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Early philosophical accounts of explanation mistook the function of boundary conditions for that of contingent facts. I diagnose where this misunderstanding arose and establish that it persists. I... | |
While the predominant focus of the philosophical literature on scientific modeling has been on single-scale models, most systems in nature exhibit complex multiscale behavior, requiring new modeling methods. This challenge of modeling phenomena across a vast range of spatial and temporal scales has been called the tyranny of scales problem. Drawing on research in the geosciences, I synthesize and analyze a number of strategies for taming this tyranny in the context of conceptual, physical, and mathematical modeling. This includes several strategies (...) that can be deployed in physical modeling, even when strict dynamical scaling fails. In all cases, I argue that having an adequate conceptual model—given both the nature of the system and the particular purpose of the model—is essential. I draw a distinction between depiction and representation, and use this research in the geosciences to advance a number of debates in the philosophy of modeling. (shrink) | |
Häggqvist and Wikforss argued that in the case of so-called natural kind terms, semantic externalism relies on an untenable metaphysics of kinds: microessentialism. They further claimed that this metaphysics fails, for largely empirical reasons. Focussing on the case of water, Hoefer and Martí European Journal for the Philosophy of Science, 9, rejoin that suitably construed, microessentialism is correct. I argue that their defence of microessentialism fails. | |
This paper argues that scale-dependence of physical and biological processes offers resistance to reductionism and has implications that support a specific kind of downward causation. I demonstrate how insights from multiscale modeling can provide a concrete mathematical interpretation of downward causation as boundary conditions for models used to represent processes at lower scales. The autonomy and role of macroscale parameters and higher-level constraints are illustrated through examples of multiscale modeling in physics, developmental biology, and systems biology. Drawing on these examples, (...) I defend the explanatory importance of constraining relations for understanding the behavior of biological systems. (shrink) No categories | |
Systems biologists often distance themselves from reductionist approaches and formulate their aim as understanding living systems “as a whole.” Yet, it is often unclear what kind of reductionism they have in mind, and in what sense their methodologies would offer a superior approach. To address these questions, we distinguish between two types of reductionism which we call “modular reductionism” and “bottom-up reductionism.” Much knowledge in molecular biology has been gained by decomposing living systems into functional modules or through detailed studies (...) of molecular processes. We ask whether systems biology provides novel ways to recompose these findings in the context of the system as a whole via computational simulations. As an example of computational integration of modules, we analyze the first whole-cell model of the bacterium M. genitalium. Secondly, we examine the attempt to recompose processes across different spatial scales via multi-scale cardiac models. Although these models rely on a number of idealizations and simplifying assumptions as well, we argue that they provide insight into the limitations of reductionist approaches. Whole-cell models can be used to discover properties arising at the interfaces of dynamically coupled processes within a biological system, thereby making more apparent what is lost through decomposition. Similarly, multi-scale modeling highlights the relevance of macroscale parameters and models and challenges the view that living systems can be understood “bottom-up.” Specifically, we point out that system-level properties constrain lower-scale processes. Thus, large-scale modeling reveals how living systems at the same time are more and less than the sum of the parts. (shrink) | |
The study of active matter systems demonstrates how interactions might co-constitute agential dynamics. Active matter systems are comprised of self-propelled independent entities which, en masse, take part in complex and interesting collective group behaviors at a far-from-equilibrium state (Menon, 2010 ; Takatori & Brady, 2015 ). These systems are modelled using very simple rules (Vicsek at al. 1995), which reveal the interactive nature of the collective behaviors seen from humble to highly complex entities. Here I show how the study of (...) active matter systems supports two related proposals regarding interaction and agency. First, I argue that the study of interactive dynamics in these systems evidences the utility of treating interaction as an ontological category (Longino, 2021 ) and challenges methodological individualism as the received explanatory primitive in the study of agency. Second, the methods used to research active matter systems demonstrate how a minimal approach to agency can scale up in studying interactive agential dynamics in more complex systems. The examples of coordination dynamics (Kelso, 2001 ) and participatory sense-making (De Jaegher & Di Paolo, 2007 ) are provided to show how understanding agency requires us to look beyond the individuals to the interactive agential dynamics that can guide, scaffold, or constrain their activity. (shrink) No categories | |
