本发明实施例涉及信号检测技术领域，尤其涉及一种基于金刚石量子传感器的乳腺癌检测装置。The embodiments of the present invention relate to the field of signal detection technology, and in particular to a breast cancer detection device based on a diamond quantum sensor.
乳腺癌位居我国女性恶性肿瘤发病率第一，晚期癌症具有极高的致死率。近年来，我国女性乳腺癌发病率呈上升趋势。针对乳腺癌进行早期筛查，做出快速、准确的诊断能够极大的降低乳腺癌的致死率，提高病人的生存率。所以需要一种安全、灵敏度与分辨率高、价格便宜的乳腺癌检测手段。Breast cancer ranks first in the incidence of malignant tumors among women in my country, and advanced cancer has a very high mortality rate. In recent years, the incidence of breast cancer in women in my country has been on the rise. Early screening for breast cancer and making a quick and accurate diagnosis can greatly reduce the mortality rate of breast cancer and improve the survival rate of patients. Therefore, a safe, sensitive, high-resolution, and inexpensive breast cancer detection method is needed.
乳腺X射线检测是目前主要的影像学筛查手段，但是该检测手段有电离辐射损伤，对于致密型乳腺检测灵敏度低的劣势。乳腺超声检测无电离辐射，且适用于致密型乳腺的检测，但是其检测灵敏度与分辨率较低。磁共振成像技术具有极高的检测灵敏度与分辨率且没有电离辐射损伤，但是该技术测量时间长需要被检测对象保持静止，否则会产生伪影从而影响检测结果的准确性，不仅如此磁共振成像技术检测成本极高，不适用于作为乳腺癌早期筛查的手段。Breast X-ray examination is currently the main imaging screening method, but this detection method has the disadvantage of ionizing radiation damage and low sensitivity for dense breast detection. Breast ultrasound detection has no ionizing radiation and is suitable for the detection of dense breasts, but its detection sensitivity and resolution are low. Magnetic resonance imaging technology has extremely high detection sensitivity and resolution and no ionizing radiation damage, but this technology has a long measurement time and requires the subject to remain still, otherwise artifacts will be generated, affecting the accuracy of the test results. Not only that, the detection cost of magnetic resonance imaging technology is extremely high, and it is not suitable as a means of early screening for breast cancer.
乳腺微波成像技术作为一种无电离辐射的检测手段，理论上有着较高灵敏度与分辨率，成本适中，十分适合乳腺癌的早期筛查。目前已有的基于传统电磁感应原理的乳腺癌微波检测技术灵敏度与分辨率指标仍有提升空间。As a detection method without ionizing radiation, breast microwave imaging technology has high sensitivity and resolution in theory, moderate cost, and is very suitable for early screening of breast cancer. The sensitivity and resolution indicators of the existing breast cancer microwave detection technology based on the traditional electromagnetic induction principle still have room for improvement.
为了解决现有技术中的问题，本发明提供一种基于金刚石量子传感器的乳腺癌检测装置，以提高乳腺癌检测装置的灵敏度和分辨率。In order to solve the problems in the prior art, the present invention provides a breast cancer detection device based on a diamond quantum sensor to improve the sensitivity and resolution of the breast cancer detection device.
