本申请涉及分析仪器领域，特别是涉及样品测试卡、检测组件和医疗检测设备。The present application relates to the field of analytical instruments, and in particular to sample test cards, test components and medical test equipment.
常用的医疗检测设备为了卫生与便捷，通常将样品存放于样品测试卡中进行检测，因此在样品离开生物体离开之后需要输入样品测试卡。由于生物体内本身的含液量有限，为了避免对生物体造成不利的影响，一次性取得的样品量不会太多，所以样品测试卡中用于检测样品的液路也不会很宽敞。For the sake of hygiene and convenience, commonly used medical testing equipment usually stores samples in sample test cards for testing. Therefore, after the sample leaves the organism, it needs to be input into the sample test card. Since the amount of liquid in the organism itself is limited, in order to avoid adverse effects on the organism, the amount of sample obtained at one time will not be too much, so the liquid path used to test the sample in the sample test card will not be very spacious.
因此，在样品输入测试卡的过程中，容易在狭窄的液路、与生物体内不同的外部环境、以及其他因素的影响下形成气泡，亦或是样品本身中含有异常的杂质。而目前常用的样品检测方法包括电化学的方法，需要在样品测试卡内形成回路来对样品进行检测。当用于检测样品的液路中存在气泡等异常时，会对让最终得到的检测结果不够准确。Therefore, in the process of inputting samples into the test card, bubbles are easily formed due to the influence of narrow liquid paths, external environments different from those in the body, and other factors, or the sample itself contains abnormal impurities. Currently, commonly used sample detection methods include electrochemical methods, which require a circuit to be formed in the sample test card to detect the sample. When there are abnormalities such as bubbles in the liquid path used to detect the sample, the final test result will be inaccurate.
发明内容Summary of the invention
本申请要解决的技术问题是如何提供样品测试卡、检测组件和医疗检测设备，以提升对样品电化学参数检测的准确性。The technical problem to be solved by the present application is how to provide a sample test card, a detection component and a medical detection device to improve the accuracy of the detection of electrochemical parameters of the sample.
本申请提供一种样品测试卡，包括第一通道和第一电极组。第一电极组设置于第一通道中，包括第一检测电极、第二检测电极和对电极，对电极设置于第一检测电极与第二检测电极之间，对电极与第一检测电极形成第一回路的部分，对电极与第二检测电极形成第二回路的部分，第一回路和第二回路用于同时获取样品检测过程中第一通道中的样品的至少两个检测信号，至少两个检测信号用于进行比较以判断第一检测电极和第二检测电极之间的第一通道中的样品中是否存在异常。The present application provides a sample test card, including a first channel and a first electrode group. The first electrode group is arranged in the first channel, including a first detection electrode, a second detection electrode and a counter electrode, the counter electrode is arranged between the first detection electrode and the second detection electrode, the counter electrode and the first detection electrode form a part of a first loop, the counter electrode and the second detection electrode form a part of a second loop, the first loop and the second loop are used to simultaneously obtain at least two detection signals of a sample in the first channel during a sample detection process, and the at least two detection signals are used for comparison to determine whether there is an abnormality in the sample in the first channel between the first detection electrode and the second detection electrode.
本申请提供一种用于医疗检测设备的检测组件，包括样品测试卡、接触电极和处理器。样品测试卡包括第一通道和设置于第一通道中的第一电极组，第一电极组包括第一检测电极、第二检测电极和对电极，对电极设置于第一检测电极与第二检测电极之间，对电极与第一检测电极形成第一回路的部分，对电极与第二检测电极形成第二回路的部分，第一回路和第二回路用于同时获取样品检测过程中第一通道中的样品的至少两个检测信号，至少两个检测信号用于进行比较以判断第一检测电极和第二检测电极之间的第一通道中的样品中是否存在异常；接触电极，设置于医疗检测设备，并与第一电极组信号连接；处理器，与接触电极连接，用于接收至少两个检测信号，并根据至少两个检测信号对第一通道中的样品是否存在异常进行判断。The present application provides a detection component for medical detection equipment, including a sample test card, a contact electrode and a processor. The sample test card includes a first channel and a first electrode group arranged in the first channel, the first electrode group includes a first detection electrode, a second detection electrode and a counter electrode, the counter electrode is arranged between the first detection electrode and the second detection electrode, the counter electrode and the first detection electrode form a part of a first loop, the counter electrode and the second detection electrode form a part of a second loop, the first loop and the second loop are used to simultaneously obtain at least two detection signals of the sample in the first channel during the sample detection process, and the at least two detection signals are used for comparison to determine whether there is an abnormality in the sample in the first channel between the first detection electrode and the second detection electrode; the contact electrode is arranged in the medical detection equipment and is connected to the first electrode group signal; the processor is connected to the contact electrode, and is used to receive the at least two detection signals, and judge whether there is an abnormality in the sample in the first channel according to the at least two detection signals.
本申请提供一种样品测试卡，包括第一通道、第一电极组。第一电极组设置于第一通道中，包括至少两个检测电极，至少两个检测电极能够通过第一通道导通，用于获取样品检测过程中至少两个检测电极之间的第一通道中的样品的至少两个检测信号，至少两个检测信号用于进行比较以判断两个检测电极之间的第一通道中的样品中是否存在异常。The present application provides a sample test card, including a first channel and a first electrode group. The first electrode group is arranged in the first channel, including at least two detection electrodes, the at least two detection electrodes can be connected through the first channel, and are used to obtain at least two detection signals of the sample in the first channel between the at least two detection electrodes during the sample detection process, and the at least two detection signals are used for comparison to determine whether there is an abnormality in the sample in the first channel between the two detection electrodes.