The causal closure of physics is usually discussed in a context free way. Here I discuss it in the context of engineering systems and biology, where strong emergence takes place due to a combination of upwards emergence and downwards causation. Firstly, I show that causal closure is strictly limited in terms of spatial interactions because these are cases that are of necessity strongly interacting with the environment. Effective Spatial Closure holds ceteris parabus, and can be violated by Black Swan Events. (...) Secondly, I show that causal closure in the hierarchy of emergence is a strictly interlevel affair, and in the cases of engineering and biology encompasses all levels from the social level to the particle physics level. However Effective Causal Closure can usefully be defined for a restricted set of levels, and one can experimentally determine Effective Theories that hold at each level. This does not however imply those effective theories are causally complete by themselves. In particular, the particle physics level is not causally complete by itself in the contexts of solid state physics, digital computers, or biology. Furthermore Inextricably Intertwined Levels occur in all these contexts. (shrink) | |
The traditional practice of establishing morphological types and investigating morphological organization has found new support from evolutionary developmental biology (evo-devo), especially with respect to the notion of body plans. Despite recurring claims that typology is at odds with evolutionary thinking, evo-devo offers mechanistic explanations of the evolutionary origin, transformation, and evolvability of morphological organization. In parallel, philosophers have developed non-essentialist conceptions of natural kinds that permit kinds to exhibit variation and undergo change. This not only facilitates a construal of species (...) and higher taxa as natural kinds, but also broadens our perspective on the diversity of kinds found in biology. There are many different natural kinds relevant to the investigative and explanatory aims of evo-devo, including homologues and developmental modules. (shrink) | |
Both ecologists and statistical physicists use a variety of highly idealized models to study active matter and self-organizing critical phenomena. In this paper, I show how universality classes play a crucial role in justifying the application of highly idealized ‘minimal’ models to explain and understand the critical behaviors of active matter systems across a wide range of scales and scientific fields. Appealing to universality enables us to see why the same minimal models can be used to explain and understand behaviors (...) across these different systems despite drastic differences in the causes and mechanisms responsible for the behaviors of interest. After analyzing these cases in detail, I argue that accounts that focus on identifying common causes or mechanisms in order to explain patterns are unable to accommodate these cases. In contrast, I argue that the justification for using these minimal models is that they are within the same universality class as real systems whose causes and mechanisms are known to be different. I also use these cases to identify several different kinds of explanatory autonomy that have important implications for how scientists ought to approach the modeling of multiscale phenomena. (shrink) No categories | |
This article examines the distinction between active matter and active materials, and it offers foundational remarks toward a system of classification for active materials. Active matter is typically identified as matter that exhibits two characteristic features: self-propelling parts, and coherent dynamical activity among the parts. These features are exhibited across a wide range of organic and inorganic materials, and they are jointly sufficient for classifying matter as active. Recently, the term “active materials” has entered scientific use as a complement, supplement, (...) and extension of “active matter.” At the same time, new work in the philosophy of science has considered the problem of how to classify the products of synthetic and laboratory processes, and the extent to which the aims of classifying natural kinds compare and contrasts with the aims of classifying these synthetic kinds. In this article, I apply those considerations to the problems of classifying and characterizing active materials. In doing so, I also argue for a conception of active materials’ coherent dynamical activity as multiscale, rather than emergent, and I discuss how the special non-equilibrium status of active materials factors in to classificatory concerns. (shrink) | |
In the last decade, Systems Biology has emerged as a conceptual and explanatory alternative to reductionist-based approaches in molecular biology. However, the foundations of this new discipline need to be fleshed out more carefully. In this paper, we claim that a relational ontology is a necessary tool to ground both the conceptual and explanatory aspects of Systems Biology. A relational ontology holds that relations are prior—both conceptually and explanatory—to entities, and that in the biological realm entities are defined primarily by (...) the context they are embedded within—and hence by the web of relations they are part of. (shrink) | |
