One cannot scrutinize mediality in a pre-media age without referring to the complex issue of Christology. The idea of Christ as medium and mediator concerns not only particular theological questions but also general issues of translation and transference, as well as models of word and image. This paper sketches first the notion of Christ′s mediality up to early Scholasticism and then highlights the new conceptual patterns developed by Bonaventure (Collationes in Hexaemeron) and Nicolas of Cusa (De visione dei).