第一方面，本发明提供一种基于金刚石量子传感器的乳腺癌检测装置，包括：In a first aspect, the present invention provides a breast cancer detection device based on a diamond quantum sensor, comprising:
荧光读出装置、微波发生控制装置、激光发生控制装置、计算控制系统以及医疗诊断台；Fluorescence readout device, microwave generation control device, laser generation control device, computer control system and medical diagnosis table;
所述医疗诊断台包括金刚石微波传感探头和相机，所述金刚石微波传感探头用于在不同检测位置向待测目标辐射探测微波以及测量待测目标散射的微波信号，所述相机用于在不同检测位置处拍摄待测目标的图像并发送至所述计算控制系统；The medical diagnosis table comprises a diamond microwave sensor probe and a camera, wherein the diamond microwave sensor probe is used to radiate detection microwaves to the target to be measured at different detection positions and measure microwave signals scattered by the target to be measured, and the camera is used to take images of the target to be measured at different detection positions and send them to the computing control system;
所述微波发生控制装置用于产生输入到金刚石微波传感探头中的操控微波，所述激光发生控制装置用于产生输入到金刚石微波传感探头中的激光；The microwave generation control device is used to generate control microwaves input into the diamond microwave sensor probe, and the laser generation control device is used to generate lasers input into the diamond microwave sensor probe;
所述荧光读出装置用于收集金刚石微波传感探头发出的荧光信号并将荧光信号转换为电信号后输入计算控制系统；The fluorescence reading device is used to collect the fluorescence signal emitted by the diamond microwave sensor probe and convert the fluorescence signal into an electrical signal and then input it into the computing control system;
所述计算控制系统用于根据荧光信号的变化计算待测目标散射的微波强度，并结合不同检测位置处金刚石微波传感探头和待测目标的相对方位，以及相机拍摄的图像反解待测目标内部介电性质的分布情况，以根据待测目标内部介电性质的分布情况分辨待测目标是否存在癌变的组织。The computing control system is used to calculate the microwave intensity scattered by the target to be measured according to the change of the fluorescence signal, and to inversely analyze the distribution of dielectric properties inside the target to be measured based on the relative orientation of the diamond microwave sensor probe and the target to be measured at different detection positions, as well as the image taken by the camera, so as to distinguish whether there is cancerous tissue in the target to be measured according to the distribution of dielectric properties inside the target to be measured.
可选的，所述医疗诊断台还包括位移俯仰调节装置和用于放置待测目标的孔洞；所述位移俯仰调节装置用于调节金刚石微波传感探头的检测位置，以使相机在各个检测位置处拍摄待测目标的图像。Optionally, the medical diagnostic table further comprises a displacement pitch adjustment device and a hole for placing the target to be measured; the displacement pitch adjustment device is used to adjust the detection position of the diamond microwave sensor probe so that the camera can capture the image of the target to be measured at each detection position.
可选的，所述金刚石微波传感探头包括金刚石探针、微波辐射装置和光导结构；Optionally, the diamond microwave sensing probe comprises a diamond probe, a microwave radiation device and a light guide structure;
所述微波辐射装置用于接收微波发生控制装置输入的操控微波，并向待测目标辐射微波；所述光导结构用于将输入的激光传导到金刚石探针上，并将收集到的金刚石探针发出的荧光信号输出到荧光读出装置。The microwave radiation device is used to receive the control microwaves input by the microwave generation control device and radiate microwaves to the target to be measured; the optical guide structure is used to conduct the input laser to the diamond probe and output the collected fluorescence signal emitted by the diamond probe to the fluorescence readout device.
可选的，所述金刚石探针为金刚石中的氮-空位色心。Optionally, the diamond probe is a nitrogen-vacancy color center in diamond.
本发明利用金刚石中的氮-空位(NV)色心对微波场的高灵敏度测量，能够实现对乳腺组织内癌变组织高灵敏度、高空间分辨率的微波成像。本发明的有益效果如下：The present invention utilizes the high sensitivity measurement of nitrogen-vacancy (NV) color centers in diamond to microwave fields, and can achieve microwave imaging of cancerous tissue in breast tissue with high sensitivity and high spatial resolution. The beneficial effects of the present invention are as follows:
本发明使用的微波成像技术无电离辐射、成本适中、灵敏度与空间分辨率较高，十分适合乳腺癌的早期筛查。The microwave imaging technology used in the present invention has no ionizing radiation, moderate cost, high sensitivity and spatial resolution, and is very suitable for early screening of breast cancer.
金刚石中的NV色心为固态自旋体系，本发明使用固态自旋体系作为探针，能够克服传统微波成像测量手段的不足，可以实现高灵敏度与高空间分辨率的乳腺微波成像，成本适中，准确度高，为乳腺癌的早期筛查提供了额外的技术支持和仪器装备，有望在未来降低乳腺癌的致死率，进一步提高患者的生存率。The NV color center in diamond is a solid-state spin system. The present invention uses the solid-state spin system as a probe, which can overcome the shortcomings of traditional microwave imaging measurement methods and can achieve breast microwave imaging with high sensitivity and high spatial resolution. It has moderate cost and high accuracy, and provides additional technical support and instrument equipment for early screening of breast cancer. It is expected to reduce the mortality rate of breast cancer in the future and further improve the survival rate of patients.
