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WO2006089871A3 - Diphenylurea derivatives useful as erg channel openers for the treatment of cardiac arrhythmias - Google Patents

Diphenylurea derivatives useful as erg channel openers for the treatment of cardiac arrhythmiasDownload PDF

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Publication number
WO2006089871A3
WO2006089871A3PCT/EP2006/060093EP2006060093WWO2006089871A3WO 2006089871 A3WO2006089871 A3WO 2006089871A3EP 2006060093 WEP2006060093 WEP 2006060093WWO 2006089871 A3WO2006089871 A3WO 2006089871A3
Authority
WO
WIPO (PCT)
Prior art keywords
treatment
cardiac arrhythmias
channel openers
derivatives useful
erg channel
Prior art date
Application number
PCT/EP2006/060093
Other languages
French (fr)
Other versions
WO2006089871A2 (en
Inventor
Soeren Peter Olesen
Morten Grunnet
Joachim Demnitz
Original Assignee
Neurosearch As
Soeren Peter Olesen
Morten Grunnet
Joachim Demnitz
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurosearch As, Soeren Peter Olesen, Morten Grunnet, Joachim DemnitzfiledCriticalNeurosearch As
Publication of WO2006089871A2publicationCriticalpatent/WO2006089871A2/en
Publication of WO2006089871A3publicationCriticalpatent/WO2006089871A3/en

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Abstract

The present invention relates to the medical use of a certain group of diphenyl urea derivatives as ERG channel openers for the treatment of cardiac arrhythmias.
PCT/EP2006/0600932005-02-232006-02-20Diphenylurea derivatives useful as erg channel openers for the treatment of cardiac arrhythmiasWO2006089871A2 (en)

Applications Claiming Priority (2)

Application NumberPriority DateFiling DateTitle
DKPA2005002712005-02-23
DKPA2005002712005-02-23

Publications (2)

Publication NumberPublication Date
WO2006089871A2 WO2006089871A2 (en)2006-08-31
WO2006089871A3true WO2006089871A3 (en)2007-04-26

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PCT/EP2006/060093WO2006089871A2 (en)2005-02-232006-02-20Diphenylurea derivatives useful as erg channel openers for the treatment of cardiac arrhythmias

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WO (1)WO2006089871A2 (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
US8871797B2 (en)2003-07-222014-10-28Arena Pharmaceuticals, Inc.Diaryl and arylheteroaryl urea derivatives as modulators of the 5-HT2A serotonin receptor useful for the prophylaxis and treatment of disorders related thereto
US9034911B2 (en)2008-10-282015-05-19Arena Pharmaceuticals, Inc.Composition of a 5-HT2A serotonin receptor modulator useful for the treatment of disorders related thereto
US9126946B2 (en)2008-10-282015-09-08Arena Pharmaceuticals, Inc.Processes useful for the preparation of 1-[3-(4-bromo-2-methyl-2H-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)urea and crystalline forms related thereto
US9434692B2 (en)2006-10-032016-09-06Arena Pharmaceuticals, Inc.Pyrazole derivatives as modulators of the 5-HT2A serotonin receptor useful for the treatment of disorders related thereto
US9556149B2 (en)2008-04-022017-01-31Arena Pharmaceuticals, Inc.Processes for the preparation of pyrazole derivatives useful as modulators of the 5-HT2A serotonin receptor
US9567327B2 (en)2007-08-152017-02-14Arena Pharmaceuticals, Inc.Imidazo[1,2-a]pyridine derivatives as modulators of the 5-HT2A serotonin receptor useful for the treatment of disorders related thereto

Families Citing this family (12)

