WO2016039333A1 - Dispositif de piqûre - Google Patents
Dispositif de piqûreDownload PDFInfo
- Publication number
- WO2016039333A1 WO2016039333A1PCT/JP2015/075453JP2015075453WWO2016039333A1WO 2016039333 A1WO2016039333 A1WO 2016039333A1JP 2015075453 WJP2015075453 WJP 2015075453WWO 2016039333 A1WO2016039333 A1WO 2016039333A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- blade
- puncture device
- blade portion
- base
- view
- Prior art date
Links
- 239000003814drugSubstances0.000claimsdescription56
- 229940079593drugDrugs0.000claimsdescription40
- 229910052751metalInorganic materials0.000claimsdescription10
- 239000002184metalSubstances0.000claimsdescription10
- 229920003002synthetic resinPolymers0.000claimsdescription5
- 239000000057synthetic resinSubstances0.000claimsdescription5
- 229920006167biodegradable resinPolymers0.000claimsdescription3
- 229920000747poly(lactic acid)Polymers0.000claimsdescription3
- 239000004626polylactic acidSubstances0.000claimsdescription3
- 230000003014reinforcing effectEffects0.000claims1
- 210000003491skinAnatomy0.000description33
- 238000012986modificationMethods0.000description9
- 230000004048modificationEffects0.000description9
- 239000000126substanceSubstances0.000description7
- 239000000243solutionSubstances0.000description5
- PXHVJJICTQNCMI-UHFFFAOYSA-NNickelChemical compound[Ni]PXHVJJICTQNCMI-UHFFFAOYSA-N0.000description4
- 230000000694effectsEffects0.000description4
- 230000000149penetrating effectEffects0.000description4
- 238000007747platingMethods0.000description4
- VYZAMTAEIAYCRO-UHFFFAOYSA-NChromiumChemical compound[Cr]VYZAMTAEIAYCRO-UHFFFAOYSA-N0.000description3
- PCHJSUWPFVWCPO-UHFFFAOYSA-NgoldChemical compound[Au]PCHJSUWPFVWCPO-UHFFFAOYSA-N0.000description3
- 229910052737goldInorganic materials0.000description3
- 239000010931goldSubstances0.000description3
- 241000251730ChondrichthyesSpecies0.000description2
- 239000003795chemical substances by applicationSubstances0.000description2
- 238000001746injection mouldingMethods0.000description2
- 229910052759nickelInorganic materials0.000description2
- 230000035515penetrationEffects0.000description2
- 239000004033plasticSubstances0.000description2
- 229920003023plasticPolymers0.000description2
- BASFCYQUMIYNBI-UHFFFAOYSA-NplatinumChemical compound[Pt]BASFCYQUMIYNBI-UHFFFAOYSA-N0.000description2
- 229910001220stainless steelInorganic materials0.000description2
- 239000010935stainless steelSubstances0.000description2
- 210000000434stratum corneumAnatomy0.000description2
- 229920005992thermoplastic resinPolymers0.000description2
- 101000856746Bos taurus Cytochrome c oxidase subunit 7A1, mitochondrialProteins0.000description1
- BQCADISMDOOEFD-UHFFFAOYSA-NSilverChemical compound[Ag]BQCADISMDOOEFD-UHFFFAOYSA-N0.000description1
- RTAQQCXQSZGOHL-UHFFFAOYSA-NTitaniumChemical compound[Ti]RTAQQCXQSZGOHL-UHFFFAOYSA-N0.000description1
- 238000010521absorption reactionMethods0.000description1
- 239000000919ceramicSubstances0.000description1
- 229910017052cobaltInorganic materials0.000description1
- 239000010941cobaltSubstances0.000description1
- GUTLYIVDDKVIGB-UHFFFAOYSA-Ncobalt atomChemical compound[Co]GUTLYIVDDKVIGB-UHFFFAOYSA-N0.000description1
- WDHWFGNRFMPTQS-UHFFFAOYSA-Ncobalt tinChemical compound[Co].[Sn]WDHWFGNRFMPTQS-UHFFFAOYSA-N0.000description1
- 238000002347injectionMethods0.000description1
- 239000007924injectionSubstances0.000description1
- 150000002739metalsChemical class0.000description1
- 239000000203mixtureSubstances0.000description1
- 230000002093peripheral effectEffects0.000description1
- 239000012466permeateSubstances0.000description1
- 229910052697platinumInorganic materials0.000description1
- 229910052703rhodiumInorganic materials0.000description1
- 239000010948rhodiumSubstances0.000description1
- MHOVAHRLVXNVSD-UHFFFAOYSA-Nrhodium atomChemical compound[Rh]MHOVAHRLVXNVSD-UHFFFAOYSA-N0.000description1
- 229910052709silverInorganic materials0.000description1
- 239000004332silverSubstances0.000description1
- 238000004513sizingMethods0.000description1
- 229910052719titaniumInorganic materials0.000description1
- 239000010936titaniumSubstances0.000description1
Images
Classifications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
Definitions
- the present inventionrelates to a puncture device, and relates to a puncture device used for transdermally administering a drug.
