相关申请Related Applications
本申请要求2023年06月13日申请的，申请号为202310698497.8，名称为“多取样活检装置及多取样方法”；2023年08月30日申请的，申请号为202311109750.8，名称为“操作手柄、取样装置以及取样方法”的中国专利申请的优先权，其全部内容通过引用结合在本申请中。This application claims priority to Chinese patent applications filed on June 13, 2023, with application number 202310698497.8 and title “Multi-sampling biopsy device and multi-sampling method”; and filed on August 30, 2023, with application number 202311109750.8 and title “Operating handle, sampling device and sampling method”, all contents of which are incorporated by reference into this application.
本申请涉及医疗器械技术领域，特别是涉及多取样活检装置、多取样方法及取样设备。The present application relates to the technical field of medical devices, and in particular to a multi-sampling biopsy device, a multi-sampling method and a sampling apparatus.
软式内窥镜手术因其微创、恢复快，正日益成为当下消化道、泌尿、心肺及血管外周领域常用的手术方式。在内窥镜的术前诊断中，通常需要对疑似病灶进行取活检操作，以便进行病理分析。现有方式主要为通过具有挠性轴的活检钳对病灶组织进行抓取。Flexible endoscopic surgery is becoming a common surgical method in the fields of digestive tract, urology, cardiopulmonary and peripheral blood vessels due to its minimally invasive and quick recovery. In the preoperative diagnosis of endoscopy, it is usually necessary to take a biopsy of the suspected lesion for pathological analysis. The existing method is mainly to grab the lesion tissue with a biopsy forceps with a flexible shaft.
目前活检钳及类似医疗器械在操作时，多为一次插镜只能完成一次取样，而在实际临床应用中往往需要进行多次取样、获取多个组织，因此采用传统活检钳进行多次取样时需要进行反复退镜、插镜的操作，存在多次的单次取样、操作繁琐、手术效率低下、时间长、病患痛苦、易感染病菌等诸多问题。At present, when biopsy forceps and similar medical devices are used, they can only complete one sampling with one insertion of the scope. However, in actual clinical applications, multiple sampling and acquisition of multiple tissues are often required. Therefore, when using traditional biopsy forceps for multiple sampling, the scope needs to be repeatedly withdrawn and inserted, which leads to many problems such as multiple single sampling, cumbersome operation, low surgical efficiency, long operation time, pain for patients, and susceptibility to infection by bacteria.
发明内容Summary of the invention
根据本申请的各种实施例，提供多取样活检装置、多取样方法及取样设备。According to various embodiments of the present application, a multi-sampling biopsy device, a multi-sampling method, and a sampling apparatus are provided.
本申请提供多取样活检装置，该多取样活检装置包括：钳体机构，包括活动连接的钳杯和钳座，钳体机构内部形成有相邻且贯通设置的采集腔和存储腔，采集腔位于存储腔远侧；伸缩件，配置在钳体机构内，伸缩件设有采集部和存储部，采集部位于存储部远侧，伸缩件能够在采集腔与存储腔内被驱动地往复位移，进而使采集部采集组织、使存储部存储组织；以及引导件，配置在伸缩件外周，用以导向伸缩件沿远近端方向相对钳体机构往复位移；在伸缩件朝向远端侧位移时，伸缩件远端能够突出于钳杯远端以将钳杯撑开，并使采集部处的组织被止挡在钳杯内，使被止挡在钳杯内的组织朝向伸缩件近侧位移至存储部。The present application provides a multi-sampling biopsy device, which includes: a clamp body mechanism, including a clamp cup and a clamp seat that are movably connected, wherein a collection chamber and a storage chamber that are adjacent and through-connected are formed inside the clamp body mechanism, and the collection chamber is located on the far side of the storage chamber; a telescopic member, which is arranged in the clamp body mechanism, and the telescopic member is provided with a collection part and a storage part, and the collection part is located on the far side of the storage part, and the telescopic member can be driven to move back and forth in the collection chamber and the storage chamber, so that the collection part collects tissue and the storage part stores tissue; and a guide member, which is arranged on the outer periphery of the telescopic member, and is used to guide the telescopic member to move back and forth relative to the clamp body mechanism in the proximal and distal directions; when the telescopic member is displaced toward the distal side, the distal end of the telescopic member can protrude beyond the distal end of the clamp cup to open the clamp cup, and the tissue at the collection part is stopped in the clamp cup, so that the tissue stopped in the clamp cup is displaced toward the proximal side of the telescopic member to the storage part.
本申请提供多取样方法，采用前述的多取样活检装置，多取样方法的步骤包括：S1：初始状态下，伸缩件远端位于钳杯内且靠近钳杯的钳杯远端处，当多取样活检装置位于待取组织处时驱动钳杯打开，使伸缩件远端的采集部进入待取组织；S2：驱动钳杯闭合使钳杯取下组织；S3：驱动伸缩件朝向远端侧位移，使伸缩件远端将钳杯撑开且使S2取下的组织被止挡在钳杯内，进而使被止挡在钳杯内的组织朝向伸缩件近侧位移至存储部，空出采集部；S4：驱动伸缩件沿近端方向位移使伸缩件回复至初始状态，同时存储部处的组织跟随伸缩件沿近端方向位移，使存储部处的组织离开采集腔而进入存储腔；此时，完成一次组织取样；以及S5：重复S1至S4，完成N次组织取样。The present application provides a multi-sampling method, which adopts the aforementioned multi-sampling biopsy device, and the steps of the multi-sampling method include: S1: in the initial state, the distal end of the telescopic member is located in the forceps cup and close to the distal end of the forceps cup. When the multi-sampling biopsy device is located at the tissue to be collected, the forceps cup is driven to open, so that the collection part at the distal end of the telescopic member enters the tissue to be collected; S2: the forceps cup is driven to close so that the forceps cup removes the tissue; S3: the telescopic member is driven to move toward the distal side, so that the distal end of the telescopic member opens the forceps cup and the tissue removed by S2 is stopped in the forceps cup, and then the tissue stopped in the forceps cup is moved toward the proximal side of the telescopic member to the storage part, freeing up the collection part; S4: the telescopic member is driven to move in the proximal direction so that the telescopic member returns to the initial state, and at the same time, the tissue at the storage part follows the telescopic member to move in the proximal direction, so that the tissue at the storage part leaves the collection chamber and enters the storage chamber; at this time, one tissue sampling is completed; and S5: S1 to S4 are repeated to complete N tissue samplings.
本申请提供取样设备，该取样设备包括：操作机构；及前述的多取样活检装置，钳体机构和伸缩件分别受到操作机构的驱动。The present application provides a sampling device, which includes: an operating mechanism; and the aforementioned multi-sampling biopsy device, wherein the clamp body mechanism and the telescopic member are respectively driven by the operating mechanism.
本申请提供操作机构，该操作机构包括手柄本体和多个控制件；多个控制件活动连接于手柄本体上，每个控制件均连接有驱动件，驱动件用于连接远端部件；其中，各个控制件均能够相对手柄本体沿远近端方向做往复运动，且各个控制件具有朝向远端侧或朝向近端侧复位的运动趋势，各个控制件能够带动对应的驱动件同步移动进而带动远端部件动作。The present application provides an operating mechanism, which includes a handle body and multiple control members; the multiple control members are movably connected to the handle body, and each control member is connected to a driving member, which is used to connect to a distal component; wherein each control member can reciprocate relative to the handle body in the distal and proximal directions, and each control member has a movement tendency to reset toward the distal side or toward the proximal side, and each control member can drive the corresponding driving member to move synchronously and thereby drive the distal component to move.
本申请还提供一种取样设备，该取样设备包括：远端部件；前述的操作机构，操作机构用于控制远端部件；及驱动件，驱动件连接操作机构与远端部件。The present application also provides a sampling device, which includes: a distal component; the aforementioned operating mechanism, which is used to control the distal component; and a driving member, which connects the operating mechanism and the distal component.
本申请提供取样方法，该取样方法基于前述的取样设备，该取样方法包括以下步骤：S10：初始状态下，伸缩件远端位于钳杯内且靠近钳杯远端处，当取样设备位于待取组织处时，驱动第一控制件朝向远端侧移动，驱动钳杯打开，使伸缩件远端的采集部进入待取组织；S20：在复位的运动趋势下，第一控制件朝向近端侧移动，驱动钳杯闭合使钳杯取下组织；S30：驱动第二控制件朝向远端侧移动，使伸缩件远端将钳杯撑开且将S20取下的组织始终被止挡在钳杯内，进而使被止挡在钳杯内的组织朝向伸缩件近侧移动至存储部，空出采集部；S40：在复位的运动趋势下，第二控制件朝向近端侧移动，使伸缩件回复至初始状态，同时存储部处的组织跟随伸缩件朝向近端侧移动，使得存储部处的组织离开采集腔而进入存储腔；此时，完成一次组织取样；以及S50：重复S10至S40，完成N次组织取样。The present application provides a sampling method, which is based on the aforementioned sampling device and includes the following steps: S10: in the initial state, the distal end of the telescopic member is located in the forceps cup and close to the distal end of the forceps cup. When the sampling device is located at the tissue to be collected, the first control member is driven to move toward the distal end, the forceps cup is driven to open, and the collection portion at the distal end of the telescopic member enters the tissue to be collected; S20: under the movement trend of resetting, the first control member moves toward the proximal end, the forceps cup is driven to close, and the forceps cup removes the tissue; S30: the second control member is driven to move toward the distal end, the telescopic member is driven to close, and the collection portion at the distal end of the telescopic member enters the tissue to be collected; The distal end of the retracting member opens the forceps cup and the tissue removed in S20 is always stopped in the forceps cup, so that the tissue stopped in the forceps cup moves toward the proximal side of the telescopic member to the storage part, leaving the collection part empty; S40: under the resetting movement trend, the second control member moves toward the proximal side, so that the telescopic member returns to the initial state, and at the same time, the tissue at the storage part moves with the telescopic member toward the proximal side, so that the tissue at the storage part leaves the collection chamber and enters the storage chamber; at this time, one tissue sampling is completed; and S50: S10 to S40 are repeated to complete N tissue samplings.
本申请的一个或多个实施例的细节在下面的附图和描述中提出。本申请的其它特征、目的和优点将从说明书、附图以及权利要求书变得明显。The details of one or more embodiments of the present application are set forth in the following drawings and description. Other features, objects, and advantages of the present application will become apparent from the description, drawings, and claims.
为了更好地描述和说明这里公开的那些发明的实施例和/或示例，可以参考一幅或多幅附图。用于描述附图的附加细节或示例不应当被认为是对所公开的发明、目前描述的实施例和/或示例以及目前理解的这些发明的最佳模式中的任何一者的范围的限制。In order to better describe and illustrate the embodiments and/or examples of the inventions disclosed herein, reference may be made to one or more drawings. The additional details or examples used to describe the drawings should not be considered as limiting the scope of any of the disclosed inventions, the embodiments and/or examples currently described, and the best modes of these inventions currently understood.
图1为根据一个或多个实施例的多取样活检装置的部分结构示意图；FIG1 is a partial schematic diagram of a multi-sampling biopsy device according to one or more embodiments;
图2为图1中钳杯的整体结构示意图；FIG2 is a schematic diagram of the overall structure of the clamp cup in FIG1 ;
图3为根据一个或多个实施例的伸缩件的整体结构示意图；FIG3 is a schematic diagram of the overall structure of a telescopic member according to one or more embodiments;
图4为根据一个或多个实施例的多取样活检装置的内部结构示意图；FIG4 is a schematic diagram of the internal structure of a multi-sampling biopsy device according to one or more embodiments;
图5为根据一个或多个实施例的多取样活检装置的内部结构示意图；FIG5 is a schematic diagram of the internal structure of a multi-sampling biopsy device according to one or more embodiments;
图6为根据一个或多个实施例的多取样活检装置的内部结构示意图；FIG6 is a schematic diagram of the internal structure of a multi-sampling biopsy device according to one or more embodiments;
图7为根据一个或多个实施例的多取样活检装置的内部结构示意图；FIG7 is a schematic diagram of the internal structure of a multi-sampling biopsy device according to one or more embodiments;
图8为根据一个或多个实施例的多取样活检装置的内部结构示意图；FIG8 is a schematic diagram of the internal structure of a multi-sampling biopsy device according to one or more embodiments;
图9为根据一个或多个实施例的多取样活检装置的内部结构示意图；FIG9 is a schematic diagram of the internal structure of a multi-sampling biopsy device according to one or more embodiments;
图10为根据一个或多个实施例的取样设备的第一局部示意图；FIG10 is a first partial schematic diagram of a sampling device according to one or more embodiments;
图11为根据一个或多个实施例的操作机构的第一局部剖视图；FIG11 is a first partial cross-sectional view of an operating mechanism according to one or more embodiments;
图12为图11中提供的A处局部放大图；FIG12 is a partial enlarged view of point A provided in FIG11;
图13为图11中提供的B处局部放大图；FIG13 is a partial enlarged view of point B provided in FIG11;
图14为图11中提供的C处局部放大图；FIG14 is a partial enlarged view of point C provided in FIG11;
图15为根据一个或多个实施例的操作机构的第二局部剖视图；15 is a second partial cross-sectional view of an operating mechanism according to one or more embodiments;
图16为根据一个或多个实施例的取样设备的第一局部剖视图；16 is a first partial cross-sectional view of a sampling device according to one or more embodiments;
图17为根据一个或多个实施例的钳杯的第二示意图；17 is a second schematic diagram of a clamp cup according to one or more embodiments;
图18为根据一个或多个实施例的钳杯的第三示意图；FIG. 18 is a third schematic diagram of a clamp cup according to one or more embodiments;
图19为根据一个或多个实施例的取样设备中伸缩件的第二示意图。19 is a second schematic diagram of a telescopic member in a sampling device according to one or more embodiments.