Precision medicine and molecular systems medicine (MSM) are highly utilized and successful approaches to improve understanding, diagnosis, and treatment of many diseases from bench-to-bedside. Especially in the COVID-19 pandemic, molecular techniques and biotechnological innovation have proven to be of utmost importance for rapid developments in disease diagnostics and treatment, including DNA and RNA sequencing technology, treatment with drugs and natural products and vaccine development. The COVID-19 crisis, however, has also demonstrated the need for systemic thinking and transdisciplinarity and the limits (...) of MSM: the neglect of the bio-psycho-social systemic nature of humans and their context as the object of individual therapeutic and population-oriented interventions. COVID-19 illustrates how a medical problem requires a transdisciplinary approach in epidemiology, pathology, internal medicine, public health, environmental medicine, and socio-economic modeling. Regarding the need for conceptual integration of these different kinds of knowledge we suggest the application of general system theory (GST). This approach endorses an organism-centered view on health and disease, which according to Ludwig von Bertalanffy who was the founder of GST, we call Organismal Systems Medicine (OSM). We argue that systems science offers wider applications in the field of pathology and can contribute to an integrative systems medicine by (i) integration of evidence across functional and structural differentially scaled subsystems, (ii) conceptualization of complex multilevel systems, and (iii) suggesting mechanisms and non-linear relationships underlying the observed phenomena. We underline these points with a proposal on multi-level systems pathology including neurophysiology, endocrinology, immune system, genetics, and general metabolism. An integration of these areas is necessary to understand excess mortality rates and polypharmacological treatments. In the pandemic era this multi-level systems pathology is most important to assess potential vaccines, their effectiveness, short-, and long-time adverse effects. We further argue that these conceptual frameworks are not only valid in the COVID-19 era but also important to be integrated in a medicinal curriculum. (shrink) | |
There has been much controversy over weak and strong emergence in physics and biology. As pointed out by Phil Anderson in many papers, the existence of broken symmetries is the key to emergence of properties in much of solid state physics. By carefully distinguishing between different types of symmetry breaking and tracing the relation between broken symmetries at micro and macro scales, I demonstrate that the emergence of the properties of semiconductors is a case of strong emergence. This is due (...) to the existence of quasiparticles such as phonons. Furthermore time dependent potentials enable downward causation as in the case of digital computers. Additionally I show that the processes of evolutionary emergence of living systems is also a case of strong emergence, as is the emergence of properties of life out of the underlying physics. A useful result emerges: standard physics theories and the emergent theories arising out of them are all effective theories that are equally valid. (shrink) | |
There is a general conception of levels in philosophy which says that the world is arrayed into a hierarchy of levels and that there are different modes of analysis that correspond to each level of this hierarchy, what can be labelled the ‘Hierarchical Correspondence View of Levels” (or HCL). The trouble is that despite its considerable lineage and general status in philosophy of science and metaphysics the HCL has largely escaped analysis in specific domains of inquiry. The goal of this (...) paper is to take up a recent call to domain-specificity by examining the role of the HCL in cognitive science. I argue that the HCL is, in fact, a conception of levels that has been employed in cognitive science and that cognitive scientists should avoid its use where possible. The argument is that the HCL is problematic when applied to cognitive science specifically because it fails to distinguish two important kinds of shifts used when analysing information processing systems: shifts in grain and shifts in analysis. I conclude by proposing a revised version of the HCL which accommodates the distinction. (shrink) | |
Multiscale modeling techniques have attracted increasing attention by philosophers of science, but the resulting discussions have almost exclusively focused on issues surrounding explanation (e.g., reduction and emergence). In this paper, I argue that besides explanation, multiscale techniques can serve important exploratory functions when scientists model systems whose organization at different scales is ill-understood. My account distinguishes explanatory and descriptive multiscale modeling based on which epistemic goal scientists aim to achieve when using multiscale techniques. In explanatory multiscale modeling, scientists use multiscale (...) techniques to select information that is relevant to explain a particular type of behavior of the target system. In descriptive multiscale modeling scientists use multiscale techniques to explore lower-scale features which could be explanatorily relevant to many different types of behavior, and to determine which features of a target system an upper-scale data pattern could refer to. Using multiscale models from data-driven neuroscience as a case study, I argue that descriptive multiscale models have an exploratory function because they are a sources of potential explanations and serve as tools to reassess our conception of the target system. (shrink) | |
Dynamical models of cognition have played a central role in recent cognitive science. In this paper, we consider a common strategy by which dynamical models describe their target systems neither as purely static nor as purely dynamic, but rather using a hybrid approach. This hybridity reveals how dynamical models involve representational choices that are important for understanding the relationship between dynamical and non-dynamical representations of a system. | |
