Movatterモバイル変換

Direct download(7 more)   Export citation   Bookmark   1 citation  

The somatic mutation theory (SMT) of cancer has been and remains the prevalent theory attempting to explain how neoplasms arise and progress. This theory proposes that cancer is a clonal, cell‐based disease, and implicitly assumes that quiescence is the default state of cells in multicellular organisms. The SMT has not been rigorously tested, and several lines of evidence raise questions that are not addressed by this theory. Herein, we propose experimental strategies that may validate the SMT. We also call attention (...) to an alternative theory of carcinogenesis, the tissue organization field theory (TOFT), which posits that cancer is a tissue‐based disease and that proliferation is the default state of all cells. Based on epistemological and experimental evidence, we argue that the TOFT compellingly explains carcinogenesis, while placing it within an evolutionarily relevant context.magnified imagemagnified imageAna Soto and Carlos Sonnenschein are at Tufts University School of Medicine, Boston, MA, USA. (shrink)

Direct download(2 more)   Export citation   Bookmark   45 citations  

Aggregating snippets from the semantic memories of many individuals may not yield a good map of an individual’s semantic memory. The authors analyze the structure of semantic networks that they sampled from individuals through a new snowball sampling paradigm during approximately 6 weeks of 1-hr daily sessions. The semantic networks of individuals have a small-world structure with short distances between words and high clustering. The distribution of links follows a power law truncated by an exponential cutoff, meaning that most words (...) are poorly connected and a minority of words has a high, although bounded, number of connections. Existing aggregate networks mirror the individual link distributions, and so they are not scale-free, as has been previously assumed; still, there are properties of individual structure that the aggregate networks do not reflect. A simulation of the new sampling process suggests that it can uncover the true structure of an individual’s semantic memory. (shrink)

Direct download(2 more)   Export citation   Bookmark   13 citations  

Festschrift honoring Maṇḍana Miśra, b. 1929, Sanskrit philosopher; comprises articles chiefly on Mīmāṃsā school in Hindu philosophy.

Direct download   Export citation   Bookmark  

No categories

Export citation   Bookmark  

The integration of nanotechnology’s ‘social and ethical issues’ (SEI) at the research and development stage is one of the defining features of nanotechnology governance in the United States. Mandated by law, integration extends the field of nanotechnology to include a role for the “social”, the “public” and the social sciences and humanities in research and development (R&D) practices and agendas. Drawing from interviews with scientists, engineers and policymakers who took part in an oral history of the “Future of Nanotechnology” symposium (...) at the Cornell NanoScale Facility, this article examines how nanotechnology’s ‘social and ethical issues’ are brought to life by these practitioners. From our analysis, three modes of enactment emerge: enacting SEI as obligations and problems-to-be-solved, enacting SEI by ‘not doing it’ in the laboratory, and enacting SEI as part of scientific practice. Together they paint a complex picture where SEI are variously defined, made visible or invisible, included and excluded, with participants showing their skill at both boundary-work (Gieryn Am Sociol Rev 48:781–795, 1983, 1999) and at integration. We conclude by reflecting on what this may mean for the design and implementation of SEI integration policies, suggesting that we need to transform SEI from obligations into ‘matters of care’ (Puig de la Bellacasa Soc Stud Sci 41(1):85–106, 2011) that tend to existing relationalities between science and society and implicate practitioners themselves. (shrink)