本申请提供一种医疗检测设备，包括接触电极和处理器。接触电极与样品测试卡的第一通道中的第一电极组信号连接，至少两个检测电极能够通过第一通道导通，接触电极用于传输第一电极组获取的第一通道中的样品的检测信号；处理器与接触电极连接，用于接收检测信号，并根据检测信号对第一通道中是否存在异常进行判断。The present application provides a medical detection device, including a contact electrode and a processor. The contact electrode is connected to a first electrode group signal in a first channel of a sample test card, at least two detection electrodes can be conducted through the first channel, and the contact electrode is used to transmit a detection signal of a sample in the first channel obtained by the first electrode group; the processor is connected to the contact electrode, and is used to receive the detection signal, and judge whether there is an abnormality in the first channel according to the detection signal.
本申请提供一种样品测试卡的检测方法，包括获取在第一通道中进行样品检测得到的两个检测信号，样品测试卡包括第一通道和设置于第一通道中的第一电极组，第一电极组包括第一检测电极、第二检测电极和对电极，对电极设置于第一检测电极与第二检测电极之间，对电极与第一检测电极形成第一回路的部分，对电极与第二检测电极形成第二回路的部分，利用第一回路和第二回路能够分别获得至少两个检测信号中的一个；响应于至少两个检测信号的差异大于阈值，得出存在异常的结果。The present application provides a detection method for a sample test card, including obtaining two detection signals obtained by performing sample detection in a first channel, the sample test card including a first channel and a first electrode group arranged in the first channel, the first electrode group including a first detection electrode, a second detection electrode and a counter electrode, the counter electrode being arranged between the first detection electrode and the second detection electrode, the counter electrode and the first detection electrode forming part of a first loop, the counter electrode and the second detection electrode forming part of a second loop, and using the first loop and the second loop to respectively obtain one of the at least two detection signals; in response to the difference between the at least two detection signals being greater than a threshold value, a result of the presence of an abnormality is obtained.
区别于现有技术的情况，本申请公开了样品测试卡、检测组件和医疗检测设备，能够利用设置在第一液路内的第一电极组对样品进行检测，并同时获取到第一通道中的两个检测信号，从而能够利用比较两个检测信号来对第一通道的样品中是否存在异常进行判断，能够对第一通道中是否存在气泡、凝块等影响样品的流动性和均匀性的异常进行检测，从而减少异常造成的测量结果不稳定和误差，能够有效提升对样品电化学参数检测的准确性。Different from the prior art, the present application discloses a sample test card, a detection component and a medical The medical detection equipment can detect the sample by using the first electrode group arranged in the first liquid circuit, and simultaneously obtain two detection signals in the first channel, so as to judge whether there is an abnormality in the sample of the first channel by comparing the two detection signals, and can detect whether there are bubbles, clots and other abnormalities that affect the fluidity and uniformity of the sample in the first channel, thereby reducing the instability and errors of the measurement results caused by the abnormalities, and can effectively improve the accuracy of the detection of the electrochemical parameters of the sample.
为了更清楚地说明本申请实施例中的技术方案，下面将对实施例描述中所需要使用的附图作简单的介绍，显而易见地，下面描述中的附图仅仅是本申请的一些实施例，对于本领域普通技术人员来讲，在不付出创造性劳动的前提下，还可以根据这些附图获得其他的附图。其中：In order to more clearly illustrate the technical solutions in the embodiments of the present application, the following briefly introduces the drawings required for use in the description of the embodiments. Obviously, the drawings described below are only some embodiments of the present application. For ordinary technicians in this field, other drawings can be obtained based on these drawings without creative work. Among them:
图1是本申请样品测试卡一实施例的装配结构示意图。FIG. 1 is a schematic diagram of the assembly structure of an embodiment of a sample test card of the present application.
图2是图1中样品测试卡的爆炸结构示意图。FIG. 2 is a schematic diagram of the exploded structure of the sample test card in FIG. 1 .
图3是图1中第一板件的基板结构示意图。FIG. 3 is a schematic diagram of the substrate structure of the first plate member in FIG. 1 .
图4是本申请用于医疗检测设备的检测组件的结构示意图。FIG. 4 is a schematic diagram of the structure of a detection component used in a medical detection device of the present application.
图5是图4中A区域的局部放大示意图。FIG. 5 is a partial enlarged schematic diagram of area A in FIG. 4 .
为使本申请的上述目的、特征和优点能够更为明显易懂，下面结合附图，对本申请的具体实施方式做详细的说明。可以理解的是，此处所描述的具体实施例仅用于解释本申请，而非对本申请的限定。另外还需要说明的是，为了便于描述，附图中仅示出了与本申请相关的部分而非全部结构。基于本申请中的实施例，本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其它实施例，都属于本申请保护的范围。In order to make the above-mentioned purposes, features and advantages of the present application more obvious and easy to understand, the specific implementation methods of the present application are described in detail below in conjunction with the accompanying drawings. It is understandable that the specific embodiments described herein are only used to explain the present application, rather than to limit the present application. It should also be noted that, for ease of description, only some structures related to the present application are shown in the accompanying drawings, rather than all structures. Based on the embodiments in the present application, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of this application.