图1为本发明实施例提供的一种基于金刚石量子传感器的乳腺癌检测装置的整体结构图；FIG1 is an overall structural diagram of a breast cancer detection device based on a diamond quantum sensor provided by an embodiment of the present invention;
图2为本发明实施例提供的一种金刚石微波传感探头结构示意图。FIG. 2 is a schematic diagram of the structure of a diamond microwave sensor probe provided in an embodiment of the present invention.
本实施例的技术方案基于微波成像技术，微波成像技术利用微波在不同利用人身体不同生理组织和不同生理状态具有不同的介电性质，比如电导率与介电常数。通过测量微波经过不同介电性质的组织间散射后的幅度分布，结合电磁反解算法，实现对身体组织的微波成像。通过这种方法可以非破坏非侵入的对生物体内的生理状态进行检测。The technical solution of this embodiment is based on microwave imaging technology, which uses microwaves to have different dielectric properties in different physiological tissues and different physiological states of the human body, such as conductivity and dielectric constant. By measuring the amplitude distribution of microwaves after scattering between tissues with different dielectric properties, combined with electromagnetic inverse solution algorithms, microwave imaging of body tissues is achieved. This method can detect the physiological state of the body in a non-destructive and non-invasive manner.
下面结合附图和实施例对本发明作进一步的详细说明。可以理解的是，此处所描述的具体实施例仅仅用于解释本发明，而非对本发明的限定。另外还需要说明的是，为了便于描述，附图中仅示出了与本发明相关的部分而非全部结构。The present invention will be further described in detail below in conjunction with the accompanying drawings and embodiments. It is to be understood that the specific embodiments described herein are only used to explain the present invention, rather than to limit the present invention. It should also be noted that, for ease of description, only parts related to the present invention, rather than all structures, are shown in the accompanying drawings.
实施例Example
图1为本发明实施例提供的一种基于金刚石量子传感器的乳腺癌检测装置的整体结构图。参见图1，该装置包括荧光读出装置、微波发生控制装置、激光发生控制装置、计算控制系统以及医疗诊断台。Figure 1 is an overall structural diagram of a breast cancer detection device based on a diamond quantum sensor provided by an embodiment of the present invention. Referring to Figure 1 , the device includes a fluorescence readout device, a microwave generation control device, a laser generation control device, a computing control system, and a medical diagnosis table.
其中，医疗诊断台包括一个用于放置患者乳房的孔洞、金刚石微波传感探头、位移俯仰调节装置以及相机。The medical diagnostic table includes a hole for placing the patient's breast, a diamond microwave sensor probe, a displacement and pitch adjustment device, and a camera.
可选的，本实施例中的金刚石探针为金刚石中的NV色心。NV色心作为金刚石中的一种点缺陷，在室温大气环境下有着优良的相干性质。在外部连续激光的作用下，NV色心会产生连续的荧光。如果此时存在一个与NV色心能级相匹配的待测微波，NV色心的荧光会发生下降，该下降幅度正比于微波幅度的平方。进一步的，如果主动施加一个幅度远大于待测微波幅度的操控微波，此时NV色心由于待测微波引起的幅度下降为待测微波与操控微波幅度的乘积，所以使用该方法可以实现对乳房组织高灵敏度、高分辨率的微波成像，达到高效的对乳腺癌进行早期筛查的目的。Optionally, the diamond probe in this embodiment is an NV color center in diamond. As a point defect in diamond, the NV color center has excellent coherence properties in room temperature and atmospheric environment. Under the action of an external continuous laser, the NV color center will produce continuous fluorescence. If there is a microwave to be measured that matches the energy level of the NV color center at this time, the fluorescence of the NV color center will decrease, and the decrease is proportional to the square of the microwave amplitude. Furthermore, if a control microwave with an amplitude much larger than the amplitude of the microwave to be measured is actively applied, the amplitude decrease of the NV color center caused by the microwave to be measured is the product of the amplitude of the microwave to be measured and the control microwave. Therefore, this method can be used to achieve high-sensitivity and high-resolution microwave imaging of breast tissue, so as to achieve the purpose of efficient early screening of breast cancer.
