jurors’ Selective Retrieval During Deliberation.Alexander C. V. Jay,Charles B. Stone,Robert Meksin,Clinton Merck,Natalie S. Gordon &William Hirst -2019 -Topics in Cognitive Science 11 (4):627-643.detailsIn this empirical paper, Jay, Stone, Meksin, Merck, Gordon and Hirst examine whether jury deliberations, in which individuals collaboratively recall and discuss evidence of a trial, shape the jurors’ memories. In doing so, Jay and colleagues provide a highly ecologically valid baseline for future investigation into why, how and when selective recall either facilitates remembering or leads to forgetting during jury deliberations. In particular, Jay et al. explore the specific social and cognitive mechanisms that might lead to either memory facilitation (...) (RIFA – Retrieval Induced Facilitation) and forgetting (RIF ‐ Retrieval Induced Forgetting) during jury deliberation. (shrink)
Integration of genome-wide approaches identifies lncRNAs of adult neural stem cells and their progeny in vivo.Alexander D. Ramos,AaronDiaz,Abhinav Nellore,Ryan N. Delgado,Ki-Youb Park,Gabriel Gonzales-Roybal,Michael C. Oldham,Jun S. Song &Daniel A. Lim -unknowndetailsLong noncoding RNAs have been described in cell lines and various whole tissues, but lncRNA analysis of development in vivo is limited. Here, we comprehensively analyze lncRNA expression for the adult mouse subventricular zone neural stem cell lineage. We utilize complementary genome-wide techniques including RNA-seq, RNA CaptureSeq, and ChIP-seq to associate specific lncRNAs with neural cell types, developmental processes, and human disease states. By integrating data from chromatin state maps, custom microarrays, and FACS purification of the subventricular zone lineage, we (...) stringently identify lncRNAs with potential roles in adult neurogenesis. shRNA-mediated knockdown of two such lncRNAs, Six3os and Dlx1as, indicate roles for lncRNAs in the glial-neuronal lineage specification of multipotent adult stem cells. Our data and workflow thus provide a uniquely coherent in vivo lncRNA analysis and form the foundation of a user-friendly online resource for the study of lncRNAs in development and disease. © 2013 Elsevier Inc. (shrink)
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Embedding Ethics Education in Clinical Clerkships by Identifying Clinical Ethics Competencies: The Vanderbilt Experience.Alexander Langerman,William B. Cutrer,Elizabeth Ann Yakes &Keith G. Meador -2020 -HEC Forum 32 (2):163-174.detailsThe clinical clerkships in medical school are the first formal opportunity for trainees to apply bioethics concepts to clinical encounters. These clerkships are also typically trainees’ first sustained exposure to the “reality” of working in clinical teams and the full force of the challenges and ethical tensions of clinical care. We have developed a specialized, embedded ethics curriculum for Vanderbilt University medical students during their second year to address the unique experience of trainees’ first exposure to clinical care. Our embedded (...) curriculum is centered around core “ethics competencies” specific to the clerkship: for Medicine, advanced planning and end-of-life discussions; for Surgery, informed consent; for Pediatrics, the patient-family-provider triad; for Obstetrics and Gynecology, women’s autonomy, unborn child’s interests, and partner’s rights; and for Neurology/Psychiatry, decision-making capacity. In this paper, we present the rationale for these competencies, how we integrated them into the clerkships, and how we assessed these competencies. We also review the additional ethical issues that have been identified by rotating students in each clerkship and discuss our strategies for continued evolution of our ethics curriculum. (shrink)
BCI-FES With Multimodal Feedback for Motor Recovery Poststroke.Alexander B. Remsik,Peter L. E. van Kan,Shawna Gloe,Klevest Gjini,Leroy Williams,Veena Nair,Kristin Caldera,Justin C. Williams &Vivek Prabhakaran -2022 -Frontiers in Human Neuroscience 16:725715.detailsAn increasing number of research teams are investigating the efficacy of brain-computer interface (BCI)-mediated interventions for promoting motor recovery following stroke. A growing body of evidence suggests that of the various BCI designs, most effective are those that deliver functional electrical stimulation (FES) of upper extremity (UE) muscles contingent on movement intent. More specifically, BCI-FES interventions utilize algorithms that isolate motor signals—user-generated intent-to-move neural activity recorded from cerebral cortical motor areas—to drive electrical stimulation of individual muscles or muscle synergies. BCI-FES (...) interventions aim to recover sensorimotor function of an impaired extremity by facilitating and/or inducing long-term motor learning-related neuroplastic changes in appropriate control circuitry. We developed a non-invasive, electroencephalogram (EEG)-based BCI-FES system that delivers closed-loop neural activity-triggered electrical stimulation of targeted distal muscles while providing the user