附图标记：1、钳杯远端；2、钳杯近端；3、采集腔近端；4、钳体机构近端；5、钳座近端；6、钳座内近端；20、外周面；21、驱动件近端；22、弹簧管近端；23、杆状连接部远端；24、握持杆体远端；25、牵引绳近端；26、控制件近端；27、控制件远端；28、操作机构远端；30、鞘管机构远端；31、鞘管远端；Figure numerals: 1, distal end of clamp cup; 2, proximal end of clamp cup; 3, proximal end of collection chamber; 4, proximal end of clamp body mechanism; 5, proximal end of clamp seat; 6, proximal end of clamp seat inner part; 20, outer peripheral surface; 21, proximal end of driving member; 22, proximal end of spring tube; 23, distal end of rod-shaped connecting part; 24, distal end of holding rod body; 25, proximal end of traction rope; 26, proximal end of control member; 27, distal end of control member; 28, distal end of operating mechanism; 30, distal end of sheath mechanism; 31, distal end of sheath;
100、钳体机构；101、远端部件；110、钳杯；111、杯体；1110、杯口部分；1111、端部刃口；1112、侧部刃口；1113、敞口；1114、存放腔；1115、引流孔；1116、固定孔；1117、铰接孔；1118、引导槽；112、连接件；113、销轴；120、钳座；121、管座；122、连接柱；130、采集腔；140、存储腔；141、在周向上密封的存储腔部分；150、伸缩件；1502、伸缩件远端；1503、伸缩件近端；151、倒刺结构；1511、防滑凸起；1512、防滑凹陷；152、采集部；1521、针体；153、存储部；154、第一限位件；1550、释放件；155、第二限位件；1551、连接管；156、小径断离部；160、引导件；161、引导件远端；162、引导件近端；100, clamp body mechanism; 101, distal component; 110, clamp cup; 111, cup body; 1110, cup mouth; 1111, end edge; 1112, side edge; 1113, open mouth; 1114, storage chamber; 1115, drainage hole; 1116, fixing hole; 1117, hinge hole; 1118, guide groove; 112, connector; 113, pin shaft; 120, clamp seat; 121, tube seat; 122, connecting column; 130, collection chamber; 140, storage chamber; 141, A storage cavity portion sealed in the circumferential direction; 150, telescopic member; 1502, telescopic member distal end; 1503, telescopic member proximal end; 151, barb structure; 1511, anti-slip protrusion; 1512, anti-slip depression; 152, collection part; 1521, needle body; 153, storage part; 154, first stopper; 1550, release member; 155, second stopper; 1551, connecting tube; 156, small-diameter disconnection part; 160, guide member; 161, guide member distal end; 162, guide member proximal end;
200、鞘管机构；210、鞘管；211、伸缩用驱动件；212、开合用驱动件；213、弹簧管；214、支撑管；215、润滑管；300、组织；301、第一次组织；302、第二次组织；200, sheath tube mechanism; 210, sheath tube; 211, telescopic drive member; 212, opening and closing drive member; 213, spring tube; 214, support tube; 215, lubrication tube; 300, tissue; 301, first tissue; 302, second tissue;
400、操作机构；410、手柄本体；411、握持杆体；412、连接套；4121、连接腔；413、握持环；4101、装配腔；4102、导向开槽；4103、释放空间；420、控制件；4201、第一控制件；4202、第二控制件；421、连接孔；422、弯折段；430、驱动件；4311、杆状连接部；4312、钩回段；431、牵引绳；432、结合件；433、主绳；440、限位座；441、第一限位座；442、第二限位座；450、弹性件；451、第一弹性件；452、第二弹性件；4401、第二贯穿孔；4402、定位槽；4403、定位柱；1000、多取样活检装置；2000、取样设备。400, operating mechanism; 410, handle body; 411, grip rod body; 412, connecting sleeve; 4121, connecting cavity; 413, grip ring; 4101, assembly cavity; 4102, guide slot; 4103, release space; 420, control member; 4201, first control member; 4202, second control member; 421, connecting hole; 422, bending section; 430, driving member; 4311, rod-shaped connecting member Connecting part; 4312, hooking section; 431, traction rope; 432, coupling piece; 433, main rope; 440, limiting seat; 441, first limiting seat; 442, second limiting seat; 450, elastic member; 451, first elastic member; 452, second elastic member; 4401, second through hole; 4402, positioning groove; 4403, positioning column; 1000, multi-sampling biopsy device; 2000, sampling equipment.
以下将结合附图，对本申请进行更为详细的描述，需要说明的是，下参照附图对本申请进行的描述仅是示意性的，而非限制性的。各个不同实施例之间可以进行相互组合，以构成未在以下描述中示出的其他实施例。The present application will be described in more detail below in conjunction with the accompanying drawings. It should be noted that the description of the present application with reference to the accompanying drawings is only illustrative and not restrictive. The various embodiments can be combined with each other to form other embodiments not shown in the following description.
需要说明的是，当组件被称为“固定于”或“设置于”另一个组件，它可以直接在另一个组件上或者也可以存在居中的组件。当一个组件被认为是“连接”另一个组件，它可以是直接连接到另一个组件或者可能同时存在居中组件。本申请的说明书所使用的术语“垂直的”、“水平的”、“上”、“下”、“左”、“右”以及类似的表述只是为了说明的目的，并不表示是唯一的实施方式。It should be noted that when a component is referred to as being "fixed to" or "disposed on" another component, it may be directly on the other component or there may also be a central component. When a component is considered to be "connected to" another component, it may be directly connected to the other component or there may be a central component at the same time. The terms "vertical", "horizontal", "upper", "lower", "left", "right" and similar expressions used in the specification of this application are for illustrative purposes only and do not represent the only implementation method.
此外，术语“第一”、“第二”仅用于描述目的，而不能理解为指示或暗示相对重要性或者隐含指明所指示的技术特征的数量。由此，限定有“第一”、“第二”的特征可以明示或者隐含地包括至少一个该特征。在本申请的描述中，“多个”的含义是至少两个，例如两个，三个等，除非另有明确具体的限定。In addition, the terms "first" and "second" are used for descriptive purposes only and should not be understood as indicating or implying relative importance or implicitly indicating the number of the indicated technical features. Therefore, the features defined as "first" and "second" may explicitly or implicitly include at least one of the features. In the description of this application, the meaning of "plurality" is at least two, such as two, three, etc., unless otherwise clearly and specifically defined.
在本申请中，除非另有明确的规定和限定，第一特征在第二特征“上”、“下”可以是第一特征直接和第二特征接触，或第一特征和第二特征间接地通过中间媒介接触。而且，第一特征在第二特征“之上”、“上方”和“上面”可是第一特征在第二特征正上方或斜上方，或仅表示第一特征水平高度高于第二特征。第一特征在第二特征“之下”、“下方”和“下面”可以是第一特征在第二特征正下方或斜下方，或仅表示第一特征水平高度小于第二特征。In the present application, unless otherwise clearly specified and limited, a first feature being “above” or “below” a second feature may mean that the first feature is directly in contact with the second feature, or the first feature and the second feature are indirectly in contact through an intermediate medium. Moreover, a first feature being “above”, “above” or “above” a second feature may mean that the first feature is directly above or obliquely above the second feature, or simply means that the first feature is higher in level than the second feature. A first feature being “below”, “below” or “below” a second feature may mean that the first feature is directly below or obliquely below the second feature, or simply means that the first feature is lower in level than the second feature.
除非另有定义，本申请的说明书所使用的所有的技术和科学术语与属于本申请的技术领域的技术人员通常理解的含义相同。在本申请的说明书中所使用的术语只是为了描述具体的实施方式的目的，不是旨在于限制本申请。本申请的说明书所使用的术语“及/或”包括一个或多个相关的所列项目的任意的和所有的组合。Unless otherwise defined, all technical and scientific terms used in the specification of this application have the same meaning as those commonly understood by those skilled in the art to which this application belongs. The terms used in the specification of this application are only for the purpose of describing specific embodiments and are not intended to limit this application. The term "and/or" used in the specification of this application includes any and all combinations of one or more related listed items.
需要说明的是，其中图4至图8中除伸缩件150、钳杯110为非剖视图外，其余为剖视图，并且为了更为清楚地显示伸缩件150、组织300在钳杯110内的运动状态，此处做了透视效果，其中图1至图3为正常显示。另外采集腔130、存储腔140、采集部152、存储部153位于虚线框内对应部件的位置上。It should be noted that, except for the telescopic member 150 and the forceps cup 110 which are non-sectional views, the rest of Figures 4 to 8 are sectional views, and in order to more clearly show the movement of the telescopic member 150 and the tissue 300 in the forceps cup 110, a perspective effect is provided here, and Figures 1 to 3 are normal displays. In addition, the collection cavity 130, the storage cavity 140, the collection part 152, and the storage part 153 are located at the positions of the corresponding parts in the dotted frame.
需要说明的是，本申请中所称的远端和近端，以医生为基准，靠近医生的一端为近端或近端部分，远离医生的一端为远端或远端部分。朝向医生的一侧为近侧或近端侧，背向医生的一侧为远侧或远端侧。另外远端方向、近端方向代表两个方向；远近端方向则平行于远端方向和近端方向，且远近端方向不特指正向或反向。It should be noted that the distal and proximal ends referred to in this application are based on the doctor, the end close to the doctor is the proximal end or the proximal part, and the end away from the doctor is the distal end or the distal part. The side facing the doctor is the proximal side or the proximal side, and the side facing away from the doctor is the distal side or the distal side. In addition, the distal direction and the proximal direction represent two directions; the proximal-distal direction is parallel to the distal direction and the proximal direction, and the proximal-distal direction does not specifically refer to the forward or reverse direction.
目前活检钳及类似医疗器械在操作时，多为一次插镜只能完成一次取样，而在实际临床应用中往往需要进行多次取样、获取多个组织，因此采用传统活检钳进行多次取样时需要进行反复退镜、插镜的操作，存在多次的单次取样、操作繁琐、手术效率低下、时间长、病患痛苦、易感染病菌等诸多问题。At present, when biopsy forceps and similar medical devices are used, they can only complete one sampling with one insertion of the scope. However, in actual clinical applications, multiple sampling and acquisition of multiple tissues are often required. Therefore, when using traditional biopsy forceps for multiple sampling, the scope needs to be repeatedly withdrawn and inserted, which leads to many problems such as multiple single sampling, cumbersome operation, low surgical efficiency, long operation time, pain for patients, and susceptibility to infection by bacteria.
为了解决上述技术问题，本申请提出一种多取样活检装置及多取样方法，本申请包括以下优点：只需一次插镜便可以完成多次取样，无需进行反复退镜、插镜操作，具有多次取样、操作简化、手术效率高、时间大幅缩短、减少病患痛苦、卫生安全、活检准确率高等诸多优势，在多次取样的过程中，还具有取样稳定性高、位置准确、多取样过程简易、避免误操作、顺畅无卡顿等优势。In order to solve the above-mentioned technical problems, the present application proposes a multi-sampling biopsy device and a multi-sampling method. The present application includes the following advantages: multiple samplings can be completed with only one insertion of the mirror, without the need to repeatedly withdraw and insert the mirror. It has many advantages such as multiple samplings, simplified operation, high surgical efficiency, greatly shortened time, reduced patient pain, hygiene and safety, and high biopsy accuracy. In the process of multiple sampling, it also has the advantages of high sampling stability, accurate positioning, simple multi-sampling process, avoidance of misoperation, and smooth and no jamming.
参考图1至图9，本申请提供一种多取样活检装置1000，该多取样活检装置1000可包括：钳体机构100、伸缩件150以及引导件160。1 to 9 , the present application provides a multi-sampling biopsy device 1000 , which may include: a clamp body mechanism 100 , a telescopic member 150 , and a guide member 160 .
示例性地，钳体机构100包括活动连接的钳杯110和钳座120。钳体机构100的内部形成有相邻且贯通设置的采集腔130和存储腔140。采集腔130位于存储腔140的远侧。Exemplarily, the clamp body mechanism 100 includes a clamp cup 110 and a clamp seat 120 that are movably connected. A collection chamber 130 and a storage chamber 140 that are adjacent and connected are formed inside the clamp body mechanism 100. The collection chamber 130 is located at the far side of the storage chamber 140.
示例性地，伸缩件150配置在钳体机构100内。伸缩件150设有采集部152和存储部153，采集部152位于存储部153远侧。伸缩件150能够在采集腔130与存储腔140内被驱动地往复位移，进而使采集部152采集组织300、使存储部153存储组织300。Exemplarily, the telescopic member 150 is disposed in the clamp body mechanism 100. The telescopic member 150 is provided with a collection portion 152 and a storage portion 153, wherein the collection portion 152 is located far from the storage portion 153. The telescopic member 150 can be driven to move back and forth in the collection cavity 130 and the storage cavity 140, so that the collection portion 152 collects the tissue 300 and the storage portion 153 stores the tissue 300.
示例性地，采集部152和存储部153可设置于伸缩件150外周。伸缩件150包括伸缩件远端1502和伸缩件近端1503。示例性地，采集部152的一部分可设置在伸缩件远端1502。伸缩件150的外周可以指伸缩件150径向的外周。伸缩件150的外周所指代的空间可与伸缩件150等长，也可延伸到伸缩件150的近侧和/或远侧。Exemplarily, the collecting portion 152 and the storage portion 153 may be disposed on the periphery of the telescopic member 150. The telescopic member 150 includes a telescopic member distal end 1502 and a telescopic member proximal end 1503. Exemplarily, a portion of the collecting portion 152 may be disposed on the telescopic member distal end 1502. The periphery of the telescopic member 150 may refer to the radial periphery of the telescopic member 150. The space referred to by the periphery of the telescopic member 150 may be the same length as the telescopic member 150, or may extend to the proximal side and/or the distal side of the telescopic member 150.
钳杯110的远端和近端可称为钳杯远端1和钳杯近端2；类似地，伸缩件150的远端和近端可称为伸缩件远端1502和伸缩件近端1503。或者，可将钳杯110的远端称为第一远端，伸缩件150的远端称为第二远端。The distal end and the proximal end of the forceps cup 110 may be referred to as the distal end 1 of the forceps cup and the proximal end 2 of the forceps cup; similarly, the distal end and the proximal end of the telescopic member 150 may be referred to as the telescopic member distal end 1502 and the telescopic member proximal end 1503. Alternatively, the distal end of the forceps cup 110 may be referred to as the first distal end, and the distal end of the telescopic member 150 may be referred to as the first distal end. The second far end.
示例性地，引导件160配置在伸缩件150外周，用以导向伸缩件150沿远近端方向相对钳体机构100往复位移。引导件160可以沿伸缩件150的周向围绕360°，也可以围绕一部分；引导件160可以是断续的多段。Exemplarily, the guide member 160 is disposed on the outer periphery of the telescopic member 150 to guide the telescopic member 150 to move back and forth relative to the clamp body mechanism 100 in the distal and proximal directions. The guide member 160 may surround 360° along the circumference of the telescopic member 150, or surround a portion thereof; the guide member 160 may be discontinuous in multiple sections.
多取样活检装置1000整体具有远端侧和近端侧。在伸缩件150相对钳体机构100朝向远端侧位移时，伸缩件远端1502能够突出于钳杯远端1以将钳杯110撑开，并使采集部152处的组织300被止挡在钳杯110内，使被止挡在钳杯110内的组织300朝向伸缩件近端1503位移至存储部153。换言之，伸缩件150相对组织300朝向远侧移动；继而相当于使组织300朝向伸缩件150近侧位移到存储部153处。本申请钳体机构100内采集腔130、存储腔140之间贯通(无论钳杯110是打开还是关闭)，保证伸缩件150及其上的组织300可以顺畅无阻地在钳体机构100内往复位移；引导件160保证伸缩件150位移的稳定性、方向性；每次采样后能为下一次采样提供准备，多次取样后得到的组织300依次排串在伸缩件150上，便于用户收集标记。The multi-sampling biopsy device 1000 as a whole has a distal side and a proximal side. When the telescopic member 150 is displaced toward the distal side relative to the clamp body mechanism 100, the telescopic member distal end 1502 can protrude from the distal end 1 of the forceps cup to open the forceps cup 110, and the tissue 300 at the collection portion 152 is stopped in the forceps cup 110, so that the tissue 300 stopped in the forceps cup 110 is displaced toward the proximal end 1503 of the telescopic member to the storage portion 153. In other words, the telescopic member 150 moves toward the distal side relative to the tissue 300; which is equivalent to causing the tissue 300 to displace toward the proximal side of the telescopic member 150 to the storage portion 153. The collection chamber 130 and the storage chamber 140 in the clamp body mechanism 100 of the present application are connected (regardless of whether the clamp cup 110 is open or closed), ensuring that the telescopic member 150 and the tissue 300 thereon can be smoothly and unimpededly moved back and forth in the clamp body mechanism 100; the guide member 160 ensures the stability and directionality of the displacement of the telescopic member 150; each sampling can provide preparation for the next sampling, and the tissue 300 obtained after multiple samplings are arranged in sequence on the telescopic member 150, which is convenient for users to collect and mark.