此外，也可以用磷硅体系、砷化镓量子点、砷化铟量子点等作为金刚石探针。In addition, phosphorus silicon system, gallium arsenide quantum dots, indium arsenide quantum dots, etc. can also be used as diamond probes.
具体的，金刚石微波传感探头用于不同检测位置向待测目标辐射探测微波并测量待测目标散射的微波信号，相机用于在不同检测位置处拍摄待测目标的图像并发送至计算控制系统，位移俯仰调节装置用于调节金刚石微波传感探头的检测位置，以使相机在各个不同的检测位置处拍摄待测目标的图像。Specifically, the diamond microwave sensor probe is used to radiate detection microwaves to the target to be measured at different detection positions and measure the microwave signals scattered by the target to be measured, the camera is used to take images of the target to be measured at different detection positions and send them to the computing control system, and the displacement and pitch adjustment device is used to adjust the detection position of the diamond microwave sensor probe so that the camera can take images of the target to be measured at each different detection position.
本发明实施例将相机与金刚石微波传感探头配合使用，相机拍摄的图像信号用于记录患者乳房的形态以及定位金刚石微波传感探头，该方法可以降低电磁反解问题的复杂度，从而提供更精准的测量结果。The embodiment of the present invention uses a camera in conjunction with a diamond microwave sensor probe. The image signal captured by the camera is used to record the shape of the patient's breast and position the diamond microwave sensor probe. This method can reduce the complexity of the electromagnetic inverse solution problem, thereby providing more accurate measurement results.
进一步的，微波发生控制装置用于产生输入到金刚石微波传感探头中的操控微波，激光发生控制装置用于产生输入到金刚石微波传感探头中的激光。上述微波发生控制装置和激光发生控制装置均通过计算控制系统进行控制。Furthermore, the microwave generation control device is used to generate control microwaves input into the diamond microwave sensor probe, and the laser generation control device is used to generate lasers input into the diamond microwave sensor probe. The microwave generation control device and the laser generation control device are both controlled by a computing control system.
荧光读出装置用于收集金刚石微波传感探头发出的荧光信号并将荧光信号转换为电信号后输入计算控制系统。The fluorescence readout device is used to collect the fluorescence signal emitted by the diamond microwave sensor probe and convert the fluorescence signal into an electrical signal and then input it into the computing control system.
本实施例中，计算控制系统根据荧光信号的变化计算待测目标散射的微波强度，并结合不同检测位置处金刚石微波传感探头和待测目标的相对方位，以及相机拍摄的图像反解待测目标内部介电性质的分布情况，以根据待测目标内部介电性质的分布情况分辨待测目标是否存在癌变的组织。In this embodiment, the computing control system calculates the microwave intensity scattered by the target to be measured according to the change of the fluorescence signal, and combines the relative position of the diamond microwave sensor probe and the target to be measured at different detection positions, as well as the image taken by the camera to inversely analyze the distribution of the internal dielectric properties of the target to be measured, so as to distinguish whether the target to be measured has cancerous tissue according to the distribution of the internal dielectric properties of the target to be measured.
计算机控制系统中具体的反解步骤如下：The specific inverse solution steps in the computer control system are as follows:
步骤1、在不放置待测目标的情况下，使用金刚石微波传感探头在各个检测位置进行微波强度的测量，从而得到荧光信号变化的信息，传输至计算控制系统，计算可得该位置的本征微波磁场强度Binc；Step 1: Without placing the target to be measured, use a diamond microwave sensor probe to measure the microwave intensity at each detection position, so as to obtain the information of the change of the fluorescence signal, transmit it to the computing control system, and calculate the intrinsic microwave magnetic field intensity Binc at the position;
步骤2、在放置待测目标后，使用金刚石微波传感探头在待测目标各个检测位置进行微波强度的测量，从而得到荧光信号变化的信息，传输至计算控制系统，计算可得该位置的总微波磁场强度B，由待测目标散射导致的微波磁场强度Bscat为总微波磁场强度与本征微波磁场强度之差；Step 2: After placing the target to be measured, use a diamond microwave sensor probe to measure the microwave intensity at each detection position of the target to be measured, so as to obtain information on the change of the fluorescence signal, transmit it to the computing control system, and calculate the total microwave magnetic field intensity B at the position. The microwave magnetic field intensity Bscat caused by the scattering of the target to be measured is the difference between the total microwave magnetic field intensity and the intrinsic microwave magnetic field intensity;
步骤3、记录各个检测位置处金刚石微波传感探头与待测目标的相对方位以及待测目标的表面形状，传输至计算控制系统，可以得到计算所需的边界条件。Step 3: Record the relative position between the diamond microwave sensor probe and the target to be measured at each detection position and the surface shape of the target to be measured, and transmit them to the computing control system to obtain the boundary conditions required for the calculation.
