Responsive Neurostimulation Targeting the Anterior, Centromedian and Pulvinar Thalamic Nuclei and the Detection of Electrographic Seizures in Pediatric and Young Adult Patients.Cameron P. Beaudreault,Carrie R. Muh,Alexandria Naftchi,Eris Spirollari,Ankita Das,Sima Vazquez,Vishad V. Sukul,Philip J. Overby,Michael E. Tobias,Patricia E. McGoldrick &Steven M. Wolf -2022 -Frontiers in Human Neuroscience 16.detailsBackgroundResponsive neurostimulation has been utilized as a treatment for intractable epilepsy. The RNS System delivers stimulation in response to detected abnormal activity, via leads covering the seizure foci, in response to detections of predefined epileptiform activity with the goal of decreasing seizure frequency and severity. While thalamic leads are often implanted in combination with cortical strip leads, implantation and stimulation with bilateral thalamic leads alone is less common, and the ability to detect electrographic seizures using RNS System thalamic leads is (...) uncertain.ObjectiveThe present study retrospectively evaluated fourteen patients with RNS System depth leads implanted in the thalamus, with or without concomitant implantation of cortical strip leads, to determine the ability to detect electrographic seizures in the thalamus. Detailed patient presentations and lead trajectories were reviewed alongside electroencephalographic analyses.ResultsAnterior nucleus thalamic leads, whether bilateral or unilateral and combined with a cortical strip lead, successfully detected and terminated epileptiform activity, as demonstrated by Cases 2 and 3. Similarly, bilateral centromedian thalamic leads or a combination of one centromedian thalamic alongside a cortical strip lead also demonstrated the ability to detect electrographic seizures as seen in Cases 6 and 9. Bilateral pulvinar leads likewise produced reliable seizure detection in Patient 14. Detections of electrographic seizures in thalamic nuclei did not appear to be affected by whether the patient was pediatric or adult at the time of RNS System implantation. Sole thalamic leads paralleled the combination of thalamic and cortical strip leads in terms of preventing the propagation of electrographic seizures.ConclusionThalamic nuclei present a promising target for detection and stimulation via the RNS System for seizures with multifocal or generalized onsets. These areas provide a modifiable, reversible therapeutic option for patients who are not candidates for surgical resection or ablation. (shrink)
Transparency and the KK Principle.Nilanjan Das &Bernhard Salow -2018 -Noûs 52 (1):3-23.detailsAn important question in epistemology is whether the KK principle is true, i.e., whether an agent who knows that p is also thereby in a position to know that she knows that p. We explain how a “transparency” account of self-knowledge, which maintains that we learn about our attitudes towards a proposition by reflecting not on ourselves but rather on that very proposition, supports an affirmative answer. In particular, we show that such an account allows us to reconcile a version (...) of the KK principle with an “externalist” or “reliabilist” conception of knowledge commonly thought to make that principle particularly problematic. (shrink)
Virtue ethics and right action.R. Das -2003 -Australasian Journal of Philosophy 81 (3):324 – 339.detailsIn this paper I evaluate some recent virtue-ethical accounts of right action [Hursthouse 1999; Slote 2001; Swanton 2001]. I argue that all are vulnerable to what I call the insularity objection : evaluating action requires attention to worldly consequences external to the agent, whereas virtue ethics is primarily concerned with evaluating an agent's inner states. More specifically, I argue that insofar as these accounts are successful in meeting the insularity objection they invite the circularity objection : they end up relying (...) upon putatively virtue-ethical considerations that themselves depend on unexplained judgments of rightness. Such accounts thus face a dilemma that is characteristic of virtue-ethical accounts of right action. They avoid the insularity objection only at the cost of inviting the circularity objection: they become intuitively plausible roughly to the extent that they lose their distinctively virtue-ethical character. (shrink)
The Open.Saitya Brata Das -2009 -Kritike 3 (2):116-127.detailsIn the Open darkness and light, remembrance and oblivion, coming into existence and disappearing in death play their originary co-belonging, or co-figuration. Existence belongs to this opening and is exposed to its coming to presence: it is on the basis of this originary opening, this originary historical which is revealed to this mortal being called ‘man,’ on the basis of this revelation, man founds something like politics and history. There thus comes into existence out of this freedom, out of this (...) “play space”2, this field called ‘polis’3 where there takes place war and festival, where historical revolutions tear apart history, brings ruptures and discontinuities in the very mode of his existence, where man seeks the foundation of his own foundation, where occurs the dialectics of negativity between man and man, where man puts at stake his own death, his own dissolution, and by the power of his own dissolution stands in relation to the total world that he seeks to dominate. This means that man’s attempts to metaphysically found his own political and historical existence must presuppose a far more originary non-foundation, the differentiating revealing of the open, the ungrounded spacing play, or playing space of natality and mortality. (shrink)
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The Surgeon-in-Chief Should Oversee Innovative Surgical Practice.Sunit Das &Martin McKneally -2019 -American Journal of Bioethics 19 (6):34-36.detailsVolume 19, Issue 6, June 2019, Page 34-36.
