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The etiology of Tauopathies, a diverse class of neurodegenerative diseases associated with the Microtubule Associated Protein (MAP) Tau, is usually described by a common mechanism in which Tau dysfunction results in the loss of axonal microtubule stability. Here, we reexamine and build upon the canonical disease model to encompass other Tau functions. In addition to regulating microtubule dynamics, Tau acts as a modulator of motor proteins, a signaling hub, and a scaffolding protein. This diverse array of functions is related to (...) the dynamic nature of Tau isoform expression, post‐translational modification (PTM), and conformational flexibility. Thus, there is no single mechanism that can describe Tau dysfunction. The effects of specific pathogenic mutations or aberrant PTMs need to be examined on all of the various functions of Tau in order to understand the unique etiology of each disease state. (shrink)

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There is a growing recognition that fictions have a number of legitimate functions in science, even when it comes to scientific explanation. However, the question then arises, what distinguishes an explanatory fiction from a nonexplanatory one? Here I examine two cases—one in which there is a consensus in the scientific community that the fiction is explanatory and another in which the fiction is not explanatory. I shall show how my account of “model explanations” is able to explain this asymmetry, and (...) argue that realism—of a more subtle form—does have a role in distinguishing explanatory from non- explanatory fictions. (shrink)

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This book reformulates the sociological subdiscipline known as the sociology of knowledge. Knowledge is presented as more than ideology, including as well false consciousness, propaganda, science and art.

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Scientific models invariably involve some degree of idealization, abstraction, or nationalization of their target system. Nonetheless, I argue that there are circumstances under which such false models can offer genuine scientific explanations. After reviewing three different proposals in the literature for how models can explain, I shall introduce a more general account of what I call model explanations, which specify the conditions under which models can be counted as explanatory. I shall illustrate this new framework by applying it to the (...) case of Bohr's model of the atom, and conclude by drawing some distinctions between phenomenological models, explanatory models, and fictional models. (shrink)

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Classical mechanics and quantum mechanics are two of the most successful scientific theories ever discovered, and yet how they can describe the same world is far from clear: one theory is deterministic, the other indeterministic; one theory describes a world in which chaos is pervasive, the other a world in which chaos is absent. Focusing on the exciting field of 'quantum chaos', this book reveals that there is a subtle and complex relation between classical and quantum mechanics. It challenges the (...) received view that classical and quantum mechanics are incommensurable, and revives another, largely forgotten tradition due to Niels Bohr and Paul Dirac. By artfully weaving together considerations from the history of science, philosophy of science, and contemporary physics, this book offers a new way of thinking about intertheory relations and scientific explanation. It will be of particular interest to historians and philosophers of science, philosophically-inclined physicists, and interested non-specialists. (shrink)

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It has frequently been suggested that quantum mechanics may provide a genuine case of ontic vagueness or metaphysical indeterminacy. However, discussions of quantum theory in the vagueness literature are often cursory and, as I shall argue, have in some respects been misguided. Hitherto much of the debate over ontic vagueness and quantum theory has centered on the “indeterminate identity” construal of ontic vagueness, and whether the quantum phenomenon of entanglement produces particles whose identity is indeterminate. I argue that this way (...) of framing the debate is mistaken. A more thorough examination of quantum theory and the phenomenon of entanglement reveals that quantum mechanics is best interpreted as supporting what I call the “vague property” construal of ontic vagueness, where vague properties are understood in terms of determinable properties without the corresponding determinates. (shrink)

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How can black feminist and women of color feminist theoretical interventions help create frameworks for discerning agentic action in the context of power, oppression, and violence? In this paper, I explore the social dimension of agency and argue that intention is not just authored by the agent as a function of practical reasoning, but is also socially authored through others' discernment and translation of her action. Further, when facilitated by reasoning designed to reinforce and rationalize systems of domination, social authoring (...) systematically distorts the intentions of some agents. Although some theorists have argued that those agents whose intentions are not recognized by others are forced to exercise a diminished agency, I contend that this account obscures agency that is practiced despite or through conditions of oppression. As an alternative, I propose that feminist of color theory that examines the structural and existential erasures of women of color maps a conceptual space to help us better discern agentic action that is practiced by those subjects whose acts are defined away from them. (shrink)