with multimodal sensory feedback. This BCI-FES system consists of three components: (1) EEG acquisition and signal processing to extract real-time volitional and task-dependent neural command signals from cerebral cortical motor areas, (2) FES of muscles of the impaired hand contingent on the motor cortical neural command signals, and (3) multimodal sensory feedback associated with performance of the behavioral task, including visual information, linked activation of somatosensory afferents through intact sensorimotor circuits, and electro-tactile stimulation of the tongue. In this report, we describe device parameters and intervention protocols of our BCI-FES system which, combined with standard physical rehabilitation approaches, has proven efficacious in treating UE motor impairment in stroke survivors, regardless of level of impairment and chronicity. (shrink)
Resolution of Algebraic Systems of Equations in the Variety of Cyclic Post Algebras.J. P. Díaz Varela &B. F. López Martinolich -2011 -Studia Logica 98 (1-2):307-330.detailsThere is a constructive method to define a structure of simple k -cyclic Post algebra of order p , L p , k , on a given finite field F ( p k ), and conversely. There exists an interpretation Φ 1 of the variety $${\mathcal{V}(L_{p,k})}$$ generated by L p , k into the variety $${\mathcal{V}(F(p^k))}$$ generated by F ( p k ) and an interpretation Φ 2 of $${\mathcal{V}(F(p^k))}$$ into $${\mathcal{V}(L_{p,k})}$$ such that Φ 2 Φ 1 ( B ) (...) = B for every $${B \in \mathcal{V}(L_{p,k})}$$ and Φ 1 Φ 2 ( R ) = R for every $${R \in \mathcal{V}(F(p^k))}$$. In this paper we show how we can solve an algebraic system of equations over an arbitrary cyclic Post algebra of order p, p prime, using the above interpretation, Gröbner bases and algorithms programmed in Maple. (shrink)
The Impact of Regulatory Policies on the Future of Fecal Microbiota Transplantation.Alexander Khoruts,Diane E. Hoffmann &Francis B. Palumbo -2019 -Journal of Law, Medicine and Ethics 47 (4):482-504.detailsIn this article, the authors explore the impact of a potential future regulatory decision by FDA whether or not to continue its enforcement discretion policy allowing physicians to perform, and stool banks to sell, stool product for fecal microbiota transplantation as a treatment for recurrent Clostridium Difficile infection without an Investigative New Drug application. The paper looks at the Agency's regulatory options in light of the current gut microbiota based products that are in the FDA pipeline for drug approval and (...) the potential impact and repercussions of their approval on FDA action. In laying out FDA's options we consider the implications of market exclusivity and off-label use of newly approved drugs. Ultimately, we explore the potential impact of FDA's decision on patients, research, and innovation. (shrink)
Systematic review and metasummary of attitudes toward research in emergency medical conditions.Alexander T. Limkakeng,Lucas Lentini Herling de Oliveira,Tais Moreira,Amruta Phadtare,Clarissa Garcia Rodrigues,Michael B. Hocker,Ross McKinney,Corrine I. Voils &Ricardo Pietrobon -2014 -Journal of Medical Ethics 40 (6):401-408.detailsEmergency departments are challenging research settings, where truly informed consent can be difficult to obtain. A deeper understanding of emergency medical patients’ opinions about research is needed. We conducted a systematic review and meta-summary of quantitative and qualitative studies on which values, attitudes, or beliefs of emergent medical research participants influence research participation. We included studies of adults that investigated opinions toward emergency medicine research participation. We excluded studies focused on the association between demographics or consent document features and participation (...) and those focused on non-emergency research. In August 2011, we searched the following databases: MEDLINE, EMBASE, Google Scholar, Scirus, PsycINFO, AgeLine and Global Health. Titles, abstracts and then full manuscripts were independently evaluated by two reviewers. Disagreements were resolved by consensus and adjudicated by a third author. Studies were evaluated for bias using standardised scores. We report themes associated with participation or refusal. Our initial search produced over 1800 articles. A total of 44 articles were extracted for full-manuscript analysis, and 14 were retained based on our eligibility criteria. Among factors favouring participation, altruism and personal health benefit had the highest frequency. Mistrust of researchers, feeling like a ‘guinea pig’ and risk were leading factors favouring refusal. Many studies noted limitations of informed consent processes in emergent conditions. We conclude that highlighting the benefits to the participant and society, mitigating risk and increasing public trust may increase research participation in emergency medical research. New methods for conducting informed consent in such studies are needed. (shrink)