Direct download(6 more)   Export citation   Bookmark   5 citations  

Fundamentación: la educación integral del estudiante de Medicina incluye el desarrollo de las habilidades comunicativas y lingüísticas en idioma Inglés, que le posibiliten mantenerse informado y comunicarse en medios anglófonos. La prensa escrita es un medio de información que permite que los estudiantes reflexionen, valoren, interpreten y se comuniquen. Objetivo: Contribuir al desarrollo de las habilidades lingüísticas y comunicativas con la prensa escrita en clases de inglés. Método: Se realizó un estudio pre-experimental que consistió en elaborar ejercicios a partir de (...) la utilización de artículos de la prensa escrita relacionados con medicina y salud pública, como medios de enseñanza. El estudio se realizó con 40 estudiantes del quinto año de Medicina y 15 profesionales matriculados en un curso de posgrado de la Facultad de Ciencias Médicas de Mayabeque. Resultados: La información sobre aspectos de medicina y salud pública publicados en la prensa y los hábitos de lectura de la prensa de los estudiantes del quinto año era baja antes de la intervención y después de la puesta en práctica de la experiencia mejoró significativamente. Los resultados de los cuatro cortes evaluativos muestran la eficacia de la experiencia, por cuanto el desarrollo de las habilidades se comportó de manera ascendente. Conclusiones: Este sistema de trabajo facilitó la motivación de las clases, se desarrollaron habilidades lingüísticas y comunicativas y sirvió de base para fomentar el trabajo educativo, aumentó el vocabulario general y técnico de los estudiantes. Foundation: the medical students’ integral education includes the development of linguistic and communicative abilities in the English language, in such a way, they have the possibility to be informed and communicate properly in English-speaking contexts. The printing press is a means of information which allows them to reflect, valuate interpretate and communicate properly. Objective: to contribute to the development of linguistic and communicative abilities with the printing press in the English lessons Method: it was carried out a pre-experimental study which consisted in the elaboration of exercises related to the content of medical articles taken from the printing press. The study was carried out with 40 5th year medical students and 15 health professionals registered for a post graduated course of English in the Faculty of medicine from Mayabeque. Results: the information concerning medicine and public health published in the printing press and the 5th year medical students reading habits before putting into practice the didactic experience were low. Meanwhile, it improved considerably after its implementation. The results of the four evaluative breaks show the effectiveness of the didactic experience. The development of reading abilities was increased. Conclusions: this system of work facilitated motivation during the learning activities, linguistic and communicative abilities were developed considerably; it served as a base to promote educative work, and to increase the students general and technical vocabulary. (shrink)

Direct download   Export citation   Bookmark  

Direct download   Export citation   Bookmark  

Direct download   Export citation   Bookmark  

Direct download   Export citation   Bookmark  

The execution of critical thinking depends on a set of skills and dispositions. It is unanimously accepted that skills represent the cognitive component, but consensus varies with regard to dispositions. Although most theoreticians admit that this is a complex construct integrated by motivations and mental habits, they don’t explain further. We have performed a study attempting to explore the internal structure of dispositions. We suggest a possible hypothesis of “Motivational Genesis of Dispositions,” according to which disposition would be formed by (...) motivation and by mental habits, although the contribution of each of these factors would change depending on the practice gained in critical thinking. Thus, when a person is not practised in critical thinking, motivation makes a greatercontribution than mental habits. Nevertheless, with practice and motivated exercise of the skills of critical thinking, the influence of these mental habits increases. The regression analyses carried out support such a hypothesis. (shrink)

Direct download(3 more)   Export citation   Bookmark   3 citations  

At a certain time, the disjunction between philosophy and poetry seemed to denominate the foundational moment which gave a singular life to philosophy, making it unnecessary to refer to anything that was not philosophy. The voice of thought that stopped being relevant to philosophy was the fable..

Direct download   Export citation   Bookmark  

"Identidad personal y donación. La configuración del yo en la acción dramática", de Ana Álvarez Garrido, relata como un deseo de verdad y una intuición genuina, unidos a la insatisfacción acerca de las corrientes dominantes en el estudio de la identidad personal, llevaron a su autora a iniciar este trabajo. Con una pregunta casi infantil, por su atrevimiento y por la esperanza que la anima de una respuesta justa, se abre esta aventura de la búsqueda del yo, a la que (...) es invitado el lector desde la primera página: ¿Quién soy yo? Este interrogante nos conduce, atravesando el fuego positivo de la duda, a veces de tintes narrativos, hasta un espacio y un tiempo capaces de vestir al yo, de darle una voz y un gesto únicos, capaces de regalarle un nombre. Un teatro será ese lugar donde Yo puedo ser y donde vengo a ser Yo, porque en él se puede representar una acción esencial. Ésta, como el yo, se revelará al final de nuestra aventura investigadora, sorprendente y deliberadamente dramática. Como la vida misma. (shrink)

