WO2022185434A1 - Inhalateur d'arôme de type à chauffage sans combustion, et cartouche - Google Patents
Inhalateur d'arôme de type à chauffage sans combustion, et cartoucheDownload PDFInfo
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- WO2022185434A1 WO2022185434A1PCT/JP2021/008098JP2021008098WWO2022185434A1WO 2022185434 A1WO2022185434 A1WO 2022185434A1JP 2021008098 WJP2021008098 WJP 2021008098WWO 2022185434 A1WO2022185434 A1WO 2022185434A1
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- aerosol
- flavor inhaler
- source
- aerosol source
- tobacco
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- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/10—Chemical features of tobacco products or tobacco substitutes
- A24B15/16—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes
- A24B15/167—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes in liquid or vaporisable form, e.g. liquid compositions for electronic cigarettes
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/18—Treatment of tobacco products or tobacco substitutes
- A24B15/28—Treatment of tobacco products or tobacco substitutes by chemical substances
- A24B15/30—Treatment of tobacco products or tobacco substitutes by chemical substances by organic substances
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/18—Treatment of tobacco products or tobacco substitutes
- A24B15/28—Treatment of tobacco products or tobacco substitutes by chemical substances
- A24B15/30—Treatment of tobacco products or tobacco substitutes by chemical substances by organic substances
- A24B15/32—Treatment of tobacco products or tobacco substitutes by chemical substances by organic substances by acyclic compounds
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
- A24F40/00—Electrically operated smoking devices; Component parts thereof; Manufacture thereof; Maintenance or testing thereof; Charging means specially adapted therefor
- A24F40/10—Devices using liquid inhalable precursors
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
- A24F40/00—Electrically operated smoking devices; Component parts thereof; Manufacture thereof; Maintenance or testing thereof; Charging means specially adapted therefor
- A24F40/40—Constructional details, e.g. connection of cartridges and battery parts
Definitions
- the present inventionrelates to a non-combustion heating flavor inhaler and cartridge.
- Non-combustion heated flavor inhalersfor supplying ingredients to users are known (eg, Patent Documents 1 and 2).
- the non-combustion heating type flavor inhalercomprises, for example, a cartridge including an aerosol source and atomization means for heating and atomizing the aerosol source, a power supply unit for supplying power to the atomization means, and downstream of the cartridge. and a flavoring cartridge containing a tobacco source positioned thereon.
- the aerosol sourcemay also contain perfume ingredients such as menthol.
- non-combustion heated flavor inhalersthat do not have a flavoring cartridge, but instead the aerosol source contains tobacco-derived components.
- tobacco-derived componentssuch as nicotine and flavoring components such as menthol contained in the aerosol may deposit and be lost at the mouthpiece.
- the non-combustion heating type flavor inhaleris provided with a flavoring cartridge, the tobacco-derived component and the flavoring component that have migrated to the aerosol are deposited and lost in the flavoring cartridge even in the flavoring cartridge. There is Such loss within the aerosol pathway reduces the delivery of flavoring ingredients to the user.
- An object of the present inventionis to provide a non-combustion heating flavor inhaler in which the loss of flavor components in the aerosol path is suppressed, and a cartridge used for the non-combustion heating flavor inhaler.
- the present inventionincludes the following embodiments.
- R 1 , R 2 and R 3are each independently an alkyl group having 3 to 6 carbon atoms.
- atomization means for atomizing the aerosol source to produce an aerosolcomprising:
- a cartridge for a non-combustion heating flavor inhalercontaining an aerosol source containing a compound represented by the following formula (1).
- R 1 , R 2 and R 3are each independently an alkyl group having 3 to 6 carbon atoms.
- the present inventionit is possible to provide a non-combustion heating flavor inhaler in which the loss of flavor components in the aerosol path is suppressed, and a cartridge used for the non-combustion heating flavor inhaler.
- FIG. 2is a schematic diagram showing a cartridge in which a flavor imparting cartridge is incorporated in FIG. 1.
- FIG. 1is a graph showing the delivery amount of nicotine in Examples 1-5 and Comparative Example 1.
- FIG. 2is a graph showing nicotine delivery amounts in Examples 6 to 9 and Comparative Example 2.
- FIG. 2is a graph showing the delivery amount of menthol in Examples 6-9 and Comparative Example 2.
- FIG. 10is a graph showing the delivery amount of nicotine in Examples 10-13 and Comparative Example 3.