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From the Federal Theater Projects of the Great Depression to the disruptive performances of the 1960s and 1970s, theater has played an important role in American radicalism. This special issue of_ _Theater_ reports on socially conscious, politically active theaters in the United States. Despite the evaporation of Cold War passions and the rise of conservatism in the 1980s and 1990s, such theater work remains a persistent and evolving presence on the political landscape. Since the first inauguration of George W. Bush, (...) new opportunities have arisen for political performance and for significant new challenges to these artists. T_heater and Social Change_ not only tracks the historical evolution of political theater but also explores the current state and future prospects of different modes, including agit-prop, demonstrations, solo performance, Augusto Boal’s Theater of the Oppressed, and community-based production. With such notable contributors as Anna Deavere Smith, Jonathan Kalb, Holly Hughes, and Tony Kushner, the issue offers a diverse assemblage of personal statements, conversations, photographs, interviews, and performance text. _Contributors include:_ Reverend Billy, Jan Cohen-Cruz, Arlene Goldbard, Sharon Green, Lani Guinier, Holly Hughes, Jonathan Kalb, Tony Kushner, Judith Malina, Robbie McCauley, John O'Neal, Claudia Orenstein, Bill Rauch, Julie Salverson, Anna Deavere Smith,Alisa Solomon, Roberta Uno. (shrink)

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This book will be of particular interest to those philosophers, scientists, and mathematicians who are interested in the foundations of science.

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In semiclassical mechanics one finds explanations of quantum phenomena that appeal to classical structures. These explanations are prima facie problematic insofar as the classical structures they appeal to do not exist. Here I defend the view that fictional structures can be genuinely explanatory by introducing a model-based account of scientific explanation. Applying this framework to the semiclassical phenomenon of wavefunction scarring, I argue that not only can the fictional classical trajectories explain certain aspects of this quantum phenomenon, but also that (...) an explanation that does not make reference to these classical structures is, in a certain sense, deficient. (shrink)

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A dimensional reduction algorithm is applied to an intelligent classification model with the purpose of improving the efficiency and accuracy. The proposed classification model, used to distinguish the operating mode: Hard- and Soft-Switching, is presented and an analysis of the synchronized rectified step-down converter is done. With the aim of improving the accuracy and reducing the computational cost of the model, three different methods for dimensional reduction are applied to the input dataset of the model: self-organizing maps, principal component analysis (...) and correlation matrix. The obtained results show how the number of variable is highly reduced and the performance of the classification model is boosted: the results manifest an improve in the accuracy and efficiency of the classification. (shrink)

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Narratives of artificial intelligence frame public perceptions and expectations, and have a performative role, potentially leading to increased attention and resource allocation, acceptance of AI, or resistance to the technology. However, research on AI narratives frequently produces generalized and decontextualized accounts. This paper argues for closer examination of the specific processes that shape AI narratives in particular contexts. To explore this, nine AI-related exhibitions held in German museums from 2022 to 2023 were analyzed. The study draws on interviews with curatorial (...) teams and exhibition materials to investigate what narratives of AI museums are formed and how those relate to the dominant AI narratives described in previous research. It is shown that curators are critical of dominant AI narratives and aim to deconstruct common myths and present more nuanced portrayals of AI. Yet, they also face challenges in balancing this critical stance with the need for creating engaging, accessible exhibitions. The analysis reveals that while some curatorial strategies successfully counter AI stereotypes, others fail or inadvertently reproduce mainstream imaginaries. Curators discover that avoiding problematic understandings of AI in the way they had initially intended is challenging or even impossible. In other cases, when elements of mainstream AI discourse resurface in museum exhibits despite the critical stance of the curators, they remain unexamined, or are regarded as insignificant and inconsequential. (shrink)

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Trust is more than mere reliance on another person. To trust someone is to rely on her goodwill for the care of something valuable. It is to have a confident expectation that the other person will take care of the valuable thing because she recognizes its value to you. It is to expect her to take care of it because she recognizes that she should take care of it. Therefore trust is a robustly moral attitude.