Moral rationalism has long been an attractive position within moral philosophy. However, among empirical-minded philosophers, it is widely dismissed as scientifically untenable. In this essay, I argue that moral rationalism’s lack of uptake in the empirical domain is due to the widespread supposition that moral rationalists must hold that moral judgments and actions are produced by rational capacities. But this construal is mistaken: moral rationalism’s primary concern is not with the relationship between moral judgments and rational capacities per se, but (...) rather with developing a conception objectivity normativity that avoids Platonism. In light of this, I develop an alternative approach to translating moral rationalism into the empirical domain that builds on the common rationalist view that normative requirements are explained by the relationship between agents and the social structures and practices in which they are embedded. I propose that this social conception of normativity can be translated into a scientific framework by interpreting it as a claim about the importance of constraint-based explanation when accounting for norm-governed behavior. In order to develop this point more concretely and show that it is empirically tractable, I turn to research on macaque social organization that highlights the ways in which normative standards are generated by empirically observable social structures. The insights garnered from the macaque case allow me to then locate moral rationalism’s core claims about the relationship between morality and the standards of practical rationality within an empirically plausible framework. (shrink) No categories | |
Gallagher [2019] defends a form of naturalised phenomenology based on a non-classical view of science. A central component of this argument involves an analogy between phenomenology and quantum-mechanics: Gallagher suggests that both require us to give up key components of a classical view of the natural world. Here, I try to clarify this analogy and consider two associated problems. The first problem concerns the concept of subjectivity and its different roles in physics and phenomenology, and the second concerns the concept (...) of complementarity in quantum mechanics. I argue that complementarity is poorly suited to the integrative view of science that Gallagher ultimately wishes to defend. Instead, a better model of integration can be found in examples of multiscale modelling, which is widespread in science, including classical physics. Gallagher is right to reject an overly narrow view of naturalism, but we do not need to consider the peculiarities of quantum mechanics to find inspiration for a broader view. (shrink) No categories | |
‘Mapping accounts’ of applied mathematics hold that the application of mathematics in physical science is best understood in terms of ‘mappings’ between mathematical structures and physical structures. In this paper, I suggest that mapping accounts rely on the assumption that the mathematics relevant to any application of mathematics in empirical science can be captured in an appropriate mathematical structure. If we are interested in assessing the plausibility of mapping accounts, we must ask ourselves: how plausible is this assumption as a (...) working hypothesis about applied mathematics? In order to do so, we examine the role played by mathematics in the multiscalar modelling of sea ice melting behaviour and examine whether we can indeed capture the mathematics involved in the kind of mathematical structure employed by the mapping account. Along the way, we note that the cases of applied mathematics that appear in discussions of mapping accounts almost exclusively involve the employment of a single clearly circumscribed mathematical field or domain. While the core assumption of mapping accounts may appear plausible in such situations, we ultimately suggest that the mapping account is not able to handle the important added complexities involved in our sea ice case study. In particular, the notion of mathematical structure around which such accounts are framed does not seem to be able to capture the way in which some applications of mathematics require that very different pieces of mathematics be related to one another on the basis of both mathematical and empirical information. (shrink) | |
This essay considers a mixed-effects modeling practice and its implications for the philosophical debate surrounding reductive explanation. Mixed-effects modeling is a species of the multilevel modeling practice, where a single model incorporates simultaneously two levels of explanatory variables to explain a phenomenon of interest. I argue that this practice makes the position of explanatory reductionism held by many philosophers untenable because it violates two central tenets of explanatory reductionism: single-level preference and lower-level obsession. No categories | |
This paper addresses the topic of determinism in contemporary microbiome research. I distinguish two types of deterministic claims about the microbiome, and I show evidence that both types of claims are present in the contemporary literature. First, the idea that the host genetics determines the composition of the microbiome which I call “host-microbiome determinism”. Second, the idea that the genetics of the holobiont (the individual unit composed by a host plus its microbiome) determines the expression of certain phenotypic traits, which (...) I call “microbiome-phenotype determinism”. Drawing on the stability of traits conception of individuality (Suárez in Hist Philos Life Sci 42:11, 2020) I argue that none of these deterministic hypotheses is grounded on our current knowledge of how the holobiont is transgenerationally assembled, nor how it expresses its phenotypic traits. (shrink) | |
