A positive role for yeast extrachromosomal rDNA circles?Anthony M. Poole,Takehiko Kobayashi &Austen RdGanley -2012 -Bioessays 34 (9):725-729.detailsGraphical AbstractYeast mitochondria frequently mutate, and some dysfunctional mitochondria out-compete wild-type versions. The retrograde response enables yeast to tolerate dysfunction, but also produces ribosomal DNA circles (ERCs). We propose that ERC accumulation increases expression of the rDNA antisense gene, TAR1, which counteracts spread of respiration-deficient mitochondria in matings with wild-type yeast.
Striving for clarity about the “Lamarckian” nature of CRISPR-Cas systems.Sam Woolley,Emily C. Parke,David Kelley,Anthony M. Poole &Austen R. D.Ganley -2019 -Biology and Philosophy 34 (1):11.detailsKoonin argues that CRISPR-Cas systems present the best-known case in point for Lamarckian evolution because they satisfy his proposed criteria for the specific inheritance of acquired adaptive characteristics. We see two interrelated issues with Koonin’s characterization of CRISPR-Cas systems as Lamarckian. First, at times he appears to confuse an account of the CRISPR-Cas system with an account of the mechanism it employs. We argue there is no evidence for the CRISPR-Cas system being “Lamarckian” in any sense. Second, it is unclear (...) whether the mechanism is more “Lamarckian” than many other forms of genetic change already well-characterized in Darwinian terms. We present three conceptually distinct senses in which the mechanism of IAC may be considered Lamarckian and argue that only the strongest sense of goal-directed IAC would be difficult to accommodate in a Darwinian account. As the CRISPR-Cas mechanism does not qualify as “Lamarckian” in this strong sense, we argue there is no conceptual value in calling it “Lamarckian”. Finally, we suggest that CRISPR-Cas systems do hold the potential for genuinely non-Darwinian, directed evolution in a way that Koonin did not discuss, involving their potential use as a human gene-editing tool. (shrink)
Northanger Abbey and Persuasion: JaneAusten ; Edited by R.W. Chapman.JaneAusten -1933 - Oxford University Press USA.detailsThis is part of a complete set of JaneAusten's novels collating the editions published during the author's lifetime and previously unpublished manuscripts. The books are illustrated with 19th century plates and incorporate revisions by experts in the light of subsequent research.
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Reading vs. Scanning: Notes on Re:Print.DuncanGanley -forthcoming -AI and Society:1-14.detailsPublished in 2018, ‘Re:Print’ is an experimental artists’ book, edited by Véronique Chance and DuncanGanley, that brings together images and text by 20 contributors whose work addresses the role and language of the reproducible image. This article by DuncanGanley discusses the challenges of translating artworks and text originally presented in the context of an exhibition and symposium, into a work of print an artists’ book. The range of contributors emphasizes the diverse scope of forms, processes and (...) ideas in the expanded field of Printmaking. Addressing a variety of approaches to integrating and repurposing this visual and textual material for the printed page, the article outlines the theoretical underpinning of the creation of ‘Re:Print’ and the editorial and design decisions taken to create a hybridized form that is both document and artwork and aims to draw out new agencies of the ‘book’ in a digital world. (shrink)
Darwin and the general reader: the reception of Darwin's theory of evolution in the British periodical press, 1859-1872.Alvar Ellegȧrd -1958 - Chicago: University of Chicago Press.detailsDrawing on his investigation of over one hundred mid-Victorian British newspapers and periodicals, Alvar Ellegård describes and analyzes the impact of Darwin's theory of evolution during the first dozen years after the publication of the Origin of Species . Although Darwin's book caused an immediate stir in literary and scientific periodicals, the popular press largely ignored it. Only after the work's implications for theology and the nature of man became evident did general publications feel compelled to react; each social group (...) responded according to his own political and religious prejudices. Ellegård charts the impact of this revolution in science, maintaining that although the idea of evolution was generally accepted, Darwin's primary contribution, the theory of natural selection, was either ignored or rejected among the public. (shrink)
Minor Works: The Oxford Illustrated JaneAusten.JaneAusten -1933 - Oxford University Press USA.details"First edition 1954. Reprinted 1958, with revisions 1963, 1965, with further revisions by B.C. Southam 1969...".