- FIG. 2is a graph showing the delivery amount of menthol in Examples 14-17 and Comparative Example 4.
- FIG. 1is a graph showing the delivery amount of nicotine in Examples 1-5 and Comparative Example 1.
- FIG. 2is a graph showing nicotine delivery amounts in Examples 6 to 9 and Comparative Example 2.
- FIG. 2is a graph showing the delivery amount of menthol in Examples 6-9 and Comparative Example 2.
- FIG. 10is a graph showing the delivery amount of nicotine in Examples 10-13 and Comparative Example 3.
- FIG. 2is
- the non-combustion-heating flavor inhalerincludes an aerosol source containing a compound represented by the following formula (1), and atomization means for atomizing the aerosol source to generate an aerosol.
- R 1 , R 2 and R 3are each independently an alkyl group having 3 to 6 carbon atoms.
- the non-combustion heating type flavor inhalerwhen the aerosol source is atomized to generate an aerosol, the compound represented by the formula (1) migrates to the aerosol. Since the compound represented by the formula (1) has a high boiling point, when the compound represented by the formula (1) is contained in the aerosol, the aerosol particles are less likely to evaporate and stabilize. In addition, the compound represented by the formula (1) has a high solubility of tobacco-derived components such as nicotine and flavoring components such as menthol. Therefore, by including the compound represented by the formula (1) in the aerosol particles, the tobacco-derived component and the flavoring component can be contained in a larger amount in the aerosol particles, and the tobacco-derived component and the flavoring component can be included in the aerosol particles. less likely to be released to the outside. It is considered that the non-combustion heating type flavor inhaler according to the present embodiment suppresses the loss of flavor components in the aerosol path.
- the non-combustion-heating flavor inhalerincludes an aerosol source containing the compound represented by the formula (1), and an atomizing means for atomizing the aerosol source to generate an aerosol.
- an aerosol sourcecontaining the compound represented by the formula (1)
- an atomizing meansfor atomizing the aerosol source to generate an aerosol.
- itmay include other configurations than the aerosol source and the atomization means.
- Other configurationsinclude, for example, a tobacco source containing tobacco-derived components located downstream of the aerosol source.
- the aerosol source according to this embodimentcontains the compound represented by formula (1) above.
- R 1 , R 2 and R 3are each independently an alkyl group having 3 to 6 carbon atoms.
- R 1 , R 2 and R 3are alkyl groups having 3 or more carbon atoms, the boiling point of the compound represented by the formula (1) is increased and the aerosol particles are stabilized.
- R 1 , R 2 and R 3are alkyl groups having 6 or less carbon atoms, the temperature required to vaporize the compound represented by the formula (1) can be lowered, and the aerosol source can be The temperature during atomization can be lowered.
- R 1 , R 2 and R 3are each independently preferably an alkyl group having 4 to 6 carbon atoms.
- the compound represented by formula (1)is preferably tributyl citrate (TBC).
- TBCtributyl citrate
- the aerosol sourcemay contain one compound represented by the formula (1), or may contain two or more compounds.
- the content of the compound represented by formula (1) in the aerosol sourceis preferably 5 to 70% by mass with respect to 100% by mass of the aerosol source.
- the contentis 5% by mass or more, the aerosol particles are sufficiently stabilized, and the loss of the flavor component in the aerosol path can be sufficiently suppressed.
- the contentis 70% by mass or less, the content of other components such as an aerosol generating agent, which will be described later, can be maintained.
- the contentis more preferably 5 to 60% by mass, even more preferably 10 to 50% by mass.
- the aerosol sourcepreferably contains triethyl citrate (TEC) in addition to the compound represented by formula (1).
- TECtriethyl citrate
- the added amount of the compound represented by the formula (1)can be reduced while maintaining the effect of suppressing the loss of flavor components in the aerosol path. Thereby, the characteristic odor derived from the compound represented by the formula (1) can be reduced.
- the compound represented by the formula (1)can express the body feeling and stereoscopic effect of tobacco-derived components such as nicotine at the time of use, and triethyl citrate causes discomfort such as irritation derived from the tobacco-derived components. can be reduced.
- the compound represented by the formula (1)can express the body feeling and three-dimensional effect of perfume ingredients such as menthol when used, and triethyl citrate can express the features such as brightness of the perfume ingredients. Therefore, by using both together, it is possible to further improve the sensation based on the tobacco-derived component and the flavoring component during use.
