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Tbio
LTBP1
Latent-transforming growth factor beta-binding protein 1

Protein Summary
Description
Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space (PubMed:2022183, PubMed:8617200, PubMed:8939931). Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta (PubMed:8617200, PubMed:8939931, PubMed:15184403). Outcompeted by LRRC32/GARP for binding to LAP regulatory chain of TGF-beta (PubMed:22278742). The protein encoded by this gene belongs to the family of latent TGF-beta binding proteins (LTBPs). The secretion and activation of TGF-betas is regulated by their association with latency-associated proteins and with latent TGF-beta binding proteins. The product of this gene targets latent complexes of transforming growth factor beta to the extracellular matrix, where the latent cytokine is subsequently activated by several differen ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000404525
  • ENSP00000385359
  • ENSG00000049323
  • ENST00000404816
  • ENSP00000386043
  • ENST00000407925
  • ENSP00000384091
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.99
protein domain
0.92
transcription factor
0.88
transcription factor perturbation
0.88
molecular function
0.86


Protein Classes
PANTHER Classes Protein /Signaling Molecule /Latent-transforming Growth Factor Beta-binding Protein 1 Protein /Extracellular Matrix Protein /Extracellular Matrix Structural Protein /Latent-transforming Growth Factor Beta-binding Protein 1 Protein /Extracellular Matrix Protein /Extracellular Matrix Glycoprotein /Latent-transforming Growth Factor Beta-binding Protein 1 Protein /Cell Adhesion Molecule /Latent-transforming Growth Factor Beta-binding Protein 1 Protein /Calcium-binding Protein /Intracellular Calcium-sensing Protein /Calmodulin /Latent-transforming Growth Factor Beta-binding Protein 1 Protein /Calcium-binding Protein /Annexin /Latent-transforming Growth Factor Beta-binding Protein 1
DTO ClassesProtein /Calcium-binding Protein /Intracellular Calcium-sensing Protein /Calmodulin /Latent-transforming Growth Factor Beta-binding Protein 1
IDG Development Level Summary
Tdark
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 122.72   (req: >= 5)
Gene RIFs: 70   (req: > 3)
Antibodies: 193   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of< 30 nM- AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug- AND - satisfies the preceding conditions

Active Drug: 0
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Description of the protein which includes the UniProt Function and the NCBI Gene Summary.
Uniprot linked accession values, symbols or commonly used abbreviations associated with this particular target.
Approved gene symbol with link to HUGO Gene Nomenclature Committee.
Ensembl identifier links.
Radar plot depicting the variety of knowledge obtained by Pharos for a particular target. The more spikes in the plot, the more variety. The longer the length, the higher the quantity of that particular knowledge. Clicking the illumination graph opens an expanded view to explore the plot fuller by seeing plot with annotations of the different radii.
Table representing the top 5 knowledge attributes in the illumination graph. The knowledge value property is on a scale of 0 to 1.
Gene symbols, accession ids and various other target identifiers. Also contains the illumination graph which highlights the amount of knowledge available. Click the "?" for more details.
click for section description and definitions
Hierarchical classifications for this protein from different ontologies. Click the "?" for more details.
Classes for this protein according to Protein ANalysis THrough Evolutionary Relationships (PANTHER) Classification System.
Explore targets in this PANTHER class
Classes for this protein according to by Drug Target Ontology (DTO).
Explore targets in this DTO class
Descriptions of the IDG illumination levels, highlighting the milestones attained in research for this target. Click the "?" for more details.
Jensen Lab generated fractional counting score for the prevalence of this gene in Pubmed articles.
Total count of NCBI Gene Reference Into Function hits for target listed in parenthesis, and summary table with links to publications per PMID with the specific text in article that includes the reported target.
Number of antibodies for this target listed in antibodypedia.com
Number of Gene Ontology (GO) annotations for this target, consisting of the sum of GO Functions and GO Processes.
Ligands associated with a target, listed in ChEMBL, with activity over a cutoff relative to the targetclass.
Approved drugs associated with a target.
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