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KR101276136B1 (en)2004-06-172013-06-18싸이토키네틱스, 인코포레이티드Compounds, compositions and methods
PE20061130A1 (en)2004-11-192007-01-05Arena Pharm Inc 3-PHENYL-PIRAZOLE DERIVATIVES AS MODULATORS OF THE SEROTONIN 5-HT2A RECEPTOR
JP2009511599A (en)*2005-10-122009-03-19バーテックス ファーマシューティカルズ インコーポレイテッド Biphenyl derivatives as regulators of voltage-gated ion channels
EP1959960B1 (en)*2005-12-152013-04-10Cytokinetics, Inc.Certain chemical entities, compositions and methods
US7989455B2 (en)2005-12-192011-08-02Cytokinetics, Inc.Compounds, compositions and methods
NZ594353A (en)2006-05-182013-02-22Arena Pharm IncCrystalline forms and processes for the preparation of phenyl-pyrazoles useful as modulators of the 5-HT2A serotonin receptor
EP3395816A1 (en)2006-05-182018-10-31Arena Pharmaceuticals, Inc.Ethers, secondary amines and derivatives thereof as modulators of the 5-ht2a serotonin receptor useful for the treatment of disorders related thereto
JP5406018B2 (en)2006-05-182014-02-05アリーナ ファーマシューティカルズ， インコーポレイテッド Primary amines as modulators of 5-HT2A serotonin receptors useful for the treatment of disorders associated with 5-HT2A serotonin receptors, and derivatives thereof
US8980891B2 (en)2009-12-182015-03-17Arena Pharmaceuticals, Inc.Crystalline forms of certain 3-phenyl-pyrazole derivatives as modulators of the 5-HT2A serotonin receptor useful for the treatment of disorders related thereto
JP2018516992A (en)2015-06-122018-06-28アクソファント サイエンシーズ ゲーエムベーハーＡｘｏｖａｎｔ Ｓｃｉｅｎｃｅｓ Ｇｍｂｈ Diaryl and arylheteroaryl urea derivatives useful for the prevention and treatment of REM sleep behavior disorder
CA2992518A1 (en)2015-07-152017-01-19Axovant Sciences GmbhDiaryl and arylheteroaryl urea derivatives as modulators of the 5-ht2a serotonin receptor useful for the prophylaxis and treatment of hallucinations associated with a neurodegenerative disease
JP7336133B2 (en)*2019-08-072023-08-31国立大学法人東北大学 Diphenylurea compound derivative

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WO1994022807A1 (en)*1993-04-071994-10-13Neurosearch A/SUrea and amide derivatives and their use in the control of cell membrane potassium channels
EP0790240A1 (en)*1996-02-151997-08-20Tanabe Seiyaku Co., Ltd.Phenol-derivatives having pharmaceutical activity and process for preparing the same
JPH09227495A (en)*1996-02-161997-09-02Tanabe Seiyaku Co Ltd Phenol derivative and its manufacturing method
WO2000076495A1 (en)*1999-06-162000-12-21Smithkline Beecham CorporationIl-8 receptor antagonists
WO2003000245A1 (en)*2001-06-222003-01-03Poseidon Pharmaceuticals A/SCompounds for use in disorders associated with mast cell or basophil activity
WO2005012254A1 (en)*2003-07-222005-02-10Arena Pharmaceuticals, Inc.Diaryl and arylheteroaryl urea derivatives as modulators of the 5-ht2a serotonin receptor useful for the prophylaxis and treatment of disorders related therto
WO2005023237A1 (en)*2003-09-042005-03-17Poseidon Pharmaceuticals A/SErg channel openers for the treatment of cardiac arrhythmias
WO2005092843A1 (en)*2004-03-292005-10-06Neurosearch A/SNovel urea derivatives and their medical use
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Patent Citations (9)