本申请中的术语“第一”、“第二”等是用于区别不同对象，而不是用于描述特定顺序。此外，术语“包括”和“设置有”以及它们任何变形，意图在于覆盖不排他的包含。例如包含了一系列步骤或单元的过程、方法、系统、产品或设备没有限定于已列出的步骤或单元，而是可选地还包括没有列出的步骤或单元，或可选地还包括对于这些过程、方法、产品或设备固有的其他步骤或单元。The terms "first", "second", etc. in this application are used to distinguish different objects rather than to describe a specific order. In addition, the terms "including" and "provided with" and any variations thereof are intended to cover non-exclusive inclusions. For example, a process, method, system, product or device that includes a series of steps or units is not limited to the listed steps or units, but can be Optionally, steps or units not listed may be included, or other steps or units inherent to these processes, methods, products or devices may be included.
在本文中提及“实施例”意味着，结合实施例描述的特定特征、结构或特性可以包含在本申请的至少一个实施例中。在说明书中的各个位置出现该短语并不一定均是指相同的实施例，也不是与其它实施例互斥的独立的或备选的实施例。本领域技术人员显式地和隐式地理解的是，本文所描述的实施例可以与其它实施例相结合。Reference to "embodiments" herein means that a particular feature, structure, or characteristic described in conjunction with the embodiments may be included in at least one embodiment of the present application. The appearance of the phrase in various locations in the specification does not necessarily refer to the same embodiment, nor is it an independent or alternative embodiment that is mutually exclusive with other embodiments. It is explicitly and implicitly understood by those skilled in the art that the embodiments described herein may be combined with other embodiments.
随着仪器分析技术的发展，通常会采用测试卡的形式来实现对生化样品的测试，以便于在提升测试效率的同时保持样品不被污染，从而保证测试的准确性。这些样品测试卡可以采用测量电化学参数的方法来对样品进行检测，而在进行检测前，需要将样品或其他试剂输入测试卡中，这样才能利用测试卡内的器件对样品的生化参数进行检测。With the development of instrumental analysis technology, test cards are usually used to test biochemical samples, so as to improve test efficiency while keeping samples from being contaminated, thereby ensuring test accuracy. These sample test cards can detect samples by measuring electrochemical parameters, and before the test, the sample or other reagents need to be input into the test card, so that the biochemical parameters of the sample can be detected using the devices in the test card.
但在利用电化学的方法进行检测时，需要在样品或其他试剂中形成回路，而若是用于形成回路的部分液体中存在气泡、不均匀的凝块等异常因素时，电化学器件(例如检测电极)测得的样品的电化学参数便会受到不同程度的影响，导致测试结果不准确。然而目前的检测技术中却难以对这些异常进行检测，因此如何提供样品测试卡、检测组件和医疗检测设备，在保证不影响样品的电化学参数检测的同时，对样品中是否存在异常进行检测，以提升对样品电化学参数检测的准确性，是本申请提供的样品测试卡、检测组件和医疗检测设备想要解决的一大问题。However, when using electrochemical methods for detection, a loop needs to be formed in the sample or other reagents. If there are abnormal factors such as bubbles, uneven clots, etc. in part of the liquid used to form the loop, the electrochemical parameters of the sample measured by the electrochemical device (such as the detection electrode) will be affected to varying degrees, resulting in inaccurate test results. However, it is difficult to detect these abnormalities in current detection technology. Therefore, how to provide a sample test card, a detection component, and a medical detection device to detect whether there is an abnormality in the sample while ensuring that the electrochemical parameter detection of the sample is not affected, so as to improve the accuracy of the electrochemical parameter detection of the sample, is a major problem that the sample test card, the detection component, and the medical detection device provided by the present application want to solve.
参阅图1至图3，图1是本申请样品测试卡一实施例的装配结构示意图。图2是图1中样品测试卡的爆炸结构示意图。图3是图1中第一板件的基板结构示意图。Referring to Figures 1 to 3, Figure 1 is a schematic diagram of the assembly structure of an embodiment of a sample test card of the present application. Figure 2 is a schematic diagram of the exploded structure of the sample test card in Figure 1. Figure 3 is a schematic diagram of the base plate structure of the first plate in Figure 1.
本申请提供了一种样品测试卡9，包括第一通道1和设置于第一通道1中的第一电极组41a。第一电极组41a则包括第一检测电极413、第二检测电极414和对电极412。其中，对电极412用于作为辅助电极与第一检测电极413和第二检测电极414分别形成两个回路，使得第一检测电极413和第二检测电极414电流畅通，以保证检测电化学参数的反应在第一检测电极413和第二检测电极414上发生。对电极412设置于第一检测电极413和第二检测电极414之间，并且对电极412与第一检测电极413形成部分第一回路，对电极412与第二检测电极414形成部分第二回路，而第一回路和第二回路则用于同时获取样品检测过程中第一通道1中样品的至少两个检测信号。该至少两个检测信号用于进行比较以判断第一检测电极413和第二检测电极414之间的第一通道1中的样品中是否存在异常。The present application provides a sample test card 9, including a first channel 1 and a first electrode group 41a disposed in the first channel 1. The first electrode group 41a includes a first detection electrode 413, a second detection electrode 414 and a counter electrode 412. The counter electrode 412 is used as an auxiliary electrode to form two loops with the first detection electrode 413 and the second detection electrode 414, respectively, so that the current of the first detection electrode 413 and the second detection electrode 414 is smooth, so as to ensure that the reaction of detecting the electrochemical parameter occurs on the first detection electrode 413 and the second detection electrode 414. The counter electrode 412 is disposed between the first detection electrode 413 and the second detection electrode 414, and the counter electrode 412 and the first detection electrode 413 and the second detection electrode 414 are connected. The detection electrode 413 forms part of the first loop, the counter electrode 412 and the second detection electrode 414 form part of the second loop, and the first loop and the second loop are used to simultaneously obtain at least two detection signals of the sample in the first channel 1 during the sample detection process. The at least two detection signals are used for comparison to determine whether there is an abnormality in the sample in the first channel 1 between the first detection electrode 413 and the second detection electrode 414.