- the aerosol sourcedoes not contain the compound represented by the formula (1) and contains only triethyl citrate, the effect of the present embodiment cannot be obtained.
- the content of triethyl citrate in the aerosol sourceis 3 to 50% by mass with respect to 100% by mass of the aerosol source, from the viewpoint of sufficiently obtaining the effects described above. preferably 5 to 40% by mass, even more preferably 10 to 30% by mass.
- the content ratio of the compound represented by the formula (1) and triethyl citrateis preferably 50 to 90:10 to 50. , 50-70:30-50, more preferably 50-60:40-50.
- the aerosol sourcecan contain an aerosol-generating agent.
- the aerosol generating agentis atomized by heating to generate an aerosol.
- the aerosol-generating agentis not particularly limited as long as it can be atomized by heating to generate an aerosol, and can be selected from extracts from various natural products and constituents thereof.
- Aerosol-generating agentsinclude, for example, polyhydric alcohols such as glycerin (G), propylene glycol (PG), 1,3-butanediol, sorbitol, xylitol and erythritol, and triacetin. These may be used alone or in combination of two or more. Among these, propylene glycol and At least one of glycerin is preferred.
- the content of the aerosol generating agent in the aerosol sourceis 30 to 30% with respect to 100% by mass of the aerosol source, from the viewpoint of ensuring a sufficient amount of aerosol generation and sufficiently delivering the tobacco-derived component and the fragrance component. It is preferably 95% by mass, more preferably 40 to 90% by mass, even more preferably 45 to 75% by mass.
- the aerosol sourcepreferably further contains at least one selected from the group consisting of nicotine, nicotine salts, and perfume ingredients.
- the aerosol sourceincludes nicotine, nicotine salts, and/or flavoring ingredients such that these ingredients are included in the aerosol when the aerosol is generated. Since the aerosol contains the compound represented by the formula (1), the aerosol particles are stabilized and the components are less likely to be released outside the aerosol particles. As a result, loss of said components in the aerosol path is reduced.
- the nicotine and nicotine saltmay be a liquid containing both nicotine and nicotine salt.
- Nicotine saltsinclude, for example, nicotine salts produced by mixing citric acid, tartaric acid, malic acid, levulinic acid, benzoic acid, etc. with nicotine.
- the content of nicotine and/or nicotine salt in the aerosol sourceis preferably 1 to 15% by mass with respect to 100% by mass of the aerosol source. , more preferably 2 to 10% by mass, more preferably 3 to 5% by mass.
- perfume componentsinclude, but are not limited to, terpenes such as menthol and linalool, aromatic aldehydes such as furfural, and aldehydes such as nonanal. These may be used alone or in combination of two or more.
- the content of the perfume component in the aerosol sourceis preferably 1 to 15% by mass, more preferably 2 to 10% by mass relative to 100% by mass of the aerosol source. and more preferably 3 to 5% by mass.
- the aerosol source according to this embodimentcan contain other components such as water in addition to the components described above.
- the aerosol sourcecan be arranged, for example, in a cartridge as described below.
- the compound represented by the formula (1)must be contained in the aerosol source.
- the tobacco source disposed downstream of the aerosol sourcecontains the compound represented by the formula (1), the compound represented by the formula (1) does not sufficiently migrate into the aerosol. No morphological effect is obtained.
- the non-combustion heating flavor inhalerincludes atomization means for atomizing the aerosol source to generate an aerosol.
- the atomization meansis not particularly limited as long as it can atomize the aerosol source to generate an aerosol, but it can be, for example, a heating atomization means. Specifically, it can be a heating resistor such as a heating wire that generates heat by electric power supplied from a power source as described later.
- the atomizing meanscan be arranged, for example, in a cartridge as described below.
- the non-combustion-heated flavor inhaler according to this embodimentcan further include a tobacco source containing a tobacco-derived component located downstream of the aerosol source.
- tobacco-derived components contained in the tobacco sourceare transferred to the aerosol and supplied to the user. Examples of tobacco-derived components include nicotine and the like. Since the tobacco-derived component contained in the tobacco source is delivered by the aerosol, it is not necessary to heat the tobacco source itself during use.
- the non-combustion heating flavor inhaler according to this embodimentmay not contain a tobacco source, in which case the aerosol source may contain a tobacco-derived component.
- the tobacco sourceis immersed in the aerosol source, the liquid tobacco-derived component extracted from the tobacco source is mixed with the aerosol source, the tobacco-derived component obtained by chemical synthesis is mixed with the aerosol source, and the like.