Vātsyāyana’s Guide to Liberation.Nilanjan Das -2020 -Journal of Indian Philosophy 48 (5):791-825.detailsIn this essay, my aim is to explain Vātsyāyana’s solution to a problem that arises for his theory of liberation. For him and most Nyāya philosophers after him, liberation consists in the absolute cessation of pain. Since this requires freedom from embodied existence, it also results in the absolute cessation of pleasure. How, then, can agents like us be rationally motivated to seek liberation? Vātsyāyana’s solution depends on what I will call the Pain Principle, i.e., the principle that we should (...) treat all aspects of our embodied existence as pain. If we were to follow this advice, we would come to apply the label of pain to all aspects of our embodied existence, including pleasure. This would undermine our attachment to our own embodied existence. I show that this fits with Vātsyāyana’s general theory of motivation. According to this theory, by manipulating the labels using which we think about the world and ourselves, we can induce radical shifts in our patterns of motivation. (shrink)
The Divided Principle of Justice: Ethical Decision-Making at Surge Capacity.Sunit Das &Connor T. A. Brenna -2021 -American Journal of Bioethics 21 (8):37-39.detailsAs Alfandre and colleagues describe in “Between Usual and Crisis Phases of a Public Health Emergency: The Mediating Role of Contingency Measures”, efforts to maintain standards of care durin...
A Pneumatological Kālī-logy and Imago Dei: Contribution of the Yoginī Tantra and Hindu Goddess Traditions to Reconceptualizing the Christian Trinity.Arunjana Das -2021 -Journal of Dharma Studies 4 (1):135-149.detailsGoddess traditions have much to contribute to reflections on the feminine in Imago Dei. Christian theologians and scholars have found goddess traditions in Hinduism as a source of enrichment for Christian theology. Using the Yogini Tantra, a seventeenth-century Tāntric text from India, I argue that the role of Kālï in the Tāntric Trinity and the conceptualization of Kālï-ness as explicated in Hindu Tantra helps us reconsider the role of the feminine in the Christian conception of the trinitarian Godhead and Imago (...) Dei. Kālï-ness offers the feminist scholar of theology a way of doing “thealogy.” Reflecting on the pneumatological dimension of the Tāntric trinitarian godhead and the role of Kālï as pneuma manifesting within and outside of the Godhead helps us reflect on the theological understandings of the Christian trinitarian godhead. I explore the kind of possibilities that such a comparison opens us up to in interreligious learning. (shrink)
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Correction to: Gaṅgeśa on Epistemic Luck.Nilanjan Das -2021 -Journal of Indian Philosophy 49 (2):203-204.detailsIn the original publication of the article, on page 20, the section heading should be “Gaṅgeśa on Testimony and Epistemic Luck” instead of “Testimony and Epistemic Luck”.