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Towards a critical theory of nature: capital, ecology, and dialectics.Carl Cassegård -2021 - New York: Bloomsbury Academic.detailsThis book offers a bold new theoretical understanding of the current ecological crisis via the Frankfurt School. Focusing on key notions of dialectics, natural history, and materialism, a critical theory of nature is outlined in favor of a more traditional Marxist theory of nature, albeit one which still builds on Marxist concepts to confirm humanity's centrality in manufacturing environmental misery. Pre-eminent thinkers including Georg Lukács, Ernst Bloch, and Theodor Adorno are highlighted for their potential to diagnose the interpenetration of capitalism (...) and nature in a way that neither absolutizes nor obliterates the boundary between the social and natural. (shrink)
(1 other version)Sensory Qualities.Austen Clark -1992 - Oxford, GB: Clarendon Press.detailsDrawing on work in psychophysics, psychometrics, and sensory neurophysiology, Clark analyzes the character and defends the integrity of psychophysical explanations of qualitative facts, arguing that the structure of such explanations is sound and potentially successful.
A Theory of Sentience.Austen Clark (ed.) -2000 - New York: Oxford University Press.detailsDrawing on the findings of neuroscience, this text proposes and defends the hypothesis that the various modalities of sensation share a generic form that the author,Austen Clark, calls feature-placing.
The Constitution of the Sea: New boundaries and identity through watery, transdisciplinary artistic practice.KatAusten -2024 -Technoetic Arts 22 (2):183-196.detailsWhat is it to be the sea? Explorations of the constitution of the sea – what it comprises, where its borders are, how it incorporates novel entities – offer meaningful insights into the nature of boundaries and identity that are as relevant for humans as they are for the imperilled oceans. At the advent of the post-Anthropocene, when global processes perceptibly react to human impacts, this article elaborates on watery artistic investigations inspired by the mutability and permeability of seas. Anchoring (...) its arguments in wide-ranging examples from transdisciplinary artistic practices, the article challenges conventional notions of boundaries and identity, proposing a new way of conceiving of the self, inspired for and by the seas: The Constitution of the Sea. (shrink)
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Inversions spectral and bright: Comments on Melinda Campbell.Austen Clark -1996detailsSpectrum inversion is a thought experiment, and I would wager that there is no better diagnostic test to the disciplinary affiliation of a randomly selected member of the audience than your reaction to a thought experiment. It is a litmus test. If you find that you are paying close attention, subvocalizing objections, and that your heart-rate and metabolism go up, you have turned pink: you are a philosopher. If on the other hand the thought experiment leaves you cold, and you (...) wonder why otherwise sensible people would worry about such things, you have turned blue and you are a psychologist. (shrink)
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Spatial Organization and the Appearances Thereof in Early Vision.Austen Clark -2012 - In Gary Hatfield & Sarah Allred,Visual Experience: Sensation, Cognition, and Constancy. Oxford University Press. pp. 135.detailsThe perception of the lightness of surfaces has been shown to be affected by information about the spatial configuration of those surfaces and their illuminants. For example, two surfaces of equal luminance can appear to be of very different lightness if one of the two appears to lie in a shadow. How are we to understand the character of the processes that integrate such spatial configuration information so as to yield the eventual appearance of lightness? This paper makes some simple (...) observations about the vocabulary of appearance used in these contexts, and proposes that the end results can be called "phenomenal" in a traditional sense of that word. Processes whose products are phenomenal are next distinguished from processes characterized in other terms: (a) processes of perceptual grouping; (b) processes of perceptual organization; and (c) attentional (as opposed to preattentive) processes. These four categories are conceptually and empirically distinct. In particular, the paper reviews some evidence that appearances as of contours, occlusion, and amodally completed shapes can occur preattentively. Some implications for understanding gestalt grouping processes are briefly discussed. (shrink)
Ethical issues raised by intergenerational monitoring in clinical trials of germline gene modification.Austen Yeager -2021 -Journal of Medical Ethics 47 (4):267-270.detailsAs research involving gene editing continues to advance, we are headed in the direction of being able to modify the human germline. Should we reach a point where an argument can be made that the benefits of preventing unborn children and future generations from inheriting genetic conditions that cause tremendous suffering outweigh the risks associated with altering the human germline, the next step will be to design clinical trials using this technology in humans. These clinical trials will likely require careful (...) follow-up and monitoring of future generations born with altered genes. This paper addresses some of the ethical issues raised by intergenerational monitoring and sets out to show that these issues can be avoided with careful consideration and clinical trial design. (shrink)