- Tobacco-derived ingredientscan be included.
- the tobacco sourcecan be composed of raw material pieces that impart tobacco-derived components to the aerosol generated by atomization of the aerosol source.
- the size of the raw material piecesis preferably 0.2 to 1.2 mm, more preferably 0.2 to 0.7 mm. Since the smaller the size of the raw material pieces, the greater the specific surface area, the tobacco-derived components are more likely to be released from the raw material pieces. Therefore, the amount of raw material pieces can be reduced in applying the desired amount of tobacco-derived component to the aerosol.
- shredded tobaccoa molded product obtained by molding tobacco raw material into granules, a molded product obtained by molding tobacco raw material into a sheet shape, and the like can be used.
- the raw material piecesare obtained by sieving according to JIS Z 8815 using a stainless steel sieve according to JIS Z 8801, for example.
- a stainless steel sieve with an opening of 0.71 mmthe raw material pieces are sieved for 20 minutes by a dry and mechanical shaking method to pass through a stainless steel sieve with an opening of 0.71 mm.
- using a stainless sieve with an opening of 0.212 mmthe raw material pieces are sieved for 20 minutes by a dry and mechanical shaking method to pass through a stainless sieve with an opening of 0.212 mm. remove the raw material pieces.
- the tobacco sourcemay contain flavor components in addition to tobacco-derived components.
- the raw material piecemay contain a flavor component in addition to the tobacco-derived component.
- the perfume componentinclude the perfume components described above, and it is preferable that menthol is included.
- the raw material piecesmay also contain plants other than tobacco, such as mint and herbs.
- the tobacco sourcecan be placed in a flavoring cartridge, for example provided downstream of the cartridge as described below.
- the cartridge according to this embodimentincludes an aerosol source containing the compound represented by Formula (1) above.
- the cartridgeis detachably attached to a non-combustion heated flavor inhaler.
- the cartridgemay comprise atomization means for atomizing the aerosol source to produce an aerosol, as described below.
- FIG. 1An example of the non-combustion heating type flavor inhaler according to this embodiment is shown in FIG.
- the non-combustion-heating flavor inhaler 100 shown in FIG. 1is a device for inhaling flavor components without combustion, and has a shape extending along a predetermined direction A, which is the direction from the non-suction end to the suction end.
- FIG. 2is a diagram showing the cartridge 111 in which the flavor imparting cartridge 130 is incorporated in FIG. Note that the non-combustion heating type flavor inhaler 100 may be simply referred to as the flavor inhaler 100 hereinafter.
- the flavor inhaler 100has an inhaler body 110 and a flavoring cartridge 130 with a tobacco source.
- the inhaler main body 110constitutes the main body of the flavor inhaler 100 and has a shape to which the flavor imparting cartridge 130 can be connected.
- the aspirator body 110has an aspirator housing 110X, and the flavoring cartridge 130 is connected to the mouthpiece end of the aspirator housing 110X.
- the inhaler body 110comprises a cartridge 111 comprising an aerosol source and atomization means according to the present embodiment, configured to atomize the aerosol source without combustion, and a power supply unit 112 .
- the cartridge 111has a first cylindrical body 111X that forms part of the aspirator housing 110X.
- the cartridge 111as shown in FIG. 2, has a reservoir 111P, a wick 111Q and an atomizing means 111R.
- the reservoir 111P, the wick 111Q and the atomizing means 111Rare accommodated in the first cylindrical body 111X.
- the first tubular body 111Xhas a tubular shape (for example, a cylindrical shape) extending along the predetermined direction A.
- Reservoir 111Pholds an aerosol source according to this embodiment.
- the reservoir 111Pis a porous body made of a material such as a resin web.
- the wick 111Qis an example of a liquid retaining member that retains the aerosol source supplied from the reservoir 111P.
- the wick 111Qis made of glass fiber.
- the atomizing means 111Ratomizes the aerosol source held by the wick 111Q.
- the atomization means 111Rcan be composed of, for example, a heating resistor (for example, a heating wire) wound around the wick 111Q at a predetermined pitch.
- An absorption member 111S that absorbs condensed aerosolis provided on the wall surface exposed to the flow path of the aerosol generated by the atomization means 111R.
- the wall surfaces exposed to the aerosol flow pathare, for example, the inner surface of the first cylindrical body 111X exposed to the aerosol flow path, the outer surface of the reservoir 111P exposed to the aerosol flow path, and the like.