步骤4、散射微波磁场强度满足磁场积分方程(magnetic field integral equations，MFIEs)，可以简略的写为B＝Binc+AB的形式，其中A为与待测目标介电性质依赖的算符，通过步骤1、2得到的多组B与Binc的值，以及步骤3中的边界限制条件，可以反解得到待测目标的介电性质的分布情况。根据介电性质的分布状况，可以进一步判断待测目标中是否存在癌变组织，例如，癌变组织具有更高的电导率与介电常数，如果介电性质的分布中存在高电导率聚集的部分，该位置有很大可能性存在癌变组织。Step 4: The scattered microwave magnetic field intensity satisfies the magnetic field integral equation (MFIEs), which can be simply written as B=Binc +AB, where A is an operator dependent on the dielectric properties of the target to be measured. The distribution of the dielectric properties of the target to be measured can be obtained by inversely solving the multiple sets of B and Binc values obtained in steps 1 and 2, and the boundary constraints in step 3. According to the distribution of dielectric properties, it can be further determined whether there is cancerous tissue in the target to be measured. For example, cancerous tissue has higher conductivity and dielectric constant. If there is a part with high conductivity concentration in the distribution of dielectric properties, there is a high possibility that cancerous tissue exists at this location.
进一步参见图2，金刚石微波传感探头包括金刚石探针、微波辐射装置、光导结构和将各部件固定起来的框架结构。其中，微波辐射装置用于接收输入的微波，并向待测目标辐射微波以及提供金刚石探针测量所需的操控微波。示例性的，光导结构可选用光纤，用于将输入的激光传导到金刚石探针上，并收集金刚石探针的荧光将其输出到荧光读出装置。金刚石探针在激光和微波的作用下可以测量待测目标散射的微波，散射微波的强度可以通过荧光信号的变化来读出。Further referring to FIG2 , the diamond microwave sensor probe includes a diamond probe, a microwave radiation device, a light-conducting structure, and a frame structure for fixing the components. The microwave radiation device is used to receive input microwaves, radiate microwaves to the target to be measured, and provide the control microwaves required for the diamond probe measurement. Exemplarily, the light-conducting structure can use optical fiber to transmit the input laser to the diamond probe, collect the fluorescence of the diamond probe and output it to the fluorescence reading device. Under the action of laser and microwave, the diamond probe can measure the microwaves scattered by the target to be measured, and the intensity of the scattered microwaves can be read out by the change of the fluorescence signal.
本实施例的技术方案，得益于金刚石量子传感器对微波的高灵敏响应以及其亚波长的探测器尺寸，使用金刚石量子传感器的乳腺癌检测装置的灵敏度和分辨率可以更高。The technical solution of this embodiment, thanks to the high sensitivity response of the diamond quantum sensor to microwaves and its sub-wavelength detector size, the sensitivity and resolution of the breast cancer detection device using the diamond quantum sensor can be higher.
进一步的，本实施例还提供一种基于金刚石量子传感器的乳腺癌检测装置的检测方法，具体包括以下步骤：Furthermore, this embodiment also provides a detection method of a breast cancer detection device based on a diamond quantum sensor, which specifically includes the following steps:
步骤1：金刚石NV探针制备。Step 1: Diamond NV probe preparation.