示例性地，钳杯110内部至少包括采集腔130，在采集腔近端3与钳座近端5或靠近钳座近端5处之间形成存储腔140，保证存储腔140足够大。Exemplarily, the interior of the forceps cup 110 includes at least a collection chamber 130 , and a storage chamber 140 is formed between the proximal end 3 of the collection chamber and the proximal end 5 of the forceps seat or near the proximal end 5 of the forceps seat, ensuring that the storage chamber 140 is large enough.
示例性地，在初始状态下，采集腔130的位置对应有伸缩件150的采集部152，存储腔140的位置对应有伸缩件150的存储部153。Exemplarily, in the initial state, the position of the collecting cavity 130 corresponds to the collecting portion 152 of the telescopic member 150 , and the position of the storage cavity 140 corresponds to the storage portion 153 of the telescopic member 150 .
示例性地，引导件160配置在钳体机构100内。Exemplarily, the guide member 160 is disposed within the caliper mechanism 100 .
示例性地，引导件160配置在钳座内近端6处或靠近钳座近端5处。Exemplarily, the guide 160 is disposed at the proximal end 6 of the clamp seat or near the proximal end 5 of the clamp seat.
示例性地，钳杯110内部至少包括采集腔130，在采集腔近端3与引导件远端161之间形成存储腔140。Exemplarily, the forceps cup 110 includes at least a collection chamber 130 therein, and a storage chamber 140 is formed between the proximal end 3 of the collection chamber and the distal end 161 of the guide.
示例性地，引导件160配置在伸缩件150外周上，引导件160外周可与钳体机构100内部滑动连接。Exemplarily, the guide member 160 is disposed on the outer periphery of the telescopic member 150 , and the outer periphery of the guide member 160 can be slidably connected to the interior of the caliper mechanism 100 .
示例性地，钳体机构100内连接有位于引导件160远端侧的第一限位件154，或/和，位于引导件160近端侧第二限位件155。Exemplarily, a first limiting member 154 located at the distal end side of the guide member 160 , or/and a second limiting member 155 located at the proximal end side of the guide member 160 are connected to the clamp body mechanism 100 .
示例性地，伸缩件150为针状体，伸缩件远端1502为针尖状，能够提高采集效率。Exemplarily, the telescopic member 150 is a needle-shaped body, and the distal end 1502 of the telescopic member is in the shape of a needle tip, which can improve the collection efficiency.
示例性地，伸缩件150外周布设有防滑凸起1511或/和防滑凹陷1512，保证组织300稳定地固定在伸缩件150上。Exemplarily, the telescopic member 150 is provided with anti-slip protrusions 1511 and/or anti-slip depressions 1512 on its periphery to ensure that the tissue 300 is stably fixed on the telescopic member 150 .
在一些实施方式中，多取样活检装置1000还包括鞘管机构200，鞘管机构远端30与钳体机构近端4连接，包括有鞘管210，鞘管210内部设有与伸缩件近端1503相连的伸缩用驱动件211、与钳杯近端2相连的可使钳杯110开合的开合用驱动件212。In some embodiments, the multi-sampling biopsy device 1000 also includes a sheath mechanism 200, the distal end 30 of the sheath mechanism is connected to the proximal end 4 of the clamp body mechanism, and includes a sheath 210. The sheath 210 is internally provided with a telescopic driving member 211 connected to the proximal end 1503 of the telescopic member, and an opening and closing driving member 212 connected to the proximal end 2 of the clamp cup and capable of opening and closing the clamp cup 110.
示例性地，伸缩件150、伸缩用驱动件211之间可拆卸连接。便于完成多次取样后，取下全部样本。Exemplarily, the telescopic member 150 and the telescopic driving member 211 are detachably connected to facilitate taking out all samples after completing multiple samplings.
示例性地，伸缩件150、伸缩用驱动件211之间通过释放件1550可拆卸连接。示例性地，引导件160配置在钳体机构100上，引导件近端162与鞘管远端31相接触。引导件160与鞘管210接触，可增加引导件160本身的稳定性，避免由于伸缩件150的频繁往复位移而导致引导件160松动。Exemplarily, the telescopic member 150 and the telescopic driving member 211 are detachably connected via a release member 1550. Exemplarily, the guide member 160 is disposed on the clamp body mechanism 100, and the proximal end 162 of the guide member contacts the distal end 31 of the sheath tube. The contact between the guide member 160 and the sheath tube 210 can increase the stability of the guide member 160 itself and prevent the guide member 160 from loosening due to the frequent reciprocating movement of the telescopic member 150.
本申请的一实施例中提供一种多取样活检装置1000，请参阅图1至图9，包括：In one embodiment of the present application, a multi-sampling biopsy device 1000 is provided, referring to FIGS. 1 to 9 , comprising:
钳体机构100，包括铰接的钳杯110、钳座120，其内部形成有相邻且贯通设置的采集腔130、存储腔140，采集腔130位于存储腔140远端，其中采集腔130用以容纳新采的组织300，存储腔140用以存储已采集完成的组织300；The clamp body mechanism 100 includes a hinged clamp cup 110 and a clamp seat 120, and has a collection chamber 130 and a storage chamber 140 formed therein, which are adjacent and connected to each other. The collection chamber 130 is located at the far end of the storage chamber 140, wherein the collection chamber 130 is used to accommodate newly collected tissue 300, and the storage chamber 140 is used to store the collected tissue 300;
伸缩件150，具体为远端呈针尖状、外周布设倒刺结构151的针状体，伸缩件150配置在钳体机构100内，伸缩件150设有采集部152、存储部153，采集部152位于存储部153远端，驱动伸缩件150使伸缩件150可在采集腔130、存储腔140内往复位移，进而使采集部152采集组织300、存储部153存储组织300；The telescopic member 150 is specifically a needle-shaped body with a needle tip at the distal end and a barb structure 151 arranged on the periphery. The telescopic member 150 is disposed in the clamp body mechanism 100. The telescopic member 150 is provided with a collecting part 152 and a storage part 153. The collecting part 152 is located at the distal end of the storage part 153. The telescopic member 150 is driven so that the telescopic member 150 can be moved back and forth in the collecting cavity 130 and the storage cavity 140, so that the collecting part 152 collects the tissue 300 and the storage part 153 stores the tissue 300.
引导件160，固定连接在钳座120内的靠近近端处，伸缩件150滑动穿设于引导件160，使引导件160可导向伸缩件150在远近端方向上相对钳体机构100往复位移；The guide member 160 is fixedly connected to the proximal end of the clamp seat 120, and the telescopic member 150 is slidably arranged through the guide member 160, so that the guide member 160 can guide the telescopic member 150 to move back and forth relative to the clamp body mechanism 100 in the proximal and distal directions;
鞘管机构200，鞘管机构200远端与钳体机构100近端连接、鞘管机构200近端与例如图11所示的操作机构400连接，鞘管机构200包括与引导件160近端相接触的鞘管210，鞘管210内部设有与伸缩件150近端相连的伸缩用驱动件211、与钳杯110近端相连的可使钳杯110开合的开合用驱动件212，伸缩用驱动件211、开合用驱动件212近端与操作机构400连接；The sheath tube mechanism 200 has a distal end connected to the proximal end of the clamp body mechanism 100, and a proximal end of the sheath tube mechanism 200 is connected to an operating mechanism 400, for example, as shown in FIG. 11 . The sheath tube mechanism 200 includes a sheath tube 210 in contact with the proximal end of the guide member 160, and the sheath tube 210 is provided with a telescopic driving member 211 connected to the proximal end of the telescopic member 150, and an opening and closing driving member 212 connected to the proximal end of the clamp cup 110 to open and close the clamp cup 110. The proximal ends of the telescopic driving member 211 and the opening and closing driving member 212 are connected to the operating mechanism 400;
在伸缩件150朝向远端侧位移时，伸缩件150远端可突出于钳杯110远端以将钳杯110撑开，并将采集部152处的组织300被止挡在钳杯110内，使组织300朝向伸缩件150近端位移至存储部153。When the telescopic member 150 moves toward the distal side, the distal end of the telescopic member 150 can protrude from the distal end of the forceps cup 110 to open the forceps cup 110, and the tissue 300 at the collection portion 152 is stopped in the forceps cup 110, so that the tissue 300 moves toward the proximal end of the telescopic member 150 to the storage portion 153.
示例性地，在初始状态下，无论钳杯110打开还是关闭，伸缩件150的远端置于钳杯110内且靠近钳杯110远端处，在钳杯110张开后伸缩件150可直接进入组织300，无需进行其他操作，操作过程简易；然后钳杯110咬取组织300，可见在初始状态下，伸缩件150远端不会干涉钳杯110的开合；在伸缩件150朝向远端侧位移时，伸缩件150远端可突出于钳杯110远端，突出于钳杯110远端的长度≤4mm。Exemplarily, in the initial state, no matter the forceps cup 110 is open or closed, the distal end of the telescopic member 150 is placed inside the forceps cup 110 and close to the distal end of the forceps cup 110. After the forceps cup 110 is opened, the telescopic member 150 can directly enter the tissue 300 without any other operations, and the operation process is simple; then the forceps cup 110 bites the tissue 300. It can be seen that in the initial state, the distal end of the telescopic member 150 will not interfere with the opening and closing of the forceps cup 110; when the telescopic member 150 is displaced toward the distal side, the distal end of the telescopic member 150 can protrude beyond the distal end of the forceps cup 110, and the length protruding from the distal end of the forceps cup 110 is ≤4 mm.
关于钳体机构100具体地说，钳座120包括管座121，管座121朝向远端侧延伸形成有两个连接柱122，钳杯110包括一对一体设置的杯体111、连接件112，两个杯体111分别通过一连接件112以分别通过销轴113铰接在两个连接柱122上，其中相连的杯体111、连接件112、连接柱122之间位于同侧；保证采集腔130、存储腔140之间的贯通无阻。其中，在远近端方向上，管座121的长度大于连接柱122的长度，保证在周向上密封的存储腔部分141相对较长，组织300不易被污染。Specifically, regarding the clamp body mechanism 100, the clamp seat 120 includes a tube seat 121, and the tube seat 121 extends toward the distal side to form two connecting columns 122. The clamp cup 110 includes a pair of cup bodies 111 and connecting pieces 112 that are integrally arranged. The two cup bodies 111 are respectively hinged on the two connecting columns 122 through a connecting piece 112 and a pin 113, wherein the connected cup bodies 111, connecting pieces 112, and connecting columns 122 are located on the same side; ensuring that the collection chamber 130 and the storage chamber 140 are unobstructed. In the distal and proximal directions, the length of the tube seat 121 is greater than the length of the connecting column 122, ensuring that the storage chamber portion 141 sealed in the circumferential direction is relatively long, and the tissue 300 is not easily contaminated.
示例性地，杯体111的杯口部分1110包括位于杯体111远端的端部刃口1111、端部刃口1111朝向近端侧延伸成位于两侧的侧部刃口1112以及位于杯体111近端的敞口1113，其中端部刃口1111、侧部刃口1112连续布置。其中敞口1113设计使采集腔130、存储腔140之间贯通无止挡；其中连续布置的端部刃口1111、侧部刃口1112锋利，在咬合后无缝隙，其形状可以为刀口状、锯齿状。Exemplarily, the cup mouth portion 1110 of the cup body 111 includes an end cutting edge 1111 located at the distal end of the cup body 111, side cutting edges 1112 extending from the end cutting edge 1111 toward the proximal side and located at both sides, and an open opening 1113 located at the proximal end of the cup body 111, wherein the end cutting edge 1111 and the side cutting edge 1112 are arranged continuously. The open opening 1113 is designed to allow the collection chamber 130 and the storage chamber 140 to pass through without a stop; wherein the continuously arranged end cutting edge 1111 and the side cutting edge 1112 are sharp, and there is no gap after biting, and their shapes may be knife-shaped or saw-tooth-shaped.
关于采集腔130、存储腔140、采集部152、存储部153具体地说，本实施例的钳杯110内部包括采集腔130(具体为钳杯110内部位于钳杯110远端处的部分空间)，在采集腔130近端与引导件160之间形成存储腔140；其中采集腔130位置对应有伸缩件150的采集部152，存储腔140位置对应有伸缩件150的存储部153。Regarding the collection chamber 130, the storage chamber 140, the collection portion 152, and the storage portion 153, specifically, the forceps cup 110 of the present embodiment includes a collection chamber 130 (specifically, a portion of the space inside the forceps cup 110 located at the distal end of the forceps cup 110), and a storage chamber 140 is formed between the proximal end of the collection chamber 130 and the guide member 160; wherein the position of the collection chamber 130 corresponds to the collection portion 152 of the telescopic member 150, and the position of the storage chamber 140 corresponds to the storage portion 153 of the telescopic member 150.
为了限制伸缩件150往复位移的行程，在伸缩件150上固定连接有位于引导件160远端侧的第一限位件154和位于引导件160近端侧的第二限位件155。In order to limit the reciprocating stroke of the telescopic member 150 , a first limiting member 154 located at the distal end of the guide member 160 and a second limiting member 155 located at the proximal end of the guide member 160 are fixedly connected to the telescopic member 150 .
示例性地，至少在位于引导件160远端侧的伸缩件150部分上设有第一限位件154。示例性地，伸缩件150上设有位于引导件160远端侧的第一限位件154，或/和，位于引导件160近端侧的第二限位件155。第一限位件154、第二限位件155可分别单向限制伸缩件150位移的行程，当第一限位件154、第二限位件155结合时可双向限制伸缩件150的行程，便于用户判断和控制取样，提高效率，取样安全；其中远端方向上的限制可避免伸缩件远端1502过于突出而损伤更内层组织，近端方向上的限制避免组织300被其他部件挤压、脱落等情况。Exemplarily, a first stopper 154 is provided on at least the portion of the telescopic member 150 located at the distal end of the guide member 160. Exemplarily, the telescopic member 150 is provided with a first stopper 154 located at the distal end of the guide member 160, or/and a second stopper 155 located at the proximal end of the guide member 160. The first stopper 154 and the second stopper 155 can limit the displacement stroke of the telescopic member 150 in one direction respectively, and when the first stopper 154 and the second stopper 155 are combined, the stroke of the telescopic member 150 can be limited in two directions, which is convenient for users to judge and control sampling, improve efficiency, and ensure sampling safety; wherein the restriction in the distal direction can prevent the telescopic member distal end 1502 from protruding too much and damaging the inner tissue, and the restriction in the proximal direction can prevent the tissue 300 from being squeezed or falling off by other components.
