
本发明涉及胰岛素注射控制领域,尤其涉及一种无创式血糖仪。The invention relates to the field of insulin injection control, in particular to a non-invasive blood glucose meter.
血糖,指的是血液中所含的葡萄糖。消化后的葡萄糖由小肠进入血液,并被运输到机体中的各个细胞,是细胞的主要能量来源。正常人的血糖浓度相对稳定,落在一个可确定的血糖浓度范围之内。Blood sugar refers to the glucose contained in the blood. Digested glucose enters the bloodstream from the small intestine and is transported to individual cells in the body, which is the main source of energy for the cells. Normal people's blood glucose levels are relatively stable and fall within a determinable range of blood glucose concentrations.
血糖必须保持一定的水平才能维持体内各个器官和组织的需要。血糖浓度一般在进食一到二个小时后升高,而在早餐降到最低。血糖浓度失调会导致多种疾病,持续性血糖浓度过高的高血糖和过低的低血糖都会给人们身体造成严重的影响,而由多种原因导致的持续性高血糖就会引起糖尿病,这也是血糖浓度相关的最显著的疾病。Blood sugar must be maintained at a certain level to maintain the needs of various organs and tissues in the body. Blood glucose levels generally increase after eating for one to two hours, while minimizing breakfast. Unbalanced blood glucose levels can lead to a variety of diseases. Hyperglycemia and excessive hypoglycemia with persistently high blood glucose levels can have serious effects on the body, and persistent hyperglycemia caused by a variety of causes can cause diabetes. It is also the most significant disease associated with blood glucose levels.
现有技术中存在一些检测血糖的医疗仪器,但这些血糖仪都存在以下缺陷:(1)检测模式单一,只能检测血糖浓度;(2)检测机制落后,结构冗余度过高,精度满足不了日趋增加的精度需求;(3)没有血糖检测和胰岛素供给的控制机制,无法根据被测人体的血糖含量自适应调整被测人员的胰岛素的供给参数,例如,供给速度、供给量等,还需要人工观察血糖含量、人工决策胰岛素供给参数,自动化水平落后;(4)无线通信接口匮乏,不能将与血糖相关的各个参数及时反馈到医疗服务器端,即使存在一些简单的无线通信接口,例如蓝牙通信接口,其匹配机制和连接机制效率低下,满足不了医疗器件的高速度传输数据的要求。There are some medical instruments for detecting blood sugar in the prior art, but these blood glucose meters have the following defects: (1) the detection mode is single, and only the blood glucose concentration can be detected; (2) the detection mechanism is backward, the structural redundancy is too high, and the precision is satisfied. There is no increasing demand for precision; (3) there is no control mechanism for blood glucose detection and insulin supply, and it is impossible to adaptively adjust the insulin supply parameters of the test subject according to the blood sugar content of the measured human body, for example, supply speed, supply amount, etc. Manual observation of blood glucose levels, artificial decision-making insulin supply parameters, automation level backward; (4) lack of wireless communication interface, can not timely feedback the various parameters related to blood glucose to the medical server, even if there are some simple wireless communication interfaces, such as Bluetooth The communication interface, its matching mechanism and connection mechanism are inefficient, and can not meet the requirements of high-speed transmission of data of medical devices.
为此,本发明提出了一种无创式血糖仪,能够改善落后的血糖仪的结构,将血氧饱和度检测融入到血糖仪中,拓宽检测的生理参数的范围,提高血糖检测的精度,能够建立血糖自动控制的胰岛素供给体系,减少人工参与,另外,还能够改善现有的蓝牙通信机制,提高无线数据传输的速度和效率。To this end, the present invention proposes a non-invasive blood glucose meter, which can improve the structure of the backward blood glucose meter, integrate blood oxygen saturation detection into the blood glucose meter, broaden the range of physiological parameters detected, and improve the accuracy of blood glucose detection. Establish an insulin supply system with automatic blood glucose control to reduce manual participation. In addition, it can improve the existing Bluetooth communication mechanism and improve the speed and efficiency of wireless data transmission.
发明内容Summary of the invention
为了解决现有技术存在的技术问题,本发明提供了一种无创式血糖仪,将血氧饱和度检测设备和血糖检测设备集中在一个检测仪器内同时工作,优化现有的血糖检测设备的结构,提高血糖检测的精度,同时,加入胰岛素泵和胰岛素供给控制机制,实现血糖浓度的自动控制,尤为重要的是,通过改善现有蓝牙通信接口的匹配机制和连接机制,提高血糖仪器无线连接的通信性能。In order to solve the technical problems existing in the prior art, the present invention provides a non-invasive blood glucose meter, which simultaneously concentrates the blood oxygen saturation detecting device and the blood glucose detecting device in one detecting instrument, and optimizes the structure of the existing blood sugar detecting device. To improve the accuracy of blood glucose detection, at the same time, to add insulin pump and insulin supply control mechanism to achieve automatic control of blood glucose concentration, it is especially important to improve the wireless connection of blood glucose instruments by improving the matching mechanism and connection mechanism of existing Bluetooth communication interfaces. Communication performance.