Loving Your Enemy.Austen McDougal -forthcoming -Oxford Studies in Philosophy of Religion.detailsThis paper begins by bringing love and hate into tension via the ideal that you ought to love your enemy. The trouble with loving your enemy is that they may seem to merit hate instead, especially in cases of serious injustice. I develop this simple thought into a challenge for loving your enemy: that you cannot be required to do what makes no sense to you. This challenge is not adequately met by extant explanations for why you ought to love (...) your enemy within the Christian tradition and its heirs, which tend to give reasons that are either insufficient or else instrumentalize love. The second half of the paper presents a solution with a very different shape to the challenge. I argue that love may still be fitting even when your enemy fails to merit love, notwithstanding the contemporary orthodoxy about fittingness. What makes it fitting to love your enemy depends on the fact (if it is one) that you yourself have received unmerited love. You may thereby have reason to exclude the issue of merit from consideration; what is more, you have reason to love out of gratitude for the unmerited love that you yourself received. (shrink)
Psychological Models and Neural Mechanisms: An Examination of Reductionism in Psychology.Austen Clark -1980 - Oxford University Press.detailsThis book offers a systematic account of the reduction of psychological models of behavior to underlying neural mechanisms. "Clark has approached an extremely difficult and important issue in a systematic masnner and has done much to clarify concepts that are all too often mismanaged and confused in the psychological literature." --American Scientist.
Contemporary problems in the philosophy of perception.Austen Clark -1994 -American Journal of Psychology 107 (4):613-22.detailsImagine, if you will, that the entire community of investigators interested in the problems of perception all lived together in the same town. Some continual shuffling of neighbors would be inevitable, and there might be occasional episodes of mass relocation and energetic bulldozing, but after a while the residents would probably settle down and find themselves living in districts defined roughly by disciplinary boundaries. The experimental psychologists would occupy the newer part of town, laced with superhighways, workshops and factories, machines (...) and measuring instruments, computers and overhead display units. But the town also has an Old City, marked by the complete absence of highways and factories, where the streets are lined with ancient hovels. There are, to be sure, some colossal palaces and museums in this part of town, breathtaking monuments to the grandeur of past centuries, but the current residents lack the inclination to construct such buildings, and many of the old palaces have been boarded up and condemned as unfit for human habitation. The somewhat scraggly and irascible inhabitants of this district have few viable economic enterprises, and no free markets, but rather organize themselves in units resembling nothing so much as medieval guilds. Congratulations. You have stumbled into the neighborhood where the philosophers live. (shrink)
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Perception, philosophical issues about.Austen Clark -2003 - In L. Nadel,Encyclopedia of Cognitive Science. Nature Publishing Group.detailsthe philosophical regions. I will identify three: three obvious zones of The first and third of these kinds of problem are studied almost tectonic conflict within contemporary cognitive approaches to exclusively within departments of philosophy. Applied to perception.
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True theories, false colors.Austen Clark -1996 -Philosophy of Science (Supplement) 63 (3):143-50.detailsUniversity of Connecticut Storrs, CT 06279-2054. Recent versions of objectivism can reply to the argument from metamers. The deeper rift between subjectivists and objectivists lies in the question of how to explain the structure of qualitative similarities among the colors. Subjectivism grounded in this fashion can answer the circularity objection raised by Dedrick. It endorses skepticism about the claim that there is some one property of objects that it is the function of color vision to detect. Color vision may enable (...) us to detect differences in spectral composition without granting us the capacity to detect identities. (shrink)
How to respond to philosophers on raw feels.Austen Clark -1997detailsI address this talk to anyone who believes in the possibility of an informative empirical science about sensory qualities. Potentially this is a large audience. By "sensory quality" I mean those qualities manifest in various sensory experiences: color, taste, smell, touch, pain, and so on. We should include sensory modalities humans do not share, such as electro-reception in fish, echolocation in bats, or the skylight compass in birds. Those pursuing empirical science about this large domain might pursue it in the (...) halls of experimental psychology, psycho-physics, psychometrics, psycho-physiology, sensory physiology, neuroscience, neuro-biology, comparative psychology, neuro-anatomy, and so on and on. These days even molecular genetics has kicked in with some notable recent contributions to the sequencing of genes for photopigments and for olfactory receptors. But to all those investigators in all those halls I bring bad news. Your discipline is _a priori_ impossible. Philosophers whom you do not know have uncovered _a priori_ proofs that empirical investigation which proceeds along the lines currently underway, or which will proceed along lines that are currently _imaginable_, does not, will not, and cannot explain the sensory qualities of experience. Or at least so they say. You might as well give up now. (shrink)