示例性地，伸缩件150与伸缩用驱动件211之间通过释放件1550可拆卸连接，本实施例释放件1550为连接管1551；具体地说，在位于引导件160近端侧的伸缩件150部分上设有连接管1551，本实施例中，连接管1551直接与作为用以限制伸缩件150朝向远端位移行程的第二限位件155为同一部件，即一个部件实现两个功能。将释放件1550、第二限位件155合二为一，简化结构。Exemplarily, the telescopic member 150 is detachably connected to the telescopic driving member 211 via a release member 1550. In this embodiment, the release member 1550 is a connecting tube 1551. Specifically, a connecting tube 1551 is provided on the portion of the telescopic member 150 located on the proximal side of the guide member 160. In this embodiment, the connecting tube 1551 is directly the same component as the second stopper 155 used to limit the displacement stroke of the telescopic member 150 toward the distal end, that is, one component realizes two functions. The release member 1550 and the second stopper 155 are combined into one to simplify the structure.
在一个或多个实施例中，伸缩件150、连接管1551为过盈配合可通过第一限位件154与引导件160之间反向相抵直至使连接管1551释放伸缩件150，或/和，连接管1551、伸缩用驱动件211为过盈配合可通过第一限位件154与引导件160之间反向相抵直至使伸缩件150通过连接管1551与伸缩用驱动件211的释放而释放。In one or more embodiments, the telescopic member 150 and the connecting tube 1551 are interference fit and can be pressed against each other in the opposite direction between the first limit member 154 and the guide member 160 until the connecting tube 1551 releases the telescopic member 150, or/and, the connecting tube 1551 and the telescopic driving member 211 are interference fit and can be pressed against each other in the opposite direction between the first limit member 154 and the guide member 160 until the telescopic member 150 is released by the release of the connecting tube 1551 and the telescopic driving member 211.
一种采用所述多取样活检装置1000的多取样方法，具体步骤如下：A multi-sampling method using the multi-sampling biopsy device 1000 includes the following specific steps:
S1：初始状态下，伸缩件150远端位于钳杯110内且靠近其远端处，当多取样活检装置1000位于待取组织300处时驱动钳杯110打开，使伸缩件150远端的采集部152进入组织300；S1: In the initial state, the distal end of the telescopic member 150 is located in the forceps cup 110 and close to the distal end thereof. When the multi-sampling biopsy device 1000 is located at the tissue 300 to be collected, the forceps cup 110 is driven to open, so that the collection portion 152 at the distal end of the telescopic member 150 enters the tissue 300;
S2：驱动钳杯110闭合使其取下组织300；S2: driving the forceps cup 110 to close so as to remove the tissue 300;
S3：驱动伸缩件150朝向远端侧位移，使伸缩件150远端将钳杯110撑开且将S2取下的组织300始终被止挡在钳杯110内，进而使组织300朝向伸缩件150近端位移至存储部153，空出采集部152；S3: driving the telescopic member 150 to move toward the distal side, so that the distal end of the telescopic member 150 opens the forceps cup 110 and the tissue 300 removed in S2 is always stopped in the forceps cup 110, thereby causing the tissue 300 to move toward the proximal end of the telescopic member 150 to the storage part 153, leaving the collection part 152 empty;
S4：驱动伸缩件150朝向近端侧位移使其回复至初始状态，同时组织300跟随伸缩件150朝向近端侧位移使组织300离开采集腔130而进入存储腔140；此时，完成一次组织取样；S4: driving the telescopic member 150 to move toward the proximal side to restore it to the initial state, and at the same time, the tissue 300 follows the telescopic member 150 to move toward the proximal side so that the tissue 300 leaves the collection chamber 130 and enters the storage chamber 140; at this time, one tissue sampling is completed;
S5：重复S1至S4，完成N次组织取样。S5: Repeat S1 to S4 to complete N times of tissue sampling.
N为大于或等于2的正整数。示例性地，第一次组织301位于第二次组织302的近端侧；后一步取样的组织300位于前一次取样的组织300的远端侧。N is a positive integer greater than or equal to 2. For example, the first tissue 301 is located at the proximal side of the second tissue 302; The sampled tissue 300 is located on the distal side of the tissue 300 sampled the previous time.
本申请将多次取样得到的组织300依次排串在伸缩件150上，操作简易，无需反复开合钳杯110、驱动伸缩件150等操作，有效避免误操作，提高多取样效率、准确性。The present application arranges the tissues 300 obtained by multiple samplings in sequence on the telescopic member 150, which is easy to operate and does not require repeated opening and closing of the forceps cup 110, driving of the telescopic member 150, etc., thereby effectively avoiding misoperation and improving the efficiency and accuracy of multiple sampling.
在一些实施方式中，完成S5之后，操作S6：In some implementations, after completing S5, operation S6 is performed:
S6：驱动伸缩件150朝向近端侧位移使第一限位件154与引导件160反向相抵，直至释放伸缩件150，用户将释放后伸缩件150上的N个样本组织依次取出并收集。S6: driving the telescopic member 150 to move toward the proximal side so that the first limiting member 154 and the guiding member 160 are opposed to each other in the opposite direction until the telescopic member 150 is released. The user sequentially takes out and collects the N sample tissues on the released telescopic member 150 .
多次取样得到的组织300依次排串在伸缩件150上，便于用户收集标记。The tissues 300 obtained by multiple samplings are sequentially arranged on the telescopic member 150, which is convenient for the user to collect and mark.
参考图10，本申请提供取样设备2000，取样设备2000可包括：操作机构400及多取样活检装置1000。多取样活检装置1000可以为前述实施例的多取样活检装置1000。10 , the present application provides a sampling device 2000, which may include: an operating mechanism 400 and a multi-sampling biopsy device 1000. The multi-sampling biopsy device 1000 may be the multi-sampling biopsy device 1000 of the aforementioned embodiment.
钳体机构100和伸缩件150分别受到操作机构400的驱动。示例性地，取样设备2000还包括驱动件430，多取样活检装置1000通过驱动件430而受到操作机构400的驱动。The clamp body mechanism 100 and the telescopic member 150 are respectively driven by the operating mechanism 400. Exemplarily, the sampling device 2000 further includes a driving member 430, and the multi-sampling biopsy device 1000 is driven by the operating mechanism 400 through the driving member 430.
本申请的取样设备2000能够实现单次进出中的多个样本取样。The sampling device 2000 of the present application can achieve multiple sample sampling in a single entry and exit.
参考图10，本申请提供一种操作机构400，本申请包括以下优点：实现单次进出中的多个样本取样，无需医生频繁进出，提高操作效率、缩减手术时间，并且降低患者痛苦，提高了取样准确性。10 , the present application provides an operating mechanism 400 , which has the following advantages: it can realize the sampling of multiple samples in a single entry and exit, without the need for doctors to frequently enter and exit, thereby improving operating efficiency, reducing operation time, reducing patient pain, and improving sampling accuracy.
本申请的操作机构400是一种可以分别控制远端部件101独立运动的结构，使其可以连续动作，例如进行连续取样，使其在单次进出时可以快速完成对同一病灶或同一例活检的多次取样，提高操作效率，缩减手术时间，并且降低患者痛苦。示例性地，远端部件101可以是钳杯110或伸缩件150。The operating mechanism 400 of the present application is a structure that can control the independent movement of the distal component 101, so that it can be continuously operated, such as continuous sampling, so that it can quickly complete multiple sampling of the same lesion or the same biopsy in a single entry and exit, thereby improving operation efficiency, reducing operation time, and reducing patient pain. Exemplarily, the distal component 101 can be a forceps cup 110 or a telescopic member 150.
请参阅图10，本申请提供了一种操作机构400，该操作机构400可以为操作手柄。操作机构400包括手柄本体410和多个控制件420，多个控制件420均活动连接于手柄本体410上，每个控制件420均连接有驱动件430，驱动件430用于连接远端部件101。其中，各个控制件420均能够相对手柄本体410沿第一方向做往复运动，且各个控制件420具有朝向沿第一方向其中一侧复位的运动趋势，各个控制件420能够带动对应的驱动件430同步移动进而带动远端部件101动作。其中，手柄本体410的远端和近端所在的方向为第一方向，也称远近端方向。Please refer to FIG. 10 . The present application provides an operating mechanism 400, which can be an operating handle. The operating mechanism 400 includes a handle body 410 and a plurality of control members 420, wherein the plurality of control members 420 are movably connected to the handle body 410, and each control member 420 is connected to a driving member 430, and the driving member 430 is used to connect the distal component 101. Among them, each control member 420 can reciprocate relative to the handle body 410 along a first direction, and each control member 420 has a movement tendency to reset toward one side along the first direction, and each control member 420 can drive the corresponding driving member 430 to move synchronously and then drive the distal component 101 to move. Among them, the direction where the distal end and the proximal end of the handle body 410 are located is the first direction, also called the distal-proximal direction.
可以理解的是，利用多个控制件420以及对应驱动件430的设置，以满足对远端部件101的动作控制。在这个过程中，各个控制件420可以相对手柄本体410独立的沿第一方向往复运动，且各个控制件420具有朝向沿第一方向其中一侧独立复位的运动趋势，使得每次动作后的控制件420均可以独立且自动的回复初始状态；即：各个控制件420可以独立动作且互不干涉、互不影响，进而以便各个控制件420对应的远端部件101可以互不干涉，以便各个控制件420对应的远端部件101可以持续工作。故而，当以其中一个远端部件101为取样用结构时，如取样针时，可以在单次进入病灶区域时，进行多次操作以满足多个样本的取样，也就无需医生频繁进出人体，提高了操作效率，缩减了手术时间，并降低了患者痛苦。It can be understood that the arrangement of multiple control members 420 and corresponding drive members 430 is used to control the motion of the distal member 101. In this process, each control member 420 can independently reciprocate along the first direction relative to the handle body 410, and each control member 420 has a motion tendency to independently reset toward one side along the first direction, so that the control member 420 can independently and automatically return to the initial state after each action; that is, each control member 420 can independently act without interfering with or affecting each other, so that the distal member 101 corresponding to each control member 420 can not interfere with each other, so that the distal member 101 corresponding to each control member 420 can continue to work. Therefore, when one of the distal members 101 is used as a sampling structure, such as a sampling needle, multiple operations can be performed to meet the sampling of multiple samples when entering the lesion area at a single time, so that the doctor does not need to frequently enter and exit the human body, which improves the operation efficiency, reduces the operation time, and reduces the pain of the patient.
请参阅图10和图11，示例性的，多个控制件420沿第一方向间隔布置。一方面，使得多个控制件420分布在各自相对手柄本体410的移动路径上，缩减沿其他方向的分力，更便于控制；另一方面，这样的设置，充分利用手柄本体410沿第一方向的空间，缩减沿其他方向的空间；特别是当第一方向为手柄本体410的轴向时，缩减了该操作机构400沿手柄本体410径向的空间占用。在可替换的实施例中，多个控制件420也可以沿手柄本体410的径向间隔布置。Please refer to FIG. 10 and FIG. 11 , illustratively, multiple control members 420 are arranged at intervals along the first direction. On the one hand, multiple control members 420 are distributed on their respective moving paths relative to the handle body 410, reducing the force components along other directions, making it easier to control; on the other hand, such an arrangement makes full use of the space of the handle body 410 along the first direction and reduces the space along other directions; especially when the first direction is the axial direction of the handle body 410, the space occupied by the operating mechanism 400 along the radial direction of the handle body 410 is reduced. In an alternative embodiment, multiple control members 420 can also be arranged at intervals along the radial direction of the handle body 410.
请参阅图11和图12，进一步地，由于多个控制件420沿第一方向(即移动方向，也可以为手柄本体410的轴向)，则为了降低驱动件430与控制件420之间的干涉，至少位于靠近远端的控制件420构造有第一贯穿孔，用于引导位于靠近近端的控制件420所对应的驱动件430穿设。如此，不仅确保各个控制件420对应的驱动件430沿第一方向延伸，缩减传递路径，且利用第一贯穿孔对驱动件430的移动起到导向效果。Please refer to FIG. 11 and FIG. 12. Further, since the plurality of control members 420 are along the first direction (i.e., the moving direction, which may also be the axial direction of the handle body 410), in order to reduce the interference between the driving member 430 and the control member 420, at least the control member 420 located near the distal end is configured with a first through hole for guiding the driving member 430 corresponding to the control member 420 located near the proximal end to pass through. In this way, not only is it ensured that the driving member 430 corresponding to each control member 420 extends along the first direction, reducing the transmission path, but also the first through hole is used to guide the movement of the driving member 430.
再进一步地，每个控制件420沿第一方向的横截面呈“工”字形设置，便于医生握持操作。Furthermore, the cross section of each control member 420 along the first direction is arranged in an "I" shape, which is convenient for the doctor to hold and operate.
请参阅图10和图11，在一些具体的实施例中，以控制件420的数量为两个，分别为第一控制件4201和第二控制件4202，例如第一控制件4201连接钳夹，第二控制件4202连接取样针。第一控制件4201对应开合用驱动件212，以满足钳夹的张开和闭合；第二控制件4202对应伸缩用驱动件211，以满足取样针的伸缩。Please refer to Figures 10 and 11. In some specific embodiments, the number of control members 420 is two, namely a first control member 4201 and a second control member 4202. For example, the first control member 4201 is connected to the clamp, and the second control member 4202 is connected to the sampling needle. The first control member 4201 corresponds to the opening and closing driving member 212 to meet the opening and closing of the clamp; the second control member 4202 corresponds to the telescopic driving member 211 to meet the telescopic of the sampling needle.
以手柄本体410的远端和近端所在的方向为第一方向为例。第一控制件4201位于靠近远端的位置，第二控制件4202位于靠近近端的位置，此时第一控制件4201构造有第一贯穿孔，以引导伸缩用驱动件211穿设。第一控制件4201可以朝向远端移动，以通过开合用驱动件212带动钳夹张开；且，第一控制件4201可以具有朝向近端的运动趋势，以通过开合用驱动件212带动钳夹闭合。第二控制件4202朝向远端移动，以通过伸缩用驱动件211带动取样针伸出钳夹；且，第二控制件4202具有朝向近端的运动趋势，以通过伸缩用驱动件211带动取样针后退。此处仅做举例说明。Take the direction where the distal end and the proximal end of the handle body 410 are located as the first direction as an example. The first control member 4201 is located near the distal end, and the second control member 4202 is located near the proximal end. At this time, the first control member 4201 is configured with a first through hole to guide the telescopic drive member 211 to pass through. The first control member 4201 can move toward the distal end to drive the clamp to open through the opening and closing drive member 212; and the first control member 4201 can have a movement tendency toward the proximal end to drive the clamp to close through the opening and closing drive member 212. The second control member 4202 moves toward the distal end to drive the sampling needle to extend out of the clamp through the telescopic drive member 211; and the second control member 4202 has a movement tendency toward the proximal end to drive the sampling needle to retreat through the telescopic drive member 211. This is just an example.
