A Model of Causation Is Not Causation.B. Edmonds -2016 -Constructivist Foundations 12 (1):12-14.detailsOpen peer commentary on the article “Circularity and the Micro-Macro-Difference” by Manfred Füllsack. Upshot: The target article is criticised because it conflates models of causation with causation itself. The arguments used in the target article to avoid a straightforward distinction between fine-grained measurements and the abstractions used to model them are discussed. The value of using the word “causation” to refer to atemporal models is questioned.
Christian Ethics and Human Germ Line Genetic Modification.B. Waters -2012 -Christian Bioethics 18 (2):171-186.detailsThe principal objective of this article is to develop an overtly theological interpretive lens for assessing the ethics of human germ line genetic modification (GGM). In constructing this lens, I draw upon four selected doctrinal or thematic strands: Incarnation, resurrection, procreative mandate, and sin. In turn, I derive four corresponding moral claims: there is no Christian essentialist understanding of the body, the body cannot be perfected, offspring remain a good of marriage, and sin is a universal human disability. In conclusion, (...) I contend that for Christians there are three possible broad options for assessing the ethics of GGM: refusal, endorsement, and ambivalence. In each, I assess the principal strengths, weaknesses, and limitations of the respective theological themes, moral claims, and options. In addition, for the sake of this inquiry I assume that the technologies at issue are safe, efficacious, and do not entail the destruction of embryos or fetuses. (shrink)
The Date of Delivery of Cicero'sIn Pisonem.B. A. Marshall -1975 -Classical Quarterly 25 (01):88-.detailsIf one were to find a date for the games put on by Pompey to celebrate the opening of his theatre in 55 B.C., it would be possible to assign a more precise date to the delivery of Cicero's speech in Pisonem than seems to have been done so far. Asconius states quite firmly that the in Pisonem was delivered in the second consulship of Pompey and Crassus, a few days before the lavish games celebrating the opening of Pompey's theatre. (...) Asconius rejects a counter-view that the speech was delivered late in the following year. (shrink)
Functional characterization of three single-nucleotide polymorphisms present in the human APOE promoter sequence: Differential effects in neuronal cells and on DNA-protein interactions.B. Maloney,Y. W. Ge,R. C. Petersen,J. Hardy,J. T. Rogers,J. Perez-Tur &D. K. Lahiri -2010 -Am J Med Genet B Neuropsychiatr Genet 153:185-201.detailsVariations in levels of apolipoprotein E have been tied to the risk and progression of Alzheimer's disease . Our group has previously compared and contrasted the promoters of the mouse and human ApoE gene promoter sequences and found notable similarities and significant differences that suggest the importance of the APOE promoter's role in the human disease. We examine here three specific single-nucleotide polymorphisms within the human APOE promoter region, specifically at -491 , -427 , and at -219 upstream from the (...) +1 transcription start site. The -219 and -491 polymorphic variations have significant association with instance of AD, and -491AA has significant risk even when stratified for the APOEepsilon4 allele. We also show significant effects on reporter gene expression in neuronal cell cultures, and, notably, these effects are modified by species origin of the cells. The -491 and -219 polymorphisms may have an interactive effect in addition to any independent activity. DNA-protein interactions differ between each polymorphic state. We propose SP1 and GATA as candidates for regulatory control of the -491 and -219 polymorphic sites. This work's significance lies in drawing connection among APOE promoter polymorphisms' associations with AD to functional promoter activity differences and specific changes in DNA-protein interactions in cell culture-based assays. Taken together, these results suggest that APOE expression levels are a risk factor for AD irrespective of APOEepsilon4 allele status. (shrink)
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Causality.B. F. Mcguinness &Friedrich Waismann -2011 -Vienna Circle Institute Yearbook 15:91-184.detailsThe problem of causality is one of the central topics of Hume’s philosophy. There are several reasons for its importance: Of all the relations it is the only one in virtue of which we can pass beyond the immediate impression of the senses or an idea of the memory and thus step outside the realm of the given. The only relation “that can be trac’d beyond our senses, and informs us of existences and objects, which we do not see or (...) feel, is causation.” It is a relation which underlies our belief in an external world. To quote another passage from the Treatise: “We readily suppose an object may continue individually the same, tho’ several times absent and present to the senses; and ascribe to it an identity, notwithstanding the interruption of the perception, whenever we conclude, that if we had kept our eye or hand constantly upon it, it would have convey’d an invariable and uninterrupted perception. (shrink)
The Feynman-Wheeler Perfect Absorber Theory in a New Light.B. G. Sidharth -2010 -Foundations of Physics 40 (8):1134-1140.detailsThe original Feynman-Wheeler perfect absorber theory lead to the Instantaneous Action at a Distance formulation. We observe that this is perfectly meaningful in the light of recent studies pointing to a small but non-zero photon mass. The Quantum Mechanical effects within the Compton scale of such a small mass photon would lead to the above formulation.