步骤2：组装金刚石微波传感探头，如图2所示。使用光纤作为光导结构连接金刚石探针，光导结构用于激光传输以及荧光收集；然后安装固定微波辐射装置，使其产生的操控微波的磁场方向垂直于金刚石探针表面；最后使用外框架将各个组件固定起来。Step 2: Assemble the diamond microwave sensor probe, as shown in Figure 2. Use optical fiber as a light guide structure to connect the diamond probe, which is used for laser transmission and fluorescence collection; then install and fix the microwave radiation device so that the magnetic field direction of the manipulated microwave generated by it is perpendicular to the surface of the diamond probe; finally, use an external frame to fix each component.
步骤3：组装基于金刚石量子传感器的乳腺癌检测装置。将步骤2中组装的金刚石微波传感固定于位移俯仰调节装置上，将一个相机与金刚石微波传感探头平行放置，用于成像定位金刚石微波传感探头探测的位置。将以上装置装载在带有孔洞的医疗诊断台上，接下来连接各个装置，用以实现如图1所示的控制与读出的功能。Step 3: Assemble a breast cancer detection device based on diamond quantum sensor. Fix the diamond microwave sensor assembled in step 2 on the displacement pitch adjustment device, and place a camera parallel to the diamond microwave sensor probe to image and locate the position detected by the diamond microwave sensor probe. Load the above device on a medical diagnostic table with holes, and then connect each device to achieve the control and readout functions as shown in Figure 1.
步骤4：将待测目标放置于孔洞中，在金刚石微波传感探头与待测目标之间使用超声凝胶作为填充用的耦合剂，来降低待测目标表面的反射。Step 4: Place the target to be measured in the hole, and use ultrasonic gel as a coupling agent to fill between the diamond microwave sensor probe and the target to be measured to reduce the reflection of the surface of the target to be measured.
步骤5：调整固定位移俯仰调节装置，使得金刚石微波传感探头朝向待测目标。Step 5: Adjust the fixed displacement pitch adjustment device so that the diamond microwave sensor probe faces the target to be measured.
步骤6：相机拍摄并将图像传输至计算控制系统，得到金刚石微波传感探头与待测目标的相对位置与角度以及待测目标的表面形状信息。Step 6: The camera takes pictures and transmits the images to the computer control system to obtain the relative position and angle between the diamond microwave sensor probe and the target to be measured and the surface shape information of the target to be measured.
步骤：7：由计算控制系统控制连续的波长为532nm的激光与频率为2.87GHz微波输入进金刚石微波传感探头，测量由于待测目标散射的微波而导致的荧光信号的下降，从而计算得到该位置待测目标散射的微波强度。Step 7: The computing control system controls the continuous input of 532nm wavelength laser and 2.87GHz frequency microwave into the diamond microwave sensor probe, measures the decrease of the fluorescence signal caused by the microwave scattered by the target to be measured, and thus calculates the microwave intensity scattered by the target to be measured at that position.
步骤8：再次调节位移俯仰调节装置，改变金刚石微波传感探头的位置与角度，重复步骤6到步骤7，直到测量遍历了待测目标的各个方位。Step 8: Adjust the displacement and pitch adjustment device again to change the position and angle of the diamond microwave sensor probe, and repeat steps 6 to 7 until all directions of the target are measured.
步骤9：根据上述步骤得到的待测目标各个方位散射的微波强度，将待测目标的表面形状信息作为边界条件，根据电磁反解算法，可以得到待测目标内部介电性质的分布情况，如果分布均匀，则存在癌变组织的概率很低，反之，则有癌症风险。Step 9: Based on the microwave intensity scattered from all directions of the target obtained in the above steps, the surface shape information of the target is used as the boundary condition. According to the electromagnetic inverse algorithm, the distribution of the dielectric properties inside the target can be obtained. If the distribution is uniform, the probability of the presence of cancerous tissue is very low. Otherwise, there is a risk of cancer.