- a puncture deviceAs a puncture device, there is disclosed a microneedle device that includes a plurality of fine needles that can puncture the skin and that can administer a drug non-invasively.
- the microneedle deviceadministers a drug transcutaneously by puncturing the stratum corneum, which is the outermost layer of the skin, with a fine needle.
- Various sizes and shapes of microneedleshave been proposed to promote percutaneous absorption of drugs (for example, Patent Document 1).
- Patent Document 1discloses a fine needle having a cone shape or a knife shape. It is disclosed that the fine needle can be formed of metal, ceramic, or plastic.
- the tip of the fine needle disclosed in Patent Document 1is thin, for example, when it is formed of plastic, the tip is deformed when pressed against the skin, and the skin is punctured to such an extent that a drug can be administered. There is a problem that can not be.
- an object of the present inventionis to provide a puncture device that can puncture the skin more reliably.
- the puncture devicecomprises a base and a plurality of blades formed on the base, wherein the blades are flat and the tip is formed in a mountain shape. .
- the blade portionis flat, it is less likely to be deformed than the needle shape, and the tip portion is formed in a mountain shape, so that it is easily pierced into the skin.
- the blade portioncan be cut in the skin by being moved in the longitudinal direction of the needle teeth while being pressed against the skin and applied with a force in one direction. Therefore, the puncture device can puncture the skin more reliably by including a plurality of blade portions that can cut the skin.
- FIG. 2Ais a front view
- FIG. 2Bis a top view
- FIG. 2Cis a side view.
- FIG. 3Ais a front view
- FIG. 3Bis a top view
- FIG. 3Cis a side view.
- FIG. 4Ais a front view
- FIG. 4Bis a top view
- FIG. 4Cis IVC sectional drawing of FIG.
- FIG. 5Ais a front view
- FIG. 5Bis a top view
- FIG. 5Cis VC sectional drawing of FIG.
- FIG. 6Ais a top view
- FIG. 6Bis a X arrow directional view
- FIG. 6Cis VIC sectional drawing of FIG.
- FIG. 7Ais a front view
- FIG. 7Bis a top view
- FIG. 7Cis a side view.
- FIG. 8Ais a front view
- FIG. 8Bis a top view
- FIG. 8Cis VIIIC sectional drawing of FIG.
- FIG. 9Ais a front view
- FIG. 9Bis a top view
- FIG. 9Cis a side view.
- a puncture device 10 shown in FIG. 1includes a base portion 12 and a puncture portion 14 and is formed of a synthetic resin, for example, a thermoplastic resin.
- the base 12 shown in this figureis formed in a disk shape.
- a puncture portion 14is formed on one side surface of the base portion 12.
- the puncture device 10may be formed with a flow path 18 for guiding a drug.
- the flow path 18is configured by a hole penetrating in the thickness direction of the base portion 12.
- the puncture unit 14includes a plurality of blade portions 16A.
- the puncture part 14may form a metal film on the surface in order to improve mechanical strength.
- the blade portion 16Ais flat, and the front end portion 17 is formed in a mountain shape in a front view.