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This article intervenes in a critical debate about the use of consent to distinguish sex from rape. Drawing from critical contract theories, it argues that sexual consent is a cruel optimism that often operates to facilitate, rather than alleviate, sexual violence. Sexual consent as a cruel optimism promises to simplify rape allegations in the popular cultural imagination, confounds the distinction between victims and agents of sexual violence, and establishes certainty for potential victimizers who rely on it to convince themselves and (...) others that their partners implicitly or explicitly agreed to sex. In each of these cases, the power of consent rests in its tendency to obscure sexual violence in a set of questions around victimhood and agency, rather than to clarify whether or when it has occurred. Following in the critical contract tradition, this article argues that the optimistic attachment to the clarifying power of consent helps to explain the persistent commitment to better sexual consent as a ‘solution’ to the problems of rape and sexual violence, and that this ‘solution’ is insufficient to the task. (shrink)

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: An examination of two thought experiments in contemporary physics reveals that the same thought experiment can be reanalyzed from the perspective of different and incompatible theories. This fact undermines those accounts of thought experiments that claim their justificatory power comes from their ability to reveal the laws of nature. While thought experiments do play a genuine evaluative role in science, they do so by testing the nonempirical virtues of a theory, such as consistency and explanatory power. I conclude that, (...) while their interpretation presupposes a whole set of background theories and putative laws, thought experiments nonetheless can evolve and be retooled for different theories and ends. (shrink)

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Das Fragen nach dem Anfang der Welt und des Menschen gehört zum Menschsein dazu. Eine Vielzahl von Texten, die den unterschiedlichsten kulturellen Einflüssen und Denktraditionen, historischen Zeiträumen und Gegebenheiten entstammen, überliefern kosmogonische Theorien. Die Untersuchung wendet sich fünf Weltanfangsdarstellungen in Texten zu, die als früheste überlieferte Zeugnisse europäischer volkssprachlicher Literatur gelten und zu Beginn und im Verlauf der Christianisierung im heutigen europäischen Raum entstanden sind. Es wird zum einen geprüft, ob und inwieweit die jeweiligen konkreten Gestaltungen des Themas übereinstimmen. Zum (...) anderen wird gefragt, was es ist, das die Darstellung des Weltanfangs verlangt und wie der Weltanfang funktionalisiert wird. Es zeigt sich, dass die Texte keine gemeinsame Geschichte vom Anfang erzählen. Vielmehr wird mit dem Erzählen vom Weltanfang eine Frage geklärt, die viel vorrangiger ist als die Frage nach dem Weltanfang selbst: die Frage, wer in den Besitz des Wortes kommen kann und darf. Es geht um die Frage nach den Grundvoraussetzungen des menschlichen Sprechens von heiligen Inhalten. (shrink)

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The fact that the same equations or mathematical models reappear in the descriptions of what are otherwise disparate physical systems can be seen as yet another manifestation of Wigner's “unreasonable effectiveness of mathematics.” James Clerk Maxwell famously exploited such formal similarities in what he called the “method of physical analogy.” Both Maxwell and Hermann von Helmholtz appealed to the physical analogies between electromagnetism and hydrodynamics in their development of these theories. I argue that a closer historical examination of the different (...) ways in which Maxwell and Helmholtz each deployed this analogy gives further insight into debates about the representational and explanatory power of mathematical models. (shrink)

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Despite widespread evidence that fictional models play an explanatory role in science, resistance remains to the idea that fictions can explain. A central source of this resistance is a particular view about what explanations are, namely, the ontic conception of explanation. According to the ontic conception, explanations just are the concrete entities in the world. I argue this conception is ultimately incoherent and that even a weaker version of the ontic conception fails. Fictional models can succeed in offering genuine explanations (...) by correctly capturing relevant patterns of counterfactual dependence and licensing correct inferences. Using the example of Newtonian force explanations of the tides, I show how, even in science, fiction can be a vehicle for truth. (shrink)