请继续参阅图11，进一步地，各个控制件420的远端连接有弹性件450，弹性件450用于驱动对应的控制件420朝向近端复位。其中，弹性件450连接于对应的控制件420与手柄本体410之间，控制件420向远端侧移动促使弹性件450形变，以便施加朝向近端的作用力，使得控制件420具有朝向近端侧移动复位的运动趋势；即，此时，弹性件450可以为压簧。在其他的实施例中，也可以是控制件420的近端即控制件近端26连接有弹性件450，此时，弹性件450可以为拉簧；或者，在控制件420的近端和控制件远端27均设置有弹性件450，近端的为拉簧，远端的为压簧。Please continue to refer to FIG. 11. Further, the distal end of each control member 420 is connected with an elastic member 450, and the elastic member 450 is used to drive the corresponding control member 420 to reset toward the proximal end. The elastic member 450 is connected between the corresponding control member 420 and the handle body 410. The control member 420 moves toward the distal end to cause the elastic member 450 to deform, so as to apply a force toward the proximal end, so that the control member 420 has a movement tendency to move toward the proximal end and reset; that is, at this time, the elastic member 450 can be a compression spring. In other embodiments, the proximal end of the control member 420, that is, the proximal end 26 of the control member, can also be connected with the elastic member 450. At this time, the elastic member 450 can be a tension spring; or, the proximal end and the distal end 27 of the control member 420 are both provided with elastic members 450, the proximal end is a tension spring, and the distal end is a compression spring.
在又一其他的实施例中，也可以是控制件420朝向近端移动以带动远端部件101工作，朝向远端移动而带动远端部件101复位；此时，弹性件450用于驱动对应的控制件420朝向远端复位，以满足远端部件101的复位。此处仅做举例说明，具体的设置方式需要根据实际的远端部件101结构进行相适应调整。In another embodiment, the control member 420 may move toward the proximal end to drive the distal member 101 to work, and move toward the distal end to drive the distal member 101 to reset; in this case, the elastic member 450 is used to drive the corresponding control member 420 to reset toward the distal end to meet the reset of the distal member 101. This is only an example, and the specific setting method needs to be adjusted according to the actual structure of the distal member 101.
需要说明的是，上述的靠近近端、靠近远端均是以多个控制件420之间的相对位置而言。比如，如图10所示，第二控制件4202相较于第一控制件4201更靠近近端，第一控制件4201相较于第二控制件4202更靠近远端，则第一控制件4201构造有第一贯穿孔，以穿设伸缩用驱动件211。It should be noted that the aforementioned near the proximal end and near the distal end are both relative positions between the multiple control members 420. For example, as shown in FIG10 , the second control member 4202 is closer to the proximal end than the first control member 4201, and the first control member 4201 is closer to the distal end than the second control member 4202, and the first control member 4201 is configured with a first through hole for the telescopic drive member 211 to penetrate.
在另一些实施例中，当控制件为三个时，分为第一控制件、第二控制件和第三控制件。其中：第二控制件和第三控制件相较第一控制件更靠近远端，第三控制件相较于第二控制件更靠近远端；反之，第二控制件和第一控制件相较第三控制件更靠近近端，且第一控制件相较第二控制件更靠近近端。此时，第二控制件和第三控制件上均设置有第一贯穿孔，第二控制件上的第一贯穿孔用于穿设第一控制件对应的驱动件，第三控制件上的第一贯穿孔用于穿设第一控制件和第二控制件对应的驱动件。In other embodiments, when there are three control members, they are divided into a first control member, a second control member, and a third control member. Among them: the second control member and the third control member are closer to the distal end than the first control member, and the third control member is closer to the distal end than the second control member; conversely, the second control member and the first control member are closer to the proximal end than the third control member, and the first control member is closer to the proximal end than the second control member. At this time, the second control member and the third control member are both provided with a first through hole, and the first through hole on the second control member is used to penetrate the driving member corresponding to the first control member, and the first through hole on the third control member is used to penetrate the driving member corresponding to the first control member and the second control member.
还需要说明的是，由于钳夹和取样针进入人体时，需要考虑对患者的病灶区影响，若是钳夹张开进入，则会导致创口受损，导致患者不适；且，取样针相对钳夹伸出过多，则可能导致钳夹相对病灶区域位置靠后，不便取样。故而在实际使用时以钳夹闭合，且取样针相对钳夹位于靠后的位置，可以作为初始位置。It should also be noted that when the clamp and the sampling needle enter the human body, the impact on the patient's lesion area needs to be considered. If the clamp is opened, the wound will be damaged, causing discomfort to the patient. In addition, if the sampling needle extends too much relative to the clamp, the clamp may be positioned backward relative to the lesion area, making it inconvenient to take samples. Therefore, in actual use, the clamp is closed and the sampling needle is positioned backward relative to the clamp, which can be used as the initial position.
请继续参阅图11，在可选的实施例中，手柄本体410上设置有至少一个限位座440，各个控制件420至少对应一个限位座440，且各个限位座440和各个控制件420均沿第一方向间隔布置。也就是说，一个控制件420对应一个限位座440，以便于对控制件420的移动进行限位，避免远端部件101运动过多；且，正是由于限位座440的限位作用，可以避免各个控制件420之间的移动干涉。其中，各个控制件420和各个限位座440交错布置，且各个限位座440相对各自对应控制件420位于靠近远端的一侧；如此，在满足各个控制件420朝向远端移动限位的同时，避免任意相邻两个控制件420之间的移动干涉而影响各自对应的远端部件101操作，确保各个远端部件101独立操作。Please continue to refer to FIG. 11. In an optional embodiment, at least one limiting seat 440 is provided on the handle body 410, each control member 420 corresponds to at least one limiting seat 440, and each limiting seat 440 and each control member 420 are arranged at intervals along the first direction. In other words, one control member 420 corresponds to one limiting seat 440, so as to limit the movement of the control member 420 and avoid excessive movement of the distal member 101; and, it is precisely because of the limiting effect of the limiting seat 440 that the movement interference between each control member 420 can be avoided. Among them, each control member 420 and each limiting seat 440 are arranged alternately, and each limiting seat 440 is located on the side close to the distal end relative to the corresponding control member 420; in this way, while satisfying the movement limit of each control member 420 toward the distal end, the movement interference between any two adjacent control members 420 is avoided to affect the operation of the corresponding distal member 101, ensuring that each distal member 101 operates independently.
在一些具体的实施例中，第一控制件4201对应第一限位座441，第一限位座441位于第一控制件4201的远端，第二控制件4202对应第二限位座442，第二限位座442位于第二控制件4202的远端，以对第一控制件4201和第二控制件4202朝向远端的运动进行限位。如此，即可尽可能避免对应的钳夹张开角度过大而影响病灶区域，导致患者不适，同时尽可能避免取样针移动过多而此处病灶区域以外的位置；且，可以防止第一控制件4201和第二控制件4202移动干涉而影响钳夹和取样针操作。In some specific embodiments, the first control member 4201 corresponds to the first limit seat 441, which is located at the distal end of the first control member 4201, and the second control member 4202 corresponds to the second limit seat 442, which is located at the distal end of the second control member 4202, so as to limit the movement of the first control member 4201 and the second control member 4202 toward the distal end. In this way, it is possible to avoid the corresponding clamp opening angle being too large to affect the lesion area and cause discomfort to the patient, and at the same time, it is possible to avoid the sampling needle moving too much and being outside the lesion area; and it is possible to prevent the first control member 4201 and the second control member 4202 from interfering with each other and affecting the operation of the clamp and the sampling needle.
请参阅图11、图13和图14，进一步地，由于各个限位座440相较对应的控制件420均位于靠近远端的位置，故而每个限位座440上均构造有第二贯穿孔4401，以通过第二贯穿孔4401引导对应的驱动件430穿设，以避免干涉。并且，这样的设置，还可以对各个驱动件430的移动起到移动导向。在可替换的实施例中，正是由于各个控制件420均相对手柄本体410具有沿第一方向的往复运动，限位座440也可以位于对应控制件420靠近近端的位置，或者各个控制件420的近端和远端处均设置有限位座440。此时，以位于近端的第一个控制件420为基准，位于该控制件420远端一侧的所有限位座440均需要设置第二贯穿孔4401，且剩余的控制件420均需要设置第一贯穿孔，以引导靠近近端控制件420所对应的驱动件430穿设。Please refer to Figures 11, 13 and 14. Furthermore, since each limit seat 440 is located near the distal end compared to the corresponding control member 420, a second through hole 4401 is constructed on each limit seat 440 to guide the corresponding driving member 430 to pass through the second through hole 4401 to avoid interference. Moreover, such a setting can also guide the movement of each driving member 430. In a replaceable embodiment, precisely because each control member 420 has a reciprocating motion along the first direction relative to the handle body 410, the limit seat 440 can also be located at a position close to the proximal end of the corresponding control member 420, or a limit seat 440 is provided at the proximal and distal ends of each control member 420. At this time, taking the first control member 420 located at the proximal end as a reference, all limit seats 440 located on the distal side of the control member 420 need to be provided. The second through hole 4401 is provided, and the remaining control members 420 all need to be provided with a first through hole to guide the driving member 430 corresponding to the proximal control member 420 to pass through.
请结合图13和图14，在实际使用时，当需要控制件420朝向近端复位时，则安装于控制件420的远端的限位座440可以作为安装弹性件450的基座；即，弹性件450的轴向与第一方向相同，弹性件450的两端分别连接于对应的控制件420和限位座440。此时，各个限位座440朝向对应控制件420的一端面构造有定位槽4402，对应的弹性件450的一端部可以深入定位槽4402内，以对弹性件450的装配起到定位作用。在可替换的实施例中，也可以是在各个限位座440朝向对应控制件420的一端面构造有定位柱4403，对应的弹性件450套设于定位柱4403；或者，可以是定位槽4402与定位柱4403的组合，此时定位柱4403位于定位槽4402内，弹性件450套设于定位柱4403的外侧并部分位于定位槽4402内。Please refer to Figures 13 and 14. In actual use, when the control member 420 needs to be reset toward the proximal end, the stopper 440 installed at the distal end of the control member 420 can be used as a base for installing the elastic member 450; that is, the axial direction of the elastic member 450 is the same as the first direction, and the two ends of the elastic member 450 are respectively connected to the corresponding control member 420 and the stopper 440. At this time, each stopper 440 is configured with a positioning groove 4402 on one end surface facing the corresponding control member 420, and one end of the corresponding elastic member 450 can be deeply inserted into the positioning groove 4402 to play a positioning role in the assembly of the elastic member 450. In a replaceable embodiment, a positioning column 4403 may be constructed on one end face of each limit seat 440 facing the corresponding control member 420, and the corresponding elastic member 450 may be sleeved on the positioning column 4403; or, it may be a combination of the positioning groove 4402 and the positioning column 4403, in which case the positioning column 4403 is located in the positioning groove 4402, and the elastic member 450 is sleeved on the outer side of the positioning column 4403 and partially located in the positioning groove 4402.
其中，第一控制件4201对应第一弹性件451，第一弹性件451连接于第一控制件4201与第一限位座441之间；第二控制件4202对应第二弹性件452，第二弹性件452连接于第二控制件4202与第二限位座442之间。此时，第一限位座441上用于定位装配第一弹性件451的结构，与第二限位座442上用于定位装配第二弹性件452的结构，可以相同，也可以不同，其只要满足对应弹性件450的定位装配即可。The first control member 4201 corresponds to the first elastic member 451, and the first elastic member 451 is connected between the first control member 4201 and the first limiting seat 441; the second control member 4202 corresponds to the second elastic member 452, and the second elastic member 452 is connected between the second control member 4202 and the second limiting seat 442. At this time, the structure on the first limiting seat 441 for positioning and assembling the first elastic member 451 and the structure on the second limiting seat 442 for positioning and assembling the second elastic member 452 can be the same or different, as long as they meet the positioning and assembly of the corresponding elastic member 450.
请继续参阅图10和图11，在可选的实施例中，在手柄本体410上于至少一个控制件420朝向近端的一侧构造有释放空间4103，为远端部件101相对对应驱动件430的释放提供用于控制件420移动的空间。在实际使用时，以图11为例，第二控制件4202通过伸缩用驱动件211连接到取样针，取样针需要相对伸缩用驱动件211释放，便于收集取样针上的样本。此时，就需要第二控制件4202带动伸缩用驱动件211朝向近端移动以释放取样针，因此手柄本体410上位于第二控制件4202近端的部分区域即可作为释放空间4103。其中，具体的释放方式后续内容中会详细提出。Please continue to refer to Figures 10 and 11. In an optional embodiment, a release space 4103 is constructed on the handle body 410 on the side of at least one control member 420 toward the proximal end, providing space for the control member 420 to move when the distal component 101 is released relative to the corresponding drive member 430. In actual use, taking Figure 11 as an example, the second control member 4202 is connected to the sampling needle through the telescopic drive member 211, and the sampling needle needs to be released relative to the telescopic drive member 211 to facilitate the collection of samples on the sampling needle. At this time, the second control member 4202 is required to drive the telescopic drive member 211 to move toward the proximal end to release the sampling needle, so the partial area on the handle body 410 located at the proximal end of the second control member 4202 can be used as the release space 4103. Among them, the specific release method will be detailed in the subsequent content.
如图11和图12所示，示例性的，每个控制件420构造有连接孔421，各个驱动件430的近端部分即驱动件近端21可以直接与连接孔421的孔壁连接，以满足控制件420对驱动件430的带动。直接连接的方式，简化了装配步骤，提高装配效率。在其他的实施例中，各个驱动件430的近端部分可以间接的与连接孔421的孔壁连接，即可以通过一过渡部件将驱动件430与对应的控制件420连接成整体结构，实现控制件420对驱动件430的带动。这样的设置，当控制件420和驱动件430其中一者出现损坏时，可以通过拆卸过渡部件的方式，进行维修，提高保护性。As shown in Figures 11 and 12, illustratively, each control member 420 is configured with a connecting hole 421, and the proximal portion of each driving member 430, that is, the proximal end 21 of the driving member, can be directly connected to the hole wall of the connecting hole 421 to meet the driving of the driving member 430 by the control member 420. The direct connection method simplifies the assembly steps and improves the assembly efficiency. In other embodiments, the proximal portion of each driving member 430 can be indirectly connected to the hole wall of the connecting hole 421, that is, the driving member 430 can be connected to the corresponding control member 420 into an integral structure through a transition component to realize the driving of the driving member 430 by the control member 420. With such a setting, when one of the control member 420 and the driving member 430 is damaged, it can be repaired by disassembling the transition component to improve the protection.
在可选的实施例中，各个驱动件430的近端部分连接有杆状连接部4311，各个驱动件430的近端部分通过杆状连接部4311插接与对应的控制件420的连接孔421；即：驱动件430与对应控制件420间接连接。此外，利用杆状连接部4311的设置，因其具有一定的结构硬度，可以对驱动件430的移动起到导向效果。具体的，杆状连接部4311可以是空心结构，一端插设于连接孔421内，另一端与驱动件430连接。In an optional embodiment, the proximal portion of each driving member 430 is connected with a rod-shaped connecting portion 4311, and the proximal portion of each driving member 430 is plugged into the connecting hole 421 of the corresponding control member 420 through the rod-shaped connecting portion 4311; that is, the driving member 430 is indirectly connected to the corresponding control member 420. In addition, the rod-shaped connecting portion 4311 has a certain structural hardness, which can guide the movement of the driving member 430. Specifically, the rod-shaped connecting portion 4311 can be a hollow structure, one end of which is inserted into the connecting hole 421, and the other end is connected to the driving member 430.
