“You would not be in a hurry to go back home”: patients’ willingness to participate in HIV/AIDS clinical trials at a clinical and research facility in Kampala, Uganda.Deborah Ekusai Sebatta,Godfrey Siu,Henry W. Nabeta,Godwin Anguzu,Stephen Walimbwa,Mohammed Lamorde,Badru Bukenya &AndrewKambugu -2020 -BMC Medical Ethics 21 (1):1-14.detailsBackgroundFew studies have examined factors associated with willingness of people living with HIV to participate in HIV treatment clinical trials in Sub-Saharan Africa. We assessed the factors associated with participation of PLHIV in HIV treatment clinical trials research at a large urban clinical and research facility in Uganda.MethodsA mixed methods study was conducted at the Infectious Diseases Institute, adult HIV clinic between July 2016 and January 2017. Data were collected using structured questionnaires, focused group discussions with respondents categorised as either (...) participated or never participated in clinical trials and key informant interviews with IDI staff. A generalized linear model with a logit link function was used for multivariate analyses while the qualitative data were summarized using a thematic approach.ResultsWe enrolled a total of 202 and analysed 151 participants, 77 of whom were male with mean age of 41 years. The majority 127 expressed willingness to participate in treatment clinical trials if given an opportunity. At bivariate analysis, willingness to participate was significantly associated with respondents’ perception of a satisfactory compensation package, special status accorded and belief that their health status would improve while on the clinical trial. At multivariate analysis, a satisfactory compensation package and special status accorded in clinical trials remained significant. The qualitative data analysis confirmed these findings as participants valued the privilege of jumping the clinic waiting queues and spending less time in clinic, the wide range of free tests offered to trial participants, unrestricted access to senior physicians and regular communication from study team. Additionally, free meals offered during clinic visits meant that participants were not in a hurry to go back home. Barriers to participation included the perception that new drugs were being tested on them, fear of side effects like treatment failure and the uncertainty about privacy of their data.ConclusionWe found overwhelming willingness to participate in HIV treatment clinical trials. This was largely extrinsically influenced by the perceived material and health-related benefits. Investigators should pay attention to participants’ concerns for benefits which may override the need to understand study procedures and risks. (shrink)
The ruthless critique of everything existing: nature and revolution in Marcuse's philosophy of Praxis.Andrew Feenberg -2023 - Brooklyn, NY: Verso.detailsExplains Marcuse's philosophy, especially his critique of science and technology.
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A Philosophical Introduction to Higher-order Logics.Andrew Bacon -2023 - Routledge.detailsThis is the first comprehensive textbook on higher order logic that is written specifically to introduce the subject matter to graduate students in philosophy. The book covers both the formal aspects of higher-order languages -- their model theory and proof theory, the theory of λ-abstraction and its generalizations -- and their philosophical applications, especially to the topics of modality and propositional granularity. The book has a strong focus on non-extensional higher-order logics, making it more appropriate for foundational metaphysics than other (...) introductions to the subject from computer science, mathematics, and linguistics. A Philosophical Introduction to Higher Order Logics assumes only that readers have a basic knowledge of first-order logic. With an emphasis on exercises, it can be used as a textbook though is also ideal for self-study. AuthorAndrew Bacon organizes the book's 18 chapters around four main parts: I. Typed Language II. Higher Order Languages III. General Higher-Order Languages IV. Higher-Order Model Theory In addition, two appendices cover the Curry-Howard isomorphism and its applications for modeling propositional structure. Each chapter includes exercises that move from easier to more difficult, strategically placed throughout the chapter, and concludes with an annotated suggested reading list providing graduate students with most valuable additional resources. Key Features Is the first comprehensive introduction to higher-order logic as a grounding for addressing problems in metaphysics Introduces the basic formal tools that are needed to theorize in, and model, higher order languages Offers an abundance of: - Simple exercises throughout the book, serving as comprehension checks on basic concepts and definitions - More difficult exercises designed to facilitate long-term learning Contains annotated sections on further reading, pointing the reader to related literature, learning resources, and historical context. (shrink)
The Unique and Practical Advantages of Applying A Capability Approach to Brain Computer Interface.Andrew Ko &Nancy S. Jecker -2022 -Philosophy and Technology 35 (4):1-22.detailsIntelligent neurotechnology is an emerging field that combines neurotechnologies like brain-computer interface (BCI) with artificial intelligence. This paper introduces a capability framework to assess the responsible use of intelligent BCI systems and provide practical ethical guidance. It proposes two tests, the threshold and flourishing tests, that BCI applications must meet, and illustrates them in a series of cases. After a brief introduction (Section 1), Section 2 sets forth the capability view and the two tests. It illustrates the threshold test using (...) examples from clinical medicine of BCI applications that enable patients with profound disabilities to function at a threshold level through computer mediation. Section 3 illustrates the flourishing test by exploring possible future applications of BCI involving neuroenhancements for healthy people, using examples adapted from research currently underway in the US military. Section 3 applies a capability lens to a complex case involving dual effects, both therapeutic and non-therapeutic, showing how the threshold and flourishing tests resolve the case. Section 4 replies to three objections: neurorights are the best tool for assessing BCI; the two tests are moving targets; and the analysis utilizes a capability view to do work it is not designed for. The paper concludes that a capability view offers unique advantages and gives practical guidance for evaluating the responsible use of present and future BCI applications. Extrapolating from our analysis may help guide other emerging technologies, such as germline gene editing, expected to impact central human capabilities. (shrink)