根据本发明的一方面,提供了一种无创式血糖仪,所述注射平台包括胰岛素自动注射设备、血氧饱和度检测设备、无创式血糖检测设备和DSP处理芯片,所述血氧饱和度检测设备和所述无创式血糖检测设备分别用于提取被测人员的血氧饱和度数据和血糖数据,所述DSP处理芯片与所述胰岛素自动注射设备、所述血氧饱和度检测设备和所述无创式血糖检测设备分别连接,基于所述血氧饱和度数据确定被测人员的血氧供给状态,还基于所述血糖数据确定所述胰岛素自动注射设备的注射参数。According to an aspect of the present invention, a non-invasive blood glucose meter is provided, the injection platform comprising an automatic insulin injection device, a blood oxygen saturation detecting device, a non-invasive blood glucose detecting device, and a DSP processing chip, the blood oxygen saturation detecting The device and the non-invasive blood glucose detecting device are respectively configured to extract blood oxygen saturation data and blood glucose data of the test subject, the DSP processing chip and the automatic insulin injection device, the blood oxygen saturation detecting device, and the The non-invasive blood glucose detecting devices are respectively connected, determine a blood oxygen supply state of the measured person based on the blood oxygen saturation data, and determine an injection parameter of the automatic insulin injection device based on the blood glucose data.
更具体地,在所述无创式血糖仪中,包括:直接数字频率合成器,用于产生频率和相位能够调整的正弦波信号以作为射频频率源用作混频使用;脉冲序列发生器,用于产生脉冲序列;混频器,与所述直接数字频率合成器和所述脉冲序列发生器分别连接,采用脉冲序列对正弦波信号进行混频调制;功率放大器,与所述混频器连接,用于将混频调制后的信号进行放大;开关电源,用作探头与功率放大器之间的接口电路,将放大后的信号加载到探头的射频收发线圈中;钕铁硼永磁型磁体结构,在容纳被测人员手指的空间内产生一个场强均匀的静态磁场;探头,放置在被测人员手指位置,缠绕射频收发线圈以将加载的信号送入所述钕铁硼永磁型磁体结构内,产生核磁共振现象,还用于将经过被测人员手指内氢质子共振后获得的衰减信号送出;发光二极管,设置在被测人员手指指尖毛细血管位置,与光源驱动电路连接,用于基于光源驱动电路发送的发光控制信号,交替发射红外光和红光;光源驱动电路,内置定时器,用于向所述发光二极管发送发光控制信号;光电转换器,设置在被测人员手指指尖上,位于所述发光二极管的相对位置,用于接收透射被测人员手指指尖毛细血管后的红外光和红光,并将透射红外光和透射红光分别转换为模拟电流信号,以获得模拟红外光电流和模拟红光电流;电流电压转换电路,与所述光电转换器连接,用于对模拟红外光电流和模拟红光电流分别进行电流电压转换,以分别获得模拟红外光电压和模拟红光电压;信号放大器,与所述电流电压转换电路连接,用于对模拟红外光电压和模拟红光电压分别进行放大,以获得模拟红外光放大电压和模拟红光放大电压;信号检测电路,与所述信号放大器连接,包括直流信号检测子电路和交流信号检测子电路,用于检测模拟红外光电压中的直流成分和交流成分,以作为第一直流电压和第一交流电压输出,还用于检测模拟红光电压中的直流成分和交流成分,以作为第二直流电压和第二交流电压输出;模数转换器,与所述信号检测电路连接,用于对第一直流电压、第一交流电压、第二直流电压和第二交流电压分别进行模数转换,以获得第一数字化直流电压、第一数字化交流电压、第二数字化直流电压和第二数字化交流电压;血氧饱和度运算电路,与所述模数转换器连接,将第二数字化交流电压与第二数字化直流电压的比值除以第一数字化交流电压与第一数字化直流电压的比值以获得吸收光比值因子,并基于吸收光比值因子计算血氧饱和度,其中,血氧饱和度与吸收光比值因子成线性关系;DSP处理芯片,与所述探头连接,接收所述衰减信号,分析所述衰减信号的谱线,并计算其中葡萄糖所占比例,从而获取被测人员的血糖浓度,所述DSP处理芯片还与血氧饱和度运算电路连接以获得血氧饱和度;所述DSP处理芯片当所述血糖浓度在预设血糖上限浓度时,发出血糖浓度过高识别信号,当所述血糖浓度在预设血糖下限浓度时,发出血糖浓度过低识别信号;当所述血氧饱和度在预设血氧饱和度上限浓度时,发出血氧饱和度过高识别信号,当所述血氧饱和度在预设血氧饱和度下限浓度时,发出血氧饱和度过低识别信号;胰岛素存储设备,用于预先存储预设容量的胰岛素;液位检测设备,位于所述胰岛素存储设备内,用于实时检测胰岛素存储设备内的胰岛素液位,并在胰岛素液位等于或低于预设基准液位时,发出胰岛素不足报警信号,所述液位检测设备还与所述DSP处理芯片连接以将所述胰岛素不足报警信号发送给所述DSP处理芯片;胰岛素驱动设备,与所述DSP处理芯片连接,当接收到所述血糖浓度过高识别信号时,根据所述DSP处理芯片转发的血糖浓度和所述预设血糖上限浓度的差值确定胰岛素泵驱动信号,所述胰岛素泵驱动信号决定了胰岛素泵的供应胰岛素的量值和速度;胰岛素泵,与所述胰岛素存储设备和胰岛素注射设备分别相接,与所述胰岛素驱动设备连接,用于在所述胰岛素驱动设备的控制下,将所述胰岛素存储设备内的胰岛素通过胰岛素注射设备注射到被测人员体内;胰岛素注射设备,可拆卸式埋设在被测人员体内,用于向被测人员注射胰岛素;串口通信电路,位于DSP处理芯片与蓝牙匹配通信设备之间,用于将所述血糖浓度和所述胰岛素不足报警信号发送到蓝牙匹配通信设备;蓝牙匹配通信设备,用于将所述血糖浓度和所述胰岛素不足报警信号无线发送到连接上的目标蓝牙设备;所述蓝牙匹配通信设备包括第一搜索子设备、第二搜索子设备和匹配连接子设备;其中,第一搜索子设备,根据蓝牙散射网中MAC地址浓度确定蓝牙MAC地址浓度最高的蓝牙微微网作为目标微微网,一个蓝牙散射网由多个蓝牙微微网组成;第二搜索子设备,与所述第一搜索子设备连接,在所述目标微微网中,寻找按信号强度排名在前的、数量不大于7的一个或多个蓝牙匹配通信设备作为一个或多个目标蓝牙设备;设备连接子设备,与所述第二搜索子设备连接,启动与所述一个或多个目标蓝牙设备的蓝牙通信连接;其中,所述光电转换器为一光电二极管;其中,所述发光二极管发射的红外光的波长为940nm,所述发光二极管发射的红光的波长为660nm;其中,在所述信号放大器和所述信号检测电路之间还设置信号滤波电路,用于分别滤除模拟红外光放大电压和模拟红光放大电压中的噪声成分;其中,所述探头缠绕的射频收发线圈为鸟笼线圈、螺旋管线圈、鞍状线圈、相控阵列线圈和环状线圈中的一种;其中,直接数字频率合成器所采用的频率合成选用直接数字合成、模拟锁相环和数字锁相环中的一种;其中,当所述目标微微网中有信号的蓝牙匹配通信设备的数量为大于等于7时,所述一个或多个目标蓝牙设备的数量为7个,当所述目标微微网中有信号的蓝牙匹配通信设备的数量为小于7时,所述一个或多个目标蓝牙设备的数量为所述目标微微网中有信号的蓝牙匹配通信设备的数量。More specifically, in the non-invasive blood glucose meter, comprising: a direct digital frequency synthesizer for generating a sine wave signal whose frequency and phase can be adjusted for use as a radio frequency frequency source for mixing; a pulse sequence generator, Generating a pulse sequence; a mixer, respectively connected to the direct digital frequency synthesizer and the pulse sequence generator, mixing a sinusoidal signal by a pulse sequence; a power amplifier connected to the mixer, For amplifying the mixed modulated signal; the switching power supply is used as an interface circuit between the probe and the power amplifier, and the amplified signal is loaded into the RF transceiver coil of the probe; the neodymium iron boron permanent magnet type magnet structure, A static magnetic field having a uniform field strength is generated in a space for accommodating the finger of the test subject; the probe is placed at the finger position of the test subject, and the RF transceiver coil is wound to feed the loaded signal into the NdFeB permanent magnet type magnet structure. , generating nuclear magnetic resonance phenomenon, and also used to send the attenuation signal obtained after the resonance of the protons in the finger of the tested person; the light emitting diode, Placed on the capillary position of the fingertip of the person to be tested, and connected with the light source driving circuit for alternately emitting infrared light and red light based on the light emission control signal sent by the light source driving