Direct download   Export citation   Bookmark  

Direct download(3 more)   Export citation   Bookmark  

Direct download   Export citation   Bookmark  

Direct download(2 more)   Export citation   Bookmark   1 citation  

El objetivo de este artículo es contribuir a un conocimiento más exhaustivo de la historia socio-económica de al-Andalus en general y del tema de la pobreza involuntaria en particular. La literatura paremiológica andalusí proporciona un caudal de información nada desdeñable en relación con los diferentes aspectos relativos al tema en cuestión, tales como la concepción de la pobreza, sus causas y consecuencias, así como las distintas formas de contrarrestarla por parte de los afectados y del prójimo. El refranero andalusí pone (...) a nuestra disposición una serie de imágenes establecidas con respecto a los pobres y a su estado, permitiéndonos conocer los estímulos que esta realidad social provocaba entre la población. Desde este punto de vista, este tipo de documentación permite apreciar las prácticas sociales existentes en al-Andalus, las cuales dejan traslucir los valores morales y éticos de esta sociedad. (shrink)

No categories

Direct download(3 more)   Export citation   Bookmark  

Export citation   Bookmark  

Direct download   Export citation   Bookmark  

Bibliography of the works of Yaśovijaya, 1624-1688, Jaina philosopher.

No categories

Export citation   Bookmark  

O artigo objetiva compreender como o termo “espiritualidade” tem sido utilizado na área da saúde, discutindo os problemas decorrentes e as possíveis adversidades de sua polissemia. Para tanto, dividimos o estudo em três partes. Na primeira, apresentamos as diferentes definições de “espiritualidade” nas ciências humanas, sua relação histórica com a teologia cristã, e recente ressignificação pela Nova Era. Na sequência, demonstramos como a maior parte das produções sobre a temática na área da saúde adota uma concepção reificada e essencializada de (...) espiritualidade. Na terceira, discutimos as principais fragilidades identificadas no estudo. O termo espiritualidade está sendo utilizado nas ciências médicas para que a religião adentre seus espaços, inclusive de políticas públicas, ainda que de modo secularizado. Um paralelo com a fenomenologia da religião foi traçado para demonstrar as consequências da má conceituação de uma categoria em longo prazo. Por fim, identificamos uma supervalorização da dimensão psicológica da espiritualidade em detrimento das dimensões morais e rituais. (shrink)

Direct download(2 more)   Export citation   Bookmark  

The emergence and development of 'national sciences' in Latin American countries were not, until very recently, part of the agenda of historians of science because the 'traditional' history of sciences was not interested in the scientific activity of peripheral areas. The history of science is a recent discipline in Mexican historiographic studies. The methodological interest in the history of science, the creation of schools and institutes that deal with it, the establishment of particular chairs, the organization of national societies, and (...) the publication of books and periodicals are all very recent. It is important to carry out studies in the history of science that examine the development of Mexican science introducing the 'local' context, and study how this development has influenced the formation of scientific societies and the development of scientific disciplines in the country. We want to explore the introduction of genetics in Mexico as applied to agriculture between 1930 and 1960. This matter has not been investigated in Mexico and therefore this work would represent one of the first studies of this subject and one of the first studies in the general field of Mexican scientific history. (shrink)

Direct download   Export citation   Bookmark   2 citations  

Export citation   Bookmark  

Just Ecological Integrity presents a collection of revised and expanded essays originating from the international conference "Connecting Environmental Ethics, Ecological Integrity, and Health in the New Millennium" held in San Jose, Costa Rica in June 2000. It is a cooperative venture of the Global Ecological Integrity Project and the Earth Charter Initiative.

