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ZW290A1 - 2-aminopyrimidinone derivatives - Google Patents

2-aminopyrimidinone derivatives

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Publication number
ZW290A1
ZW290A1ZW2/90AZW290AZW290A1ZW 290 A1ZW290 A1ZW 290A1ZW 2/90 AZW2/90 AZW 2/90AZW 290 AZW290 AZW 290AZW 290 A1ZW290 A1ZW 290A1
Authority
ZW
Zimbabwe
Prior art keywords
6alkyl
hydrogen
chem
compounds
pharmaceutical compositions
Prior art date
Application number
ZW2/90A
Inventor
Edmond Josephine Kennis Ludo
Vandenberk Jan
Martin Boey Jozef
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica NvfiledCriticalJanssen Pharmaceutica Nv
Publication of ZW290A1publicationCriticalpatent/ZW290A1/en

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Abstract

Novel 2-aminopyrimidinone derivatives of formula <CHEM> wherein R<1> is <CHEM> R<3> is hydrogen or C1-6alkyl; R<4> is hydrogen, C1-6alkyl or substituted C1-6alkyl; R<5> is hydrogen, C1-6alkyl, C1-6alkylaminocarbonyl, Ar-aminocarbonyl, C1-6alkylcarbonyl or Ar-carbonyl; R<6> is hydrogen, C1-6alkyl or Ar-C1-6alkyl; or R<5> and R<6> taken together is -CH2-CH2-, -CH2-CH2-CH2-, -CH=CH-, -CH=N-, -N=CH- or -N=CH-CH2-; the pharmaceutically acceptable acid addition salts and possible stereochemically isomeric forms thereof; pharmaceutical compositions containing such compounds as an active ingredient and methods of preparing said compounds and pharmaceutical compositions.
ZW2/90A1989-01-091990-01-082-aminopyrimidinone derivativesZW290A1 (en)

Applications Claiming Priority (1)

Application NumberPriority DateFiling DateTitle
GB898900382AGB8900382D0 (en)1989-01-091989-01-092-aminopyrimidinone derivatives

Publications (1)

Publication NumberPublication Date
ZW290A1true ZW290A1 (en)1991-09-11

Family

ID=10649779

Family Applications (1)

Application NumberTitlePriority DateFiling Date
ZW2/90AZW290A1 (en)1989-01-091990-01-082-aminopyrimidinone derivatives

Country Status (25)

CountryLink
EP (1)EP0378255B1 (en)
JP (1)JP2938492B2 (en)
KR (1)KR0159099B1 (en)
CN (1)CN1034865C (en)
AT (1)ATE104971T1 (en)
AU (1)AU617918B2 (en)
CA (1)CA2007200C (en)
DE (1)DE69008366T2 (en)
DK (1)DK0378255T3 (en)
ES (1)ES2055860T3 (en)
FI (1)FI94525C (en)
GB (1)GB8900382D0 (en)
HU (1)HU203747B (en)
IE (1)IE62874B1 (en)
IL (1)IL92730A (en)
JO (1)JO1605B1 (en)
MA (1)MA21722A1 (en)
MY (1)MY106259A (en)
NO (1)NO173139C (en)
NZ (1)NZ231788A (en)
PT (1)PT92806B (en)
RU (1)RU2028297C1 (en)
TN (1)TNSN90003A1 (en)
ZA (1)ZA90123B (en)
ZW (1)ZW290A1 (en)

