JamesHutchisonStirling, his life and work.AmeliaHutchisonStirling -1912 - London [etc.]: T. F. Unwin.detailsThis work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work was reproduced from the original artifact, and remains as true to the original work as possible. Therefore, you will see the original copyright references, library stamps (as most of these works have been housed in our most important libraries around the world), and other notations in the work. This work is in the public domain (...) in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. As a reproduction of a historical artifact, this work may contain missing or blurred pages, poor pictures, errant marks, etc. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant. (shrink)
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As Regards Protoplasm, in Relation to Professor Huxley's Essasy on the Physical Basis of Life.JamesHutchisonStirling &Thomas Henry Huxley -2016 - Palala Press.detailsThis work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work was reproduced from the original artifact, and remains as true to the original work as possible. Therefore, you will see the original copyright references, library stamps (as most of these works have been housed in our most important libraries around the world), and other notations in the work. This work is in the public domain (...) in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. As a reproduction of a historical artifact, this work may contain missing or blurred pages, poor pictures, errant marks, etc. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant. (shrink)
Philosophy of the Unconditioned ; On the Philosophy of Kant ; The Development from Kant to Hegel ; and Lectures on the Philosophy of Kant.JamesHutchisonStirling -1993 - London: Psychology Press.detailsComprising some of the key texts, this collection illustrates not only Kant's influence on British thought in the 19th century, but also gives a greater insight into British intellectual attitudes of that time.
Handbook of the History of Philosophy.Albert Schwegler &JamesHutchisonStirling -1874 - Palala Press.detailsThis work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work was reproduced from the original artifact, and remains as true to the original work as possible. Therefore, you will see the original copyright references, library stamps (as most of these works have been housed in our most important libraries around the world), and other notations in the work. This work is in the public domain (...) in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. As a reproduction of a historical artifact, this work may contain missing or blurred pages, poor pictures, errant marks, etc. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant. (shrink)
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The Ethics of Surgical Research and Innovation.Wendy A. Rogers &KatrinaHutchison -2022 - In Tomas Zima & David N. Weisstub,Medical Research Ethics: Challenges in the 21st Century. Springer Verlag. pp. 217-232.detailsSurgical advances can provide great benefits to patients but can come at a cost. The successes are often matched by failures that cause harm to patients. The risks of surgery create a strong ethical imperative for research to establish the safety and efficacy of new treatments. Surgical research is, however, challenging for a number of reasons including the lack of a clear boundary between variations in practice, innovation and research, its irreversible nature, the difficulty of performing placebo-controlled randomised trials, confounding (...) factors such as surgeon learning curves and conflicts of interest. In this chapter the ethical issues raised by surgical innovation are explored with the use of a case study based on the uptake of vaginal mesh to treat vaginal prolapse to highlight these issues (Sects. 12.1 and 12.2). In Sect. 12.3 the argument for the value of a structured approach to introducing innovations, such as that developed by the IDEAL Collaboration, which clarifies both ethical and methodological issues at each stage of research is proposed. This chapter recognises that ethical challenges extend beyond adequate ethical evaluation of the innovation in the care of individual patients to include broader issues such as justice in access to any new interventions. (shrink)
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A Re-examination of Sir William Hamilton’s Philosophy.Gordon Graham -2015 - InScottish Philosophy in the Nineteenth and Twentieth Centuries. Oxford, GB: Oxford University Press.detailsThis chapter recounts the rise, eminence, and rapid fall in the philosophical standing of Sir William Hamilton. It sets out the philosophical resources that Hamilton called upon to amend and sustain the ‘common sense’ philosophy of Thomas Reid, responding especially to the criticisms of Thomas Brown. It examines in detail the criticisms that were brought against his philosophy from both sympathizers and opponents. Special attention is given to books on Hamilton published in the nineteenth by Henry Calderwood,Hutchison (...) class='Hi'>Stirling, and most notably J. S. Mill’s hugely influential ‘Examination’ of Hamilton. The chapter aims to explain both the high regard in which Hamilton was widely held and the reasons for his speedy relegation to the status of a minor philosopher. It also aims at a ‘Re-examination’ by assessing the cogency of Mill’s criticisms. (shrink)