本实施例提供的方法能够利用将第一检测电极413与第二检测电极414之间的样品分为两段检测并测得两个检测信号，基于同样的环境下，相同的液体的电化学参数相同的原理，从而将这两个检测信号对照比较以对这两段第一通道1的样品中是否存在异常进行判断。当两个检测信号得到的电化学参数相同或极其相近时，可以认为第一检测电极413与第二检测电极414之间的样品为近似或是相同的，即两段样品中都不存在异常，从而判断此时测得的其他电化学参数也是可靠、准确的；而当两个检测信号不同时，则可判断出第一检测电极413与第二检测电极414之间的样品中存在影响某一回路导通的异常，例如气泡或是凝块，从而影响了测出来的电化学参数。The method provided in this embodiment can utilize the method of dividing the sample between the first detection electrode 413 and the second detection electrode 414 into two sections for detection and measuring two detection signals. Based on the principle that the electrochemical parameters of the same liquid are the same under the same environment, the two detection signals are compared to determine whether there is an abnormality in the samples of the two sections of the first channel 1. When the electrochemical parameters obtained by the two detection signals are the same or extremely similar, it can be considered that the samples between the first detection electrode 413 and the second detection electrode 414 are similar or the same, that is, there is no abnormality in the two sections of the sample, so it can be determined that other electrochemical parameters measured at this time are also reliable and accurate; and when the two detection signals are different, it can be determined that there is an abnormality in the sample between the first detection electrode 413 and the second detection electrode 414 that affects the conduction of a certain circuit, such as bubbles or clots, thereby affecting the measured electrochemical parameters.
可选地，异常可以为样品中本身存在的因素，例如血液样本中的血液凝块，异常还可以为样品由于外界的环境因素产生的异常，例如由于样品测试卡9内气体未排干净或第一通道1内壁不平整而因湍流产生的气泡。Optionally, the abnormality may be a factor existing in the sample itself, such as a blood clot in a blood sample. The abnormality may also be an abnormality caused by external environmental factors, such as bubbles generated by turbulence due to the failure to exhaust the gas in the sample test card 9 or the uneven inner wall of the first channel 1.
可选的，第一检测电极413、对电极412、第二检测电极414沿着第一通道1的长度方向间隔设置。Optionally, the first detection electrode 413 , the counter electrode 412 , and the second detection electrode 414 are arranged at intervals along the length direction of the first channel 1 .
可选地，对电极412与第一检测电极413之间的距离可以大于对电极412与第二检测电极414之间的距离，从而增加两个回路的检测对象之间的差异，提升异常检测的准确性。Optionally, the distance between the counter electrode 412 and the first detection electrode 413 may be greater than the distance between the counter electrode 412 and the second detection electrode 414 , thereby increasing the difference between the detection objects of the two circuits and improving the accuracy of abnormality detection.
本实施例中，第一通道1还可以包括用于容置样品的测量通道11，测量通道11中还设有第一电极41以对样品的其他电化学参数进行检测，而第一检测电极413和第二检测电极414分别布设于测量通道11两端，从而第一电极组41a能够对整个测量通道11中的样品进行异常检测，以在其他电极测量测量通道11内样品其他生化参数时保证一定的准确性。In this embodiment, the first channel 1 can also include a measuring channel 11 for accommodating samples. The measuring channel 11 is also provided with a first electrode 41 to detect other electrochemical parameters of the sample, and the first detection electrode 413 and the second detection electrode 414 are respectively arranged at both ends of the measuring channel 11, so that the first electrode group 41a can perform abnormal detection on the sample in the entire measuring channel 11 to ensure a certain accuracy when other electrodes measure other biochemical parameters of the sample in the measuring channel 11.
可选地，第一电极组41a可以在第一电极41测量样品其他电化学参数的同时对测量通道11中样品是否存在异常进行测量，以便掌握样品检测时的实时数据。Optionally, the first electrode group 41a can measure whether there is any abnormality in the sample in the measurement channel 11 while the first electrode 41 measures other electrochemical parameters of the sample, so as to obtain real-time data during sample detection.
可选地，测量通道11的两端各设有一个输液孔4d，两个输液孔4d用于向测量通道11内通入和通出样品或其他液体。当第一检测电极413和第二检测电极414分别设置在靠近这两个输液孔4d的位置时，第一检测电极413和第二检测电极414还可用于对测量通道11内的液位进行检测。Optionally, an infusion hole 4d is respectively provided at both ends of the measurement channel 11, and the two infusion holes 4d are used to pass samples or other liquids into and out of the measurement channel 11. When the first detection electrode 413 and the second detection electrode 414 are respectively arranged at positions close to the two infusion holes 4d, the first detection electrode 413 and the second detection electrode 414 can also be used to detect the liquid level in the measurement channel 11.