Export citation   Bookmark  

Direct download   Export citation   Bookmark  

No categories

Export citation   Bookmark  

Export citation   Bookmark  

No categories

Direct download(5 more)   Export citation   Bookmark  

No categories

Direct download(6 more)   Export citation   Bookmark  

O presente trabalho focaliza o fenômeno dos longos litígios em Varas de Família, com o objetivo de discutir a inscrição do judiciário na trama conjugal. Ressalta-se que alguns casais, mesmo após o divórcio, ficam aprisionados numa dinâmica de repetição que atua por meio do litígio, representado nas ..

No categories

Direct download(2 more)   Export citation   Bookmark  

Soledad Murillo, ha ocupado el primer cargo político en materia de igualdad en la octava legislatura 2004-2008 como Secretaria de Políticas de Igualdad, participando activamente en la Ley contra la Violencia de Género y la Ley de Igualdad efectiva entre Mujeres y Hombres.Actualmente es la Directora de la Unidad de Igualdad de la Universidad de Salamanca, donde trabaja como profesora de sociología. Y es miembro del Comité Antidiscriminación de la Mujer de Naciones Unidas. (CEDAW). Sus principales líneas de investigación son (...) el análisis del tiempo en cuanto a las tensiones que genera compatibilizar mercado de trabajo con vida familiar —analizando por qué es un problema femenino y no masculino la conciliación—. (shrink)

No categories

Direct download(2 more)   Export citation   Bookmark  

Direct download   Export citation   Bookmark   1 citation  

No categories

Export citation   Bookmark  

Estudo comparado sobre o tratamento dado à reprodução humana assistida no direito do Brasil, Estados Unidos, Portugal, Espanha e Itália.

Direct download(2 more)   Export citation   Bookmark  

Dworkin respondeu afirmativamente à pergunta título do seu texto “Não existe mesmo nenhuma resposta certa em casos controversos?”. Posner criticou Dworkin e respondeu a mesma pergunta negativamente. Discute-se neste artigo as diferentes maneiras como cada filósofo entendeu a pergunta que acarreta diferentes respostas a ela, isto é, de que modo diferenças na concepção do que é o Direito acarretam diferenças a respeito da existência de respostas certas para questões jurídicas.

Direct download(5 more)   Export citation   Bookmark  

Partiendo de un pasaje de una obra de Shakespeare, se revisará el papel de la fidelidad en la configuración de la identidad personal. el artículo se centra en dos tendencias principales en la concepción de la misma, enraizadas en la comprensión narrativa del yo: la fidelidad como permanencia frente al cambio y la fidelidad como apertura y avance hacia aquello que hace ser, que da unidad y sentido. Pero el yo se descubre en ambos casos dividido, necesitado de narrar para (...) ser, luchando con el tiempo, ya se presente como amenaza o como obstáculo para ser uno y distinto. la alternativa que aquí se propone consiste en una fidelidad como retorno a lo esencial, donde el ser y la unidad del yo permanecen, en tanto que éste se abre a la novedad de aquéllo fundamental. dicha apertura consiste básicamente en un diálogo, en el cual el yo recibe y entrega lo propio, poniendo en juego su ser en el espacio dramático, actualizando así cada vez el yo, su unidad y su sentido. (shrink)

Direct download(6 more)   Export citation   Bookmark  

This book brings together a number of contributions dealing with certain fundamental structures of practical rationality, as they are presented in the areas of the philosophy of action and normative ethics, namely: intentionality, normativity, and reflexivity. With the term “intentionality,” is meant a set of problems that are linked not only with the teleological structure of praxis-oriented rationality, but also with its temporal structure. “Normativity”, in turn, refers to a distinct set of problems, which cannot simply be reduced to those (...) entailed in the intentional nature of human action, even if this notion incorporates a reference to the good or value in its very structure. Finally, with the term “reflexivity” we point at the linkage between the normative dimension of reason with both the contingent circumstances of action and the moral receptivity of the agent, as it is experienced in moral judgment. (shrink)

Direct download(2 more)   Export citation   Bookmark  

No categories

Direct download   Export citation   Bookmark  

No categories

Export citation   Bookmark  

No categories

Direct download(6 more)   Export citation   Bookmark  

Every legitimate exercise of political power owes its very existence to Church. On the other hand, every Church power lies in papal power. Therefore, the power of the Pope himself, even in earthy matters, is a total, absolute power, sine pondere, numero et mensura, as Egidio points out. Two powers, two swords but just a unique authority: that of the Pope.