circuit; the light source driving circuit and the built-in timer for the The light emitting diode sends an illumination control signal; the photoelectric converter is disposed on the fingertip of the test subject at a relative position of the light emitting diode, and is configured to receive infrared light and red light after transmitting the capillary of the fingertip of the test subject And translating the transmitted infrared light and the transmitted red light into an analog current signal to obtain an analog infrared light current and an analog red light current; a current voltage conversion circuit connected to the photoelectric converter for simulating the infrared light current and The analog red light current is respectively subjected to current-voltage conversion to obtain an analog infrared light voltage and an analog red light voltage, respectively; a signal amplifier is connected to the current-voltage conversion circuit for respectively amplifying the analog infrared light voltage and the analog red light voltage To obtain analog infrared light amplification voltage and analog red light amplification voltage; signal detection electricity And connecting to the signal amplifier, comprising a DC signal detecting sub-circuit and an AC signal detecting sub-circuit, for detecting a DC component and an AC component in the analog infrared light voltage, as the first DC voltage and the first AC voltage output, Detecting a DC component and an AC component in the analog red voltage to output as a second DC voltage and a second AC voltage; and an analog to digital converter coupled to the signal detection circuit for using the first DC voltage, An alternating voltage, a second direct current voltage, and a second alternating current voltage are respectively subjected to analog-to-digital conversion to obtain a first digitized direct current voltage, a first digitized alternating current voltage, a second digitized direct current voltage, and a second digitized alternating current voltage; blood oxygen saturation calculation a circuit, coupled to the analog to digital converter, dividing a ratio of the second digitized alternating current voltage to the second digitized direct current voltage by a ratio of the first digitized alternating current voltage to the first digitized direct current voltage to obtain an absorbed light ratio factor, and based on the absorption The light ratio factor calculates the blood oxygen saturation, wherein the blood oxygen saturation and the absorbed light ratio factor are in line a DSP processing chip, connected to the probe, receiving the attenuation signal, analyzing a spectral line of the attenuation signal, and calculating a proportion of glucose therein, thereby obtaining a blood glucose concentration of the measured person, the DSP processing chip Also connected to the blood oxygen saturation computing circuit to obtain blood oxygen saturation; the DSP processing chip emits a blood glucose concentration too high identification signal when the blood glucose concentration is at a preset upper blood glucose concentration concentration, when the blood glucose concentration is preset At the lower blood glucose concentration concentration, the blood glucose concentration is too low to identify the signal; when the blood oxygen saturation is at the preset upper blood oxygen saturation upper limit concentration, the blood oxygen saturation is too high to identify the signal, when the blood oxygen saturation is in advance When the blood oxygen saturation lower limit concentration is set, the blood oxygen saturation low recognition signal is issued; the insulin storage device is configured to pre-store the preset volume of insulin; and the liquid level detecting device is located in the insulin storage device for real-time detection The insulin level in the insulin storage device, and the insulin deficiency alarm signal is issued when the insulin level is equal to or lower than the preset reference level. The liquid level detecting device is further connected to the DSP processing chip to send the insulin deficiency alarm signal to the DSP processing chip; the insulin driving device is connected to the DSP processing chip, and when the blood glucose concentration is too high, the recognition is received. In the signal, determining an insulin pump driving signal according to a difference between the blood glucose concentration forwarded by the DSP processing chip and the preset blood glucose upper limit concentration, the insulin pump driving signal determining the amount and speed of insulin supply by the insulin pump; a pump, respectively connected to the insulin storage device and the insulin injection device, connected to the insulin driving device, forUnder the control of the insulin-driven device, insulin in the insulin storage device is injected into the body of the test subject through the insulin injection device; the insulin injection device is detachably embedded in the body