- the blade portion 16Ahas a tip portion 17 that is gently curved in a front view, expands in the width direction toward the proximal end, and is formed in a mountain shape like a shark's teeth as a whole. ing.
- the blade portion 16Ahas a substantially elliptical shape in plan view.
- the blade portion 16Ahas a thick base end and a tapered shape from the base end toward the front end in a side view. 16 A of blade parts shown to this figure have a shape similar to the side surface of a clam in side view.
- the blade portion 16A formed in this wayis arranged on the base portion 12 with the direction of the distal end portion 17 aligned (the arrow direction in FIG. 2B) to form the puncture portion 14 (FIG. 1). .
- the puncture device 10can be produced by general injection molding.
- the mold(not shown) is preferably formed by combining a plurality of molds in accordance with the shape of the puncture device 10.
- the blade portion 16Acan be formed by a die that is divided into two in the thickness direction. Then, after the molten thermoplastic resin is poured into the mold and held for a predetermined time, the puncture device 10 can be obtained by opening the mold.
- the puncture device 10configured as described above is attached to a device (not shown) in which the other side of the base 12 holds a medicine. Then, the puncture unit 14 is brought into contact with the skin and is slid in one direction, for example, left and right (in the direction of the arrow in FIG. 2B) while being pressed in the longitudinal direction. Then, the puncture unit 14 punctures the stratum corneum of the skin. Thereby, the medicine guided from the other surface of the base 12 to the one surface through the flow path 18 formed in the base 12 is transcutaneously administered through the cut of the skin cut by the puncture unit 14.
- the blade portion 16A constituting the puncture portion 14is flat, and the distal end portion 17 is formed in a mountain shape in front view. Easy to bite into.
- the blade portion 16Acan cut the skin by applying a force in one direction while being pressed against the skin. Therefore, the puncture device 10 can puncture the skin more reliably by including the puncture portion 14 including the plurality of blade portions 16A that can cut the skin.
- the blade portion 16Ahas a thick base end in a side view and is formed in a tapered shape from the base end toward the front end, so that the front end is deformed when pressed against the skin. Can be suppressed.
- the blade part according to the present embodimentis different from the first embodiment in that a drug penetrating part is formed.
- the blade part according to the present embodimentwill be described with reference to FIG. 3 with the same reference numerals as in FIG.
- the blade portion 16B shown in FIG. 3is flat, the front end portion 17 is formed in a mountain shape in a front view, and a widened portion 20 as a drug permeation portion is provided.
- the widened portion 20is configured by a ridge formed linearly from the proximal end of the blade portion 16B toward the distal end.
- the widened portion 20is formed on both surfaces of the blade portion 16B and substantially at the center in a front view.
- the blade portion 16Bis flat, and when the front end portion 17 is formed in a mountain shape in a front view, the same effect as in the first embodiment can be obtained. Furthermore, the blade portion 16B widens the cut formed in the skin by the widened portion 20 when the skin is cut. The drug penetrates into the skin through the cut surface widened by the blade portion 16B and the widened portion 20. This allows the drug to be administered more efficiently.
- the drug penetrating partis not limited to the widened part 20 and may be constituted by a groove 22 as shown in FIG.
- the groove 22is configured by a groove 22 formed linearly from the base end of the blade portion 16C toward the tip end.
- the grooves 22are formed on both surfaces of the blade portion 16C and substantially at the center when viewed from the front.
- a gapis formed by the groove 22 between the cut end and the blade portion 16C. The drug penetrates into the skin through the gap. This allows the drug to be administered more efficiently.
- the blade portion 16Cmay form a flow path at the base portion at the base end of the groove 22.
- the flow pathis preferably formed by a hole penetrating the base in the thickness direction.
- the blade partcomprises the blade edge
- the puncture portion of the puncture deviceis constituted by the plurality of bladed drug supply bodies. In such a puncture device, the blade portion is fixed to the base portion via the support portion.
- the bladed medicine supply body having a blade portion as a blade edgewill be described with reference to FIG.
- This puncture devicecan be used by attaching it to a syringe or the like to supply a chemical solution like an injection.