注意，上述仅为本发明的较佳实施例及所运用技术原理。本领域技术人员会理解，本发明不限于这里所述的特定实施例，对本领域技术人员来说能够进行各种明显的变化、重新调整和替代而不会脱离本发明的保护范围。因此，虽然通过以上实施例对本发明进行了较为详细的说明，但是本发明不仅仅限于以上实施例，在不脱离本发明构思的情况下，还可以包括更多其他等效实施例，而本发明的范围由所附的权利要求范围决定。Note that the above are only preferred embodiments of the present invention and the technical principles used. Those skilled in the art will understand that the present invention is not limited to the specific embodiments described herein, and that various obvious changes, readjustments and substitutions can be made by those skilled in the art without departing from the scope of protection of the present invention. Therefore, although the present invention has been described in more detail through the above embodiments, the present invention is not limited to the above embodiments, and may include more other equivalent embodiments without departing from the concept of the present invention, and the scope of the present invention is determined by the scope of the appended claims.
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202311668871.6 | 2023-12-07 | ||
| CN202311668871.6ACN117357072B (en) | 2023-12-07 | 2023-12-07 | Breast cancer detection device based on diamond quantum sensor |
| Publication Number | Publication Date |
|---|---|
| WO2025119209A1true WO2025119209A1 (en) | 2025-06-12 |
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/CN2024/136705PendingWO2025119209A1 (en) | 2023-12-07 | 2024-12-04 | Diamond quantum sensor-based breast cancer detection apparatus |
| Country | Link |
|---|---|
| CN (1) | CN117357072B (en) |
| WO (1) | WO2025119209A1 (en) |
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117357072B (en)* | 2023-12-07 | 2024-03-19 | 中国科学技术大学苏州高等研究院 | Breast cancer detection device based on diamond quantum sensor |
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107356820A (en)* | 2017-06-07 | 2017-11-17 | 南京邮电大学 | A kind of electromagnetic field near field imaging system and method based on pulse optical detection magnetic resonance |
| CN111568418A (en)* | 2020-06-03 | 2020-08-25 | 中北大学 | Magnetometer and magnetocardiogram measuring system based on diamond NV color center for magnetocardiogram measurement |
| CN115825033A (en)* | 2023-02-08 | 2023-03-21 | 安徽省国盛量子科技有限公司 | Microwave reflection detection device and method based on diamond NV color center |
| US20230160930A1 (en)* | 2021-11-22 | 2023-05-25 | Anhui Guosheng Quantum Technology Co., Ltd. | Fiber-optic current transformer based on nitrogen-vacancy (nv) centers in diamond, and measurement method |
| CN117357072A (en)* | 2023-12-07 | 2024-01-09 | 中国科学技术大学苏州高等研究院 | Breast cancer detection device based on diamond quantum sensor |
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7970458B2 (en)* | 2004-10-12 | 2011-06-28 | Tomophase Corporation | Integrated disease diagnosis and treatment system |
| JP5408617B2 (en)* | 2009-11-24 | 2014-02-05 | 株式会社産学連携機構九州 | Microwave imaging system |
| CN103549939B (en)* | 2013-11-13 | 2015-07-15 | 华南师范大学 | Close-contact ultrasonic coupling adaptive device for photoacoustic/thermoacoustic mammary gland imaging detection, and detection method of adaptive device |
| US20210220480A1 (en)* | 2015-12-21 | 2021-07-22 | Gholam A. Peyman | Cancer Treatment And Imaging Methods Using Thermotherapy And Drug Delivery |
| CN107194197B (en)* | 2017-06-30 | 2020-07-14 | 上海芭雅医疗科技股份有限公司 | Be used for mammary gland diagnostic analysis instrument |
| CN107713990A (en)* | 2017-10-31 | 2018-02-23 | 华南师范大学 | A kind of thermoacoustic, optoacoustic, ultrasonic three mode tumor of breast detection means and method |
| KR102565160B1 (en)* | 2020-11-05 | 2023-08-11 | 한국표준과학연구원 | Appratus for sensing temperature using diamond nitrogen vacancy sensor and method for fabricating the same |
| CA3208867A1 (en)* | 2021-02-17 | 2022-08-25 | Bo Tan | Apparatus and method for early cancer detection and cancer prognosis using a nanosensor with raman spectroscopy |
| US20240377328A1 (en)* | 2021-08-27 | 2024-11-14 | The University Of Melbourne | Determining Properties of Samples Using Quantum Sensing |