例如：当样品通过第一检测电极413附近的输液孔4d进入测量通道11时，第一检测电极413可以通过接触样品产生与样品对应的检测信号，而由于样品尚未流至靠近另一个输液孔4d的第二检测电极414，第二检测电极414同时产生的检测信号为未接触样品的检测信号，通过两个不同的检测信号，便可判断出样品开始进入测量通道11中。同理，当样品充满测量通道11时，两个检测信号相同，从而可以判断出样品已经充满了测量通道11。For example, when the sample enters the measurement channel 11 through the infusion hole 4d near the first detection electrode 413, the first detection electrode 413 can generate a detection signal corresponding to the sample by contacting the sample, and because the sample has not yet flowed to the second detection electrode 414 near another infusion hole 4d, the detection signal generated by the second detection electrode 414 at the same time is a detection signal that does not contact the sample. Through the two different detection signals, it can be determined that the sample begins to enter the measurement channel 11. Similarly, when the sample fills the measurement channel 11, the two detection signals are the same, so it can be determined that the sample has filled the measurement channel 11.
可选地，第一电极组41a可以在第一电极41测量样品其他电化学参数前、同时和/或之后对测量通道11中样品是否存在异常进行测量，以得到多组检测信号，从而综合时段先后对样品的异常情况进行更为精准的测量和判断。Optionally, the first electrode group 41a can measure whether there is any abnormality in the sample in the measurement channel 11 before, simultaneously and/or after the first electrode 41 measures other electrochemical parameters of the sample to obtain multiple groups of detection signals, thereby comprehensively measuring and judging the abnormality of the sample in sequence over a more accurate period of time.
可选地，如图2所示，其他电极可以设置于第一检测电极413和第二检测电极414之间的测量通道11中的第一电极41，从而使第一检测电极413、第二检测电极414以及对电极412能够有效地对第一电极41所检测的样品中是否存在异常进行检测，进一步的保证了样品其他生化参数时的准确性。Optionally, as shown in Figure 2, other electrodes can be arranged on the first electrode 41 in the measuring channel 11 between the first detection electrode 413 and the second detection electrode 414, so that the first detection electrode 413, the second detection electrode 414 and the counter electrode 412 can effectively detect whether there is an abnormality in the sample detected by the first electrode 41, further ensuring the accuracy of other biochemical parameters of the sample.
可选地，第一检测电极413和第二检测电极414可以为电导电极，第一回路和第二回路获取的检测信号可以分别为第一电导率和第二电导率，第一电导率为对电极412与所述第一检测电极413之间的所述样品的所述电导率，所述第二电导率为所述对电极412与所述第二检测电极414之间的所述样品的所述电导率。Optionally, the first detection electrode 413 and the second detection electrode 414 may be conductivity electrodes, and the detection signals acquired by the first loop and the second loop may be the first conductivity and the second conductivity, respectively, the first conductivity being the conductivity of the sample between the counter electrode 412 and the first detection electrode 413, and the second conductivity being the conductivity of the sample between the counter electrode 412 and the second detection electrode 414.
可选的，两个检测信号的检测获取可以是在第一电极41进行常规电化学参数检测过程的同一时间，也可以是在第一电极41进行常规电化学参数检测过程的不同时间，比如间隔较短的时间。Optionally, the two detection signals may be detected and acquired at the same time when the first electrode 41 performs a conventional electrochemical parameter detection process, or at different times when the first electrode 41 performs a conventional electrochemical parameter detection process, such as at a short interval.
参阅图2，本申请提供的样品测试卡9还可以包括第一板件4、第二板件5和第一壳体6。第一板件4上布设有第一电极组41a。第二板件5上开设有第一贯穿口51，且第二板件5设置于第一板件4布设有第一电极组41a的一侧，且该第一电极组41a通过第一贯穿口51暴露。第一壳体6则与第一板件4配合夹持第二板件5，以在对应第一贯穿口51的位置形成第一通道1，使第一电极组41a暴露于第一通道1中。Referring to FIG. 2 , the sample test card 9 provided in the present application may further include a first plate 4, a second plate 5 and a first shell 6. A first electrode group 41a is arranged on the first plate 4. A first through hole 51 is opened on the second plate 5, and the second plate 5 is arranged on the side of the first plate 4 where the first electrode group 41a is arranged, and the first electrode group 41a is exposed through the first through hole 51. The first shell 6 cooperates with the first plate 4 to clamp the second plate 5, so as to form a first channel 1 at a position corresponding to the first through hole 51, so that the first electrode group 41a is exposed in the first channel 1.
可选地，第一板件4上还布设有第三电极8，第三电极8与第一电极组41a信号连接，以用于将第一电极组41a获取的样品的检测信号输出。Optionally, a third electrode 8 is further disposed on the first plate 4 , and the third electrode 8 is signal-connected to the first electrode group 41 a so as to output a detection signal of the sample acquired by the first electrode group 41 a .
可选地，如图3所示，第一电极组41a和第三电极8可以通过引线47b连接，第一检测电极413、第二检测电极414以及对电极412分别连接至不同的第三电极8，从而将检测信号输出。Optionally, as shown in FIG. 3 , the first electrode group 41 a and the third electrode 8 may be connected via a lead 47 b , and the first detection electrode 413 , the second detection electrode 414 and the counter electrode 412 are respectively connected to different third electrodes 8 , thereby outputting a detection signal.
可选地，第一电极41也可利用引线47b与第三电极8连接，以将第一电极41测得的样品的其他电化学参数信号传输至第三电极8。Optionally, the first electrode 41 may also be connected to the third electrode 8 by using a lead 47 b to transmit other electrochemical parameter signals of the sample measured by the first electrode 41 to the third electrode 8 .