Amnesia and Punishment.Austen McDougal -2024 -Ethics 135 (1):36-64.detailsShould punishment be abated for offenders suffering from amnesia? Philosophers have largely overlooked this question. Extant views cluster around a straightforward answer: deserving punishment depends on remembering one’s crime. However, arguments for that view rely on implausible assumptions; the view also implies that offenders could manipulate how much punishment they deserve. Instead, uneasiness about punishing amnesiacs should be traced to distinctive grounds for showing mercy. Amnesiacs who cannot access their past motives are unable to fully comprehend their own role in (...) bringing punishment upon themselves and unable to situate their decisions within a satisfying narrative arc of their lives. (shrink)
Feature-placing and proto-objects.Austen Clark -2004 -Philosophical Psychology 17 (4):443-469.detailsThis paper contrasts three different schemes of reference relevant to understanding systems of perceptual representation: a location-based system dubbed "feature-placing", a system of "visual indices" referring to things called "proto-objects", and the full sortal-based individuation allowed by a natural language. The first three sections summarize some of the key arguments (in Clark, 2000) to the effect that the early, parallel, and pre-attentive registration of sensory features itself constitutes a simple system of nonconceptual mental representation. In particular, feature integration--perceiving something as (...) being both F and G, where F and G are sensible properties registered in distinct parallel streams--requires a referential apparatus. Section V. reviews some grounds for thinking that at these earliest levels this apparatus is location-based: that it has a direct and nonconceptual means of picking out places. Feature-placing is contrasted with a somewhat more sophisticated system that can identify and track four or five "perceptual objects" or "proto-objects", independently of their location, for as long as they remain perceptible. Such a system is found in Zenon Pylyshyn's fascinating work on "visual indices", in Dana Ballard's notion of deictic codes, and in Kahneman, Treisman, and Wolfe's accounts of systems of evanescent representations they call "object files". Perceptual representation is a layered affair, and I argue that it probably includes both feature-placing and proto-objects. Finally, both nonconceptual systems are contrasted with the full-blooded individuation allowed in a natural language. (shrink)
Three varieties of visual field.Austen Clark -1996 -Philosophical Psychology 9 (4):477-95.detailsThe goal of this paper is to challenge the rather insouciant attitude that many investigators seem to adopt when they go about describing the items and events in their " visual fields". There are at least three distinct categories of interpretation of what these reports might mean, and only under one of those categories do those reports have anything resembling an observational character. The others demand substantive revisions in one's beliefs about what one sees. The ur-concept of a " visual (...) field" is that of the "sum of things seen", but one can interpret the latter in very different ways. The first is the "field of view", or the sum of physical things seen. The second is an array of visual impressions, whose spatial relations are distinct from those of physical phenomena in front of the eyes. The third is an intentional object: the world as it is represented visually. These three categories are described, and various locutions of vision science--such as "optic array", "retinocentric space", " visual geometry", "virtual object" and others--are analyzed and variously located within them. Finally, a recent argument purporting to necessitate the existence of a version two visual field is examined and shown wanting. (shrink)
Preattentive precursors to phenomenal properties.Austen Clark -manuscriptdetailsWhat are the relations between preattentive feature-placing and states of perceptual awareness? For the purposes of this paper, states of "perceptual awareness" are confined to the simplest possible exemplars: states in which one is aware of some aspect of the appearance of something one perceives. Subjective contours are used as an example. Early visual processing seems to employ independent, high-bandwidth, preattentive feature "channels", followed by a selective process that directs selective attention. The mechanisms that yield subjective contours are found very (...) early in this processing. An experiment by Greg Davis and Jon Driver is described; it seems to show that multiple subjective figures can be coded in these preattentive, parallel stages of visual processing. I propose that some of these preattentive states might register the very same differences that, were one aware of them, would be phenomenal differences. Some arguments pro and con on this possibility are assessed. (shrink)
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