of the test object for injecting insulin into the test subject a serial communication circuit between the DSP processing chip and the Bluetooth matching communication device for transmitting the blood glucose concentration and the insulin deficiency alarm signal to the Bluetooth matching communication device; the Bluetooth matching communication device for using the blood glucose concentration And the insulin deficiency alarm signal is wirelessly transmitted to the connected target Bluetooth device; the Bluetooth matching communication device includes a first search sub-device, a second search sub-device, and a matching connection sub-device; wherein, the first search sub-device, according to The Bluetooth piconet in the Bluetooth scatter network determines the Bluetooth piconet with the highest Bluetooth MAC address concentration as the target piconet, and one Bluetooth scatter network is composed of multiple Bluetooth piconets; the second search sub-device is connected to the first search sub-device. In the target piconet, look for the top ranked by signal strength One or more Bluetooth-matched communication devices having a number of no more than 7 as one or more target Bluetooth devices; the device connection sub-devices, connected to the second search sub-device, initiating Bluetooth with the one or more target Bluetooth devices a communication connection; wherein the photoelectric converter is a photodiode; wherein the light emitting diode emits infrared light having a wavelength of 940 nm, and the light emitting diode emits red light having a wavelength of 660 nm; wherein, the signal amplifier And a signal filtering circuit is further disposed between the signal detecting circuit and the noise component of the simulated infrared light amplifying voltage and the simulated red light amplifying voltage, wherein the RF transmitting and receiving coil wound by the probe is a bird cage coil, One of a spiral coil, a saddle coil, a phased array coil, and a toroidal coil; wherein the frequency synthesis used by the direct digital frequency synthesizer uses one of a direct digital synthesis, an analog phase locked loop, and a digital phase locked loop. Wherein, when the number of Bluetooth-matched communication devices having signals in the target piconet is greater than or equal to 7, the one Or the number of the plurality of target Bluetooth devices is 7. When the number of Bluetooth-matched communication devices having signals in the target piconet is less than 7, the number of the one or more target Bluetooth devices is the target piconet. The number of Bluetooth-matched communication devices with signals in them.
更具体地,在所述无创式血糖仪中:所述DSP处理芯片的内置存储单元预先存储了所述预设血氧饱和度上限浓度、所述预设血氧饱和度下限浓度、所述预设基准液位、所述预设血糖上限浓度和所述预设血糖下限浓度。More specifically, in the non-invasive blood glucose meter, the built-in storage unit of the DSP processing chip pre-stores the preset blood oxygen saturation upper limit concentration, the preset blood oxygen saturation lower limit concentration, and the preset A reference liquid level, the preset blood glucose upper limit concentration, and the preset lower blood glucose lower limit concentration are set.
更具体地,在所述无创式血糖仪中,所述注射平台还包括:CF存储卡,用于预先存储了所述预设血氧饱和度上限浓度、所述预设血氧饱和度下限浓度、所述预设基准液位、所述预设血糖上限浓度和所述预设血糖下限浓度。More specifically, in the non-invasive blood glucose meter, the injection platform further includes: a CF memory card, configured to pre-store the preset blood oxygen saturation upper limit concentration and the preset blood oxygen saturation lower limit concentration And the preset reference liquid level, the preset blood glucose upper limit concentration, and the preset lower blood glucose lower limit concentration.
更具体地,在所述无创式血糖仪中:所述DSP处理芯片在发出血氧饱和度过高识别信号、血氧饱和度过低识别信号、血糖过高识别信号或血糖过低识别信号时,同时发出异常状态信号,否则,所述DSP处理芯片同时发出正常状态信号。More specifically, in the non-invasive blood glucose meter: when the DSP processing chip emits an oxygen saturation high recognition signal, an oxygen saturation low recognition signal, a hyperglycemia recognition signal, or a hypoglycemia recognition signal At the same time, an abnormal state signal is issued. Otherwise, the DSP processing chip simultaneously issues a normal state signal.
更具体地,在所述无创式血糖仪中:所述串口通信电路为RS485串行通信接口。More specifically, in the non-invasive blood glucose meter: the serial communication circuit is an RS485 serial communication interface.
以下将结合附图对本发明的实施方案进行描述,其中:Embodiments of the present invention will be described below with reference to the accompanying drawings, in which:
图1为本发明的无创式血糖仪的第一实施例的结构方框图。BRIEF DESCRIPTION OF THE DRAWINGS Figure 1 is a block diagram showing the configuration of a first embodiment of a non-invasive blood glucose meter of the present invention.
附图标记:1胰岛素自动注射设备;2血氧饱和度检测设备;3无创式血糖检测设备;4DSP处理芯片LIST OF
下面将参照附图对本发明的无创式血糖仪的实施方案进行详细说明。DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS Hereinafter, embodiments of the non-invasive blood glucose meter of the present invention will be described in detail with reference to the accompanying drawings.