- the absorbing member 111Sis not in contact with the reservoir 111P, the aerosol (condensed aerosol) absorbed by the absorbing member 111S is led from the absorbing member 111S to the atomizing means 111R using capillary action. is preferred.
- the absorbing member 111Swhen the absorbing member 111S is in contact with the reservoir 111P, the aerosol (condensed aerosol) absorbed by the absorbing member 111S is preferably guided from the absorbing member 111S to the reservoir 111P.
- the absorbing member 111Smay be a member having a function of absorbing condensed aerosol, and may be made of the same material (resin web) as the reservoir 111P, or the same material (glass fiber) as the wick 111Q. may be configured by
- the power supply unit 112has a second cylindrical body 112X that forms part of the aspirator housing 110X.
- the power supply unit 112has an inlet 112A. Air flowing in from the inlet 112A is guided to the cartridge 111 (atomization means 111R) as shown in FIG.
- power supply unit 112includes power supply 10 , suction sensor 20 , push button 30 , light emitting element 40 , and control circuit 50 .
- the power source 10, the suction sensor 20, the push button 30 and the control circuit 50are housed in the second cylindrical body 112X.
- the second tubular body 112Xhas a tubular shape (for example, a cylindrical shape) extending along the predetermined direction A. As shown in FIG.
- the power supply 10is, for example, a lithium ion battery.
- Power source 10stores the power required to operate flavor inhaler 100 .
- the power supply 10stores power to supply the suction sensor 20 and the control circuit 50 .
- the power source 10accumulates electric power to be supplied to the cartridge 111 (atomizing means 111R).
- the suction sensor 20detects fluid flow in a continuous suction path from the inlet 112A to the outlet 130A.
- the suction sensor 20detects suction (suction state) when the fluid flow from the inlet 112A to the outlet 130A side is equal to or greater than a predetermined threshold.
- the suction sensor 20detects non-suction (non-suction state) when the fluid flow from the inlet 112A to the outlet 130A side is less than a predetermined threshold.
- the push button 30is configured to be pushed inward from the outside of the flavor inhaler 100 .
- the push button 30is provided at the non-mouth end of the flavor inhaler 100 and is configured to be pushed in the direction from the non-mouth end toward the mouth end (that is, the predetermined direction A).
- the power of the flavor inhaler 100may be turned on when the push button 30 is continuously pushed a predetermined number of times while the power of the flavor inhaler 100 is not turned on.
- the power of the flavor inhaler 100may be turned off when the push button 30 is continuously pushed a predetermined number of times while the power of the flavor inhaler 100 is on.
- the power source of the flavor inhaler 100may be turned off when a predetermined time has passed since the puffing operation was performed without performing the puffing operation.
- the light emitting element 40is, for example, a light source such as an LED or electric light.
- the light emitting element 40is provided on a side wall extending along a predetermined direction.
- the light emitting element 40is preferably provided on the side wall near the non-mouth end.
- the light emission pattern of the light emitting element 40is a pattern for notifying the user of the state of the flavor inhaler 100 .
- the light emitting element 40may constitute a notification unit that notifies that a desired amount of aerosol can be supplied.
- the light emitting element 40may continuously notify that the desired amount of aerosol can be supplied from the start to the end of the period in which the desired amount of aerosol can be supplied.
- the light emitting element 40may constitute a notification unit that notifies that the desired amount of aerosol cannot be supplied.
- the light emitting element 40may continuously notify that the desired amount of aerosol cannot be supplied from the start to the end of the period in which the desired amount of aerosol cannot be supplied.
- the control circuit 50controls the operation of the flavor inhaler 100. Specifically, the control circuit 50 controls power output to the cartridge 111 (atomization means 111R). Also, the control circuit 50 controls the light emitting element 40 .
- the flavor imparting cartridge 130is configured to be connectable to the aspirator main body 110 that constitutes the flavor aspirator 100 .
- the flavor imparting cartridge 130is provided downstream of the cartridge 111 on the flow path of gas (hereinafter referred to as air) sucked from the mouthpiece.
- airgas
- the flavor imparting cartridge 130does not necessarily need to be physically spaced closer to the mouthpiece side than the cartridge 111, but is located downstream of the cartridge 111 on the aerosol flow path that guides the aerosol generated from the cartridge 111 toward the mouthpiece side. It is sufficient if it is provided.
