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Kermekchiev et al., 1987 - Google Patents

Natural point mutations within rat rDNA transcription terminator elements reveal the functional importance of single bases for factor binding and termination

Kermekchiev et al., 1987

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Document ID
17098765021434166249
Author
Kermekchiev M
Grummt I
Publication year
Publication venue
Nucleic acids research

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The rat rDNA transcription unit extends 560–565 bp into the spacer down stream of the 28S rRNA coding region. The site of 3'end formation is located in front of a conserved 18 bp sequence element which is repeated eight times in the 3'spacer between nucleotides+ 582 …
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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