Right and Wrong in the Conduct of Science.Mukunda P. Das &Frederick Green -2014 -Tattva - Journal of Philosophy 6 (2):25-43.detailsScience, in particular physics, is a collective enterprise and is so because it is, itself, a fruit of the exquisitely social nature of human living. So it is inevitable to encounter ethical issues in the natural sciences, since the contest of differing interests and views is perennial in its practice, indeed essential to its momentum. The crucial ethical question always hangs in the air: How is the truth best served? In this paper we describe some ethical aspects of our own (...) discipline of science: their cultural context and the bounds which they delineate for themselves, sometimes in transgression. We argue that the minimalist ethic espoused in science, namely loyalty to truth, is a bellwether for the much wider, more problematic, and more vital consequences of ethics – and its failure – in human relationships at large. (shrink)
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Two Pharmacological Texts on Whey by Abū Bakr Muḥammad ibn Zakariyyāʾ al-Rāzī.Aileen Das &Pauline Koetschet -2021 -Journal of the American Oriental Society 137 (1):25.detailsThis article offers the first edition and translation of two heretofore unpublished pharmacological treatises by Abū Bakr al-Rāzī, namely Fī ittikhādh māʾ al-jubn and Fī manāfiʿ māʾ al-jubn, which seem to have formed part of a lost volume on dairy products. As it demonstrates, al-Rāzī’s examination of whey is connected to his philosophical interest in the complex nature of simple substances such as milk. The article also highlights how these two treatises built on the Greek pharmacological tradition by incorporating ingredients (...) from Persia and India. (shrink)
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Urban health and pharmaceutical consumption in delhi, india.Veena Das &Ranendra K. Das -2006 -Journal of Biosocial Science 38 (1):69-82.detailsThis paper interrogates the routine and unproblematic use of terms such as in biomedical and anthropological discourse. A typical depiction of the social factors that explain the practice of in India is to put together the supply side factors (such as protection offered by the government for the production of generic drugs, especially in the small scale sector, and expansion of the number of drug store outlets), with the increasing demand for allopathic drugs. The paper provides an ethnographic account of (...) the intricate connections between households and biomedical practitioners in urban neighbourhoods in Delhi. It breaks away from the conventional opposition drawn between the practices of physicians and the beliefs of their patients, and suggests that what constitutes the medical environments of these neighbourhoods is the product of medical practices, household economies and concepts of disease. Thus pharmaceutical use is determined as much by practices of dispensation and by how practitioners understand what constitutes therapy as by household understanding of the normal and the pathological. This paper uses both quantitative data and narrative interviews to provide an in-depth understanding of the circulation of pharmaceuticals within the life worlds of the urban poor. (shrink)
Validity of the Generalized Second Law of Thermodynamics in the Logamediate and Intermediate Scenarios of the Universe.Arundhati Das,Surajit Chattopadhyay &Ujjal Debnath -2012 -Foundations of Physics 42 (2):266-283.detailsIn this work, we have investigated the validity of the generalized second law of thermodynamics in logamediate and intermediate scenarios of the universe bounded by the Hubble, apparent, particle and event horizons using and without using first law of thermodynamics. We have observed that the GSL is valid for Hubble, apparent, particle and event horizons of the universe in the logamediate scenario of the universe using first law and without using first law. Similarly the GSL is valid for all horizons (...) in the intermediate scenario of the universe using first law. Also in the intermediate scenario of the universe, the GSL is valid for Hubble, apparent and particle horizons but it breaks down whenever we consider the universe enveloped by the event horizon. (shrink)
An ethical analysis of clinical triage protocols and decision-making frameworks: what do the principles of justice, freedom, and a disability rights approach demand of us?Sunit Das,Chloë G. K. Atkins,Liam G. McCoy,Connor T. A. Brenna &Jane Zhu -2022 -BMC Medical Ethics 23 (1):1-9.detailsBackgroundThe expectation of pandemic-induced severe resource shortages has prompted authorities to draft and update frameworks to guide clinical decision-making and patient triage. While these documents differ in scope, they share a utilitarian focus on the maximization of benefit. This utilitarian view necessarily marginalizes certain groups, in particular individuals with increased medical needs.Main bodyHere, we posit that engagement with the disability critique demands that we broaden our understandings of justice and fairness in clinical decision-making and patient triage. We propose the capabilities (...) theory, which recognizes that justice requires a range of positive capabilities/freedoms conducive to the achievement of meaningful life goals, as a means to do so. Informed by a disability rights critique of the clinical response to the pandemic, we offer direction for the construction of future clinical triage protocols which will avoid ableist biases by incorporating a broader apprehension of what it means to be human.ConclusionThe clinical pandemic response, codified across triage protocols, should embrace a form of justice which incorporates a vision of pluralistic human capabilities and a valuing of positive freedoms. (shrink)