请参阅图11和图12，进一步地，连接孔421构造有沿第二方向延伸的弯折段422，杆状连接部4311构造有钩回段4312，钩回段4312插设于弯折段422内。其中，第二方向与第一方向成角度；或者说弯折段422的延伸方向与远近端方向成角度设置或不平行设置。此时，第二方向可以为手柄本体410的径向，即连接孔421呈“T”字形或者“L”字形设置。因此，这样的设置，相当于对杆状连接部4311与连接孔421的连接进行轴向限位，避免二者在移动过程中沿轴向脱离。其中，弯折段422可以是以圆心位于连接孔421轴线的圆弧槽，也可以是圆孔。在可替换的实施例中，杆状连接部4311的端部塞设于连接孔421，依靠杆状连接部4311的外壁与连接孔421的孔壁之间的摩擦力定位；当然，二者均可以设置互相配合的粗糙纹路，提高连接可靠性。Please refer to Figures 11 and 12. Further, the connecting hole 421 is configured with a bending section 422 extending along the second direction, and the rod-shaped connecting portion 4311 is configured with a hook section 4312, and the hook section 4312 is inserted into the bending section 422. Among them, the second direction is at an angle to the first direction; or the extending direction of the bending section 422 is set at an angle or is not parallel to the distal and proximal directions. At this time, the second direction can be the radial direction of the handle body 410, that is, the connecting hole 421 is set in a "T" shape or an "L" shape. Therefore, such a setting is equivalent to axially limiting the connection between the rod-shaped connecting portion 4311 and the connecting hole 421 to prevent the two from axially disengaging during movement. Among them, the bending section 422 can be a circular arc groove with the center of the circle located on the axis of the connecting hole 421, or it can be a circular hole. In an alternative embodiment, the end of the rod-shaped connecting portion 4311 is plugged into the connecting hole 421 and positioned by the friction between the outer wall of the rod-shaped connecting portion 4311 and the hole wall of the connecting hole 421; of course, both can be provided with cooperating rough textures to improve the connection reliability.
再进一步地，各个弹性件450可以套设于对应的杆状连接部4311外侧。Furthermore, each elastic member 450 can be sleeved on the outer side of the corresponding rod-shaped connecting portion 4311 .
在实际使用时，以第一控制件4201为例，由于第一控制件4201位于第二控制件4202的远端，此时位于第一控制件4201的连接孔421也可以设置为沿第一方向贯穿的通孔，则连接于第二控制件4202的伸缩用驱动件211可以穿过连接孔421与远端部件101连接。当然，也可以是第一控制件4201设置有第一贯穿孔和连接孔421，二者间隔布置。或者，就第一控制件4201而言，对应的第一贯穿孔和连接孔421连通，即该第一控制件4201构造有一沿第一方向贯穿的通孔，该通孔既用于与对应的杆状连接部4311连接，又用于伸缩用驱动件211的穿设。此时，对应的弯折段422位于该通孔的中部且靠近第一控制件4201近端的位置，如此形成“十”字形。In actual use, taking the first control member 4201 as an example, since the first control member 4201 is located at the distal end of the second control member 4202, the connection hole 421 located at the first control member 4201 can also be set as a through hole that penetrates along the first direction, so that the telescopic driving member 211 connected to the second control member 4202 can pass through the connection hole 421 to connect with the distal component 101. Of course, the first control member 4201 can also be provided with a first through hole and a connection hole 421, and the two are arranged at intervals. Alternatively, with respect to the first control member 4201, the corresponding first through hole and the connection hole 421 are connected, that is, the first control member 4201 is configured with a through hole that penetrates along the first direction, and the through hole is used to connect with the corresponding rod-shaped connection. The connecting portion 4311 is connected and used for the insertion of the telescopic driving member 211. At this time, the corresponding bending section 422 is located in the middle of the through hole and close to the proximal end of the first control member 4201, thus forming a "cross" shape.
请继续参阅图13和图14，示例性的，当驱动件430以杆状连接部4311与对应控制件420连接时，就限位座440而言，杆状连接部4311远离控制件420的一端即杆状连接部远端23穿设于对应的限位座440。由于限位座440构造有用于引导驱动件430穿设的第二贯穿孔4401，此时，杆状连接部4311可以穿设于第二贯穿孔4401。如此，杆状连接部4311的两端分别通过连接孔421的孔壁以及第二贯穿孔4401的孔壁约束，不仅对杆状连接部4311随控制件420的移动起到导向作用，并能够对杆状连接部4311的装配进行限位，尽可能避免杆状连接部4311晃动或偏移，提高操作准确性。Please continue to refer to FIG. 13 and FIG. 14. For example, when the driving member 430 is connected to the corresponding control member 420 by the rod-shaped connecting portion 4311, as far as the limiting seat 440 is concerned, the end of the rod-shaped connecting portion 4311 away from the control member 420, i.e., the distal end 23 of the rod-shaped connecting portion, is penetrated in the corresponding limiting seat 440. Since the limiting seat 440 is configured with a second through hole 4401 for guiding the driving member 430 to penetrate, at this time, the rod-shaped connecting portion 4311 can be penetrated in the second through hole 4401. In this way, the two ends of the rod-shaped connecting portion 4311 are respectively constrained by the hole wall of the connecting hole 421 and the hole wall of the second through hole 4401, which not only guides the movement of the rod-shaped connecting portion 4311 with the control member 420, but also limits the assembly of the rod-shaped connecting portion 4311, and avoids the shaking or displacement of the rod-shaped connecting portion 4311 as much as possible, thereby improving the operation accuracy.
请结合图10和图11，作为其中一些实施例中，手柄本体410包括握持杆体411，握持杆体411构造有装配腔4101和连通于装配腔4101的导向开槽4102，导向开槽4102贯通至手柄本体410的外周面20，驱动件430安装于装配腔4101内，各个控制件420的部分穿过导向开槽4102伸入装配腔4101内以与对应的驱动件430连接，各个控制件420活动连接于握持杆体411。Please refer to Figures 10 and 11. As some of the embodiments, the handle body 410 includes a gripping rod body 411, and the gripping rod body 411 is constructed with an assembly cavity 4101 and a guide groove 4102 connected to the assembly cavity 4101. The guide groove 4102 passes through the outer peripheral surface 20 of the handle body 410, and the driving member 430 is installed in the assembly cavity 4101. Parts of each control member 420 pass through the guide groove 4102 and extend into the assembly cavity 4101 to connect with the corresponding driving member 430, and each control member 420 is movably connected to the gripping rod body 411.
当控制件420在外力作用下相对手柄本体410移动时，控制件420位于导向开槽4102内的部分可以在导向开槽4102内移动，以对控制件420的移动起到导向效果。同时，装配腔4101的布置可以对驱动件430起到防护效果，避免驱动件430受损而影响远端部件101。就握持杆体411而言，上述的限位座440可以安装于装配腔4101内，限位座440的部分也可以从导向开槽4102伸出；且，杆状连接部4311位于装配腔4101内，实现与控制件420及驱动件430的连接。When the control member 420 moves relative to the handle body 410 under the action of external force, the portion of the control member 420 located in the guide slot 4102 can move in the guide slot 4102 to guide the movement of the control member 420. At the same time, the arrangement of the assembly cavity 4101 can protect the driving member 430, preventing the driving member 430 from being damaged and affecting the distal component 101. As for the gripping rod body 411, the above-mentioned limit seat 440 can be installed in the assembly cavity 4101, and part of the limit seat 440 can also extend from the guide slot 4102; and the rod-shaped connecting portion 4311 is located in the assembly cavity 4101 to achieve connection with the control member 420 and the driving member 430.
如图10、图11、图13和图15，进一步地，手柄本体410还包括连接于握持杆体411远端的连接套412，连接套412构造有与装配腔4101连通的连接腔4121。各个驱动件430能够从装配腔4101、连接腔4121伸出以便于连接远端部件101。连接套412的设置，不仅便于该手柄本体410与其他结构配合，且相当于延长了手柄本体410的长度，更便于驱动件430与控制件420的配合，甚至可以设置更多组。此外，在连接套412朝向握持杆体411的一端可以设置成限位座440，以便于进行弹性件450的装配，或者便于对远端的控制件420移动限位。例如，此处的限位座440可以作为与第一控制件4201相适配的第一限位座441。As shown in Figures 10, 11, 13 and 15, further, the handle body 410 also includes a connecting sleeve 412 connected to the distal end of the gripping rod body 411, and the connecting sleeve 412 is configured with a connecting cavity 4121 that is connected to the assembly cavity 4101. Each driving member 430 can extend from the assembly cavity 4101 and the connecting cavity 4121 to facilitate the connection of the distal component 101. The setting of the connecting sleeve 412 is not only convenient for the handle body 410 to cooperate with other structures, but also equivalent to extending the length of the handle body 410, and is more convenient for the cooperation of the driving member 430 and the control member 420, and even more groups can be set. In addition, a limit seat 440 can be set at one end of the connecting sleeve 412 facing the gripping rod body 411, so as to facilitate the assembly of the elastic member 450, or to facilitate the movement and limit of the distal control member 420. For example, the limit seat 440 here can be used as a first limit seat 441 adapted to the first control member 4201.
在实际使用时，手柄本体410还包括握持环413，用于用户手握，便于对各个控制件420施加作用力。In actual use, the handle body 410 also includes a grip ring 413 for the user to hold in order to facilitate application of force to each control member 420 .
请参阅图13，在可选的实施例中，握持杆体411的远端即握持杆体远端24设置有夹持部，连接套412套设于夹持部的外周。可以理解的是，利用夹持部的设置以便于与该手柄本体410与其他结构相适配，便于组装、拆卸。其中，夹持部包括多个绕握持杆体411轴线间隔布置的夹持片，任意相邻的两个夹持片之间构造有缺口，以便于各个夹持片形变而与其他结构配合。具体的，在夹持部的内部固定有固定管，以通过固定管与其他结构相适配，驱动件430穿过固定管以与远端部件101连接。Please refer to Figure 13. In an optional embodiment, the distal end of the gripping rod body 411, i.e., the distal end 24 of the gripping rod body, is provided with a clamping portion, and the connecting sleeve 412 is sleeved on the outer periphery of the clamping portion. It can be understood that the provision of the clamping portion is used to facilitate the adaptation with the handle body 410 and other structures, so as to facilitate assembly and disassembly. Among them, the clamping portion includes a plurality of clamping plates arranged at intervals around the axis of the gripping rod body 411, and a notch is constructed between any two adjacent clamping plates to facilitate the deformation of each clamping plate and to cooperate with other structures. Specifically, a fixing tube is fixed inside the clamping portion to adapt to other structures through the fixing tube, and the driving member 430 passes through the fixing tube to be connected with the distal component 101.
在一些实施例中，该固定管在满足与其他结构连接的同时，还可以用于对远端控制件420(例如第一控制件4201)的远端运动进行限位，此时，固定管便可以作为限位座440，满足连接与限位的双重效果，简化该操作机构400的内部结构。例如，可以在固定管与第一控制件4201之间连接弹性件450(即第一弹性件451)，以确保第一控制件4201正常复位，此时，固定管作为第一限位座441。为了满足第一弹性件451的稳定装配，固定管的近端凸设定位柱4403，第一弹性件451的端部部分套设于定位柱4403的外侧。In some embodiments, the fixing tube can be used to limit the distal movement of the distal control member 420 (e.g., the first control member 4201) while satisfying the connection with other structures. In this case, the fixing tube can be used as a limiting seat 440 to satisfy the dual effects of connection and limiting, thereby simplifying the internal structure of the operating mechanism 400. For example, an elastic member 450 (i.e., a first elastic member 451) can be connected between the fixing tube and the first control member 4201 to ensure that the first control member 4201 is normally reset. In this case, the fixing tube serves as the first limiting seat 441. In order to ensure the stable assembly of the first elastic member 451, a positioning column 4403 is protruded from the proximal end of the fixing tube, and the end portion of the first elastic member 451 is sleeved on the outer side of the positioning column 4403.
请结合图10、图11和图15，示例性的，操作机构400的远端即操作机构远端28连接有鞘管210，各个驱动件430穿设于鞘管210内。也就是说，以利用鞘管210的设置，可以对各个驱动件430的径向进行限位，使得每个驱动件430尽可能的只能沿轴向移动以作用于对应的远端部件101。10, 11 and 15, illustratively, the distal end of the operating mechanism 400, i.e., the distal end 28 of the operating mechanism, is connected to the sheath 210, and each driving member 430 is disposed in the sheath 210. In other words, by utilizing the arrangement of the sheath 210, the radial direction of each driving member 430 can be limited, so that each driving member 430 can only move in the axial direction as much as possible to act on the corresponding distal component 101.
请结合图11和图16，在实际使用时，各个驱动件430包括一个牵引绳431，此时每个牵引绳431的一端连接于对应的控制件420，另一端连接于对应的远端部件101，且远端部件101只有一个操作头，例如取样针，只需要驱动取样针沿自身轴向伸出或缩回。当部分驱动件430包括多个牵引绳431时，多个牵引绳431的近端即牵引绳近端25分别连接于一控制件420，或者在多个牵引绳431的近端通过一结合件432连接有一主绳433，主绳433的近端连接于一控制件420。这样的设置，不仅简化结构，并降低各个驱动件430之间的移动干涉。Please refer to Figures 11 and 16. In actual use, each driving member 430 includes a traction rope 431. At this time, one end of each traction rope 431 is connected to the corresponding control member 420, and the other end is connected to the corresponding distal part 101. The distal part 101 has only one operating head, such as a sampling needle, which only needs to drive the sampling needle to extend or retract along its own axis. When some driving members 430 include multiple traction ropes 431, the proximal ends of the multiple traction ropes 431, that is, the proximal ends 25 of the traction ropes are respectively connected to a control member 420, or a main rope 433 is connected to the proximal ends of the multiple traction ropes 431 through a coupling member 432, and the proximal end of the main rope 433 is connected to a control member 420. Such a setting not only simplifies the structure, but also reduces the movement interference between the various driving members 430.
如图15所示，例如，部分驱动件430包括两个牵引绳431，此时每个牵引绳431的一端可以汇聚于一个杆状连接部4311，连接对应的一个控制件420，每个牵引绳431的另一端可以分别连接于远端部件101的两个操作头，例如钳夹包括两个钳杯110，每个牵引绳431分别连接一个钳杯110，以满足钳夹的张开和闭合。如图8所示，在可替换的实施例中，两个牵引绳431可以通过结合件432汇聚至一根主绳433，通过主绳433连接对应的一个控制件420。As shown in FIG15 , for example, a partial driving member 430 includes two traction ropes 431, at which one end of each traction rope 431 can converge to a rod-shaped connecting portion 4311, connected to a corresponding control member 420, and the other end of each traction rope 431 can be respectively connected to two operating heads of the distal component 101, for example, the clamp includes two clamp cups 110, and each traction rope 431 is respectively connected to a clamp cup 110 to meet the opening and closing of the clamp. As shown in FIG8 , in an alternative embodiment, the two traction ropes 431 can converge to a main rope 433 through a coupling member 432, and the main rope 433 is connected to a corresponding control member 420.