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On the philosophy of Kant.Robert Adamson -1854 - London: Routledge/Thoemmes Press. Edited by A. G. Henderson.detailsThere has recently been a considerable amount of research into the influence of 18th century British philosophy--particularly into the thinking of David Hume on Continental philosophy and Kant. The aim of this collection is to provide some of the key texts which illustrate the impact of Kant's thought together with two important 20th century monographs on aspects of Kant's early reception and his influence on philosophical thought. Contents: Immanuel Kant in England 1793-1838 [1931] Rene Wellek 328 pp The Early Reception (...) of Kant's Thought in England 1785-1805 [1990] Giuseppe Micheli 114 pp A General and Introductory view of Professor Kant's Principles [1796] F. A. Nitsch 234 pp Text-Book to Kant [1881] (with a biographical sketch) JamesHutchisonStirling 576 pp The Development from Kant to Hegel [1882] Andrew Seth 178 pp Lectures on the Philosophy of Kant [1890] Thomas Hill Green 155 pp On the Philosophy of Kant [1879] Robert Adamson 270pp A Sketch of Kant's Life and Writings [1854] H. G. Henderson 80 pp Inquisitio Philosophica [1866], An Examination on the Principles of Kant and Hamilton M. P. W. Bolton 286 pp Philosophy of the Unconditioned [1829] William Hamilton 38 pp On the Philosophy of Kant [1856] Henry L. Mansel 45 pp The aim of this collection is to provide some of the key texts which illustrate the impact of Kant's thought together with two important 20th century monographs on aspects of Kant's early reception and his influence on philosophical thought. (shrink)
Addressing Deficits and Injustices: The Potential Epistemic Contributions of Patients to Research.KatrinaHutchison,Wendy Rogers &Vikki A. Entwistle -2017 -Health Care Analysis 25 (4):386-403.detailsPatient or public involvement in health research is increasingly expected as a matter of policy. In theory, PPI can contribute both to the epistemic aims intrinsic to research, and to extrinsically valued features of research such as social inclusion and transparency. In practice, the aims of PPI have not always been clear, although there has been a tendency to encourage the involvement of so-called ordinary people who are regarded as representative of an assumed patient perspective. In this paper we focus (...) on the epistemic potential of PPI, using theoretical work in epistemology to develop a nuanced account of patients’ experiential knowledge and how this might contribute directly to conceptual development, hypothesis generation and data interpretation. We also consider how some features of health research pose barriers to this kind of epistemic contribution. Drawing on Miranda Fricker’s idea of testimonial injustice, we explore how disciplinary indicators of credibility in clinical and academic health research contexts might be wrongly applied to those involved in PPI, undermining their potential to contribute. Finally we argue for a range of strategies to maximize opportunities for patients to engage with research teams and make epistemologically significant contributions to research. (shrink)
Device representatives in hospitals: are commercial imperatives driving clinical decision-making?Quinn Grundy,KatrinaHutchison,Jane Johnson,Brette Blakely,Robyn Clay-Wlliams,Bernadette Richards &Wendy A. Rogers -2018 -Journal of Medical Ethics 44 (9):589-592.detailsDespite concerns about the relationships between health professionals and the medical device industry, the issue has received relatively little attention. Prevalence data are lacking; however, qualitative and survey research suggest device industry representatives, who are commonly present in clinical settings, play a key role in these relationships. Representatives, who are technical product specialists and not necessarily medically trained, may attend surgeries on a daily basis and be available to health professionals 24 hours a day, 7 days a week, to provide (...) advice. However, device representatives have a dual role: functioning as commissioned sales representatives at the same time as providing advice on approaches to treatment. This duality raises the concern that clinical decision-making may be unduly influenced by commercial imperatives. In this paper, we identify three key ethical concerns raised by the relationship between device representatives and health professionals: impacts on healthcare costs, the outsourcing of expertise and issues of accountability and informed consent. These ethical concerns can be addressed in part through clarifying the boundary between the support and sales aspects of the roles of device representatives and developing clear guidelines for device representatives providing support in clinical spaces. We suggest several policy options including hospital provision of expert support, formalising clinician conduct to eschew receipt of meals and payments from industry and establishing device registries. (shrink)