- the flavoring cartridge 130has a flavoring cartridge housing 131, a tobacco source 132, a mesh 133A, and a filter 133B.
- the flavoring cartridge 130also has an outlet 130A provided in the mouthpiece.
- the flavor imparting cartridge housing 131has a cylindrical shape (for example, a cylindrical shape) extending along the predetermined direction A. Flavoring cartridge housing 131 houses tobacco source 132 . Here, flavoring cartridge housing 131 is configured to be inserted along predetermined direction A into aspirator housing 110X.
- the tobacco source 132is provided closer to the outlet 130A (mouthpiece) than the cartridge 111 on the continuous suction path from the inlet 112A to the outlet 130A.
- Tobacco source 132imparts a tobacco-derived component to the aerosol generated from the aerosol source.
- the tobacco-derived component imparted to the aerosol by tobacco source 132is conveyed to outlet 130A (mouthpiece).
- the tobacco source 132the tobacco source according to this embodiment described above can be used.
- the mesh 133Ais provided upstream of the tobacco source 132 so as to block the opening of the flavor imparting cartridge housing 131 .
- Filter 133Bis provided downstream of tobacco source 132 to block the opening of flavoring cartridge housing 131 .
- the mesh 133Ahas such roughness that the raw material pieces forming the tobacco source 132 cannot pass through.
- the mesh 133Ahas a mesh size of, for example, 0.077 to 0.198 mm.
- the filter 133Bis made of a breathable material. Filter 133B is preferably an acetate filter, for example.
- the filter 133Bhas a roughness to the extent that the raw material pieces forming the tobacco source 132 do not pass through.
- Example 1A non-combustion heating flavor inhaler having the configuration shown in FIG. 1 was produced.
- a solution containing 45.0% by weight propylene glycol (PG), 45.0% by weight glycerin (G), and 10.0% by weight tributyl citrate (TBC)was used as an aerosol source.
- PGpropylene glycol
- Gglycerin
- THCtributyl citrate
- Mtobacco-derived components
- the amount of nicotine delivered during use of the non-combustion heated flavor inhalerwas measured according to the method described above. The results are shown in FIG.
- Examples 2 to 5, Comparative Example 1A non-combustion heating flavor inhaler was produced in the same manner as in Example 1, except that an aerosol source having the composition shown in Table 1 was used as the aerosol source, and the delivery amount of nicotine during use was measured. The results are shown in FIG. In Table 1, "PG” is propylene glycol, “G” is glycerin, “TEC” is triethyl citrate, “TBC” is tributyl citrate, and “M” is menthol.
- Examples 1 and 2 in which tributyl citrate was added to the aerosol sourceshowed an increase in the amount of nicotine delivered.
- the amount deliveredincreased with increasing amounts of added tributyl citrate.
- the combined use of triethyl citrateshowed that even if the content of tributyl citrate was reduced, the delivery amount of nicotine was maintained. It was confirmed to be equal to or higher than Example 2.
- Example 5From the results of Example 5, it was confirmed that the delivery amount of nicotine was slightly increased as compared with Comparative Example 1 even when only tributyl citrate was used as an aerosol source. However, since the amount of nicotine delivered is smaller than in Examples 2 to 4, in the presence of an aerosol-generating agent such as propylene glycol or glycerin, the compound represented by the formula (1) such as tributyl citrate, or It was found that the addition of both the compound represented by formula (1) and triethyl citrate further increased the nicotine delivery.
- an aerosol-generating agentsuch as propylene glycol or glycerin
- the non-combustion heating type flavor inhalers of Comparative Example 1 and Examples 2 to 4were sensory evaluated by five expert evaluation panels.
- the sensory evaluationwas carried out by five professional evaluation panelists using the non-combustion-heating flavor inhaler in the same manner as in normal use, and making free comments.
- the above-mentioned five expert evaluation panelshave been sufficiently trained in the sensory evaluation of the non-combustion heating type flavor inhaler, and that the evaluation thresholds are the same and the panelists are unified. .
- the non-combustion-heating flavor inhaler of Example 2exhibited reduced stimulation of nicotine as compared with Comparative Example 1, expressed a better feeling of nicotine as it passed through the throat, and had a body feeling of nicotine and It was confirmed that the three-dimensional effect was expressed more.
- the peculiar smell and bitterness of tributyl citratewere felt a little.
- the non-combustion heating type flavor inhaler of Example 3was less stimulating to nicotine than Comparative Example 1, but was more stimulating to nicotine than those of Examples 2 and 4.