血液中的糖称为血糖,绝大多数情况下都是葡萄糖。体内各组织细胞活动所需的能量大部分来自葡萄糖,所以血糖必须保持在一定水平才能维持体内各器官和组织的需求。The sugar in the blood is called blood sugar, and in most cases it is glucose. Most of the energy required for cell activity in various tissues in the body comes from glucose, so blood sugar must be kept at a certain level to maintain the needs of various organs and tissues in the body.
人体中的血糖的浓度通常被控制在一个很窄的范围内,血糖过高或过低都会给人们造成一定的影响。为了有效检测人体内的血糖浓度,市面上出现了多种血糖仪,尤其为患有高血压的病人所青睐。The concentration of blood sugar in the human body is usually controlled to a very narrow range, and blood sugar too high or too low will have a certain impact on people. In order to effectively detect blood sugar levels in the human body, a variety of blood glucose meters have appeared on the market, especially for patients with high blood pressure.
然而,现有技术中的血糖仪检测参数单一、检测机制落后,缺乏血糖检测和胰岛素供给的自动控制机制,同时,配有的无线通信接口匹配和连接效率低下,已经满足不了医院和病人的现有要求。However, the prior art blood glucose meter has a single detection parameter, a backward detection mechanism, and lacks an automatic control mechanism for blood glucose detection and insulin supply. At the same time, the wireless communication interface is matched and the connection efficiency is low, and the hospital and the patient cannot be satisfied. request.
为此,本发明搭建了一种无创式血糖仪,将经过结构优化的高精度的血氧饱和度监控设备和血糖监控设备集成在一个检测仪器中,同时采用血糖检测和胰岛素供给的自动控制模式以及优化后的蓝牙通信接口,从而方便病人和医院的使用。To this end, the present invention establishes a non-invasive blood glucose meter, which integrates a structure-optimized high-precision blood oxygen saturation monitoring device and a blood glucose monitoring device into a detecting instrument, and adopts an automatic control mode of blood glucose detecting and insulin supply. And an optimized Bluetooth communication interface to facilitate patient and hospital use.
图1为本发明的无创式血糖仪的第一实施例的结构方框图,所述注射平台包括胰岛素自动注射设备、血氧饱和度检测设备、无创式血糖检测设备和DSP处理芯片,所述血氧饱和度检测设备和所述无创式血糖检测设备分别用于提取被测人员的血氧饱和度数据和血糖数据,所述DSP处理芯片与所述胰岛素自动注射设备、所述血氧饱和度检测设备和所述无创式血糖检测设备分别连接,基于所述血氧饱和度数据确定被测人员的血氧供给状态,还基于所述血糖数据确定所述胰岛素自动注射设备的注射参数。1 is a structural block diagram of a first embodiment of a non-invasive blood glucose meter according to the present invention, the injection platform including an automatic insulin injection device, a blood oxygen saturation detecting device, a non-invasive blood glucose detecting device, and a DSP processing chip, the blood oxygen The saturation detecting device and the non-invasive blood glucose detecting device are respectively configured to extract blood oxygen saturation data and blood glucose data of the test subject, the DSP processing chip and the automatic insulin injection device, and the blood oxygen saturation detecting device And the non-invasive blood glucose detecting device is respectively connected, determining a blood oxygen supply state of the tested person based on the blood oxygen saturation data, and determining an injection parameter of the automatic insulin injection device based on the blood glucose data.
接着,继续对本发明的无创式血糖仪的第二实施例的具体结构进行进一步的说明。Next, the specific structure of the second embodiment of the non-invasive blood glucose meter of the present invention will be further described.
所述注射平台包括:直接数字频率合成器,用于产生频率和相位能够调整的正弦波信号以作为射频频率源用作混频使用;脉冲序列发生器,用于产生脉冲序列;混频器,与所述直接数字频率合成器和所述脉冲序列发生器分别连接,采用脉冲序列对正弦波信号进行混频调制;功率放大器,与所述混频器连接,用于将混频调制后的信号进行放大。The injection platform includes: a direct digital frequency synthesizer for generating a sine wave signal whose frequency and phase can be adjusted for use as a frequency mixing source for mixing; a pulse sequence generator for generating a pulse sequence; a mixer, Connecting the direct digital frequency synthesizer and the pulse sequence generator respectively, mixing the sinusoidal signal by using a pulse sequence; and a power amplifier connected to the mixer for mixing the mixed modulated signal Zoom in.
所述注射平台包括:开关电源,用作探头与功率放大器之间的接口电路,将放大后的信号加载到探头的射频收发线圈中;钕铁硼永磁型磁体结构,在容纳被测人员手指的空间内产生一个场强均匀的静态磁场;探头,放置在被测人员手指位置,缠绕射频收发线圈以将加载的信号送入所述钕铁硼永磁型磁体结构内,产生核磁共振现象,还用于将经过被测人员手指内氢质子共振后获得的衰减信号送出;发光二极管,设置在被测人员手指指尖毛细血管位置,与光源驱动电路连接,用于基于光源驱动电路发送的发光控制信号,交替发射红外光和红光。The injection platform comprises: a switching power supply, which is used as an interface circuit between the probe and the power amplifier, and loads the amplified signal into the RF transceiver coil of the probe; the NdFeB permanent magnet type magnet structure accommodates the finger of the test subject a static magnetic field with uniform field strength is generated in the space; the probe is placed at the finger position of the tested person, and the RF transceiver coil is wound to send the loaded signal into the NdFeB permanent magnet type magnet structure to generate a nuclear magnetic resonance phenomenon. It is also used to send the attenuation signal obtained by the resonance of the protons in the finger of the tested person; the light-emitting diode is disposed at the capillary position of the fingertip of the person to be tested, and is connected with the light source driving circuit for emitting light based on the light source driving circuit. The control signal alternately emits infrared light and red light.