Unravelling Discourses on COVID-19, South Asians and Punjabi Canadians.Tania Das Gupta &Sugandha Nagpal -2022 -Studies in Social Justice 16 (1):103-122.detailsThis article uses critical discourse analysis to examine how the higher COVID-19 infection rates among South Asians in general, and Punjabis more specifically, have been represented by conservative politicians and their representatives as a consequence of cultural and religious practices. Two counter-narratives are discussed. The first substitutes the negative image of the Sikh Punjabi Canadian community with a celebratory and positive view of Sikh humanitarianism and community service. The second attributes the high numbers to class attributes such as precarious jobs, (...) poverty-level wages, employment insecurity, lack of sick days, over-crowded housing, racism and lack of access to healthcare. We argue that the conservative explanation as well as the first counter-narrative reveal continuities in culturalist understandings of South Asian immigrants, albeit in slightly different ways. The second counter-narrative represents a discursive resistance by advancing a structural analysis of health and disease in immigrant communities. (shrink)
The Value of Biased Information.Nilanjan Das -2023 -British Journal for the Philosophy of Science 74 (1):25-55.detailsIn this article, I cast doubt on an apparent truism, namely, that if evidence is available for gathering and use at a negligible cost, then it’s always instrumentally rational for us to gather that evidence and use it for making decisions. Call this ‘value of information’ (VOI). I show that VOI conflicts with two other plausible theses. The first is the view that an agent’s evidence can entail non-trivial propositions about the external world. The second is the view that epistemic (...) rationality requires us to update our credences by conditionalization. These two theses, given some plausible assumptions, make room for rationally biased inquiries where VOI fails. I go on to argue that this is bad news for defenders of VOI. (shrink)
Tagore's Asian outlook.Shakti Das Gupta -1961 - Cal[cutta]: Nava Bharati.detailsThe author was a Bengali officer of India's Foreign Service. On his first foreign assignment during 1948 - 1954, he came across rare manuscripts at the National Library in Bangkok covering Rabindranath Tagore's visit to Thailand in October 1927. Having learnt the Thai language and being a Tagore aficionado, this discovery was fortuitous. "As the Poet travelled mostly without a stenographer, a great many of his speeches would have been lost to posterity. Reports about the Siam visit available in India (...) then were extremely sketchy..... Besides the material on the Poets visit to Thailand, this book contains some other important documents not readily available. The main treatise is split into four chapters: Time to Awake: A Poets Warning, Tagores Conception of History, Message to Asia And Africa and The Toiler for Peace. These chapters show what Tagore considered to be the biggest problem of human history, how he warned humanity for more than half a century against the problems and perils into which the world has been thrown today, what remedies he suggested to counter them. The author also condensed the Poet's ideas about civilisation and culture, freedom, power, diplomacy, colonialism, military alliances, racial prejudice and nationalism." This book, when first published during the Poet's centenary celebrations in 1961, provided for the first time a full account of that visit. It has since been a reference source for many Indian and international scholars on Tagore, with citations in their publications. With increased attention in recent years to Tagore's views on Nationalism, a republication for wider availability would benefit both readers and scholars on Tagore's view of global events during the inter-War period. This is the only republication of the book after sixty years. (shrink)
Bad News for Moral Error Theorists: There Is No Master Argument Against Companions in Guilt Strategies.Ramon Das -2017 -Australasian Journal of Philosophy 95 (1):58-69.detailsA ‘companions in guilt’ strategy against moral error theory aims to show that the latter proves too much: if sound, it supports an implausible error-theoretic conclusion in other areas such as epistemic or practical reasoning. Christopher Cowie [2016 Cowie, C. 2016. Good News for Moral Error Theorists: A Master Argument Against Companions in Guilt Strategies, Australasian Journal of Philosophy 94/1: 115–30.[Taylor & Francis Online], [Web of Science ®] [Google Scholar]] has recently produced what he claims is a ‘master argument’ against (...) all such strategies. The essence of his argument is that CG arguments cannot work because they are afflicted by internal incoherence or inconsistency. I argue, first, that Cowie's master argument does not succeed. Beyond this, I argue that there is no good reason to think that any such argument—one that purports to identify an internal incoherence in CG arguments—can succeed. Second, I argue that the main substantive area of disagreement between error theorists and CG theorists essentially concerns the conceptual profile of epistemic reasons—specifically, whether they are strongly categorical—not the ontological question of whether such reasons exist. I then develop an argument in favour of the CG theorist's position by considering the moral error theorist's arguments in support of the conceptual claim that moral reasons are strongly categorical. These include, notably, criticisms made by Joyce [2011] and Olson [2014] of Finlay's [2008] ‘end relational’ view of morality, according to which moral reasons are relative to some end or standard, hence not strongly categorical. Examining these criticisms, I argue that, based on what moral error theorists have said regarding the conceptual profile of moral reasons, there is a strong case to be made that moral reasons are strongly categorical if and only if epistemic reasons are. (shrink)