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WO1994022807A1 (en)*1993-04-071994-10-13Neurosearch A/SUrea and amide derivatives and their use in the control of cell membrane potassium channels
EP0790240A1 (en)*1996-02-151997-08-20Tanabe Seiyaku Co., Ltd.Phenol-derivatives having pharmaceutical activity and process for preparing the same
JPH09227495A (en)*1996-02-161997-09-02Tanabe Seiyaku Co Ltd Phenol derivative and its manufacturing method
WO2000076495A1 (en)*1999-06-162000-12-21Smithkline Beecham CorporationIl-8 receptor antagonists
WO2003000245A1 (en)*2001-06-222003-01-03Poseidon Pharmaceuticals A/SCompounds for use in disorders associated with mast cell or basophil activity
WO2005012254A1 (en)*2003-07-222005-02-10Arena Pharmaceuticals, Inc.Diaryl and arylheteroaryl urea derivatives as modulators of the 5-ht2a serotonin receptor useful for the prophylaxis and treatment of disorders related therto
WO2005023237A1 (en)*2003-09-042005-03-17Poseidon Pharmaceuticals A/SErg channel openers for the treatment of cardiac arrhythmias
WO2005092843A1 (en)*2004-03-292005-10-06Neurosearch A/SNovel urea derivatives and their medical use
WO2006064015A2 (en)*2004-12-172006-06-22Neurosearch A/SDiphenylurea derivatives useful as potassium channel activators

Non-Patent Citations (4)

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Title
DATABASE WPI Week 19, 2 September 1997 Derwent World Patents Index; Class 980, Page 1, AN 1998-002748, XP002404359, SUZUKI RIICHI ET AL.: "Phenol derivative and its production"*
HANSEN, RIE SCHULTZ ET AL: "Activation of human ether -a-go-go- related gene potassium channels by the diphenylurea 1,3-bis-(2-hydroxy-5- trifluoromethyl-phenyl)-urea (NS1643)", MOLECULAR PHARMACOLOGY , 69(1), 266-277 CODEN: MOPMA3; ISSN: 0026-895X, 2006, XP008069762*
RAVENS U ET AL: "New antiarrhythmic drugs for therapy of atrial fibrillation: I. Ion channel blockers", HERZSCHRITTMACHERTHERAPIE UND ELEKTROPHYSIOLOGIE 2006 GERMANY, vol. 17, no. 2, 2006, pages 64 - 72, XP002404357, ISSN: 0938-7412*
WICKENDEN A D: "K<+> channels as therapeutic drug targets", PHARMACOLOGY AND THERAPEUTICS 2002 UNITED STATES, vol. 94, no. 1-2, 2002, pages 157 - 182, XP002404356, ISSN: 0163-7258*

Cited By (8)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
US8871797B2 (en)2003-07-222014-10-28Arena Pharmaceuticals, Inc.Diaryl and arylheteroaryl urea derivatives as modulators of the 5-HT2A serotonin receptor useful for the prophylaxis and treatment of disorders related thereto
US9273035B2 (en)2003-07-222016-03-01Arena Pharmaceuticals, Inc.Diaryl and arylheteroaryl urea derivatives as modulators of the 5-HT2A serotonin receptor useful for the prophylaxis and treatment of disorders related thereto
US9434692B2 (en)2006-10-032016-09-06Arena Pharmaceuticals, Inc.Pyrazole derivatives as modulators of the 5-HT2A serotonin receptor useful for the treatment of disorders related thereto
US9567327B2 (en)2007-08-152017-02-14Arena Pharmaceuticals, Inc.Imidazo[1,2-a]pyridine derivatives as modulators of the 5-HT2A serotonin receptor useful for the treatment of disorders related thereto
US9556149B2 (en)2008-04-022017-01-31Arena Pharmaceuticals, Inc.Processes for the preparation of pyrazole derivatives useful as modulators of the 5-HT2A serotonin receptor
US9034911B2 (en)2008-10-282015-05-19Arena Pharmaceuticals, Inc.Composition of a 5-HT2A serotonin receptor modulator useful for the treatment of disorders related thereto
US9126946B2 (en)2008-10-282015-09-08Arena Pharmaceuticals, Inc.Processes useful for the preparation of 1-[3-(4-bromo-2-methyl-2H-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)urea and crystalline forms related thereto
US9353064B2 (en)2008-10-282016-05-31Arena Pharmaceuticals, Inc.Processes useful for the preparation of 1-[3-(4-bromo-2-methyl-2H-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)-urea and crystalline forms related thereto

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