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Virtue theory of mathematical practices: an introduction.Andrew Aberdein,Colin Jakob Rittberg &Fenner Stanley Tanswell -2021 -Synthese 199 (3-4):10167-10180.detailsUntil recently, discussion of virtues in the philosophy of mathematics has been fleeting and fragmentary at best. But in the last few years this has begun to change. As virtue theory has grown ever more influential, not just in ethics where virtues may seem most at home, but particularly in epistemology and the philosophy of science, some philosophers have sought to push virtues out into unexpected areas, including mathematics and its philosophy. But there are some mathematicians already there, ready to (...) meet them, who have explicitly invoked virtues in discussing what is necessary for a mathematician to succeed. In both ethics and epistemology, virtue theory tends to emphasize character virtues, the acquired excellences of people. But people are not the only sort of thing whose excellences may be identified as virtues. Theoretical virtues have attracted attention in the philosophy of science as components of an account of theory choice. Within the philosophy of mathematics, and mathematics itself, attention to virtues has emerged from a variety of disparate sources. Theoretical virtues have been put forward both to analyse the practice of proof and to justify axioms; intellectual virtues have found multiple applications in the epistemology of mathematics; and ethical virtues have been offered as a basis for understanding the social utility of mathematical practice. Indeed, some authors have advocated virtue epistemology as the correct epistemology for mathematics (and perhaps even as the basis for progress in the metaphysics of mathematics). This topical collection brings together several of the researchers who have begun to study mathematical practices from a virtue perspective with the intention of consolidating and encouraging this trend. (shrink)
Appraising Strict Liability.Andrew Simester (ed.) -2005 - Oxford University Press.detailsThis book is a collection of original essays offering the first full-length consideration of the problem of strict liability in the criminal law: that is, the problem of criminal offences that allow a defendant to be convicted without proof of fault. Because of its potential to convict blameless persons, strict liability is a highly controversial phenomenon in the criminal law. Including Anglo-American and European perspectives, the contributions provide a sustained and wide-ranging examination of the fundamental issues. The breadth and depth (...) of the chapters combine to present readers with a sophisticated analysis of the place and legitimacy of strict liability in the criminal law. (shrink)
Thought And Object: Essays On Intentionality.Andrew Woodfield (ed.) -1982 - New York: Oxford: Clarendon Press.detailsIn this collection of new essays, six philosophers address themselves to the question of what sort of feature this intentional content is. The topics covered in the individual papers are of great independent interest and subject to much recent discussion.
The credentials of brain-based learning.Andrew Davis -2004 -Journal of Philosophy of Education 38 (1):21–36.detailsThis paper discusses the current fashion for brain-based learning, in which value-laden claims about learning are grounded in neurophysiology. It argues that brain science cannot have the ‘authority’ about learning that some seek to give it. It goes on to discuss whether the claim that brain science is relevant to learning involves a category mistake. The heart of the paper tries to show how the contribution of brain science to our grasp of the nature of learning is limited in principle. (...) Finally the paper explores the potential of brain science to illuminate specific learning disabilities. (shrink)
A burst of conscious light: near-death experiences, the Shroud of Turin, and the limitless potential of humanity.Andrew James Silverman -2020 - Rochester, Vermont: Park Street Press.detailsProvides evidence that human consciousness can never be reproduced and exposes the perils of artificial intelligence. Explains how consciousness transcends the brain and body through quantum theory and accounts of consciousness in the clinically dead. Shares scientific evidence of how the image on the Shroud of Turin was produced and connects these findings to evidence concerning near-death experiences. Reveals how consciousness cannot be reproduced by a machine and how attempts to do so threaten what makes us human.
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Was Aristotle a virtue argumentation theorist?Andrew Aberdein -2021 - In Joseph Andrew Bjelde, David Merry & Christopher Roser,Essays on Argumentation in Antiquity. Cham: Springer. pp. 215-229.detailsVirtue theories of argumentation (VTA) emphasize the roles arguers play in the conduct and evaluation of arguments, and lay particular stress on arguers’ acquired dispositions of character, that is, virtues and vices. The inspiration for VTA lies in virtue epistemology and virtue ethics, the latter being a modern revival of Aristotle’s ethics. Aristotle is also, of course, the father of Western logic and argumentation. This paper asks to what degree Aristotle may thereby be claimed as a forefather by VTA.