- the peculiar smell and bitterness of tributyl citratewere reduced more than in Example 2.
- Example 4It was confirmed that the non-combustion-heating flavor inhaler of Example 4 exhibited the same reduction in nicotine stimulation as in Example 2, body feeling, and three-dimensional effect. Furthermore, the peculiar odor and bitterness of tributyl citrate were reduced more than in Example 2.
- Examples 6 to 9, Comparative Example 2A non-combustion heating flavor inhaler was produced in the same manner as in Example 1, except that an aerosol source having the composition shown in Table 1 was used as the aerosol source, and a tobacco source to which menthol (M) was added was used as the tobacco source. and measured the amount of nicotine and menthol delivered during use. The results are shown in FIGS. 4 and 5.
- FIG. 4An aerosol source having the composition shown in Table 1 was used as the aerosol source, and a tobacco source to which menthol (M) was added was used as the tobacco source.
- the non-combustion heating type flavor inhalers of Comparative Example 2 and Examples 7 to 9were sensory evaluated by the same five professional evaluation panel as described above. In the sensory evaluation, it was confirmed that the non-combustion heating type flavor inhaler of Example 7 expressed more menthol feeling than Comparative Example 2, and expressed more body feeling and three-dimensional effect of menthol and nicotine. rice field. On the other hand, the peculiar smell and bitterness of tributyl citrate were felt a little. In the non-combustion heating type flavor inhaler of Example 8, the feeling of menthol was expressed more than in Comparative Example 2, but to a lesser extent than in Example 9. Moreover, the body feeling and three-dimensional effect of menthol and nicotine were lower than those of Examples 7 and 9.
- Example 7On the other hand, the peculiar odor and bitterness of tributyl citrate were reduced more than in Example 7.
- the non-combustion heating type flavor inhaler of Example 9expressed more menthol feeling than Examples 7 and 8, and the body feeling and three-dimensional effect of menthol and nicotine were comparable to those of Example 7. . Furthermore, the peculiar odor and bitterness of tributyl citrate were reduced more than in Example 7.
- Example 10In FIG. 1, a non-combustion heating type flavor inhaler similar to that in FIG.
- the aerosol sourcecontains 43.0% by weight propylene glycol (PG), 43.0% by weight glycerin (G), 9.6% by weight tributyl citrate (TBC), and 4.5% by weight nicotine (NIC). solution was used.
- the amount of nicotine delivered during use of the non-combustion heated flavor inhalerwas measured according to the method described above. The results are shown in FIG.
- Example 11 to 13Comparative Example 3
- a non-combustion heating flavor inhalerwas produced in the same manner as in Example 10, except that the aerosol source having the composition shown in Table 2 was used as the aerosol source, and the delivery amount of nicotine during use was measured. The results are shown in FIG.
- Examples 10 and 11 in which tributyl citrate was added to the aerosol sourceshowed an increase in the amount of nicotine delivered.
- the amount deliveredincreased with increasing amounts of added tributyl citrate.
- Examples 12 and 13 in which glycerin was replaced with triethyl citrate and tributyl citratethe combined use of triethyl citrate showed that even if the content of tributyl citrate was reduced, the delivery amount of nicotine was maintained.
- Example 11 or morewas confirmed. Therefore, it is preferable to add both the compound represented by the formula (1) and triethyl citrate even in a non-combustion heating type flavor inhaler that does not have a tobacco source and instead the aerosol source contains tobacco-derived components. I found out.
- Examples 14 to 17, Comparative Example 4A non-combustion heating flavor inhaler was produced in the same manner as in Example 10, except that an aerosol source having the composition shown in Table 2 was used as the aerosol source, and the delivery amount of menthol during use was measured. The results are shown in FIG.
