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WO2004038370A3 - Enhancing the sensitivity of a microsphere sensor - Google Patents

Enhancing the sensitivity of a microsphere sensorDownload PDF

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Publication number
WO2004038370A3
WO2004038370A3PCT/US2003/033449US0333449WWO2004038370A3WO 2004038370 A3WO2004038370 A3WO 2004038370A3US 0333449 WUS0333449 WUS 0333449WWO 2004038370 A3WO2004038370 A3WO 2004038370A3
Authority
WO
WIPO (PCT)
Prior art keywords
microsphere
sensitivity
sensor
small
laser frequency
Prior art date
Application number
PCT/US2003/033449
Other languages
French (fr)
Other versions
WO2004038370A2 (en
Inventor
Stephen Arnold
Iwao Teraoka
Frank Vollmer
Original Assignee
Univ Polytechnic
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ PolytechnicfiledCriticalUniv Polytechnic
Priority to AU2003284319ApriorityCriticalpatent/AU2003284319A1/en
Publication of WO2004038370A2publicationCriticalpatent/WO2004038370A2/en
Publication of WO2004038370A3publicationCriticalpatent/WO2004038370A3/en

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Abstract

Microsphere sensors (i) having receptors selectively substantially provided at only an equator region, (ii) formed of a relative high IR material, and/or (iii) having a relatively small radius are provided with improved sensitivity. Such a microsphere sensor may be made by selectively treating an equator region of the microsphere forming a small concentrated receptor band on the high sensitivity portion of the microsphere surface. Changing the selected laser frequency applied to the microsphere sensor to a shorter wavelength also improves sensitivity. Physical properties of the microsphere sensor system: index of refraction, laser frequency, and microsphere radius may be adjusted in concert to match the target entity molecule size. These improvements in sensitivity may allow detection and/or identification of unknown target entities based on detectable step shifts observable in light modes due to the absorption of even a single molecule as small as about 200,000 Da.
PCT/US2003/0334492002-10-222003-10-22Enhancing the sensitivity of a microsphere sensorWO2004038370A2 (en)

Priority Applications (1)

Application NumberPriority DateFiling DateTitle
AU2003284319AAU2003284319A1 (en)2002-10-222003-10-22Enhancing the sensitivity of a microsphere sensor

Applications Claiming Priority (2)

Application NumberPriority DateFiling DateTitle
US42043602P2002-10-222002-10-22
US60/420,4362002-10-22

Publications (2)

Publication NumberPublication Date
WO2004038370A2 WO2004038370A2 (en)2004-05-06
WO2004038370A3true WO2004038370A3 (en)2005-05-06

Family

ID=32176570

Family Applications (1)

Application NumberTitlePriority DateFiling Date
PCT/US2003/033449WO2004038370A2 (en)2002-10-222003-10-22Enhancing the sensitivity of a microsphere sensor

Country Status (3)

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US (1)US20040137478A1 (en)
AU (1)AU2003284319A1 (en)
WO (1)WO2004038370A2 (en)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
US6901189B1 (en)*2002-05-172005-05-31California Institute Of TechnologyGraded-index whispering gallery mode resonators
US20040196465A1 (en)*2002-12-122004-10-07Stephen ArnoldUsing a change in one or more properties of light in one or more microspheres for sensing chemicals such as explosives and poison gases
US7444045B2 (en)2003-10-142008-10-283M Innovative Properties CompanyHybrid sphere-waveguide resonators
US7259855B2 (en)2003-10-142007-08-213M Innovative Properties CompanyPorous microsphere resonators
CA2567786C (en)2004-05-262015-01-27Genera Biosystems Pty LtdBiosensor using whispering gallery modes in microspheres
US7352933B2 (en)2004-05-272008-04-013M Innovative Properties CompanyDielectric microcavity sensors
US7271379B2 (en)2004-05-272007-09-183M Innovative Properties CompanyDielectric microcavity fluorosensors excited with a broadband light source
US7257279B2 (en)2004-09-202007-08-143M Innovative Properties CompanySystems and methods for biosensing and microresonator sensors for same
US7389025B2 (en)2006-03-292008-06-173M Innovative Properties CompanyCoupling light into microresonators
US7532790B2 (en)2006-03-292009-05-123M Innovative Properties CompanyMethod of coupling light into microresonators
US7702202B2 (en)*2006-12-012010-04-203M Innovative Properties CompanyOptical microresonator
US7903240B2 (en)*2006-12-012011-03-083M Innovative Properties CompanyOptical sensing device
US7933022B2 (en)2006-12-012011-04-263M Innovative Properties CompanyIntegrated optical disk resonator
US7512298B2 (en)*2006-12-012009-03-313M Innovative Properties CompanyOptical sensing methods
US7486855B2 (en)*2006-12-272009-02-033M Innovative Properties CompanyOptical microresonator
US7903906B2 (en)*2006-12-012011-03-083M Innovative Properties CompanyOptical sensing devices and methods
GB0711600D0 (en)*2007-06-152007-07-25Secr DefenceAn optical sensing device
US8515227B2 (en)*2009-03-132013-08-20Ofs Fitel, LlcMicrobubble optical resonator
US8779389B2 (en)*2010-06-102014-07-15Universite LavalDetection method based on whispering gallery modes in microspheres floating in a solution under test
US8493560B2 (en)*2010-08-092013-07-23Polytechnic Institute Of New York UniversityPlasmonic enhancement of whispering gallery mode biosensors
US8437591B1 (en)2011-06-212013-05-07The United States Of America As Represented By The Secretary Of The NavyReusable biochemical agent sensor and method using optical micro-resonator grid arrays
US9507178B1 (en)*2013-08-292016-11-29Charles Wesley BlackledgeElectromagnetic waveguide assembly
US9709476B2 (en)*2014-09-182017-07-18New York UniversitySystem and method for finding the size of one of more individual particles, such as nanoparticles for example, in real time utilizing a microsphere's whispering gallery modes (“WGMs”)
WO2017089501A1 (en)2015-11-252017-06-01Voith Patent GmbhHigh-precision sensor for fiber suspensions