- the puncture deviceincludes a through hole for supplying a chemical solution.
- a support portion 38 ⁇ / b> Ais integrally provided at the proximal end of the blade portion 36.
- the bladed medicine supply body 30Acuts the skin with the blade part 36 constituting the blade edge to form a cut end.
- the blade portion 36has substantially the same configuration as the blade portion 16A of the first embodiment.
- the blade part 36is flat, and the front-end
- the blade portion 36has a substantially elliptical shape in plan view.
- the blade portion 36also has a point that the distal end portion 37 is gently curved and expands in the width direction toward the proximal end in a front view, and has a mountain shape like a shark tooth as a whole. It is almost the same as the part 16A.
- the blade part 36comprises the blade edge
- the bladed medicine supply body 30Acan be configured to have the same shape and size as the blade portion 16A as a whole in front view. As will be described later, since the support portion 38A is required to have a certain thickness, the thickness of the bladed drug supply body 30A is larger than that of the blade portion 16A.
- the support portion 38Ais interposed between a base portion (not shown) and the blade portion 36, and supports the blade portion 36. Furthermore, as will be described later, the support portion 38A supplies the medicine guided from the base portion to the blade portion 36 or the cut end.
- the support portion 38Ahas an isosceles trapezoidal shape when viewed from the front. Since the support portion 38 ⁇ / b> A is integrally provided at the base end of the blade portion 36, the upper end of the support portion 38 ⁇ / b> A coincides with the base end of the blade portion 36. Since the through hole 32 is provided inside the support portion 38A, the support portion 38A is required to have a certain thickness. In the present embodiment, the support portion 38A has a bottom surface that is substantially circular in a plan view.
- the through-hole 32is formed inside the support portion 38A so that the medicine can be supplied to the blade portion 36 from the base flow path.
- One end of the through hole 32communicates with the flow path, and the other end of the through hole 32 reaches the blade portion 36. Accordingly, the medicine can be directly guided from the other side surface of the base to the blade portion 36 through the base flow path and the through hole 32 of the support portion 38A.
- the cross-sectional shape in the lateral direction of the through hole 32is not particularly limited, but is substantially circular in the present embodiment.
- the shape of the support portion 38Ais particularly limited as long as the blade portion 36 that is flat and has a mountain-shaped tip portion 37 is integrally provided at the upper end and the through-hole 32 for guiding the drug to the blade portion 36 can be formed inside. It can be configured in any shape.
- a plurality of bladed drug supply bodies 30A provided with a support portion 38A provided integrally at the lower end of the blade portion 36 and having the blade portion 36 as a cutting edgeconstitute a puncture portion of the puncture device.
- a puncture device including a plurality of bladed drug supply bodies 30A as a puncture unitcan be manufactured by general injection molding as in the first embodiment.
- the mold(not shown) is preferably formed by combining a plurality of molds so that the support part 38A and the blade part 36 integrated as described above can be formed.
- the bladed drug supplier 30Aincludes a rod for forming the through-hole 32 inside the support portion 38A, and can be formed by a die that is divided into two in the thickness direction.
- the puncture device of this embodimentcan be obtained in the same manner as in the first embodiment except that a predetermined mold is used.
- the blade portion 36is flat and the tip portion 37 is formed in a mountain shape in a front view, so that the same effect as in the first embodiment can be obtained.
- the through-hole 32 inside the support portion 38A in the bladed drug supply body 30Ais provided in communication with a base channel not shown. Since the support portion 38A has the through-hole 32 communicated with the flow path, when the skin is cut by the blade portion 36, the drug enters the through-hole 32 of the support portion 38A from the other side surface of the base through the flow path. Led.
- the medicineis supplied from the open end 34 of the through hole 32 to the blade portion 36 of the blade edge and permeates into the skin from the cut end. Thereby, since a chemical
- the skinis cut by the blade portion 36, by inserting a puncture device, at least a part of the open end 34 of the through-hole 32 in the bladed drug supply body 30A is inserted into the cut end to administer the drug. it can.