Teaching curriculum theory as a Baradian apparatus.Alexander B. Pratt -2022 -Educational Philosophy and Theory 54 (12):2029-2042.detailsThis article is a discussion of the intersection between curriculum theory and agential realism as it emerged in the development of a curriculum theory course. During the process of designing such a course, I found myself wrestling with the different theoretical understandings of curriculum. What I came to realize was that while all of the theories I encountered have merits, none individually seem to capture the whole of what researchers/teachers understand to be curriculum as they encounter it in the classroom. (...) Also, the different theories seem to be incommensurable with each other and, thus, cannot be synthesized into a single more comprehensive theory. In response to these realizations and in an effort to develop the course, I turn to Karen Barad’s agential realism and specifically her theory of the apparatus. My conclusion is that curriculum theory itself is an apparatus. This article is an explanation of both that process of realization and the applicable theories of Barad’s agential realism. I conclude this article by arguing that engaging curriculum theory as a Baradian apparatus in courses for new researchers/teachers can prepare them to engage with those theories differently and with more agility in their future practice. (shrink)
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The Consequences of Peirce's Theory of Agential Ideas for Qualitative Research.Alexander B. Pratt -2024 -Educational Theory 74 (4):551-571.detailsThe recent shift in social science research toward philosophies of the more-than-human has pushed many scholars to question their understanding of units of analysis and agency. While many engage with agencies of the material, few have attempted to address what might be called the agency of ideas. Here,Alexander Pratt argues that engaging with the agency of ideas is particularly important when dealing with issues like racism, which is the focus of this article. He believes that one reason for (...) the lack of such engagement is the seemingly undefined nature of what we might think of as ideas. In this article, Pratt offers a conception of agential ideas developed through his reading of the metaphysics of Charles S. Peirce and those who have utilized Peirce's theories. This conception will provide an entry point for posthuman researchers to incorporate the protean nature of ideas into their own research methodologies. (shrink)
The Space Domain Ontologies.Alexander P. Cox,C. K. Nebelecky,R. Rudnicki,W. A. Tagliaferri,J. L. Crassidis &B. Smith -2021 - In Alexander P. Cox, C. K. Nebelecky, R. Rudnicki, W. A. Tagliaferri, J. L. Crassidis & B. Smith,National Symposium on Sensor & Data Fusion Committee.detailsAchieving space situational awareness requires, at a minimum, the identification, characterization, and tracking of space objects. Leveraging the resultant space object data for purposes such as hostile threat assessment, object identification, and conjunction assessment presents major challenges. This is in part because in characterizing space objects we reference a variety of identifiers, components, subsystems, capabilities, vulnerabilities, origins, missions, orbital elements, patterns of life, operational processes, operational statuses, and so forth, which tend to be defined in highly heterogeneous and sometimes inconsistent (...) ways. The Space Domain Ontologies are designed to provide a consensus-based realist framework for formulating such characterizations in a way that is both consistent and computable. Space object data are aligned with classes and relations in a suite of ontologies built around the existing Space Object Ontology. They are stored in a dynamically updated Resource Description Framework triple store, which can be queried to support space situational awareness and the needs of spacecraft operators and analysts. This paper provides an overview of the Space Domain Ontologies and their development and use. It presents the motivation for and advantages of the Space Domain Ontologies, including the benefits they provide for enhancing and maintaining long-term space situational awareness. (shrink)
Confessions of a late‐blooming, “miseducated” philosopher of science.Benjamin B.Alexander -2016 -Zygon 51 (4):1043-1061.detailsThis article provides a survey of Walker Percy's criticism of what Pope Benedict XVI calls “scientificity,” which entails a constriction of the dynamic interaction of faith and reason. The process can result in the diminishment of ethical considerations raised by science's impact on public policy. Beginning in the 1950s, Percy begins speculating about the negative influence of scientificity. The threat of a political regime using weapons of mass destruction is only one of several menacing developments. The desacrilization of human life (...) from cradle to grave leads Percy to assert that modern science's impact is often radically incoherent. In The Moviegoer, Percy finds his existential and theistic voice that would enable him to advance his critique of science. (shrink)