如图15所示，在可选的实施例中，鞘管210包括弹簧管213，弹簧管213的近端即弹簧管近端22通过一支撑管214连接于手柄本体410。可以理解的是，利用弹簧管213自身的柔软性，可以深入人体，便于取样操作；且，弹簧管213可以对驱动件430的径向起到限位作用，以防止驱动件430移动过程中出现径向歪斜，保证各个驱动件430的移动准确性。其中，支撑管214套设于弹簧管213的外侧，并位于弹簧管213的近端，当弹簧管213的近端伸入固定管进行装配时，支撑管214伸入连接套412的连接腔4121，并与连接套412配合。在实际装配时，弹簧管213的一端经连接套412的连接腔4121伸入装配腔4101内，并穿设于固定管内，实现鞘管210与手柄本体410的连接。As shown in FIG. 15 , in an optional embodiment, the sheath tube 210 includes a spring tube 213, and the proximal end of the spring tube 213, i.e., the proximal end 22 of the spring tube, is connected to the handle body 410 through a support tube 214. It can be understood that the spring tube 213 can be inserted into the human body by utilizing its own softness, which is convenient for sampling operation; and the spring tube 213 can limit the radial direction of the driving member 430 to prevent radial deflection during the movement of the driving member 430, thereby ensuring the movement accuracy of each driving member 430. Among them, the support tube 214 is sleeved on the outside of the spring tube 213 and is located at the proximal end of the spring tube 213. When the proximal end of the spring tube 213 is inserted into the fixed tube for assembly, the support tube 214 is inserted into the connecting cavity 4121 of the connecting sleeve 412 and cooperates with the connecting sleeve 412. During actual assembly, one end of the spring tube 213 extends into the assembly cavity 4101 through the connecting cavity 4121 of the connecting sleeve 412 and is inserted into the fixing tube to achieve the connection between the sheath tube 210 and the handle body 410 .
进一步地，鞘管210还包括润滑管215，润滑管215和弹簧管213由内至外依次套设，即润滑管215位于弹簧管213的内侧，弹簧管213位于润滑管215的外侧。各个驱动件430穿设于润滑管215内。利用润滑管215的设置，以确保各个驱动件430沿轴向移动顺畅，降低移动堵塞的问题。Furthermore, the sheath tube 210 further includes a lubrication tube 215, and the lubrication tube 215 and the spring tube 213 are sequentially sleeved from the inside to the outside, that is, the lubrication tube 215 is located on the inside of the spring tube 213, and the spring tube 213 is located on the outside of the lubrication tube 215. Each driving member 430 is inserted into the lubrication tube 215. The lubrication tube 215 is provided to ensure that each driving member 430 moves smoothly along the axial direction, reducing the problem of movement blockage.
示例性地，本申请提供一种取样设备2000，该取样设备2000包括远端部件101和用于控制远端部件101的操作机构400。该取样设备2000操作简单，能够利用操作机构400在一次插入中多次控制远端部件101。Illustratively, the present application provides a sampling device 2000, which includes a distal component 101 and an operating mechanism 400 for controlling the distal component 101. The sampling device 2000 is easy to operate, and the operating mechanism 400 can be used to control the distal component 101 multiple times in one insertion.
请参阅图1至图19所示，本申请一实施例还提供了一种取样设备2000，包括上述的操作机构400、远端部件101以及连接于操作机构400与远端部件101的驱动件430。其中，远端部件101包括钳体机构100、伸缩件150和引导件160。具体的，钳体机构100包括钳座120和活动连接于钳座120的钳杯110，钳体机构100内部形成有相邻且贯通设置的采集腔和存储腔，采集腔位于存储腔的远端；伸缩件150配置在钳体机构100内部，伸缩件150设置有采集部和存储部，采集部位于存储部的远端，伸缩件150能够在采集腔和存储腔内往复移动，以使采集部采集组织且存储部存储组织。引导件160配置在伸缩件150的外周，用于导引伸缩件150在远端和近端方向上相对钳体机构100的往复移动。Referring to FIGS. 1 to 19 , an embodiment of the present application further provides a sampling device 2000, comprising the above-mentioned operating mechanism 400, a distal component 101, and a driving member 430 connected to the operating mechanism 400 and the distal component 101. The distal component 101 comprises a clamp body mechanism 100, a telescopic member 150, and a guide member 160. Specifically, the clamp body mechanism 100 comprises a clamp seat 120 and a clamp cup 110 movably connected to the clamp seat 120, and the clamp body mechanism 100 is formed with a collection cavity and a storage cavity which are adjacent and through-set, and the collection cavity is located at the distal end of the storage cavity; the telescopic member 150 is disposed inside the clamp body mechanism 100, and the telescopic member 150 is provided with a collection part and a storage part, and the collection part is located at the distal end of the storage part, and the telescopic member 150 can reciprocate in the collection cavity and the storage cavity, so that the collection part collects tissue and the storage part stores tissue. The guide member 160 is disposed on the outer periphery of the telescopic member 150 to guide the reciprocating movement of the telescopic member 150 relative to the clamp mechanism 100 in the distal and proximal directions.
示例性地，钳杯110通过钳杯牵引件与对应的钳杯控制件连接，伸缩件150通过伸缩牵引件与对应的伸缩控制件连接。伸缩件150被配置为响应于伸缩控制件的移动而移动，钳杯110被配置为响应于钳杯控制件的移动而开合。同时，伸缩件150能够朝向远端移动以将钳杯110撑开，伸缩件150上的样本组织能够在钳杯110的止挡作用下被移动至伸缩件150的存储部。需要补充的是，为满足描述的统一性，上述中的钳杯牵引件即为开合用驱动件212，钳杯控制件即为即为第一控制件4201，伸缩牵引件即为伸缩用驱动件211，伸缩控制件即为第二控制件4202。此外，上述中的开合，即为打开和闭合。Exemplarily, the forceps cup 110 is connected to the corresponding forceps cup control member through the forceps cup traction member, and the telescopic member 150 is connected to the corresponding telescopic control member through the telescopic traction member. The telescopic member 150 is configured to move in response to the movement of the telescopic control member, and the forceps cup 110 is configured to open and close in response to the movement of the forceps cup control member. At the same time, the telescopic member 150 can move toward the distal end to open the forceps cup 110, and the sample tissue on the telescopic member 150 can be moved to the storage part of the telescopic member 150 under the stopper action of the forceps cup 110. It should be added that, in order to meet the unity of the description, the forceps cup traction member mentioned above is the opening and closing drive member 212, the forceps cup control member is the first control member 4201, the telescopic traction member is the telescopic drive member 211, and the telescopic control member is the second control member 4202. In addition, the opening and closing mentioned above refers to opening and closing.
在实际使用时，在伸缩件150朝向远端移动时，伸缩件150的远端可突出于钳杯110远端，以将钳杯110撑开，伸缩件150上采集部处采集的组织会被止挡在钳杯110内；且，随着伸缩件150继续朝向远端移动，伸缩件150上的组织会在钳杯110的止挡作用下朝向伸缩件150的近端移动至钳体机构100的存储部，进行存储。如此，可以通过伸缩件150的多次移动以及钳杯110的多次张合，实现多个样本组织的取样，且每次取样的样本组织均存储在伸缩件150的存储部和钳体机构100的存储腔内。In actual use, when the telescopic member 150 moves toward the distal end, the distal end of the telescopic member 150 can protrude from the distal end of the forceps cup 110 to open the forceps cup 110, and the tissue collected at the collection portion of the telescopic member 150 will be stopped in the forceps cup 110; and, as the telescopic member 150 continues to move toward the distal end, the tissue on the telescopic member 150 will move toward the proximal end of the telescopic member 150 to the storage portion of the forceps body mechanism 100 under the stopping action of the forceps cup 110 for storage. In this way, the sampling of multiple sample tissues can be achieved through multiple movements of the telescopic member 150 and multiple openings and closings of the forceps cup 110, and the sample tissues sampled each time are stored in the storage portion of the telescopic member 150 and the storage cavity of the forceps body mechanism 100.
如图16至图18及图2所示，示例性的，钳体机构100包括至少两个钳杯110，至少两个钳杯110铰接于钳座120，且各个钳杯110均构造有杯口部分1110。杯口部分1110的远端构造有引导槽1118，引导槽1118贯通至钳杯110外表面或位于钳杯110远端内表面。由于伸缩件150在移动时需要撑开钳杯110，故而利用引导槽1118的设置，以对伸缩件150相对钳杯110的移动起到导向作用，更便于伸缩件150施力。As shown in FIGS. 16 to 18 and FIG. 2 , illustratively, the clamp body mechanism 100 includes at least two clamp cups 110, at least two clamp cups 110 are hinged to the clamp seat 120, and each clamp cup 110 is configured with a cup mouth portion 1110. The distal end of the cup mouth portion 1110 is configured with a guide groove 1118, which passes through the outer surface of the clamp cup 110 or is located on the distal inner surface of the clamp cup 110. Since the telescopic member 150 needs to open the clamp cup 110 when moving, the guide groove 1118 is used to guide the movement of the telescopic member 150 relative to the clamp cup 110, which is more convenient for the telescopic member 150 to apply force.
进一步地，杯口部分1110被配置为平口型或锯齿型或两者结构。根据不同的病灶区域，可以选择相适配的钳杯110，更便于钳杯110夹持咬合以将样本分离。Furthermore, the cup mouth portion 1110 is configured as a flat mouth type or a sawtooth type or both structures. According to different lesion areas, a matching forceps cup 110 can be selected to facilitate the clamping and biting of the forceps cup 110 to separate the sample.
其中，钳杯110构造有铰接孔1117，以便于利用销轴113与钳座120铰接配合；且，每个钳杯110的近端均设置有固定孔1116，对应连接有一个牵引绳431，以便于驱动钳杯110相对钳座120转动，实现张开和关闭。钳杯110凹设有存放腔1114，以便于限定出采集腔；且，钳座120呈中空设置，以便于与钳杯110配合形成存储腔。钳杯110还设置有引流孔1115，引流孔1115与采集腔连通，以使取样时留在采集腔内的血液流出。The clamp cup 110 is configured with a hinge hole 1117, so as to facilitate the hinged connection with the clamp seat 120 by means of the pin 113; and each clamp cup 110 is provided with a fixing hole 1116 at the proximal end, and a traction rope 431 is connected to the clamp cup 110 to facilitate driving the clamp cup 110 to rotate relative to the clamp seat 120 to achieve opening and closing. The clamp cup 110 is provided with a storage cavity 1114 to facilitate defining a collection cavity; and the clamp seat 120 is hollow so as to facilitate The storage chamber is formed by cooperating with the clamp cup 110. The clamp cup 110 is also provided with a drainage hole 1115, which is connected to the collection chamber to allow the blood remaining in the collection chamber to flow out during sampling.
如图16、图19和图3所示，在可选的实施例中，伸缩件150为取样针，包括针体1521和位于针体1521远端的伸缩件远端1502，伸缩件远端1502呈尖锥头，其中，针体1521呈圆柱状或棱柱状，且针体1521的外侧壁凸设有多个倒刺结构151，各个倒刺结构151沿第一方向间隔布置，且各个倒刺结构151自远端朝向近端倾斜设置。其中，伸缩件远端1502作为采集部，以用于刺入病灶区域，存储部设置在针体1521上，并设置有多个倒刺结构151。具体的，沿针体1521的轴向，任意相邻的两个倒刺结构151之间的区域可以用于存储样本。由于各个倒刺结构151倾斜布置的设置，以便于样本可以自远端向近端移动，而对样本自近端向远端的移动进行限位。As shown in FIG. 16 , FIG. 19 and FIG. 3 , in an optional embodiment, the telescopic member 150 is a sampling needle, including a needle body 1521 and a telescopic member distal end 1502 located at the distal end of the needle body 1521, wherein the telescopic member distal end 1502 is a pointed cone head, wherein the needle body 1521 is cylindrical or prismatic, and the outer wall of the needle body 1521 is convexly provided with a plurality of barb structures 151, each barb structure 151 is arranged at intervals along a first direction, and each barb structure 151 is inclined from the distal end toward the proximal end. Among them, the telescopic member distal end 1502 serves as a collection portion for piercing the lesion area, and the storage portion is arranged on the needle body 1521, and is provided with a plurality of barb structures 151. Specifically, along the axial direction of the needle body 1521, the area between any two adjacent barb structures 151 can be used to store samples. Since each barb structure 151 is arranged obliquely, the sample can move from the distal end to the proximal end, and the movement of the sample from the proximal end to the distal end is limited.
进一步地，伸缩件150的近端与伸缩用驱动件211的远端之间通过一连接管1551连接，在满足伸缩件150与伸缩用驱动件211连接而同动的基础上，便于伸缩件150相对伸缩用驱动件211拆除；且，连接管1551可以与引导件160抵接，以进行伸缩件150朝向远端的移动限位。在一些实施例中，伸缩件150近端处构造有小径断离部156。当取样完成后，可以通过小径断离部156断裂，以将伸缩件150相对伸缩用驱动件211拆除。Furthermore, the proximal end of the telescopic member 150 is connected to the distal end of the telescopic driving member 211 through a connecting tube 1551, which facilitates the removal of the telescopic member 150 relative to the telescopic driving member 211 on the basis of satisfying the connection and simultaneous movement of the telescopic member 150 and the telescopic driving member 211; and the connecting tube 1551 can abut against the guide member 160 to limit the movement of the telescopic member 150 toward the distal end. In some embodiments, a small-diameter disconnection portion 156 is configured at the proximal end of the telescopic member 150. After sampling is completed, the small-diameter disconnection portion 156 can be broken to remove the telescopic member 150 relative to the telescopic driving member 211.
再进一步地，伸缩件150位于存储部近端的一侧构造有第一限位件154，第一限位件154能够抵接于引导件160的远端端面，以对伸缩件150起到定位装配和移动限位的效果，确保伸缩件150具有充足的空间可以作为存储部；且，当第一限位件154与引导件160抵接后，可以用于对伸缩件150相对驱动件430进行释放。其中，第一限位件154可以是沿伸缩件150径向向外凸设的限位凸台。Furthermore, a first stopper 154 is configured on one side of the telescopic member 150 located at the proximal end of the storage portion, and the first stopper 154 can abut against the distal end surface of the guide member 160 to position, assemble and limit the movement of the telescopic member 150, ensuring that the telescopic member 150 has sufficient space to serve as a storage portion; and when the first stopper 154 abuts against the guide member 160, it can be used to release the telescopic member 150 relative to the driving member 430. The first stopper 154 can be a stopper boss protruding radially outwardly along the telescopic member 150.