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IL122072A (en)1996-11-142001-03-19Akzo Nobel NvPiperidine derivatives their preparation and pharmaceutical compositions containing them
ES2165274B1 (en)*1999-06-042003-04-01Almirall Prodesfarma Sa NEW DERIVATIVES OF INDOLILPIPERIDINE AS ANTIHISTAMINIC AND ANTIALERGIC AGENTS.
US6995144B2 (en)*2002-03-142006-02-07Eisai Co., Ltd.Nitrogen containing heterocyclic compounds and medicines containing the same
ES2201907B1 (en)2002-05-292005-06-01Almirall Prodesfarma, S.A. NEW DERIVATIVES OF INDOLILPIPERIDINE AS POWERFUL ANTIHISTAMINIC AND ANTIALERGIC AGENTS.
KR20050122220A (en)2003-03-252005-12-28다케다 샌디에고, 인코포레이티드Dipeptidyl peptidase inhibitors
EP1911754B1 (en)*2003-08-132013-10-09Takeda Pharmaceutical Company LimitedDipeptidyl peptidase inhibitors
US20050070531A1 (en)2003-08-132005-03-31Syrrx, Inc.Dipeptidyl peptidase inhibitors
US7790734B2 (en)2003-09-082010-09-07Takeda Pharmaceutical Company LimitedDipeptidyl peptidase inhibitors
WO2005095381A1 (en)2004-03-152005-10-13Takeda Pharmaceutical Company LimitedDipeptidyl peptidase inhibitors
RU2007125692A (en)*2004-12-072009-01-20Солвей Фармасьютикалс Б.В. (Nl) TETRAHYDROPYRIDIN-4-IL INDOLES WITH A COMBINATION OF PROPERTIES-RELATIONSHIPS FOR D2 DOPAMINE RECEPTORS D2 AND SEROTONIN REVERSION CENTERS
US7371769B2 (en)2004-12-072008-05-13Solvay Pharmaceuticals B.V.Tetrahydropyridin-4-yl indoles with a combination of affinity for dopamine-D2 receptors and serotonin reuptake sites
US20070072870A2 (en)2004-12-082007-03-29Solvay Pharmeceuticals B.V.Phenylpiperazine derivatives with a combination of partial dopamine-d2 receptor agonism and serotonin reuptake inhibition
EP1828192B1 (en)2004-12-212014-12-03Takeda Pharmaceutical Company LimitedDipeptidyl peptidase inhibitors
CA2622472C (en)2005-09-142013-11-19Takeda Pharmaceutical Company LimitedDipeptidyl peptidase inhibitors for treating diabetes
KR101368988B1 (en)2005-09-162014-02-28다케다 야쿠힌 고교 가부시키가이샤Dipeptidyl peptidase inhibitors
TW200813015A (en)2006-03-152008-03-16Mitsubishi Pharma Corp2-(cyclic amino)-pyrimidone derivatives
US8324383B2 (en)2006-09-132012-12-04Takeda Pharmaceutical Company LimitedMethods of making polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile
TW200838536A (en)2006-11-292008-10-01Takeda PharmaceuticalPolymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor
US8093236B2 (en)2007-03-132012-01-10Takeda Pharmaceuticals Company LimitedWeekly administration of dipeptidyl peptidase inhibitors
PE20091236A1 (en)*2007-11-222009-09-16Astrazeneca Ab PYRIMIDINE DERIVATIVES AS IMMUNOMODULATORS OF TLR7
BR102012024778A2 (en)*2012-09-282014-08-19Cristalia Prod Quimicos Farm Heteroaromatic compounds; PROCESS FOR PREPARING COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, USES AND TREATMENT METHOD FOR ACUTE AND CHRONIC PAIN
WO2015064714A1 (en)*2013-10-312015-05-07国立大学法人東京大学1-substituted imidazopyrimidinone derivative having autotaxin-inhibiting activity
TN2019000290A1 (en)2017-03-202021-05-07Forma Therapeutics IncPyrrolopyrrole compositions as pyruvate kinase (pkr) activators
JP7090639B2 (en)*2017-04-112022-06-24サンシャイン・レイク・ファーマ・カンパニー・リミテッド Fluoride-substituted indazole compounds and their use
CN113226356B (en)2018-09-192025-03-04诺沃挪第克健康护理股份公司 Pyruvate kinase R
MA53668B1 (en)2018-09-192024-06-28Novo Nordisk Health Care Ag TREATMENT OF SICKLE CELL DISEASE WITH A COMPOUND ACTIVATING PYRUVATE KINASE R
AU2020349555A1 (en)2019-09-192022-04-07Forma Therapeutics, Inc.Activating Pyruvate Kinase R
US12128035B2 (en)2021-03-192024-10-29Novo Nordisk Health Care AgActivating pyruvate kinase R

Family Cites Families (5)

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US4443451A (en)*1981-07-151984-04-17Janssen Pharmaceutica N.V.Bicyclic pyrimidin-5-one derivatives
US4485107A (en)*1982-11-011984-11-27Janssen Pharmaceutica N.V.[[Bis(aryl)methylene]-1-piperidinyl]alkyl-pyrimidinones
FR2537764A1 (en)*1982-12-081984-06-15Framatome Sa DEVICE FOR CONTROLLING TWO CLUSTERS OF CONTROL PADS VERTICALLY MOVABLE IN THE SAME COMBUSTIBLE ASSEMBLY OF THE HEART OF A NUCLEAR REACTOR
US4804663A (en)*1985-03-271989-02-14Janssen Pharmaceutica N.V.3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles
GB8900380D0 (en)*1989-01-091989-03-08Janssen Pharmaceutica Nv2-aminopyrimidinone derivatives

Also Published As

Publication numberPublication date
KR900011755A (en)1990-08-02
NO173139B (en)1993-07-26
PT92806B (en)1995-11-30
EP0378255A2 (en)1990-07-18
TNSN90003A1 (en)1991-03-05
NO900071D0 (en)1990-01-08
IL92730A0 (en)1990-09-17
CA2007200A1 (en)1990-07-09
JPH02225482A (en)1990-09-07
EP0378255A3 (en)1991-01-09
HU900064D0 (en)1990-03-28
FI94525C (en)1995-09-25
DK0378255T3 (en)1994-05-24
IE900069L (en)1990-07-09
CN1034865C (en)1997-05-14
IE62874B1 (en)1995-03-08
MY106259A (en)1995-04-29
KR0159099B1 (en)1998-12-01
FI94525B (en)1995-06-15
IL92730A (en)1993-06-10
PT92806A (en)1990-07-31
CA2007200C (en)1999-07-20
DE69008366D1 (en)1994-06-01
EP0378255B1 (en)1994-04-27
ZA90123B (en)1991-09-25
JO1605B1 (en)1990-07-01
CN1044094A (en)1990-07-25
ES2055860T3 (en)1994-09-01
GB8900382D0 (en)1989-03-08
AU4777990A (en)1990-07-12
FI900085A0 (en)1990-01-08
NO173139C (en)1993-11-03
NO900071L (en)1990-07-10
HUT52770A (en)1990-08-28
DE69008366T2 (en)1994-08-25
NZ231788A (en)1990-12-21
ATE104971T1 (en)1994-05-15
AU617918B2 (en)1991-12-05
JP2938492B2 (en)1999-08-23
HU203747B (en)1991-09-30
RU2028297C1 (en)1995-02-09
MA21722A1 (en)1990-10-01
FI900085L (en)1990-07-10

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