- the medicine guided from the other side surface of the base through the flow pathis directly supplied from the open end 34 into the cut end. Therefore, the drug can be administered more efficiently.
- the opening end 34 in the support portion 38Ais not limited to one, and a plurality of opening ends may be provided.
- the open ends 34can be provided on both sides of the support portion 38B with the blade portion 36 interposed therebetween as shown in FIG.
- the support portion 38 ⁇ / b> Bis integrally provided at the base end of the blade portion 36.
- An X arrow view of the bladed medicine supply body 30B provided with such a support portion 38Bis as shown in FIG. 6B.
- the Y arrow view of the bladed drug supplier 30Ais the same as the front view of FIG. 5A.
- the two open ends 34 in the bladed drug supply body 30Bare open ends of a single through hole 32 as shown in the VIC cross-sectional view of FIG. 6C, but may be open ends of separate through holes.
- the presence of the two open ends 34increases the amount of the medicine supplied to the blade 36 through the through hole 32, so that the administration efficiency is further increased.
- the present inventionis not limited to the above-described embodiment, and can be appropriately changed within the scope of the gist of the present invention.
- a substantially semicircular blade portion 16 ⁇ / b> Dmay be used in front view.
- the blade portion 16Dis flat, and the front end portion 17 is formed in a mountain shape in a front view, so that the same effect as in the first embodiment can be obtained.
- the blade portion 16 ⁇ / b> Emay have a saw tooth 24 at the tip portion 17.
- the blade portion 16Ecan cut the skin more efficiently.
- the blade portion 16Fmay include a plate-like base end portion 26 and a tip end portion 28 formed in a mountain shape.
- the blade portion 16Fhas an oval shape in plan view.
- the blade portion 16Fis flat, and when the front end portion 28 is formed in a mountain shape in a front view, the same effect as in the first embodiment can be obtained.
- the blade portion 16Fcan form the tip end portion 28 sharply. Therefore, the blade portion 16F can cut the skin more efficiently.
- the blades 16D to 16F according to the modified examplemay be provided with the drug permeation unit described in the second embodiment. It is also possible to configure the bladed drug supply body by appropriately sizing the blade portions 16D to 16F according to the above modification and integrally providing the support portion shown in the third embodiment at the lower end thereof. Furthermore, it is good also as forming a puncture part combining various blade parts which concern on the said embodiment and modification.
- the central blade portionmay protrude in the distal direction from the peripheral blade portion.
- the puncture portion having such a shapecan be obtained by forming the center of the base portion so as to be convex toward the distal end direction of the blade portion. As a result, the puncture device can form a cut having substantially the same depth with respect to the skin in the entire puncture portion.
- the puncture deviceis formed of a synthetic resin.
- the present inventionis not limited to this, and the puncture device is formed of a metal such as polylactic acid biodegradable resin, stainless steel, titanium, silver, and gold. Also good.
- a metal filmcan be provided on the surface of the blade portion in order to increase the mechanical strength.
- the puncture deviceis formed of metal, a laminated film of different metals may be used. In the metal laminated film, plating with higher strength is provided on the surface in order to further increase the mechanical strength.
- Platingis effective for increasing the strength of a puncture device made of a metal such as stainless steel or a synthetic resin.
- the platingshould be selected from, for example, bright chrome, velor chrome, bright nickel, velor nickel, bright tin cobalt, velor's cobalt, bright gold, velor gold, trivalent chrome, bright noble, velor no broy, rhodium, and platinum plating. Can do.
- the flow pathis a hole formed in the thickness direction of the base
- the present inventionis not limited to this.
- the channel in the first and second embodimentsmay be a groove formed on the side surface of the base.
- the drugis guided from the other surface of the base to the one side surface through the channel formed in the base and is administered transcutaneously, and from the channel formed in the base.
- the percutaneous from the cut endBy being guided to the blade part through the through hole provided in the support part in the bladed drug supply body, or by directly supplying the cut end from the open end of the through hole provided in the support part, the percutaneous from the cut end.
- the present inventionis not limited to this.
- the medicinemay be applied to the blade part in advance, and may be transcutaneously administered through the cut at the same time as the skin is cut.
