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WO2010094981A3 - Antibody therapy - Google Patents

Antibody therapy
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Publication number
WO2010094981A3
WO2010094981A3PCT/GB2010/050304GB2010050304WWO2010094981A3WO 2010094981 A3WO2010094981 A3WO 2010094981A3GB 2010050304 WGB2010050304 WGB 2010050304WWO 2010094981 A3WO2010094981 A3WO 2010094981A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
antibody therapy
cathepsin
antibody molecule
antibodies
Prior art date
Application number
PCT/GB2010/050304
Other languages
French (fr)
Other versions
WO2010094981A2 (en
Inventor
Shane Olwill
Richard Buick
Hang Fai Kwok
James Johnston
Christopher Scott
Claire Ward
Original Assignee
Fusion Antibodies Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fusion Antibodies LimitedfiledCriticalFusion Antibodies Limited
Publication of WO2010094981A2publicationCriticalpatent/WO2010094981A2/en
Publication of WO2010094981A3publicationCriticalpatent/WO2010094981A3/en

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Abstract

Described are methods of inhibiting angiogenesis, the methods comprising the simultaneous, sequential or separate administration of (i) an anti- Cathepsin S antibody molecule, and (ii) an anti-VEGF antibody molecule. Also described are anti-Cathepsin S humanised antibodies, pharmaceutical compositions and methods of treatment using such antibodies.
PCT/GB2010/0503042009-02-202010-02-22Antibody therapyWO2010094981A2 (en)

Applications Claiming Priority (2)

Application NumberPriority DateFiling DateTitle
GB0902916.62009-02-20
GBGB0902916.6AGB0902916D0 (en)2009-02-202009-02-20Antibody therapy

Publications (2)

Publication NumberPublication Date
WO2010094981A2 WO2010094981A2 (en)2010-08-26
WO2010094981A3true WO2010094981A3 (en)2010-12-23

Family

ID=40565474

Family Applications (1)

Application NumberTitlePriority DateFiling Date
PCT/GB2010/050304WO2010094981A2 (en)2009-02-202010-02-22Antibody therapy

Country Status (2)

CountryLink
GB (1)GB0902916D0 (en)
WO (1)WO2010094981A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
WO2013063395A1 (en)2011-10-272013-05-02Nkt Therapeutics Inc.Humanized antibodies to inkt
CN114989297B (en)*2022-06-142022-10-25北京科跃中楷生物技术有限公司Kit comprising horseradish peroxidase-labeled antibody

Citations (2)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
WO2006109045A2 (en)*2005-04-092006-10-19Fusion Antibodies LimitedCathepsin s antibody
WO2008044076A2 (en)*2006-10-122008-04-17Fusion Antibodies LimitedTherapy targeting cathepsin s

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US3773919A (en)1969-10-231973-11-20Du PontPolylactide-drug mixtures
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GB8607679D0 (en)1986-03-271986-04-30Winter G PRecombinant dna product
US5225539A (en)1986-03-271993-07-06Medical Research CouncilRecombinant altered antibodies and methods of making altered antibodies
US5283187A (en)1987-11-171994-02-01Brown University Research FoundationCell culture-containing tubular capsule produced by co-extrusion
US4892538A (en)1987-11-171990-01-09Brown University Research FoundationIn vivo delivery of neurotransmitters by implanted, encapsulated cells
US5530101A (en)1988-12-281996-06-25Protein Design Labs, Inc.Humanized immunoglobulins
DE3920358A1 (en)1989-06-221991-01-17Behringwerke Ag BISPECIFIC AND OLIGO-SPECIFIC, MONO- AND OLIGOVALENT ANTI-BODY CONSTRUCTS, THEIR PRODUCTION AND USE
GB8928874D0 (en)1989-12-211990-02-28Celltech LtdHumanised antibodies
DE69233482T2 (en)1991-05-172006-01-12Merck & Co., Inc. Method for reducing the immunogenicity of antibody variable domains
ES2136092T3 (en)1991-09-231999-11-16Medical Res Council PROCEDURES FOR THE PRODUCTION OF HUMANIZED ANTIBODIES.
JPH07501451A (en)1991-11-251995-02-16エンゾン・インコーポレイテッド Multivalent antigen binding protein
AU4528493A (en)1992-06-041994-01-04Regents Of The University Of California, TheIn vivo gene therapy with intron-free sequence of interest
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Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
WO2006109045A2 (en)*2005-04-092006-10-19Fusion Antibodies LimitedCathepsin s antibody
WO2008044076A2 (en)*2006-10-122008-04-17Fusion Antibodies LimitedTherapy targeting cathepsin s

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
BURDEN ROBERTA E ET AL: "Antibody-Mediated Inhibition of Cathepsin S Blocks Colorectal Tumor Invasion and Angiogenesis", CLINICAL CANCER RESEARCH, vol. 15, no. 19, October 2009 (2009-10-01), pages 6042 - 6051, XP002583183, ISSN: 1078-0432*
MACCALLUM R M ET AL: "Antibody-antigen interactions: Contact analysis and binding site topography", JOURNAL OF MOLECULAR BIOLOGY, LONDON, GB LNKD- DOI:10.1006/JMBI.1996.0548, vol. 262, no. 5, 1 January 1996 (1996-01-01), pages 732 - 745, XP002242391, ISSN: 0022-2836*
RUDIKOFF S ET AL: "Single amino acid substitution altering antigen-binding specificity", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES (PNAS), NATIONAL ACADEMY OF SCIENCE, US LNKD- DOI:10.1073/PNAS.79.6.1979, vol. 79, 1 March 1982 (1982-03-01), pages 1979 - 1983, XP007901436, ISSN: 0027-8424*
TOL JOLIEN ET AL: "Chemotherapy, Bevacizumab, and Cetuximab in Metastatic Colorectal Cancer", NEW ENGLAND JOURNAL OF MEDICINE, THE, MASSACHUSETTS MEDICAL SOCIETY, WALTHAM, MA, US LNKD- DOI:10.1056/NEJMOA0808268, vol. 360, no. 6, 1 February 2009 (2009-02-01), pages 563 - 572, XP002526064, ISSN: 0028-4793*
VAJDOS F F ET AL: "Comprehensive Functional Maps of the Antigen-binding Site of an Anti-ErbB2 Antibody Obtained with Shotgun Scanning Mutagenesis", JOURNAL OF MOLECULAR BIOLOGY, LONDON, GB LNKD- DOI:10.1016/S0022-2836(02)00264-4, vol. 320, no. 2, 5 July 2002 (2002-07-05), pages 415 - 428, XP004449739, ISSN: 0022-2836*
WU HERREN ET AL: "Humanization of a murine monoclonal antibody by simultaneous optimization of framework and CDR residues", JOURNAL OF MOLECULAR BIOLOGY,, vol. 294, no. 1, 19 November 1999 (1999-11-19), pages 151 - 162, XP002582261*

Also Published As

Publication numberPublication date
WO2010094981A2 (en)2010-08-26
GB0902916D0 (en)2009-04-08

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