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WO2001055355A8 - Nucleic acids, proteins, and antibodies - Google Patents

Nucleic acids, proteins, and antibodies

Info

Publication number
WO2001055355A8
WO2001055355A8PCT/US2001/001351US0101351WWO0155355A8WO 2001055355 A8WO2001055355 A8WO 2001055355A8US 0101351 WUS0101351 WUS 0101351WWO 0155355 A8WO0155355 A8WO 0155355A8
Authority
WO
WIPO (PCT)
Prior art keywords
liver
polypeptides
polynucleotides
methods
further relates
Prior art date
Application number
PCT/US2001/001351
Other languages
French (fr)
Other versions
WO2001055355A1 (en
Inventor
Craig A Rosen
Steven C Barash
Steven M Ruben
Original Assignee
Human Genome Sciences Inc
Craig A Rosen
Steven C Barash
Steven M Ruben
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Human Genome Sciences Inc, Craig A Rosen, Steven C Barash, Steven M RubenfiledCriticalHuman Genome Sciences Inc
Priority to AU2001243136ApriorityCriticalpatent/AU2001243136A1/en
Priority to EP01916068Aprioritypatent/EP1255817A1/en
Publication of WO2001055355A1publicationCriticalpatent/WO2001055355A1/en
Publication of WO2001055355A8publicationCriticalpatent/WO2001055355A8/en

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Abstract

The present invention relates to novel liver related polynucleotides and the polypeptides encoded by these polynucleotides herein collectively known as 'liver antigens', and the use of such liver antigens for detecting disorders of the liver, particularly the presence of cancer of liver and cancer metastases. More specifically, isolated liver associated nucleic acid molecules are provided encoding novel liver associated polypeptides. Novel liver polypeptides and antibodies that bind to these polypeptides are provided. Also provided are vectors, host cells, and recombinant and synthetic methods for producing human liver associated polynucleotides and/or polypeptides. The invention further relates to diagnostic and therapeutic methods useful for diagnosing, treating, preventing and/or prognosing disorders related to the liver, including cancer of liver tissues, and therapeutic methods for treating such disorders. The invention further relates to screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further relates to methods and/or compositions for inhibiting the production and function of the polypeptides of the present invention.
PCT/US2001/0013512000-01-312001-01-17Nucleic acids, proteins, and antibodiesWO2001055355A1 (en)

Priority Applications (2)

Application NumberPriority DateFiling DateTitle
AU2001243136AAU2001243136A1 (en)2000-01-312001-01-17Nucleic acids, proteins, and antibodies
EP01916068AEP1255817A1 (en)2000-01-312001-01-17Nucleic acids, proteins, and antibodies

Applications Claiming Priority (235)

Application NumberPriority DateFiling DateTitle
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US60/259,6782001-01-05

Publications (2)

Publication NumberPublication Date
WO2001055355A1 WO2001055355A1 (en)2001-08-02
WO2001055355A8true WO2001055355A8 (en)2001-09-07

Family

ID=27587117

Family Applications (48)