Every Good Path: Wisdom and Practical Reason in Christian Ethics and the Book of Proverbs.Andrew Errington -2019 - New York: T&T Clark.detailsDavid Errington brings the Book of Proverbs into discussion with two significant accounts of the nature and foundation of practical reason in Christian ethics: Thomas Aquinas and Oliver O'Donovan. Aiming to set out a coherent account of the structure of Christian moral reasoning, this book provides the first scholarly engagement with Oliver O'Donovan's moral theology. Errington argues that the way the Book of Proverbs conceives of wisdom presents an important challenge to the way practical reason has been understood in the (...) Western theological and philosophical tradition, and that instead a perfection of speculative knowledge, wisdom in the Book of Proverbs is a practical knowledge of how to act well, grounded in the reality of the world God has made. (shrink)
Dudeney's Mathematical Perplexities I.Andrew English -2025 -Mathematics in School 54 (2):26-28.detailsHenry E. Dudeney (1857-1930) was, according to pure mathematician G. H. Hardy (1877-1947), one of England’s “better makers of puzzles”. His “Perplexities” column, a regular feature in The Strand Magazine between 1910 and 1930, not only gave recreational mathematicians what they wanted – an “intellectual ‘kick’” – but also occasioned the odd sparkling display of intellect from professionals. Dudeney’s geometrical dissection puzzles are a case in point, though his ingenious solutions sometimes betray a lack of clarity about the difference between (...) a mathematical proof and an empirical procedure. His equilateral triangle to square dissection and the equally stunning regular octagon to square dissection sent to him by Hardy’s colleague G. T. Bennett (1868-1943) are both here demonstrated visually – process and result an evident unity. (shrink)
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Therapeutic Discipline? Reflections on the Penetration of Sites of Control by Therapeutic Discourse.Andrew M. Jefferson -2003 -Outlines. Critical Practice Studies 5 (1):55-73.detailsThis article addresses the way in which therapeutic practice in an English prison creates conditions whereby both prisoners and prison officers are caught up in networks and relationships of power that contribute to the constitution of particular subjects. The development of therapeutic practice, in relation to prisons and probation, is described and contextualised. Subsequently, the practices of group therapy in operation at Grendon prison - a rather unique institution built on principles of therapeutic community – are analysed with a focus (...) on five ”practices of moulding,” namely, naming, confession, assessment and surveillance, tolerance and participation. The argument that psychotherapy, under conditions of imprisonment, is a form of repression or social control is discussed and dismissed as too simple a model to account for the relations of power and constitutive practices that effect all participants, not only prisoners. Members of staff, as well as prisoners, are shown to be caught up in the disciplinary web. Discipline, as opposed to control, is advocated as a more appropriate concept for understanding therapeutic practices in prison. The work of Thomas Mathiesen, on the concept of synoptic power, is introduced to help illustrate these dynamics. The article represents a shift in my own thinking, from scepticism to a pragmatic idealist position, that creates space for institutions like Grendon to be imagined as potential least worst options for people convicted of offences and obliged to serve “time”. It is my hope, argued for in the article, that Grendon can be conceived of as a “visionary space” with emancipatory potential. (shrink)
A good life without God: atheism and a meaningful life.Andrew William Kernohan -2009 - [Raleigh, N.C.]: Lulu.detailsHow can we lead a good life in a world without God? This clear, concise book applies recent thinking in philosophy to the age-old question of what gives meaning to our lives. The prose is simple, the arguments precise, the ideas powerful and thought-provoking. The book deals with many questions: Why does death not destroy the possibility of meaning? In what way is the search for purpose misleading? Why is there not just one thing that is the meaning of life? (...) Why do pleasures and satisfied desires often seem meaningless? What role do our emotions play in discovering that which truly matters? What is the nature of truth? How do our choices and commitments play a part in leading a meaningful life? Is a meaningful life necessarily a happy one? (shrink)
Dialogue Types, Argumentation Schemes, and Mathematical Practice: Douglas Walton and Mathematics.Andrew Aberdein -2021 -Journal of Applied Logics 8 (1):159-182.detailsDouglas Walton’s multitudinous contributions to the study of argumentation seldom, if ever, directly engage with argumentation in mathematics. Nonetheless, several of the innovations with which he is most closely associated lend themselves to improving our understanding of mathematical arguments. I concentrate on two such innovations: dialogue types (§1) and argumentation schemes (§2). I argue that both devices are much more applicable to mathematical reasoning than may be commonly supposed.
The Dialectical Tradition in South Africa.Andrew Nash -2009 - Routledge.detailsThis book brings into view the most enduring and distinctive philosophical current in South African history—one often obscured or patronized as Afrikaner liberalism. It traces this current of thought from nineteenth-century disputes over Dutch liberal theology through Stellenbosch existentialism to the prison writings of Breyten Breytenbach, and examines related themes in the work of Olive Schreiner, M. K. Gandhi, and Richard Turner. At the core of this tradition is a defence of free speech in its classical sense, as a virtue (...) necessary for a good society, rather than in its modern liberal sense as an individual right. Out of this defence of free speech, conducted in the face of charges of heresy, treason, and immorality, a range of philosophical conceptions developed—of the self constituted in dialogue with others, of freedom as transcendence of the given, and of a dialectical movement of consciousness as it is educated through debate and action. This study shows the Socratic commitment to "following the argument where it leads," sustained and developed in the storm and stress of a peculiar modernity.  . (shrink)