Challenging the epistemological foundations of EBM: what kind of knowledge does clinical practice require?Katrina J.Hutchison &Wendy A. Rogers -2012 -Journal of Evaluation in Clinical Practice 18 (5):984-991.detailsThis paper raises questions about the epistemological foundations of evidence-based medicine . We argue that EBM is based upon reliabilist epistemological assumptions, and that this is appropriate - we should focus on identifying the most reliable processes for generating and collecting medical knowledge. However, we note that this should not be reduced to narrow questions about which research methodologies are the best for gathering evidence. Reliable processes for generating medical evidence might lie outside of formal research methods. We also question (...) the notion of the knower that is assumed by EBM. We argue that EBM assumes an enlightenment conception of knowers as autonomous, substitutable individuals. This conception is troubled by the way that clinicians learn the role of anecdote in health care and the role of patient choice, all of which bring into play features of clinicians and patients as situated individuals with particular backgrounds and experiences. EBM's enlightenment conception of the knower is also troubled by aspects of the way evidence is produced. Given these limitations, we argue that EBM should retain its reliabilist bent, but should look beyond formal research methodologies in identifying processes that yield reliable evidence for clinical practice. We suggest looking to feminist epistemology, with its focus on the standpoints of individual situated knowers, and the role of social context in determining what counts as knowledge. (shrink)
Cost-Related Non-Adherence to Prescribed Medicines: What Are Physicians’ Moral Duties?Narcyz Ghinea,KatrinaHutchison,Mianna Lotz &Wendy A. Rogers -forthcoming -American Journal of Bioethics:1-12.detailsAs the price of pharmaceuticals and biologicals rises so does the number of patients who cannot afford them. In this article, we argue that physicians have a moral duty to help patients access affordable medicines. We offer three grounds to support our argument: (i) the aim of prescribing is to improve health and well-being which can only be realized with secure access to treatment; (ii) there is no morally significant difference between medicines being unavailable and medicines being unaffordable, so the (...) steps physicians are willing to take in the first case should extend to the second; and (iii) as the primary stakeholder with a duty to put the individual patient’s interests first, the medical professional has a duty to address cost-barriers to patient care. In articulating this duty, we take account of important epistemic and control conditions that must be met for the attribution of this duty to be justified. (shrink)
Complete chemical synthesis, assembly, and cloning of a mycoplasma genitalium genome.Daniel Gibson,Benders G.,A. Gwynedd,Cynthia Andrews-Pfannkoch,Evgeniya Denisova,Baden-Tillson A.,Zaveri Holly,Stockwell Jayshree,B. Timothy,Anushka Brownley,David Thomas,Algire W.,A. Mikkel,Chuck Merryman,Lei Young,Vladimir Noskov,Glass N.,I. John,J. Craig Venter,ClydeHutchison,Smith A. &O. Hamilton -2008 -Science 319 (5867):1215--1220.detailsWe have synthesized a 582,970-base pair Mycoplasma genitalium genome. This synthetic genome, named M. genitalium JCVI-1.0, contains all the genes of wild-type M. genitalium G37 except MG408, which was disrupted by an antibiotic marker to block pathogenicity and to allow for selection. To identify the genome as synthetic, we inserted "watermarks" at intergenic sites known to tolerate transposon insertions. Overlapping "cassettes" of 5 to 7 kilobases (kb), assembled from chemically synthesized oligonucleotides, were joined by in vitro recombination to produce intermediate (...) assemblies of approximately 24 kb, 72 kb ("1/8 genome"), and 144 kb ("1/4 genome"), which were all cloned as bacterial artificial chromosomes in Escherichia coli. Most of these intermediate clones were sequenced, and clones of all four 1/4 genomes with the correct sequence were identified. The complete synthetic genome was assembled by transformation-associated recombination cloning in the yeast Saccharomyces cerevisiae, then isolated and sequenced. A clone with the correct sequence was identified. The methods described here will be generally useful for constructing large DNA molecules from chemically synthesized pieces and also from combinations of natural and synthetic DNA segments. 10.1126/science.1151721. (shrink)
Some Recent Theology.John A.Hutchison -1957 -Review of Metaphysics 11 (1):94 - 107.detailsThe effects of the theological revolution have been felt most acutely in European Protestantism, but it has by no means been limited either to Europe or to Protestantism. Its influence has been felt in Judaism, Catholicism, and to a lesser degree in Eastern Orthodoxy. Even Humanism has felt its force. From Europe it has spread to America, and also to Asia and Africa.
Beyond Guilty Verdicts: Human Rights Litigation and its Impact on Corporations’ Human Rights Policies.Judith Schrempf-Stirling &Florian Wettstein -2017 -Journal of Business Ethics 145 (3):545-562.detailsDuring the last years, there has been an increasing discussion on the role of business in human rights violations and an increase in human rights litigation against companies. The result of human rights litigation has been rather disillusioning because no corporation has been found guilty and most cases have been dismissed. We argue that it may nevertheless be a useful instrument for the advancement of the business and human rights agenda. We examine the determinants of successful human rights litigation in (...) terms of judicial, educational, and regulatory effects. This article reviews more than 40 corporate foreign direct liability cases and their effects on corporate human rights policies and conduct. The review shows that most corporations adjusted their human rights policies and adopted additional measures to cope with human rights issues during or shortly after the legal proceedings. Opening legal channels for human rights litigation may be one way for governments to incentivize firms to respect human rights. These findings have implications for the United Nations Guiding Principles on Business and Human Rights as well as on our interpretation of the most recent U.S. Supreme Court decision in Kiobel v. Shell. (shrink)