可选地，第三电极8可以设置于第一电极组41a的同侧表面或背侧表面，以便于第三电极8与医疗检测设备电连接以传输信号。Optionally, the third electrode 8 may be disposed on the same side surface or the back side surface of the first electrode group 41 a, so that the third electrode 8 is electrically connected to the medical detection device to transmit signals.
可选地，当第三电极8设置于第一电极组41a的同侧表面，如图4、5所示，图4是本申请用于医疗检测设备的检测组件的结构示意图。图5是图4中A区域的局部放大示意图。图中第三电极8设置于第一电极组41a的同侧表面远离第一通道1的一侧边缘，且相较于第一通道1，第三电极8位于样品测试卡9装入医疗检测设备9a的安装方向的前端。因此，第三电极8可以通过样品测试卡9的第一壳体6的接触缺口64暴露于第一壳体6之外，从而使得第三电极8可以与装配有样品测试卡9的医疗检测设备9a信号连接，以将来自第一电极组41a的检测信号输出至医疗检测设备9a中用于分析和/或计算。Optionally, when the third electrode 8 is arranged on the same side surface of the first electrode group 41a, as shown in Figures 4 and 5, Figure 4 is a schematic diagram of the structure of the detection component of the medical detection device used in the present application. Figure 5 is a partial enlarged schematic diagram of the A area in Figure 4. In the figure, the third electrode 8 is arranged on the same side surface of the first electrode group 41a away from the side edge of the first channel 1, and compared with the first channel 1, the third electrode 8 is located at the front end of the installation direction of the sample test card 9 into the medical detection device 9a. Therefore, the third electrode 8 can be exposed outside the first shell 6 through the contact notch 64 of the first shell 6 of the sample test card 9, so that the third electrode 8 can be connected to the signal of the medical detection device 9a equipped with the sample test card 9, so as to output the detection signal from the first electrode group 41a to the medical detection device 9a for analysis and/or calculation.
可选地，为了便于医疗检测设备9a的接触电极81进入接触缺口64与第三电极8连接，第二壳体7还可对应接触缺口64开设有装配缺口71，从而使接触电极81能够穿过装配缺口71与第三电极8连接。Optionally, in order to facilitate the contact electrode 81 of the medical detection device 9a to enter the contact notch 64 and connect with the third electrode 8, the second shell 7 may also be provided with an assembly notch 71 corresponding to the contact notch 64, so that the contact electrode 81 can pass through the assembly notch 71 and connect with the third electrode 8.
可选地，当第三电极8设置于第一电极组41a的背侧表面时，装配缺口71和接触缺口64可以对应第三电极8的位置进行设置。Optionally, when the third electrode 8 is disposed on the back surface of the first electrode group 41 a , the assembly notch 71 and the contact notch 64 may be disposed corresponding to the position of the third electrode 8 .
可选地，该样品测试卡9还可以包括第二通道2以及位于第二通道2中的第二电极42。其中，第二电极42被配置为用于获取第二通道2中参比液的电化学参数。第一通道1中样品与第二通道2中参比液导通，从而使第一电极41和第二电极42能够形成回路以测量样品的其他电化学参数。Optionally, the sample test card 9 may further include a second channel 2 and a second electrode 42 located in the second channel 2. The second electrode 42 is configured to obtain electrochemical parameters of a reference solution in the second channel 2. The sample in the first channel 1 is connected to the reference solution in the second channel 2, so that the first electrode 41 and the second electrode 42 can form a loop to measure other electrochemical parameters of the sample.
可选地，第二通道2和第一通道1可以通过盐桥3连接。Optionally, the second channel 2 and the first channel 1 may be connected via a salt bridge 3 .
可选地，第二电极42可以布设于第一板件4布设有第一电极41一侧表面，第二板件5上开设有与第二通道2对应的第二贯穿口52，且第二电极42通过第二贯穿口52暴露。Optionally, the second electrode 42 may be disposed on a surface of the first plate 4 on which the first electrode 41 is disposed, and a second through hole 52 corresponding to the second channel 2 is opened on the second plate 5 , and the second electrode 42 is exposed through the second through hole 52 .
可选地，样品测试卡9还可包括第二壳体7，从而实现样品测试卡9整体的装配固定，以从第一板件4远离第二板件5一侧抵压第一板件4，使得第一板件4、第二板件5、第一壳体6紧密固定，从而避免第一通道1和第二通道2中的液体泄漏或是互相污染，导致的测量结果不准或是仪器设备损坏等情况。Optionally, the sample test card 9 may further include a second shell 7 to achieve the overall assembly and fixation of the sample test card 9, so as to press the first plate 4 from the side of the first plate 4 away from the second plate 5, so that the first plate 4, the second plate 5, and the first shell 6 are tightly fixed, thereby avoiding leakage or mutual contamination of liquid in the first channel 1 and the second channel 2, resulting in inaccurate measurement results or damage to instruments and equipment.
