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WO2003024518A3 - Microstructures for delivering a composition cutaneously to skin using rotatable structures - Google Patents

Microstructures for delivering a composition cutaneously to skin using rotatable structuresDownload PDF

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Publication number
WO2003024518A3
WO2003024518A3PCT/US2002/029228US0229228WWO03024518A3WO 2003024518 A3WO2003024518 A3WO 2003024518A3US 0229228 WUS0229228 WUS 0229228WWO 03024518 A3WO03024518 A3WO 03024518A3
Authority
WO
WIPO (PCT)
Prior art keywords
skin
microelements
composition
stratum corneum
microstructures
Prior art date
Application number
PCT/US2002/029228
Other languages
French (fr)
Other versions
WO2003024518A2 (en
Inventor
Vladimir Gartstein
Faiz Feisal Sherman
Original Assignee
Procter & Gamble
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/952,391external-prioritypatent/US7108681B2/en
Priority claimed from US10/216,148external-prioritypatent/US20040087992A1/en
Application filed by Procter & GamblefiledCriticalProcter & Gamble
Priority to EP02798965ApriorityCriticalpatent/EP1425064A2/en
Priority to CA002456626Aprioritypatent/CA2456626C/en
Priority to AU2002333636Aprioritypatent/AU2002333636A1/en
Priority to JP2003528611Aprioritypatent/JP2005503210A/en
Publication of WO2003024518A2publicationCriticalpatent/WO2003024518A2/en
Publication of WO2003024518A3publicationCriticalpatent/WO2003024518A3/en

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Abstract

An improved method and apparatus (600) is provided as a system to deliver a composition, preferably a medical or pharmaceutical composition or active, through the stratum corneum of skin, without introducing bleeding or damage to tissue, and absent pain or other trauma. The dimensions and shapes of the microelements (12) are controlled so as to control the penetration depth into the skin. The microelements can be 'hollow' such that passageways (626) are created therethrough to allow the composition to flow from a chamber (476), through the microelements, and into the skin. Alternatively, the microelements can be 'solid' (622), and the composition is applied directly to the skin just before or just after the microelements are applied to the skin surface to create the openings in the stratum corneum. Another alternative embodiment uses cylindrical microstructures that are rotatably applied to the skin and which penetrate through the stratum corneum; and which can dispense fluid by various different structures.
PCT/US2002/0292282001-09-142002-09-13Microstructures for delivering a composition cutaneously to skin using rotatable structuresWO2003024518A2 (en)

Priority Applications (4)

Application NumberPriority DateFiling DateTitle
EP02798965AEP1425064A2 (en)2001-09-142002-09-13Microstructures for delivering a composition cutaneously to skin using rotatable structures
CA002456626ACA2456626C (en)2001-09-142002-09-13Microstructures for delivering a composition cutaneously to skin using rotatable structures
AU2002333636AAU2002333636A1 (en)2001-09-142002-09-13Microstructures for delivering a composition cutaneously to skin using rotatable structures
JP2003528611AJP2005503210A (en)2001-09-142002-09-13 Microstructure for delivering compositions to the skin through the skin using a rotatable structure

Applications Claiming Priority (4)

Application NumberPriority DateFiling DateTitle
US09/952,3912001-09-14
US09/952,391US7108681B2 (en)2000-10-162001-09-14Microstructures for delivering a composition cutaneously to skin
US10/216,148US20040087992A1 (en)2002-08-092002-08-09Microstructures for delivering a composition cutaneously to skin using rotatable structures
US10/216,1482002-08-09

Publications (2)

Publication NumberPublication Date
WO2003024518A2 WO2003024518A2 (en)2003-03-27
WO2003024518A3true WO2003024518A3 (en)2003-09-25

Family

ID=26910709

Family Applications (1)

Application NumberTitlePriority DateFiling Date
PCT/US2002/029228WO2003024518A2 (en)2001-09-142002-09-13Microstructures for delivering a composition cutaneously to skin using rotatable structures

Country Status (5)

CountryLink
EP (1)EP1425064A2 (en)
JP (1)JP2005503210A (en)
AU (1)AU2002333636A1 (en)
CA (1)CA2456626C (en)
WO (1)WO2003024518A2 (en)

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US9114238B2 (en)2007-04-162015-08-25Corium International, Inc.Solvent-cast microprotrusion arrays containing active ingredient