| US20250271524A1 (en)* | 2022-04-22 | 2025-08-28 | North Carolina State University | Methods for proton-only detection of hyperpolarized heteronuclear singlet states |
| CN117106906A (en)* | 2023-06-20 | 2023-11-24 | 东南大学 | Lateral chromatography test strip for breast cancer detection, preparation method thereof and detection method |
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107356820A (en)* | 2017-06-07 | 2017-11-17 | 南京邮电大学 | A kind of electromagnetic field near field imaging system and method based on pulse optical detection magnetic resonance |
| CN111568418A (en)* | 2020-06-03 | 2020-08-25 | 中北大学 | Magnetometer and magnetocardiogram measuring system based on diamond NV color center for magnetocardiogram measurement |
| US20230160930A1 (en)* | 2021-11-22 | 2023-05-25 | Anhui Guosheng Quantum Technology Co., Ltd. | Fiber-optic current transformer based on nitrogen-vacancy (nv) centers in diamond, and measurement method |
| CN115825033A (en)* | 2023-02-08 | 2023-03-21 | 安徽省国盛量子科技有限公司 | Microwave reflection detection device and method based on diamond NV color center |
| CN117357072A (en)* | 2023-12-07 | 2024-01-09 | 中国科学技术大学苏州高等研究院 | Breast cancer detection device based on diamond quantum sensor |
| Publication number | Publication date |
|---|---|
| CN117357072A (en) | 2024-01-09 |
| CN117357072B (en) | 2024-03-19 |
| Publication | Publication Date | Title |
|---|---|---|
| JP7082383B2 (en) | Inspection equipment and inspection method that combines tactile sensor and optical tomography | |
| US6490471B2 (en) | Electromagnetical imaging and therapeutic (EMIT) systems | |
| CN1211650C (en) | NIR clinical opti-scan system | |
| JP4733264B2 (en) | Detection, imaging and characterization of breast tumors | |
| WO2014073907A1 (en) | Photoacoustic scanning apparatus for breast cancer diagnosis | |
| CN101902952B (en) | Method for detecting the presence of inhomogeneities in an interior of a turbid medium and device for imaging the interior of turbid media | |
| US20130267850A1 (en) | System and method for ultrasonic examination of the breast | |
| WO2025119209A1 (en) | Diamond quantum sensor-based breast cancer detection apparatus | |
| US9360551B2 (en) | Object information acquiring apparatus and control method thereof | |
| JPS62172229A (en) | Non-contact measurement method and device for temperature distribution within an object to be inspected | |
| CN102215752A (en) | Mammography-apparatus and method for screening the occurrence of malignant cells | |
| JP2014136012A (en) | Subject information acquisition apparatus | |
| CN104023620A (en) | Subject information accumulating apparatus | |
| JP2018140217A (en) | Light measurement device and ultrasonic diagnostic apparatus | |
| WO2001020306A1 (en) | System and method for tomographic imaging of dynamic properties of a scattering medium | |
| WO2024239354A1 (en) | Ultra-wideband terahertz imaging system and imaging method | |
| CN110367931A (en) | A kind of light tomography transillumination imaging system based on femtosecond laser | |
| WO2021077521A1 (en) | Holographic magnetic induction chest cavity imaging method and imaging system based on sparse sampling | |
| CN104814736A (en) | Body tissue dielectric property real-time monitoring device and method for obtaining body tissue dielectric property parameters | |
| CN209252833U (en) | The detection device of fusion tactile sensing and optical tomograph imaging | |
| JP2017148580A (en) | Subject information acquisition device | |
| CN1112163C (en) | Digital near-infrared medical imaging and foreign body positioning unit | |
| WO2021077546A1 (en) | Magnetic induction imaging method and system | |
| Zhao et al. | MRI-guided near-infrared spectroscopic tomography (MRg-NIRST) imaging system with wearable breast optical interface for breast cancer imaging | |
| US20130079629A1 (en) | Passive, noninvasive tomography |
| Date | Code | Title | Description |
|---|---|---|---|
| 121 | Ep: the epo has been informed by wipo that ep was designated in this application | Ref document number:24899847 Country of ref document:EP Kind code of ref document:A1 |