Cell biologists, including those seeking molecular mechanistic explanations of cellular phenomena, frequently rely on experimental strategies focused on identifying the cellular context relevant to their investigations. We suggest that such practices can be understood as a guided decomposition strategy, where molecular explanations of phenomena are defined in relation to natural contextual (cell) boundaries. This “top-down” strategy contrasts with “bottom-up” reductionist approaches where well-defined molecular structures and activities are orphaned by their displacement from actual biological functions. We focus on the central (...) role of microscopic imaging in cell biology to uncover possible constraints on the system. We show how identified constraints are used heuristically to limit possible mechanistic explanations to those that are biologically meaningful. Historical examples of this process described here include discovery of the mechanism of oxidative phosphorylation in mitochondria, molecular explanation of the first steps in protein secretion, and identification of molecular motors. We suggest that these instances are examples of a form of downward causation or, more specifically, constraining relations, where higher-level structures and variables delimit and enable lower-level system states. The guided decomposition strategy in our historical cases illustrates the irreducibility of experimentally identified constraints in explaining biological activities of cells. Rather than viewing decomposition and recomposition as separate epistemic activities, we contend that they need to be iteratively integrated to account for the ontological complexity of multi-level systems. (shrink) | |
Bu makalede, biyoloji felsefesinde son derece tartışmalı bir konu olan indirgemecilik problemi ele alınmaktadır. Canlılığın fizikalist bir çerçevede değerlendirilmesinin, biyolojinin fiziğe indirgenebileceği anlamına gelmediği savunulmakta ve bu bağlamda fizikalizm ile fiziğe indirgeme arasında ne tür farklılıklar olduğu ortaya konmaktadır. İndirgemeciliğin metodolojik, epistemolojik ve ontolojik boyutları ayrı ayrı değerlendirilmekte ve öncelikle bütünü parçalarına indirgeyen metodolojik yaklaşımın eleştirisine odaklanılmaktadır. Ardından indirgemeciliğin epistemolojik boyutu incelenmektedir. Teori indirgemesi düşüncesinin temelinde, evrimsel ve tarihsel süreçlerde hiçbir mantıksal ilke bulunmadığı ve bu nedenle doğaya ilişkin nihai açıklamaları (...) sunan disiplinin, doğa yasalarını merkeze alan fiziğin olduğu varsayımı yatmaktadır. Bu düşünceye karşı bir alternatif olarak, bilimsel açıklamaların çoğulculuğu ile indirgemeci olmayan tarzda bütünleşmesinin bir arada var olabileceği ileri sürülmektedir. (shrink) No categories | |
Organoids and organs-on-a-chip are currently the two major families of 3D advanced organotypic in vitro culture systems, aimed at reconstituting miniaturized models of physiological and pathological states of human organs. Both share the tenets of the so-called “three-dimensional thinking”, a Systems Physiology approach focused on recapitulating the dynamic interactions between cells and their microenvironment. We first review the arguments underlying the “paradigm shift” toward three-dimensional thinking in the in vitro culture community. Then, through a historically informed account of the technical (...) affordances and the epistemic commitments of these two approaches, we highlight how they embody two distinct experimental cultures. We finally argue that the current systematic effort for their integration requires not only innovative “synergistic” engineering solutions, but also conceptual integration between different perspectives on biological causality. (shrink) | |
Reductionism and holism, that is, antireductionism, are two of the prevailing paradigms within the philosophy of biology. Reductionists strive to understand biological phenomena by reducing them to a series of levels of complexity with each lower level forming the foundation for the subsequent level, by mapping such biological phenomena inasmuch as possible to the principal phenomena within the fundamental sciences of chemistry and physics. In this way, complex phenomena can be reduced to assemblages of more elementary explananda. Holism, in counterpart, (...) claims that there independently exist phenomena arising from ordered levels of complexity that have intrinsic causal power and cannot be reduced in this way. When dealing with the nature of biology and its unique foundations of essentialism, determinism and ethics, the pedagogical lens through which these foundations are conveyed to learners could provide a limited perspective if only the reductive approach is followed as it would not sensitise learners to the true complexity of the phenomenon of life and the study thereof, and it is the purpose of this article to frame the reductionist–antireductionist debate in order to illustrate this.Contribution: This article contributes new knowledge to the field of the philosophy of science; more specifically, the philosophy of biology by critically evaluating the pervasive dialectic between the theoretical frameworks of reductionism and antireductionism and alluding to the pedagogical consequences thereof. (shrink) | |
In scientific modeling, continuum idealizations bridge scales but at the cost of fundamentally misrepresenting the microstructure of the system. This engenders a mystery. If continuum idealizations are dispensable in principle, this de-problematizes their representational inaccuracy, since continuum properties reduce to lower-scale properties, but the mystery of how this reduction could be carried out endures. Alternatively, if continuum idealizations are indispensable in principle, this is consistent with their explanatory and predictive success but renders their representational inaccuracy mysterious. I argue for a (...) deflationary solution, enlisting the applied scientific method of upscaling as demonstrated in a case from soil hydrology. (shrink) |
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