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US6663820B2 (en)2001-03-142003-12-16The Procter & Gamble CompanyMethod of manufacturing microneedle structures using soft lithography and photolithography
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JP5066566B2 (en)2006-07-032012-11-07ホナム ペトロケミカル コープ Micro needle roller assembly
JP4821993B2 (en)*2006-07-212011-11-24芳一 飛永 Micro-implement and manufacturing method thereof
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GB2448493B (en)2007-04-162009-10-14Dewan Fazlul Hoque ChowdhuryMicroneedle transdermal delivery device
JP2011505900A (en)*2007-12-072011-03-03ディティエス ローラーズ カンパニー リミテッド Disc needle roller
WO2009130926A1 (en)*2008-04-222009-10-29南部化成株式会社Endermic method, needle organizer and endermic injector device
WO2009144624A1 (en)*2008-05-282009-12-03Koninklijke Philips Electronics N.V.Device for controlled drug delivery
JP5357257B2 (en)*2008-09-032013-12-04ディーティーエスラッブ カンパニー リミテッド Skin stimulator
US20110144591A1 (en)*2009-12-112011-06-16Ross Russell FTransdermal Delivery Device
WO2011140274A2 (en)2010-05-042011-11-10Corium International, Inc.Method and device for transdermal delivery of parathyroid hormone using a microprojection array
US10219827B2 (en)*2010-12-172019-03-05Srgi Holdings, LlcPixel array medical devices and methods
GB201107642D0 (en)2011-05-092011-06-22Univ CorkMethod
TWI583412B (en)2012-06-122017-05-21Hisamitsu Pharmaceutical Co Micro Needle Cloth
BR112015014969B1 (en)2012-12-212021-12-07Corium, Inc MICROSTRUCTURE APPARATUS AND METHOD OF MANUFACTURING A MICROSTRUCTURE APPARATUS
EP2968887B1 (en)2013-03-122022-05-04Corium, Inc.Microprojection applicators
CA2903763C (en)2013-03-152021-11-16Corium International, Inc.Microarray with polymer-free microstructures, methods of making, and methods of use
ES2939317T3 (en)2013-03-152023-04-20Corium Pharma Solutions Inc Multi-impact micro-spray applicators
BR112015022625B1 (en)2013-03-152023-01-31Corium, Inc MICROSTRUCTURE DEVICE FOR DELIVERY OF THERAPEUTIC AGENT
AU2014233541B2 (en)2013-03-152018-11-22Corium Pharma Solutions, Inc.Microarray for delivery of therapeutic agent, methods of use, and methods of making
WO2014203911A1 (en)2013-06-182014-12-24久光製薬株式会社Applicator
JP6038310B2 (en)2013-06-192016-12-07久光製薬株式会社 applicator
US9694142B2 (en)2013-09-032017-07-04Visage Sculpture, PLLCDevice for percutaneous delivery of therapeutic agents, and a method for its use
EP3042690B1 (en)2013-09-062021-04-14Hisamitsu Pharmaceutical Co., Inc.Micro-needle sheet
CN106061544B (en)2014-02-272019-11-26久光制药株式会社 microneedle sheet
US10624843B2 (en)2014-09-042020-04-21Corium, Inc.Microstructure array, methods of making, and methods of use
EP3216484B1 (en)2014-12-052023-02-01Hisamitsu Pharmaceutical Co., Inc.Microneedle device system
US10004887B2 (en)*2015-02-182018-06-26Alma Therapeutics Ltd.Transdermal delivery assembly
WO2017004067A1 (en)2015-06-292017-01-05Corium International, Inc.Microarray for delivery of therapeutic agent, methods of use, and methods of making
KR102234331B1 (en)2015-12-152021-03-30히사미쓰 세이야꾸 가부시키가이샤 Micro needle sheet
KR102249243B1 (en)2016-09-012021-05-06히사미쓰 세이야꾸 가부시키가이샤 Micro Needle Sheet
KR101906336B1 (en)*2018-03-222018-10-10한국바이오기술공사(주)Needle disc roller apparatus with pump
CN109925590B (en)*2019-03-282021-10-08吴晓苏Coupling agent is brushed fast and wiping arrangement
CN218685709U (en)*2021-12-232023-03-24苏州纳生微电子有限公司 microneedle array chip

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DE2319591A1 (en)*1973-04-181974-11-14Kirchner & WilhelmSurgical needle roller - mounted releasably in holder for quick sterilising
US3918449A (en)*1973-06-061975-11-11Guerin A EtsDevice for cutaneous therapeutic treatment
FR2535602A1 (en)*1982-11-051984-05-11Stallergenes LabScarifying device
EP0312662A1 (en)*1984-08-241989-04-26David George VlockFluid dispenser
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DE19518974A1 (en)*1994-05-231995-11-30Samsung Electro MechPerforator for dispensing pharmaceutical product through skin
WO1996017648A1 (en)*1994-12-091996-06-13Novartis AgTransdermal system
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Cited By (5)

* Cited by examiner, † Cited by third party
Publication numberPriority datePublication dateAssigneeTitle
US7416541B2 (en)1999-06-092008-08-26Corium International, Inc.Intracutaneous microneedle array apparatus
US8911749B2 (en)2007-04-162014-12-16Corium International, Inc.Vaccine delivery via microneedle arrays
US9114238B2 (en)2007-04-162015-08-25Corium International, Inc.Solvent-cast microprotrusion arrays containing active ingredient
US9452280B2 (en)2007-04-162016-09-27Corium International, Inc.Solvent-cast microprotrusion arrays containing active ingredient
US9498524B2 (en)2007-04-162016-11-22Corium International, Inc.Method of vaccine delivery via microneedle arrays

Also Published As

Publication numberPublication date
CA2456626C (en)2009-01-20
JP2005503210A (en)2005-02-03
EP1425064A2 (en)2004-06-09
AU2002333636A1 (en)2003-04-01
WO2003024518A2 (en)2003-03-27
CA2456626A1 (en)2003-03-27

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