所述注射平台包括:光源驱动电路,内置定时器,用于向所述发光二极管发送发光控制信号;光电转换器,设置在被测人员手指指尖上,位于所述发光二极管的相对位置,用于接收透射被测人员手指指尖毛细血管后的红外光和红光,并将透射红外光和透射红光分别转换为模拟电流信号,以获得模拟红外光电流和模拟红光电流;电流电压转换电路,与所述光电转换器连接,用于对模拟红外光电流和模拟红光电流分别进行电流电压转换,以分别获得模拟红外光电压和模拟红光电压。The injection platform includes: a light source driving circuit, a built-in timer for transmitting a light emission control signal to the light emitting diode; and a photoelectric converter disposed on a fingertip of the measured person's finger at a relative position of the light emitting diode, Receiving infrared light and red light after transmitting the fingertip finger capillary of the test subject, and converting the transmitted infrared light and the transmitted red light into an analog current signal respectively to obtain an analog infrared light current and an analog red light current; current voltage conversion And a circuit connected to the photoelectric converter for respectively performing current-voltage conversion on the analog infrared photocurrent and the analog red photocurrent to obtain an analog infrared photovoltage and an analog red photovoltage, respectively.
所述注射平台包括:信号放大器,与所述电流电压转换电路连接,用于对模拟红外光电压和模拟红光电压分别进行放大,以获得模拟红外光放大电压和模拟红光放大电压;信号检测电路,与所述信号放大器连接,包括直流信号检测子电路和交流信号检测子电路,用于检测模拟红外光电压中的直流成分和交流成分,以作为第一直流电压和第一交流电压输出,还用于检测模拟红光电压中的直流成分和交流成分,以作为第二直流电压和第二交流电压输出。The injection platform includes: a signal amplifier connected to the current voltage conversion circuit for respectively amplifying the analog infrared light voltage and the analog red light voltage to obtain an analog infrared light amplification voltage and an analog red light amplification voltage;a signal detecting circuit, coupled to the signal amplifier, comprising a DC signal detecting sub-circuit and an AC signal detecting sub-circuit for detecting a DC component and an AC component in the analog infrared light voltage as the first DC voltage and the first AC voltage The output is also used to detect the DC component and the AC component in the analog red voltage to output as the second DC voltage and the second AC voltage.
所述注射平台包括:模数转换器,与所述信号检测电路连接,用于对第一直流电压、第一交流电压、第二直流电压和第二交流电压分别进行模数转换,以获得第一数字化直流电压、第一数字化交流电压、第二数字化直流电压和第二数字化交流电压;血氧饱和度运算电路,与所述模数转换器连接,将第二数字化交流电压与第二数字化直流电压的比值除以第一数字化交流电压与第一数字化直流电压的比值以获得吸收光比值因子,并基于吸收光比值因子计算血氧饱和度,其中,血氧饱和度与吸收光比值因子成线性关系。The injection platform includes: an analog-to-digital converter connected to the signal detecting circuit, configured to perform analog-to-digital conversion on the first direct current voltage, the first alternating current voltage, the second direct current voltage, and the second alternating current voltage respectively to obtain the first a digitized DC voltage, a first digitized alternating current voltage, a second digitized direct current voltage, and a second digitized alternating current voltage; a blood oxygen saturation computing circuit coupled to the analog to digital converter to convert the second digitized alternating current voltage to the second digitized direct current The ratio of the voltage is divided by the ratio of the first digitized alternating current voltage to the first digitized direct current voltage to obtain an absorbed light ratio factor, and the blood oxygen saturation is calculated based on the absorbed light ratio factor, wherein the blood oxygen saturation and the absorbed light ratio factor are linear relationship.
所述注射平台包括:DSP处理芯片,与所述探头连接,接收所述衰减信号,分析所述衰减信号的谱线,并计算其中葡萄糖所占比例,从而获取被测人员的血糖浓度,所述DSP处理芯片还与血氧饱和度运算电路连接以获得血氧饱和度;所述DSP处理芯片当所述血糖浓度在预设血糖上限浓度时,发出血糖浓度过高识别信号,当所述血糖浓度在预设血糖下限浓度时,发出血糖浓度过低识别信号;当所述血氧饱和度在预设血氧饱和度上限浓度时,发出血氧饱和度过高识别信号,当所述血氧饱和度在预设血氧饱和度下限浓度时,发出血氧饱和度过低识别信号。The injection platform includes: a DSP processing chip connected to the probe, receiving the attenuation signal, analyzing a spectral line of the attenuation signal, and calculating a proportion of glucose therein, thereby obtaining a blood glucose concentration of the measured person, The DSP processing chip is further connected to the blood oxygen saturation computing circuit to obtain blood oxygen saturation; the DSP processing chip emits an excessive blood glucose concentration identification signal when the blood glucose concentration is at a preset upper blood glucose concentration concentration, when the blood glucose concentration is When the blood glucose lower limit concentration is preset, the blood glucose concentration is too low to identify the signal; when the blood oxygen saturation is at the preset upper blood oxygen saturation upper limit concentration, the blood oxygen saturation is too high to identify the signal, when the blood oxygen saturation When the concentration of the lower limit of blood oxygen saturation is preset, the oxygen oxygen saturation low recognition signal is issued.
所述注射平台包括:胰岛素存储设备,用于预先存储预设容量的胰岛素;液位检测设备,位于所述胰岛素存储设备内,用于实时检测胰岛素存储设备内的胰岛素液位,并在胰岛素液位等于或低于预设基准液位时,发出胰岛素不足报警信号,所述液位检测设备还与所述DSP处理芯片连接以将所述胰岛素不足报警信号发送给所述DSP处理芯片。The injection platform includes: an insulin storage device for pre-storing a preset volume of insulin; a liquid level detecting device located in the insulin storage device for detecting an insulin liquid level in the insulin storage device in real time, and in the insulin liquid When the bit is equal to or lower than the preset reference level, an insulin deficiency alarm signal is issued, and the liquid level detecting device is further connected to the DSP processing chip to transmit the insulin deficiency alarm signal to the DSP processing chip.