本申请还提供一种用于医疗检测设备9a的检测组件。参阅图2至图5，该检测组件包括样品测试卡9、接触电极81和处理器(图上未示出)。其中，样品测试卡9包括第一通道1和设置于第一通道1中的第一电极组41a。第一电极组41a具有第一检测电极413、第二检测电极414和对电极412，对电极412设置于第一检测电极413与第二检测电极414之间，对电极412与第一检测电极413形成第一回路的部分，对电极412与第二检测电极414形成第二回路的部分。第一回路和第二回路可以用于同时获取样品检测过程中第一通道1中的样品的至少两个检测信号，至少两个检测信号用于进行比较以判断第一检测电极413和第二检测电极414之间的第一通道1中的样品中是否存在异常。The present application also provides a detection component for a medical detection device 9a. Referring to Figures 2 to 5, the detection component includes a sample test card 9, a contact electrode 81 and a processor (not shown in the figure). Among them, the sample test card 9 includes a first channel 1 and a first electrode group 41a arranged in the first channel 1. The first electrode group 41a has a first detection electrode 413, a second detection electrode 414 and a counter electrode 412, the counter electrode 412 is arranged between the first detection electrode 413 and the second detection electrode 414, the counter electrode 412 and the first detection electrode 413 form part of the first loop, and the counter electrode 412 and the second detection electrode 414 form part of the second loop. The first loop and the second loop can be used to simultaneously obtain at least two detection signals of the sample in the first channel 1 during the sample detection process, and the at least two detection signals are used for comparison to determine whether there is an abnormality in the sample in the first channel 1 between the first detection electrode 413 and the second detection electrode 414.
接触电极81则设置于医疗检测设备9a中，并与第一电极组41a信号连接，从而从第一电极组41a获取其测得的检测信号。处理器与接触电极81连接，用于接收其获取的至少两个检测信号，并根据至少两个检测信号对第一通道1中的样品是否存在异常进行判断。The contact electrode 81 is disposed in the medical detection device 9a and is signal-connected to the first electrode group 41a, thereby obtaining the detection signal measured by the first electrode group 41a. The processor is connected to the contact electrode 81, and is used to receive at least two detection signals obtained by it, and judge whether the sample in the first channel 1 is abnormal according to the at least two detection signals.
可选地，该接触电极81可以与样品测试卡9的第三电极8接触连通，从而利用第三电极8、接触电极81将第一电极组测得的样品的检测信号输出至医疗检测设备9a的处理器中。Optionally, the contact electrode 81 can be in contact and communicate with the third electrode 8 of the sample test card 9, so that the detection signal of the sample measured by the first electrode group is output to the processor of the medical detection device 9a using the third electrode 8 and the contact electrode 81.
可选地，对于用于医疗检测设备9a的检测组件来说，第一通道1还可以包括用于容置样品的测量通道11，第一检测电极413和第二检测电极414设置于测量通道11的两端。第一回路和第二回路获取的检测信号可以分别为第一电导率和第二电导率，第一电导率为对电极412与第一检测电极413之间的样品的电导率，第二电导率为对电极412与第二检测电极414之间的样品的电导率。当测量通道11中的样品中不存在气泡、凝块等异常时，第一电导率和第二电导率应当相同或极为接近，因此当二者出现差异时，处理器即可判断出当前测量通道11中的样品中出现了异常。Optionally, for the detection component used for the medical detection device 9a, the first channel 1 may also include a measurement channel 11 for accommodating samples, and the first detection electrode 413 and the second detection electrode 414 are arranged at both ends of the measurement channel 11. The detection signals obtained by the first loop and the second loop may be the first conductivity and the second conductivity, respectively, the first conductivity being the conductivity of the sample between the counter electrode 412 and the first detection electrode 413, and the second conductivity being the conductivity of the sample between the counter electrode 412 and the second detection electrode 414. When there are no abnormalities such as bubbles and clots in the sample in the measurement channel 11, the first conductivity and the second conductivity should be the same or very close, so when there is a difference between the two, the processor can determine that an abnormality has occurred in the sample in the current measurement channel 11.
可选地，根据其他更深层的算法，处理器还可根据不同的电导率变化规律计算得到的异常出现在测量通道11中的哪一段。甚至也可以根据电导率推出造成电导率变化的异常的类型，从而对样品得出更为细致的分析结果，并对气泡一类的外界导致的异常和凝块一类的样品本身自带的异常加以区分。Optionally, according to other more advanced algorithms, the processor can also calculate in which section of the measurement channel 11 the abnormality appears according to different conductivity change rules. It is even possible to infer the type of abnormality that causes the conductivity change based on the conductivity, thereby obtaining a more detailed analysis result for the sample and distinguishing between abnormalities caused by external factors such as bubbles and abnormalities inherent in the sample such as clots.
本申请还提供了一种样品测试卡9，包括第一通道1和第一电极组41a。其中第一电极组41a设置于第一通道1中，且包括至少两个检测电极。该至少两个检测电极能够通过第一通道1中的样本导通，从而用于获取样品检测过程中至少两个检测电极之间的第一通道1中的样品的至少两个检测信号。该至少两个检测信号可以用于进行比较以判断两个检测电极之间的第一通道1中的样品中是否存在异常。The present application also provides a sample test card 9, comprising a first channel 1 and a first electrode group 41a. The first electrode group 41a is arranged in the first channel 1 and comprises at least two detection electrodes. The at least two detection electrodes can be connected through the sample in the first channel 1, so as to obtain at least two detection signals of the sample in the first channel 1 between the at least two detection electrodes during the sample detection process. The at least two detection signals can be used for comparison to determine whether there is an abnormality in the sample in the first channel 1 between the two detection electrodes.