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Abstract
Priority Applications (3)
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|---|---|---|---|
| JP2023503588AJP7543535B2 (ja) | 2021-03-03 | 2021-03-03 | 非燃焼加熱型香味吸引器及びカートリッジ |
| PCT/JP2021/008098WO2022185434A1 (fr) | 2021-03-03 | 2021-03-03 | Inhalateur d'arôme de type à chauffage sans combustion, et cartouche |
| EP21929010.3AEP4302620A4 (fr) | 2021-03-03 | 2021-03-03 | Inhalateur d'arôme de type à chauffage sans combustion, et cartouche |
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| Application Number | Priority Date | Filing Date | Title |
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| PCT/JP2021/008098WO2022185434A1 (fr) | 2021-03-03 | 2021-03-03 | Inhalateur d'arôme de type à chauffage sans combustion, et cartouche |
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| WO2022185434A1true WO2022185434A1 (fr) | 2022-09-09 |
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| PCT/JP2021/008098CeasedWO2022185434A1 (fr) | 2021-03-03 | 2021-03-03 | Inhalateur d'arôme de type à chauffage sans combustion, et cartouche |
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| EP (1) | EP4302620A4 (fr) |
| JP (1) | JP7543535B2 (fr) |
| WO (1) | WO2022185434A1 (fr) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4581944A1 (fr)* | 2024-01-08 | 2025-07-09 | BT DE Investments Inc. | Matériau aérosolisable pour utilisation dans un article |
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| WO2015046420A1 (fr)* | 2013-09-30 | 2015-04-02 | 日本たばこ産業株式会社 | Inhalateur de saveur sans combustion |
| WO2016178377A1 (fr)* | 2015-05-01 | 2016-11-10 | 日本たばこ産業株式会社 | Inhalateur d'arôme de type sans combustion, unité source de composant d'inhalation d'arôme, et unité d'atomisation |
| JP2017518042A (ja)* | 2014-04-28 | 2017-07-06 | バットマーク・リミテッド | エアロゾル形成コンポーネント |
| US20190124982A1 (en)* | 2016-04-22 | 2019-05-02 | Juul Labs, Inc. | Aerosol Devices Having Compartmentalized Materials |
| JP2020519276A (ja) | 2017-05-15 | 2020-07-02 | ブリティッシュ アメリカン タバコ （インヴェストメンツ） リミテッドＢｒｉｔｉｓｈ Ａｍｅｒｉｃａｎ Ｔｏｂａｃｃｏ （Ｉｎｖｅｓｔｍｅｎｔｓ） Ｌｉｍｉｔｅｄ | 液体タバコ抽出物 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US20150083146A1 (en)* | 2013-09-23 | 2015-03-26 | Verso PV, LLC | Personal vaporizer liquid for emulsifying oil-soluble compounds and resins |
- 2021
- 2021-03-03WOPCT/JP2021/008098patent/WO2022185434A1/frnot_activeCeased
- 2021-03-03EPEP21929010.3Apatent/EP4302620A4/fractivePending
- 2021-03-03JPJP2023503588Apatent/JP7543535B2/jaactiveActive
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012133289A1 (fr)* | 2011-03-29 | 2012-10-04 | 日本たばこ産業株式会社 | Produit de tabac de type à aspiration mais sans combustion |
| WO2015046420A1 (fr)* | 2013-09-30 | 2015-04-02 | 日本たばこ産業株式会社 | Inhalateur de saveur sans combustion |
| JP2017518042A (ja)* | 2014-04-28 | 2017-07-06 | バットマーク・リミテッド | エアロゾル形成コンポーネント |
| WO2016178377A1 (fr)* | 2015-05-01 | 2016-11-10 | 日本たばこ産業株式会社 | Inhalateur d'arôme de type sans combustion, unité source de composant d'inhalation d'arôme, et unité d'atomisation |
| US20190124982A1 (en)* | 2016-04-22 | 2019-05-02 | Juul Labs, Inc. | Aerosol Devices Having Compartmentalized Materials |
| JP2020519276A (ja) | 2017-05-15 | 2020-07-02 | ブリティッシュ アメリカン タバコ （インヴェストメンツ） リミテッドＢｒｉｔｉｓｈ Ａｍｅｒｉｃａｎ Ｔｏｂａｃｃｏ （Ｉｎｖｅｓｔｍｅｎｔｓ） Ｌｉｍｉｔｅｄ | 液体タバコ抽出物 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| EP4581944A1 (fr)* | 2024-01-08 | 2025-07-09 | BT DE Investments Inc. | Matériau aérosolisable pour utilisation dans un article |
| WO2025149903A1 (fr)* | 2024-01-08 | 2025-07-17 | BT DE Investments Inc. | Matériau aérosolisable destiné à être utilisé dans un article |
Also Published As
| Publication number | Publication date |
|---|---|
| EP4302620A4 (fr) | 2024-12-18 |
| JPWO2022185434A1 (fr) | 2022-09-09 |
| EP4302620A1 (fr) | 2024-01-10 |
| JP7543535B2 (ja) | 2024-09-02 |
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