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We critically engage two traditional views of scientific data and outline a novel philosophical view that we call the pragmatic-representational view of data. On the PR view, data are representations that are the product of a process of inquiry, and they should be evaluated in terms of their adequacy or fitness for particular purposes. Some important implications of the PR view for data assessment, related to misrepresentation, context-sensitivity, and complementary use, are highlighted. The PR view provides insight into the common (...) but little-discussed practices of iteratively reusing and repurposing data, which result in many datasets’ having a phylogeny—an origin and complex evolutionary history—that is relevant to their evaluation and future use. We relate these insights to the open-data and data-rescue movements, and highlight several future avenues of research that build on the PR view of data. (shrink)

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Although predictive power and explanatory insight are both desiderata of scientific models, these features are often in tension with each other and cannot be simultaneously maximized. In such situations, scientists may adopt what I term a ‘division of cognitive labor’ among models, using different models for the purposes of explanation and prediction, respectively, even for the exact same phenomenon being investigated. Adopting this strategy raises a number of issues, however, which have received inadequate philosophical attention. More specifically, while one implication (...) may be that it is inappropriate to judge explanatory models by the same standards of quantitative accuracy as predictive models, there still needs to be some way of either confirming or rejecting these model explanations. Here I argue that robustness analyses have a central role to play in testing highly idealized explanatory models. I illustrate these points with two examples of explanatory models from the field of geomorphology. (shrink)

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Journal of Social Philosophy, EarlyView.

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This paper describes a long-standing, though little-known, debate between Paul Dirac and Werner Heisenberg over the nature of scientific methodology, theory change, and intertheoretic relations. Following Heisenberg’s terminology, their disagreements can be summarized as a debate over whether the classical and quantum theories are “open” or “closed.” A close examination of this debate sheds new light on the philosophical views of two of the great founders of quantum theory.

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Despite an enormous philosophical literature on models in science, surprisingly little has been written about data models and how they are constructed. In this paper, I examine the case of how paleodiversity data models are constructed from the fossil data. In particular, I show how paleontologists are using various model-based techniques to correct the data. Drawing on this research, I argue for the following related theses: first, the ‘purity’ of a data model is not a measure of its epistemic reliability. (...) Instead it is the fidelity of the data that matters. Second, the fidelity of a data model in capturing the signal of interest is a matter of degree. Third, the fidelity of a data model can be improved ‘vicariously’, such as through the use of post hoc model-based correction techniques. And, fourth, data models, like theoretical models, should be assessed as adequate for particular purposes. (shrink)

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The ontic conception of explanation, according to which explanations are "full-bodied things in the world," is fundamentally misguided. I argue instead for what I call the eikonic conception, according to which explanations are the product of an epistemic activity involving representations of the phenomena to be explained. What is explained in the first instance is a particular conceptualization of the explanandum phenomenon, contextualized within a given research program or explanatory project. I conclude that this eikonic conception has a number of (...) benefits, including making better sense of scientific practice and allowing for the full range of normative constraints on explanation. (shrink)

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In 2012, the Geological Time Scale, which sets the temporal framework for studying the timing and tempo of all major geological, biological, and climatic events in Earth’s history, had one-quarter of its boundaries moved in a widespread revision of radiometric dates. The philosophy of metrology helps us understand this episode, and it, in turn, elucidates the notions of calibration, coherence, and consilience. I argue that coherence testing is a distinct activity preceding calibration and consilience, and I highlight the value of (...) discordant evidence and trade-offs scientists face in calibration. The iterative nature of calibration, moreover, raises the problem of legacy data. (shrink)