可选地，至少两个检测信号的获取方法可以为固定的两个检测电极形成的部分回路先后对同一段样品进行至少两次检测，从而得到至少两个检测信号，从而根据先后检测信号的差异来进行判断，进而得出通入样品前后或对样品进行测量前后或对样品进行测量的过程中，样品中是否有出现异常。Optionally, the method for obtaining at least two detection signals can be that the partial loop formed by the two fixed detection electrodes detects the same section of the sample at least twice in succession, thereby obtaining at least two detection signals, and then judging according to the difference between the successive detection signals, and then obtaining the input Whether there is any abnormality in the sample before and after the sample is taken or before and after the sample is measured or during the measurement of the sample.
本申请还提供一种医疗检测设备9a，包括接触电极81和处理器。接触电极81与样品测试卡9的第一通道1中的第一电极组41a信号连接，至少两个检测电极能够通过第一通道1导通，接触电极81用于传输第一电极组41a获取的第一通道1中的样品的检测信号。处理器与接触电极81连接，用于接收检测信号，并根据检测信号对第一通道1中是否存在异常进行判断。The present application also provides a medical detection device 9a, including a contact electrode 81 and a processor. The contact electrode 81 is connected to the first electrode group 41a in the first channel 1 of the sample test card 9, at least two detection electrodes can be connected through the first channel 1, and the contact electrode 81 is used to transmit the detection signal of the sample in the first channel 1 obtained by the first electrode group 41a. The processor is connected to the contact electrode 81, and is used to receive the detection signal, and judge whether there is an abnormality in the first channel 1 according to the detection signal.
本申请还提供一种样品测试卡的检测方法，包括医疗检测设备获取在第一通道中进行样品检测得到的至少两个检测信号，其中，样品测试卡包括第一通道和设置于所述第一通道中的第一电极组，第一电极组包括第一检测电极、第二检测电极和对电极，对电极设置于第一检测电极与第二检测电极之间，对电极与第一检测电极形成第一回路的部分，对电极与第二检测电极形成第二回路的部分，利用第一回路和第二回路能够分别获得至少两个检测信号中的一个。响应于至少两个检测信号的差异大于阈值，医疗检测设备的处理器得出存在异常的结果。The present application also provides a detection method for a sample test card, including obtaining at least two detection signals obtained by a medical detection device in a first channel for sample detection, wherein the sample test card includes a first channel and a first electrode group arranged in the first channel, the first electrode group includes a first detection electrode, a second detection electrode and a counter electrode, the counter electrode is arranged between the first detection electrode and the second detection electrode, the counter electrode and the first detection electrode form a part of a first loop, the counter electrode and the second detection electrode form a part of a second loop, and one of the at least two detection signals can be obtained by using the first loop and the second loop respectively. In response to the difference between the at least two detection signals being greater than a threshold value, the processor of the medical detection device obtains a result of an abnormality.
以上仅为本申请的实施方式，并非因此限制本申请的专利范围，凡是利用本申请说明书及附图内容所作的等效结构或等效流程变换，或直接或间接运用在其他相关的技术领域，均同理包括在本申请的专利保护范围内。The above are only implementation methods of the present application, and are not intended to limit the patent scope of the present application. Any equivalent structure or equivalent process transformation made using the contents of the present application specification and drawings, or directly or indirectly applied in other related technical fields, are also included in the patent protection scope of the present application.
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CN2023/110396WO2025025107A1 (en) | 2023-07-31 | 2023-07-31 | Sample test card, testing assembly, and medical testing device |
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CN2023/110396WO2025025107A1 (en) | 2023-07-31 | 2023-07-31 | Sample test card, testing assembly, and medical testing device |
| Publication Number | Publication Date |
|---|---|
| WO2025025107A1true WO2025025107A1 (en) | 2025-02-06 |
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/CN2023/110396PendingWO2025025107A1 (en) | 2023-07-31 | 2023-07-31 | Sample test card, testing assembly, and medical testing device |
| Country | Link |
|---|---|
| WO (1) | WO2025025107A1 (en) |
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040232009A1 (en)* | 2001-10-12 | 2004-11-25 | Hisashi Okuda | Concentration measuring method and concentration measuring device |
| US20070102292A1 (en)* | 2005-05-10 | 2007-05-10 | Roche Diagnostics Operations, Inc. | Method and system for error checking an electrochemical sensor |
| CN113125528A (en)* | 2020-01-14 | 2021-07-16 | 利多(香港)有限公司 | Electrochemical test strip for multi-index parameter detection and detection method |
| CN114646678A (en)* | 2020-12-21 | 2022-06-21 | 豪夫迈·罗氏有限公司 | sensor assembly |
| US20220196632A1 (en)* | 2020-12-21 | 2022-06-23 | Roche Diagnostics Operations, Inc. | Sensor device and method of use |
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040232009A1 (en)* | 2001-10-12 | 2004-11-25 | Hisashi Okuda | Concentration measuring method and concentration measuring device |
| US20070102292A1 (en)* | 2005-05-10 | 2007-05-10 | Roche Diagnostics Operations, Inc. | Method and system for error checking an electrochemical sensor |
| CN113125528A (en)* | 2020-01-14 | 2021-07-16 | 利多(香港)有限公司 | Electrochemical test strip for multi-index parameter detection and detection method |
| CN114646678A (en)* | 2020-12-21 | 2022-06-21 | 豪夫迈·罗氏有限公司 | sensor assembly |
| US20220196632A1 (en)* | 2020-12-21 | 2022-06-23 | Roche Diagnostics Operations, Inc. | Sensor device and method of use |
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