No categories

Direct download(5 more)   Export citation   Bookmark  

As its title is meant to suggest, this paper is a reply to Sir Tim Lankester’s article “International Aid: Experience, Prospects and the Moral Case”, published in the World Economics last year 1 . Therefore, I would like to begin by expressing my gratitude for the author’s responsiveness to my interest and queries in the area of development economics. The main point of Sir Lankester’s article was, I believe, to strengthen the case for international aid by showing first, that it (...) was not just a theoretical matter 2 and second, that its efficiency was not a self-evident fait accompli, but a still-to-achieve objective, entirely contingent upon human and institutional factors such as the will, interests, and past experience of donors, as well as the system of governance and existing policies from the recipient countries. Moreover, the human factor is actually two-fold, in the sense that one can focus either on the external part engaged in the aid mission – the donor –, or on the internal one – the recipient. Sir Tim Lankester looks into what motivates the former, whereas I intend to unpack the life-experience of the latter, for I strongly believe that what ultimately decides the success or failure of development projects has more to do with understanding their life situation, than with the actual quantum of aid. Although the two cases grounded on the above-mentioned claims may seem completely separated in Tim Lankester’s article for he allocates distinct sections to them, I have reasons to believe that they are not only inter-connected, but also deeply inter-dependent, which is crucial for the kind of existentialist scenario that I intend to outline here. In order to prove this, I am going to combine two sets of argumentative tools: one will be logical, the other – empirical. The former will help us address the issues at stake in Tim Lankester’s moral case, and find ways of strengthening it; the latter will help reminding the real goal of this attempt – which is to improve the prospects of aid missions in real-life scenarios, rather than in theory. The first, rather theoretical section will consist of an extended analysis of the moral case that Sir Lankester started to build. The focus will be not only on the supposedly fruitful aspects of social justice theories, but also on their potential risks; both heroes and villains will emerge from the analysis, and new leads will be discovered. The main criterion for testing whatever findings will remain the pragmatic one: questioning their implications on the life-experiences of the poor. The other approach that I have mentioned will consist of providing a description of life in a particular community, which I have known and learnt from. In this case, the ‘empirical’ obviously means more than just the use of examples – which can be invented, or refined: it actually involves relying on a set of personal experiences and convictions, thereby testifying in – rather than just advocating – the case for aid and development projects, under discussion here. Again, the purpose will be not so much to prove that my claim has the sort of objective validity that a theoretician would normally seek to achieve, as to enforce it by whatever relevant testimonies – be them contextual, perhaps even biased; in this case, the ‘biased’ aspect consists of using an example derived from lifeexperiences in a particular developing country: my own. And it is exactly what I regard as the strength of it; indeed, I would not be writing this, had I not learnt that lesson. (shrink)

Direct download(5 more)   Export citation   Bookmark  

En el actual contexto de un nihilismo que suele afirmarse como horizonte insuperable de nuestro tiempo, urge mostrar que no es así. Nada mejor que mirar la experiencia de hombres que han sabido recorrer hasta el fondo el camino del nihilismo y redescubrir su humanidad. Giuseppe Capograssi es uno de ellos. La vida y obra de este genial filósofo del Derecho del siglo XX están traspasadas por la conciencia de que la dependencia, la tristeza y la melancolía son la misma (...) estructura del yo, el terreno abonado en el que, gracias a un encuentro, puede florecer la esperanza. (shrink)

No categories

Direct download(2 more)   Export citation   Bookmark  

No categories

Direct download(4 more)   Export citation   Bookmark  

Export citation   Bookmark  

No categories

Export citation   Bookmark  

No categories

Direct download(2 more)   Export citation   Bookmark  

No categories

Export citation   Bookmark  

No categories

Export citation   Bookmark  

Study on the Mimamsa school, as expounded by Jaimini, in Hindu philosophy.

Direct download   Export citation   Bookmark