- the basehas a disk shape
- the present inventionis not limited to this and may be a triangular or quadrangular plate member.
- the blade portionhas been described with respect to the case where the tip portion is gently curved in the front view, but the present invention is not limited to this, and the tip portion may be sharp in the front view.
- the blade portion 46may have a substantially isosceles triangular shape in a side view.
- the blade part 48is good also as having the shape which connected the base end formed thickly and the taper-shaped front-end
- the thickness of the support portions 38A and 38B of the bladed drug solution supply bodies 30A and 30Bis not particularly limited as long as the through holes 32 can be formed inside.
- the blade portion 36may be provided not only at the distal end portion 37 of the bladed chemical solution supply bodies 30A and 30B but also over the entire outer edge of the bladed chemical solution supply bodies 30A and 30B.
- the third embodimentcan be combined with the second embodiment.
- the grooves 22 as shown in FIG. 4may be formed on both surfaces, and the through holes 32 may be provided so as to open inside the grooves 22.
- channel 22can be provided from the height of about 1/3 from the bottom of the base end of bladed chemicals supply body 30A, 30B.
- the angle of the tip in side viewcan be about 15 °.
- the groove 22is not limited to a straight shape, and an angle of about 6 ° may be provided.
- Puncture device 12Base part 14 Puncture part 16A-16F, 36, 46, 48 Blade part 17, 28, 37 Tip part 18 Channel 20 Widening part (drug penetration part) 22 Groove (drug penetration part) 24 sawtooth 26 base end portion 38A, 38B support portion 30A, 30B bladed drug supply body 32 through hole 34 open end
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Medical Informatics (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15/509,486US20170259053A1 (en) | 2014-09-08 | 2015-09-08 | Puncture device |
| EP15840118.2AEP3192557B1 (fr) | 2014-09-08 | 2015-09-08 | Dispositif de piqûre |
| US16/210,457US20190105482A1 (en) | 2014-09-08 | 2018-12-05 | Puncture device |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2014182572 | 2014-09-08 | ||
| JP2014-182572 | 2014-09-08 | ||
| JP2015-175878 | 2015-09-07 | ||
| JP2015175878AJP5967595B2 (ja) | 2014-09-08 | 2015-09-07 | 穿刺器具 |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| US15/509,486A-371-Of-InternationalUS20170259053A1 (en) | 2014-09-08 | 2015-09-08 | Puncture device |
| US16/210,457DivisionUS20190105482A1 (en) | 2014-09-08 | 2018-12-05 | Puncture device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2016039333A1true WO2016039333A1 (fr) | 2016-03-17 |
Family
ID=55459079
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/JP2015/075453WO2016039333A1 (fr) | 2014-09-08 | 2015-09-08 | Dispositif de piqûre |
Country Status (1)
| Country | Link |
|---|---|
| WO (1) | WO2016039333A1 (fr) |
Citations (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5457041A (en)* | 1994-03-25 | 1995-10-10 | Science Applications International Corporation | Needle array and method of introducing biological substances into living cells using the needle array |