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In this discussion, I engage the politics of intention to explore how structural racism structures the production of meaning and the practice of reason. Building on María Lugones's analysis of intention formation as a form of practical reasoning, I explore the reasoning at work during the 2011 Stand Your Ground (SYG) hearing of black survivor of domestic violence, Marissa Alexander, to contend that structural racism—in this case, both intimate personal violence and intimate state violence against black women—enacts race/gender domination through (...) projecting constructed intentions onto black women as a strategy to rationalize punishing black women. I also discuss two key black feminist critiques of reason—Patricia Hill Collins’ discussion of “controlling images” (2000) and Michelle Cliff's concept of the “mythic mind” (1982)—to propose controlling intentions as a framework to theorize how structural racism produces fictive intentions used to rationalize the criminal punishment of survival and justify that outcome as common sense. (shrink)

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The aim of this paper is to examine in detail the similarities and dissimilarities between Werner Heisenberg’s account of closed theories and Thomas Kuhn’s model of scientific revolutions. My analysis draws on a little‐known discussion that took place between Heisenberg and Kuhn in 1963, in which Heisenberg, having just read Kuhn’s Structure of Scientific Revolutions, compares Kuhn’s views to his own account of closed theories. I conclude that while Heisenberg and Kuhn share a holist conception of theories, a revolutionary model (...) of theory change, and even a notion of incommensurability, their views diverge fundamentally when it comes to the issue of scientific realism. I show that, contrary to popular opinion, Heisenberg is not an instrumentalist, but rather a pluralistic realist. (shrink)

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At the center of quantum chaos research is a particular family of models known as quantum maps. These maps illustrate an important “horizontal” dimension to model construction that has been overlooked in the literature on models. Three ways in which quantum maps are being used to clarify the relationship between classical and quantum mechanics are examined. This study suggests that horizontal models may provide a new and fruitful framework for exploring intertheoretic relations.

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This paper examines the ‘justice’ and ‘care’ orientations in ethical theory as characterized in Carol Gilligan's research on moral development and the philosophical work it has inspired. Focus is placed on challenges to the justice orientation – in particular, to the construal of impartiality as the mark of the moral point of view, to the conception of moral judgment as essentially principle-driven and dispassionate, and to models of moral responsibility emphasizing norms of formal equality and reciprocity. Suggestions are made about (...) the implications of these challenges, and of the care orientation in ethics, for the ethical theory taught, the issues addressed, and the skills and sensitivities encouraged through bioethical education. Keywords: bioethical education, ethics of care, impartiality, moral judgment, moral psychology CiteULike Connotea Del.icio.us What's this? (shrink)

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Detailed examinations of scientific practice have revealed that the use of idealized models in the sciences is pervasive. These models play a central role in not only the investigation and prediction of phenomena, but in their received scientific explanations as well. This has led philosophers of science to begin revising the traditional philosophical accounts of scientific explanation in order to make sense of this practice. These new model-based accounts of scientific explanation, however, raise a number of key questions: Can the (...) fictions and falsehoods inherent in the modeling practice do real explanatory work? Do some highly abstract and mathematical models exhibit a noncausal form of scientific explanation? How can one distinguish an exploratory "how-possibly" model explanation from a genuine "how-actually" model explanation? Do modelers face tradeoffs such that a model that is optimized for yielding explanatory insight, for example, might fail to be the most predictively accurate, and vice versa? This chapter explores the various answers that have been given to these questions. (shrink)

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Simulations using idealized numerical models can often generate behaviors or patterns that are visually very similar to the natural phenomenon being investigated and to be explained. The question arises, when should these model simulations be taken to provide an explanation for why the natural phenomena exhibit the patterns that they do? An important distinction for answering this question is that between ‘how-possibly’ explanations and ‘how-actually’ explanations. Despite the importance of this distinction there has been surprisingly little agreement over how exactly (...) this distinction should bedrawn. I shall argue that inadequate attention has been paid to the different contexts in which an explanation can be given and the different levels of abstraction at which the explanandum phenomenon can be framed. By tracing how scientists are using model simulations to explain a striking periodic banding of vegetation known as tiger bush, I will show how our understanding of the distinction between how-possibly and how-actually model explanations needs to be revised. (shrink)

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