如图16所示，在一些实施例中，第一限位件154位于引导件160朝向远端一侧，连接管1551设置在引导件160朝向近端一侧。此时，第一限位件154可以与引导件160抵接以对伸缩件150朝向近端的移动进行限位，连接管1551可以与引导件160抵接以对伸缩件150朝向远端的移动进行限位。同时，当需要进行伸缩件150释放时，可以驱动第二控制件4202朝向近端移动，使得第一限位件154抵接于引导件160而被限制；随着施加至第二控制件4202的作用力逐渐增大，因为引导件160对第一限位件154的限位作用，使得伸缩件150可以相对伸缩用驱动件211脱离，实现伸缩件150的释放。此时，上述的释放空间4103即为满足第二控制件4202朝向近端移动的区域。As shown in FIG. 16 , in some embodiments, the first stopper 154 is located on the side of the guide member 160 toward the distal end, and the connecting tube 1551 is arranged on the side of the guide member 160 toward the proximal end. At this time, the first stopper 154 can abut against the guide member 160 to limit the movement of the telescopic member 150 toward the proximal end, and the connecting tube 1551 can abut against the guide member 160 to limit the movement of the telescopic member 150 toward the distal end. At the same time, when the telescopic member 150 needs to be released, the second control member 4202 can be driven to move toward the proximal end, so that the first stopper 154 abuts against the guide member 160 and is restricted; as the force applied to the second control member 4202 gradually increases, because of the limiting effect of the guide member 160 on the first stopper 154, the telescopic member 150 can be disengaged from the telescopic driving member 211, thereby realizing the release of the telescopic member 150. At this time, the above-mentioned release space 4103 is the area that satisfies the movement of the second control member 4202 toward the proximal end.
在释放时，由于小径断离部156的设置，可以削弱伸缩件150于此处的强度，在较大的拉力作用下，伸缩件150可以从小径断离部156相对伸缩用驱动件211断离而释放。或者，也可以是随着驱动第二控制件4202的作用力增大，使得伸缩件150和伸缩用驱动件211在连接管1551处断离而释放。When released, the small-diameter disconnection portion 156 can weaken the strength of the telescopic member 150 at this location, and under a large pulling force, the telescopic member 150 can be disconnected from the small-diameter disconnection portion 156 relative to the telescopic driving member 211 and released. Alternatively, as the force of driving the second control member 4202 increases, the telescopic member 150 and the telescopic driving member 211 are disconnected at the connecting tube 1551 and released.
如图1至图19所示，本申请一实施例还提供了一种取样方法，基于上述的取样设备2000进行取样操作。其中，该取样方法包括以下步骤：As shown in FIG. 1 to FIG. 19 , an embodiment of the present application further provides a sampling method, which performs a sampling operation based on the above-mentioned sampling device 2000. The sampling method includes the following steps:
S10：初始状态下，伸缩件150远端位于钳杯110且靠近钳杯110远端处，当取样设备2000位于待取组织处时，驱动第一控制件4201朝向远端移动，驱动钳杯110打开，以使伸缩件150远端的采集部进入组织300；S10: In the initial state, the distal end of the telescopic member 150 is located at the forceps cup 110 and close to the distal end of the forceps cup 110. When the sampling device 2000 is located at the tissue to be sampled, the first control member 4201 is driven to move toward the distal end, driving the forceps cup 110 to open, so that the collection portion at the distal end of the telescopic member 150 enters the tissue 300;
S20：在复位的运动趋势下，第一控制件4201朝向近端侧移动，驱动钳杯110闭合以取下组织300；S20: Under the movement trend of resetting, the first control member 4201 moves toward the proximal side, driving the forceps cup 110 to close to remove the tissue 300;
S30：驱动第二控制件4202朝向远端侧移动，使伸缩件150远端将钳杯110撑开且将S2中取下的组织300始终被止挡在钳杯110内，进而使组织300朝向伸缩件150近端侧移动至存储部153，空出采集部152；S30: driving the second control member 4202 to move toward the distal side, so that the distal end of the telescopic member 150 opens the forceps cup 110 and the tissue 300 removed in S2 is always stopped in the forceps cup 110, thereby moving the tissue 300 toward the proximal side of the telescopic member 150 to the storage part 153, leaving the collection part 152 empty;
S40：在复位的运动趋势下，第二控制件4202朝向近端侧移动，使伸缩件150回复至初始状态，同时组织300跟随伸缩件150朝向近端侧移动，使得组织300离开采集腔130而进入存储腔140；此时，完成一次组织取样；S40: Under the movement trend of resetting, the second control member 4202 moves toward the proximal side, so that the telescopic member 150 returns to the initial state, and at the same time, the tissue 300 follows the telescopic member 150 and moves toward the proximal side, so that the tissue 300 leaves the collection cavity 130 and enters the storage cavity 140; at this time, one tissue sampling is completed;
S50：重复S1至S4，完成N次组织取样；S50: repeat S1 to S4 to complete N times of tissue sampling;
S60：驱动第二控制件4202朝向近端侧移动，使得伸缩件150上的第一限位件154与引导件160抵接，直至释放伸缩件150，用户将释放后的伸缩件150上的N个样本组织依次取出并收集。S60: driving the second control member 4202 to move toward the proximal side so that the first stopper 154 on the telescopic member 150 abuts against the guide member 160 until the telescopic member 150 is released, and the user sequentially takes out and collects the N sample tissues on the released telescopic member 150.
需要提前说明的是，以弹性件450驱动控制件420朝向近端侧移动为复位，则控制件420朝向远端侧移动时可以是医生手推。It should be noted in advance that the elastic member 450 drives the control member 420 to move toward the proximal side for resetting, and the control member 420 can be manually pushed by the doctor when moving toward the distal side.
其中，上述初始状态，为第一控制件4201和第二控制件4202对应的第一弹性件451和第二弹性件452均处于自然状态，以该状态下用户促使鞘管210伸入至病灶区域，伸缩件150位于钳杯110内以避免在伸入过程中刺破其他区域。待钳体结构在鞘管210的作用下伸入至特定的待取样区域时，即可推动第一控制件4201朝向远端侧移动，第一控制件4201通过开合用驱动件212驱动两个钳杯110相对钳座120转动而打开，暴露出位于钳杯110内的伸缩件150，且伸缩件150远端的采集部可以在外力作用下刺入组织300。待刺入一定程度后，作用于第一控制件4201的推动力撤销，第一控制件4201在第一弹性件451的复位作用下朝向近端侧移动，开合用驱动件212驱动两个钳杯110再次转动而闭合，两个钳杯110的杯口部分1110互相配合以将组织分离，使得组织留存在伸缩件150上。The initial state is that the first elastic member 451 and the second elastic member 452 corresponding to the first control member 4201 and the second control member 4202 are 452 are in a natural state, in which the user causes the sheath 210 to extend into the lesion area, and the telescopic member 150 is located in the forceps cup 110 to avoid puncturing other areas during the extension process. When the forceps body structure extends into a specific area to be sampled under the action of the sheath 210, the first control member 4201 can be pushed to move toward the distal side, and the first control member 4201 drives the two forceps cups 110 to rotate relative to the forceps seat 120 through the opening and closing driving member 212 to open, exposing the telescopic member 150 located in the forceps cup 110, and the collection portion at the distal end of the telescopic member 150 can penetrate the tissue 300 under the action of external force. After a certain penetration, the driving force acting on the first control member 4201 is cancelled, and the first control member 4201 moves toward the proximal side under the resetting action of the first elastic member 451. The opening and closing driving member 212 drives the two forceps cups 110 to rotate again and close, and the cup mouth parts 1110 of the two forceps cups 110 cooperate with each other to separate the tissue so that the tissue remains on the telescopic member 150.
而后，推动第二控制件4202朝向远端侧移动，使得伸缩件150的远端经引导槽1118伸出而将闭合的两个钳杯110撑开；但是此时第一控制件4201仅承受第一弹性件451的作用力，因此两个钳杯110仍然具有朝向伸缩件150夹持的作用力；如此，即可随着伸缩件150朝向远端侧的移动，以将伸缩件150上的组织被钳杯110止挡在采集腔130内，且会移动至伸缩件150的存储部153，以使采集部152空出而便于下次操作。接着，撤销作用于第二控制件4202的推动力，第二控制件4202在第二弹性件452的作用下朝向近端侧移动，以便伸缩件150回复至初始状态；同时，位于存储部153的组织300随伸缩件150同步朝向近端移动，以进入存储腔140内。Then, the second control member 4202 is pushed to move toward the distal side, so that the distal end of the telescopic member 150 extends through the guide groove 1118 to open the two closed forceps cups 110; however, at this time, the first control member 4201 only bears the force of the first elastic member 451, so the two forceps cups 110 still have the force to clamp the telescopic member 150; in this way, as the telescopic member 150 moves toward the distal side, the tissue on the telescopic member 150 is stopped by the forceps cup 110 in the collection chamber 130, and moves to the storage part 153 of the telescopic member 150, so that the collection part 152 is empty and convenient for the next operation. Then, the driving force acting on the second control member 4202 is canceled, and the second control member 4202 moves toward the proximal side under the action of the second elastic member 452, so that the telescopic member 150 returns to the initial state; at the same time, the tissue 300 located in the storage part 153 moves toward the proximal end synchronously with the telescopic member 150 to enter the storage chamber 140.
按照上述的步骤进行多次操作，即可满足多次组织取样。Repeating the above steps for multiple times can satisfy multiple tissue sampling.
当完成多次组织取样后，朝向近端侧拉动第二控制件4202，第二控制件4202通过伸缩用驱动件211带动伸缩件150朝向近端移动，并在拉动的过程中缓慢增大拉力，直至伸缩件150上的第一限位件154与钳座120内的引导件160抵接；再进一步增大拉力，直至伸缩件150相对伸缩用驱动件211释放。而后用户可以取下伸缩件150，以便将伸缩件150上的N个样本组织一次取下并收集。After multiple tissue samplings are completed, the second control member 4202 is pulled toward the proximal side, and the second control member 4202 drives the telescopic member 150 to move toward the proximal end through the telescopic driving member 211, and the pulling force is slowly increased during the pulling process until the first stop member 154 on the telescopic member 150 abuts against the guide member 160 in the clamp seat 120; the pulling force is further increased until the telescopic member 150 is released relative to the telescopic driving member 211. Then the user can remove the telescopic member 150, so as to remove and collect N sample tissues on the telescopic member 150 at one time.
这样的操作，无需多次进出人体，只需一次进入即可进行多个样本的连续取样，提高操作效率，缩减手术时间，降低患者痛感和不适。This type of operation does not require multiple entries and exits of the human body. Instead, continuous sampling of multiple samples can be performed with just one entry, which improves operational efficiency, shortens surgical time, and reduces pain and discomfort for patients.
以上所述实施例的各技术特征可以进行任意的组合，为使描述简洁，未对上述实施例中的各个技术特征所有可能的组合都进行描述，然而，只要这些技术特征的组合不存在矛盾，都应当认为是本说明书记载的范围。The technical features of the above-described embodiments may be arbitrarily combined. To make the description concise, not all possible combinations of the technical features in the above-described embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.
以上所述实施例仅表达了本申请的几种实施方式，其描述较为具体和详细，但并不能因此而理解为对申请专利范围的限制。应当指出的是，对于本领域的普通技术人员来说，在不脱离本申请构思的前提下，还可以做出若干变形和改进，这些都属于本申请的保护范围。因此，本申请专利的保护范围应以所附权利要求为准。The above-described embodiments only express several implementation methods of the present application, and the descriptions thereof are relatively specific and detailed, but they cannot be construed as limiting the scope of the patent application. It should be pointed out that, for a person of ordinary skill in the art, several variations and improvements can be made without departing from the concept of the present application, and these all belong to the protection scope of the present application. Therefore, the protection scope of the patent application shall be subject to the attached claims.
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310698497.8 | 2023-06-13 | ||
| CN202310698497 | 2023-06-13 | ||
| CN202311109750.8 | 2023-08-30 | ||
| CN202311109750.8ACN117297672A (en) | 2023-08-30 | 2023-08-30 | Operating handle, sampling device and sampling method |
| Publication Number | Publication Date |
|---|---|
| WO2024255796A1true WO2024255796A1 (en) | 2024-12-19 |
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/CN2024/098988PendingWO2024255796A1 (en) | 2023-06-13 | 2024-06-13 | Multi-sampling biopsy device, multi-sampling method, and sampling apparatus |
| Country | Link |
|---|---|
| WO (1) | WO2024255796A1 (en) |
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN119437788A (en)* | 2025-01-07 | 2025-02-14 | 中国科学院大学 | Multi-channel tissue sampler and sampling method thereof |
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6142957A (en)* | 1993-09-20 | 2000-11-07 | Boston Scientific Corporation | Multiple biopsy sampling device |
| CN105686855A (en)* | 2016-03-25 | 2016-06-22 | 北京龙淼医疗器械有限公司 | Continuous-sampling biopsy forceps |
| US20160262735A1 (en)* | 2013-10-30 | 2016-09-15 | Bioscopex Aps | Endoscopic device for multiple sample biopsy |
| CN209315943U (en)* | 2018-12-06 | 2019-08-30 | 南京法迈特科技发展有限公司 | A kind of multidirectional adjustable drag hook |
| CN212788562U (en)* | 2020-05-14 | 2021-03-26 | 广州医科大学附属第一医院（广州呼吸中心） | Pleura sampling forceps |
| CN113331881A (en)* | 2021-06-07 | 2021-09-03 | 苏州法兰克曼医疗器械有限公司 | Biopsy forceps capable of sampling continuously |
| CN117297672A (en)* | 2023-08-30 | 2023-12-29 | 杭州安杰思医学科技股份有限公司 | Operating handle, sampling device and sampling method |
| CN220442684U (en)* | 2023-06-13 | 2024-02-06 | 杭州安杰思医学科技股份有限公司 | Multi-sampling biopsy device |
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6142957A (en)* | 1993-09-20 | 2000-11-07 | Boston Scientific Corporation | Multiple biopsy sampling device |
| US20160262735A1 (en)* | 2013-10-30 | 2016-09-15 | Bioscopex Aps | Endoscopic device for multiple sample biopsy |
| CN105686855A (en)* | 2016-03-25 | 2016-06-22 | 北京龙淼医疗器械有限公司 | Continuous-sampling biopsy forceps |
| CN209315943U (en)* | 2018-12-06 | 2019-08-30 | 南京法迈特科技发展有限公司 | A kind of multidirectional adjustable drag hook |
| CN212788562U (en)* | 2020-05-14 | 2021-03-26 | 广州医科大学附属第一医院（广州呼吸中心） | Pleura sampling forceps |
| CN113331881A (en)* | 2021-06-07 | 2021-09-03 | 苏州法兰克曼医疗器械有限公司 | Biopsy forceps capable of sampling continuously |
| CN220442684U (en)* | 2023-06-13 | 2024-02-06 | 杭州安杰思医学科技股份有限公司 | Multi-sampling biopsy device |
| CN117297672A (en)* | 2023-08-30 | 2023-12-29 | 杭州安杰思医学科技股份有限公司 | Operating handle, sampling device and sampling method |
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN119437788A (en)* | 2025-01-07 | 2025-02-14 | 中国科学院大学 | Multi-channel tissue sampler and sampling method thereof |
| Publication | Publication Date | Title |
|---|---|---|
| US7306613B2 (en) | Endoscopic instruments | |
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