| JP2000512529A (ja)* | 1996-06-18 | 2000-09-26 | アルザ コーポレイション | 薬剤の経皮放出又はサンプリングを高めるための装置 |
| JP2003093521A (ja)* | 2001-09-26 | 2003-04-02 | Terumo Corp | 薬剤投与具及び薬剤投与装置 |
| JP2004516868A (ja)* | 2000-10-16 | 2004-06-10 | ザ プロクター アンド ギャンブル カンパニー | 皮膚を介して組成物を皮膚に送達するための微細構造 |
| JP2004526581A (ja)* | 2001-03-14 | 2004-09-02 | ザ プロクター アンド ギャンブル カンパニー | ソフトリソグラフィ及びフォトリソグラフィを使用して微小針（ｍｉｃｒｏｎｅｅｄｌｅｓ）構造を製造する方法 |
| JP2008528192A (ja)* | 2005-01-31 | 2008-07-31 | アルザ コーポレイション | 低い変動性を有するコーティングマイクロプロジェクション、及びその生成法 |
| JP2009502261A (ja)* | 2005-07-25 | 2009-01-29 | ナノテクノロジー ビクトリア ピーティーワイ リミテッド | マイクロアレイデバイス |
| WO2009014805A2 (fr)* | 2007-05-29 | 2009-01-29 | University Of Utah Research Foundation | Réseaux de micro-aiguilles à extrémités non planes et leurs procédés de fabrication |
| JP2009535122A (ja)* | 2006-04-25 | 2009-10-01 | アルザ コーポレイション | 高薬物充填のための造形された微小突起をもつ微小突起アレイ適用 |
| DE102008052702A1 (de)* | 2008-10-22 | 2010-04-29 | Hahn-Schickard-Gesellschaft für angewandte Forschung e.V. | Nadelanordnung, Spritzgussform und Verfahren zum Herstellen |
| JP2012532709A (ja)* | 2009-07-15 | 2012-12-20 | デバイオテック・ソシエテ・アノニム | 多チャンネル・マイクロニードル |
| JP2013513408A (ja)* | 2009-12-11 | 2013-04-22 | キンバリー クラーク ワールドワイド インコーポレイテッド | 経皮送達デバイス |
| JP2014519385A (ja)* | 2011-06-10 | 2014-08-14 | キンバリー クラーク ワールドワイド インコーポレイテッド | マイクロニードルを含む経皮装置 |
- 2015
- 2015-09-08WOPCT/JP2015/075453patent/WO2016039333A1/fractiveApplication Filing
Patent Citations (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5457041A (en)* | 1994-03-25 | 1995-10-10 | Science Applications International Corporation | Needle array and method of introducing biological substances into living cells using the needle array |
| JP2000512529A (ja)* | 1996-06-18 | 2000-09-26 | アルザ コーポレイション | 薬剤の経皮放出又はサンプリングを高めるための装置 |
| JP2004516868A (ja)* | 2000-10-16 | 2004-06-10 | ザ プロクター アンド ギャンブル カンパニー | 皮膚を介して組成物を皮膚に送達するための微細構造 |
| JP2004526581A (ja)* | 2001-03-14 | 2004-09-02 | ザ プロクター アンド ギャンブル カンパニー | ソフトリソグラフィ及びフォトリソグラフィを使用して微小針（ｍｉｃｒｏｎｅｅｄｌｅｓ）構造を製造する方法 |
| JP2003093521A (ja)* | 2001-09-26 | 2003-04-02 | Terumo Corp | 薬剤投与具及び薬剤投与装置 |
| JP2008528192A (ja)* | 2005-01-31 | 2008-07-31 | アルザ コーポレイション | 低い変動性を有するコーティングマイクロプロジェクション、及びその生成法 |
| JP2009502261A (ja)* | 2005-07-25 | 2009-01-29 | ナノテクノロジー ビクトリア ピーティーワイ リミテッド | マイクロアレイデバイス |
| JP2009535122A (ja)* | 2006-04-25 | 2009-10-01 | アルザ コーポレイション | 高薬物充填のための造形された微小突起をもつ微小突起アレイ適用 |
| WO2009014805A2 (fr)* | 2007-05-29 | 2009-01-29 | University Of Utah Research Foundation | Réseaux de micro-aiguilles à extrémités non planes et leurs procédés de fabrication |
| DE102008052702A1 (de)* | 2008-10-22 | 2010-04-29 | Hahn-Schickard-Gesellschaft für angewandte Forschung e.V. | Nadelanordnung, Spritzgussform und Verfahren zum Herstellen |
| JP2012532709A (ja)* | 2009-07-15 | 2012-12-20 | デバイオテック・ソシエテ・アノニム | 多チャンネル・マイクロニードル |
| JP2013513408A (ja)* | 2009-12-11 | 2013-04-22 | キンバリー クラーク ワールドワイド インコーポレイテッド | 経皮送達デバイス |
| JP2014519385A (ja)* | 2011-06-10 | 2014-08-14 | キンバリー クラーク ワールドワイド インコーポレイテッド | マイクロニードルを含む経皮装置 |
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