所述注射平台包括:胰岛素驱动设备,与所述DSP处理芯片连接,当接收到所述血糖浓度过高识别信号时,根据所述DSP处理芯片转发的血糖浓度和所述预设血糖上限浓度的差值确定胰岛素泵驱动信号,所述胰岛素泵驱动信号决定了胰岛素泵的供应胰岛素的量值和速度;胰岛素泵,与所述胰岛素存储设备和胰岛素注射设备分别相接,与所述胰岛素驱动设备连接,用于在所述胰岛素驱动设备的控制下,将所述胰岛素存储设备内的胰岛素通过胰岛素注射设备注射到被测人员体内。The injection platform includes: an insulin driving device, connected to the DSP processing chip, when receiving the blood glucose concentration excessively high identification signal, according to the blood glucose concentration forwarded by the DSP processing chip and the preset blood glucose upper limit concentration The difference determines an insulin pump drive signal that determines the magnitude and speed of insulin supply to the insulin pump; an insulin pump that interfaces with the insulin storage device and the insulin injection device, respectively, with the insulin drive device Connected for injecting insulin in the insulin storage device into the subject by the insulin injection device under the control of the insulin-driven device.
所述注射平台包括:胰岛素注射设备,可拆卸式埋设在被测人员体内,用于向被测人员注射胰岛素。The injection platform comprises: an insulin injection device, which is detachably embedded in the body of the test object for injecting insulin into the test subject.
所述注射平台包括:串口通信电路,位于DSP处理芯片与蓝牙匹配通信设备之间,用于将所述血糖浓度和所述胰岛素不足报警信号发送到蓝牙匹配通信设备。The injection platform includes a serial communication circuit between the DSP processing chip and the Bluetooth matching communication device for transmitting the blood glucose concentration and the insulin deficiency alarm signal to the Bluetooth matching communication device.
所述注射平台包括:蓝牙匹配通信设备,用于将所述血糖浓度和所述胰岛素不足报警信号无线发送到连接上的目标蓝牙设备;所述蓝牙匹配通信设备包括第一搜索子设备、第二搜索子设备和匹配连接子设备;其中,第一搜索子设备,根据蓝牙散射网中MAC地址浓度确定蓝牙MAC地址浓度最高的蓝牙微微网作为目标微微网,一个蓝牙散射网由多个蓝牙微微网组成;第二搜索子设备,与所述第一搜索子设备连接,在所述目标微微网中,寻找按信号强度排名在前的、数量不大于7的一个或多个蓝牙匹配通信设备作为一个或多个目标蓝牙设备;设备连接子设备,与所述第二搜索子设备连接,启动与所述一个或多个目标蓝牙设备的蓝牙通信连接;其中,所述光电转换器为一光电二极管。The injection platform includes: a Bluetooth matching communication device, configured to wirelessly transmit the blood glucose concentration and the insulin deficiency alarm signal to a connected target Bluetooth device; the Bluetooth matching communication device includes a first search sub-device, and a second Searching for the child device and the matching connection sub-device; wherein, the first search sub-device determines the Bluetooth piconet with the highest Bluetooth MAC address concentration as the target piconet according to the MAC address concentration in the Bluetooth scatter network, and one Bluetooth scatter network is composed of multiple Bluetooth piconets a second search sub-device connected to the first search sub-device, in the target piconet, searching for one or more Bluetooth-matched communication devices with a quantity of not more than 7 ranked first by signal strength as one Or a plurality of target Bluetooth devices; the device connection sub-devices, connected to the second search sub-device, initiate a Bluetooth communication connection with the one or more target Bluetooth devices; wherein the photoelectric converter is a photodiode.
其中,所述发光二极管发射的红外光的波长为940nm,所述发光二极管发射的红光的波长为660nm;其中,在所述信号放大器和所述信号检测电路之间还设置信号滤波电路,用于分别滤除模拟红外光放大电压和模拟红光放大电压中的噪声成分;其中,所述探头缠绕的射频收发线圈为鸟笼线圈、螺旋管线圈、鞍状线圈、相控阵列线圈和环状线圈中的一种;其中,直接数字频率合成器所采用的频率合成选用直接数字合成、模拟锁相环和数字锁相环中的一种。Wherein, the wavelength of the infrared light emitted by the light emitting diode is 940 nm, and the wavelength of the red light emitted by the light emitting diode is 660 nm; wherein a signal filtering circuit is further disposed between the signal amplifier and the signal detecting circuit, Filtering the noise components in the simulated infrared light amplification voltage and the analog red light amplification voltage respectively; wherein the RF winding and transmitting coils of the probe are a bird cage coil, a spiral tube coil, a saddle coil, a phased array coil, and a ring One of the coils; wherein the frequency synthesis used by the direct digital frequency synthesizer uses one of a direct digital synthesis, an analog phase locked loop, and a digital phase locked loop.
其中,当所述目标微微网中有信号的蓝牙匹配通信设备的数量为大于等于7时,所述一个或多个目标蓝牙设备的数量为7个,当所述目标微微网中有信号的蓝牙匹配通信设备的数量为小于7时,所述一个或多个目标蓝牙设备的数量为所述目标微微网中有信号的蓝牙匹配通信设备的数量。Wherein, when the number of Bluetooth-matched communication devices having signals in the target piconet is greater than or equal to 7, the number of the one or more target Bluetooth devices is 7, when there is a signal Bluetooth in the target piconet When the number of matching communication devices is less than 7, the number of the one or more target Bluetooth devices is the number of Bluetooth-matched communication devices having signals in the target piconet.