Citations (10)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
US4169804A (en)*1976-08-191979-10-02Minnesota Mining And Manufacturing CompanyMagnetically responsive composite microparticle
US5231533A (en)*1991-02-151993-07-27Japan Synthetic Rubber Co., Ltd.Nonlinear optical element and uses thereof
US5496997A (en)*1994-01-031996-03-05Pope; Edward J. A.Sensor incorporating an optical fiber and a solid porous inorganic microsphere
US5786219A (en)*1996-10-281998-07-28Molecular Probes, Inc.Microspheres with fluorescent spherical zones
US6266459B1 (en)*1997-03-142001-07-24Trustees Of Tufts CollegeFiber optic sensor with encoded microspheres
US20010033587A1 (en)*2000-03-092001-10-25California Institute Of TechnologyMicro-cavity laser
US6389197B1 (en)*1999-02-102002-05-14California Institute Of TechnologyCoupling system to a microsphere cavity
US20020080842A1 (en)*2000-10-102002-06-27Korea Advanced Institute Of Science And TechnologyEvanescent-wave coupled microcavity laser
US6490039B2 (en)*2000-08-082002-12-03California Institute Of TechnologyOptical sensing based on whispering-gallery-mode microcavity
US6583399B1 (en)*1999-11-222003-06-24California Institute Of TechnologyOptical resonator microsphere sensor with altering Q-factor

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
US3984524A (en)*1975-01-141976-10-05Vladimir Ilich AlexandrovSingle crystals based on stabilized zirconium dioxide or hafniun dioxide
US4912087A (en)*1988-04-151990-03-27Ford Motor CompanyRapid thermal annealing of superconducting oxide precursor films on Si and SiO2 substrates
US5602102A (en)*1992-05-291997-02-11Board Of Regents, The Univ. Of Tx SystemDipeptidyl peptidase-I inhibitors and uses thereof
US6473218B1 (en)*1999-06-112002-10-29California Institute Of TechnologyLight modulation in whispering-gallery-mode resonators
US6507684B2 (en)*2000-06-282003-01-14The Charles Stark Draper Laboratory, Inc.Optical microcavity resonator system
US20040023396A1 (en)*2001-11-142004-02-05Boyd Robert W.Ring or disk resonator photonic biosensor and its use

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
US4169804A (en)*1976-08-191979-10-02Minnesota Mining And Manufacturing CompanyMagnetically responsive composite microparticle
US5231533A (en)*1991-02-151993-07-27Japan Synthetic Rubber Co., Ltd.Nonlinear optical element and uses thereof
US5496997A (en)*1994-01-031996-03-05Pope; Edward J. A.Sensor incorporating an optical fiber and a solid porous inorganic microsphere
US5786219A (en)*1996-10-281998-07-28Molecular Probes, Inc.Microspheres with fluorescent spherical zones
US6266459B1 (en)*1997-03-142001-07-24Trustees Of Tufts CollegeFiber optic sensor with encoded microspheres
US6389197B1 (en)*1999-02-102002-05-14California Institute Of TechnologyCoupling system to a microsphere cavity
US6583399B1 (en)*1999-11-222003-06-24California Institute Of TechnologyOptical resonator microsphere sensor with altering Q-factor
US20010033587A1 (en)*2000-03-092001-10-25California Institute Of TechnologyMicro-cavity laser
US6490039B2 (en)*2000-08-082002-12-03California Institute Of TechnologyOptical sensing based on whispering-gallery-mode microcavity
US20020080842A1 (en)*2000-10-102002-06-27Korea Advanced Institute Of Science And TechnologyEvanescent-wave coupled microcavity laser

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CAI M. ET AL.: "Fiber-optic add-drop device based on a silica microsphere-whispering gallery mode system", IEEE PHOTONIC TECHNOLOGY LETTERS, vol. 11, no. 6, June 1999 (1999-06-01), pages 686 - 687, XP000835432*
VOLLMER ET AL.: "Multiplexed DNA quantification by spectroscopic shift of two microsphere cavities", BIOPHYSICAL JOURNAL, vol. 85, September 2003 (2003-09-01), pages 1974 - 1979, XP002985465*

Also Published As

Publication numberPublication date
AU2003284319A1 (en)2004-05-13
US20040137478A1 (en)2004-07-15
WO2004038370A2 (en)2004-05-06
AU2003284319A8 (en)2004-05-13

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