可选地,在所述注射平台中:所述DSP处理芯片的内置存储单元预先存储了所述预设血氧饱和度上限浓度、所述预设血氧饱和度下限浓度、所述预设基准液位、所述预设血糖上限浓度和所述预设血糖下限浓度;所述注射平台还包括:CF存储卡,用于预先存储了所述预设血氧饱和度上限浓度、所述预设血氧饱和度下限浓度、所述预设基准液位、所述预设血糖上限浓度和所述预设血糖下限浓度;所述DSP处理芯片在发出血氧饱和度过高识别信号、血氧饱和度过低识别信号、血糖过高识别信号或血糖过低识别信号时,同时发出异常状态信号,否则,所述DSP处理芯片同时发出正常状态信号;所述串口通信电路为RS485串行通信接口。Optionally, in the injection platform, the built-in storage unit of the DSP processing chip pre-stores the preset blood oxygen saturation upper limit concentration, the preset blood oxygen saturation lower limit concentration, and the preset reference a liquid level, the preset blood glucose upper limit concentration, and the preset lower blood sugar lower limit concentration; the injection platform further includes: a CF memory card, configured to pre-store the preset blood oxygen saturation upper limit concentration, the preset a blood oxygen saturation lower limit concentration, the preset reference liquid level, the preset blood glucose upper limit concentration, and the preset lower blood glucose lower limit concentration; the DSP processing chip emits an oxygen saturation high recognition signal, and blood oxygen saturation When the low recognition signal, the hyperglycemia recognition signal or the hypoglycemia identification signal is passed, the abnormal state signal is simultaneously issued. Otherwise, the DSP processing chip simultaneously issues a normal state signal; the serial communication circuit is an RS485 serial communication interface.
另外,DSP芯片,也称数字信号处理器,是一种特别适合于进行数字信号处理运算的微处理器,其主要应用是实时快速地实现各种数字信号处理算法。In addition, the DSP chip, also known as the digital signal processor, is a microprocessor that is particularly suitable for digital signal processing operations. Its main application is to implement various digital signal processing algorithms in real time and quickly.
根据数字信号处理的要求,DSP芯片一般具有如下主要特点:(1)在一个指令周期内可完成一次乘法和一次加法;(2)程序和数据空间分开,可以同时访问指令和数据;(3)片内具有快速RAM,通常可通过独立的数据总线在两块中同时访问;(4)具有低开销或无开销循环及跳转的硬件支持;(5)快速的中断处理和硬件I/O支持;(6)具有在单周期内操作的多个硬件地址产生器;(7)可以并行执行多个操作;(8)支持流水线操作,使取指、译码和执行等操作可以重叠执行。According to the requirements of digital signal processing, DSP chips generally have the following main features: (1) one multiplication and one addition can be completed in one instruction cycle; (2) the program and data space are separated, and instructions and data can be accessed simultaneously; (3) On-chip fast RAM, usually accessible in two blocks over a separate data bus; (4) hardware support with low or no overhead loops and jumps; (5) fast interrupt handling and hardware I/O support (6) having a plurality of hardware address generators operating in a single cycle; (7) performing multiple operations in parallel; (8) supporting pipeline operations such that operations such as fetching, decoding, and execution can be performed in an overlapping manner.
采用本发明的无创式血糖仪,针对现有技术中血糖仪器结构落后且无线通信功能差的技术问题,优化现有的血糖仪器的结构,加入血氧检测设备和血糖浓度自动控制设备,同时还提高现有蓝牙通信接口的通信性能,从而提高医疗检测仪器的智能化程度。The non-invasive blood glucose meter of the invention is used to optimize the structure of the existing blood glucose instrument, and to add the blood oxygen detecting device and the blood sugar concentration automatic control device, in view of the technical problems of the prior art blood glucose instrument structure and poor wireless communication function. Improve the communication performance of the existing Bluetooth communication interface, thereby improving the intelligence of the medical detection instrument.
可以理解的是,虽然本发明已以较佳实施例披露如上,然而上述实施例并非用以限定本发明。对于任何熟悉本领域的技术人员而言,在不脱离本发明技术方案范围情况下,都可利用上述揭示的技术内容对本发明技术方案做出许多可能的变动和修饰,或修改为等同变化的等效实施例。因此,凡是未脱离本发明技术方案的内容,依据本发明的技术实质对以上实施例所做的任何简单修改、等同变化及修饰,均仍属于本发明技术方案保护的范围内。It is to be understood that while the invention has been described above in the preferred embodiments, the embodiments are not intended to limit the invention. For those skilled in the art, many possible variations and modifications may be made to the technical solutions of the present invention, or modified to equivalent changes, etc., without departing from the scope of the present invention. Effective embodiment. Therefore, any simple modifications, equivalent changes, and modifications of the above embodiments may be made without departing from the spirit and scope of the invention.
| Application Number | Priority Date | Filing Date | Title |
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| CN201680035616.XACN107949326A (en) | 2015-11-05 | 2016-08-19 | Non-invasive blood glucose meter |
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| CN201510749831.3 | 2015-11-05 | ||
| CN201510749831.3ACN105193426B (en) | 2015-11-05 | 2015-11-05 | Non-invasive blood glucose meter |
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| WO2017076104A1true WO2017076104A1 (en) | 2017-05-11 |
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| PCT/CN2016/096038CeasedWO2017076104A1 (en) | 2015-11-05 | 2016-08-19 | Noninvasive blood sugar meter |
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| WO (1) | WO2017076104A1 (en) |
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