Application NumberTitlePriority DateFiling Date
PCT/US2001/001350WO2001055350A1 (en)2000-01-312001-01-17Nucleic acids, proteins, and antibodies
PCT/US2001/001349WO2001054474A2 (en)2000-01-312001-01-17Nucleic acids, proteins, and antibodies
PCT/US2001/001314WO2001055310A2 (en)2000-01-312001-01-17Nucleic acids, proteins, and antibodies
PCT/US2001/001343WO2001055323A2 (en)2000-01-312001-01-17Nucleic acids, proteins, and antibodies
PCT/US2001/001302WO2001055304A2 (en)2000-01-312001-01-17Nucleic acids, proteins, and antibodies
PCT/US2001/001339WO2001055320A2 (en)2000-01-312001-01-17Nucleic acids, proteins, and antibodies
PCT/US2001/001308WO2001055364A2 (en)2000-01-312001-01-17Nucleic acids, proteins, and antibodies
PCT/US2001/001340WO2001055321A2 (en)2000-01-312001-01-17Nucleic acids, proteins, and antibodies
PCT/US2001/001328WO2001055316A2 (en)2000-01-312001-01-17Nucleic acids, proteins, and antibodies
PCT/US2001/001325WO2001055202A1 (en)2000-01-312001-01-17Nucleic acids, proteins, and antibodies
PCT/US2001/001315WO2001055311A2 (en)2000-01-312001-01-17Nucleic acids, proteins, and antibodies
PCT/US2001/001351WO2001055355A1 (en)2000-01-312001-01-17Nucleic acids, proteins, and antibodies
PCT/US2001/001332WO2001055318A2 (en)2000-01-312001-01-17Nucleic acids, proteins, and antibodies
PCT/US2001/001317WO2001055201A1 (en)2000-01-312001-01-17Nucleic acids, proteins, and antibodies
PCT/US2001/001345WO2001055325A2 (en)2000-01-312001-01-17Nucleic acids, proteins, and antibodies
PCT/US2001/001330WO2001055447A1 (en)2000-01-312001-01-17Nucleic acids, proteins, and antibodies
PCT/US2001/001316WO2001054473A2 (en)2000-01-312001-01-17Nucleic acids, proteins, and antibodies
PCT/US2001/001301WO2001055303A2 (en)2000-01-312001-01-17Nucleic acids, proteins, and antibodies
PCT/US2001/001353WO2001055206A1 (en)2000-01-312001-01-17Nucleic acids, proteins, and antibodies
PCT/US2001/001337WO2001055205A1 (en)2000-01-312001-01-17Nucleic acids, proteins, and antibodies
PCT/US2001/001306WO2001055307A2 (en)2000-01-312001-01-17Nucleic acids, proteins, and antibodies
PCT/US2001/001309WO2001055308A2 (en)2000-01-312001-01-17Nucleic acids, proteins, and antibodies
PCT/US2001/001324WO2001055314A2 (en)2000-01-312001-01-17Digestive system related nucleic acids, proteins and antibodies
PCT/US2001/001352WO2001055327A2 (en)2000-01-312001-01-17Nucleic acids, proteins, and antibodies
PCT/US2001/001344WO2001055324A2 (en)2000-01-312001-01-17Nucleic acids, proteins, and antibodies
PCT/US2001/001322WO2001055343A1 (en)2000-01-312001-01-17Nucleic acids, proteins, and antibodies
PCT/US2001/001354WO2001057182A2 (en)2000-01-312001-01-17Nucleic acids, proteins, and antibodies
PCT/US2001/001336WO2001055204A1 (en)2000-01-312001-01-17Nucleic acids, proteins, and antibodies
PCT/US2001/001239WO2001055301A2 (en)2000-01-312001-01-17Nucleic acids, proteins, and antibodies
PCT/US2001/001312WO2001054733A1 (en)2000-01-312001-01-17Nucleic acids, proteins and antibodies
PCT/US2001/001342WO2001059064A2 (en)2000-01-312001-01-17Nucleic acids, proteins, and antibodies
PCT/US2001/001321WO2001055312A2 (en)2000-01-312001-01-17Nucleic acids, proteins, and antibodies
PCT/US2001/001358WO2001055163A1 (en)2000-01-312001-01-17Nucleic acids, proteins, and antibodies
PCT/US2001/001356WO2001055173A2 (en)2000-01-312001-01-17Nucleic acids, proteins, and antibodies
PCT/US2001/001313WO2001055200A1 (en)2000-01-312001-01-17Nucleic acids, proteins, and antibodies
PCT/US2001/001240WO2001055302A2 (en)2000-01-312001-01-17Nucleic acids, proteins, and antibodies
PCT/US2001/001311WO2001055309A2 (en)2000-01-312001-01-17Nucleic acids, proteins, and antibodies
PCT/US2001/001355WO2001055207A1 (en)2000-01-312001-01-17Nucleic acids, proteins, and antibodies
PCT/US2001/001338WO2001055367A1 (en)2000-01-312001-01-17Nucleic acids, proteins, and antibodies
PCT/US2001/001333WO2001055448A1 (en)2000-01-312001-01-17Nucleic acids, proteins, and antibodies
PCT/US2001/001341WO2001055322A2 (en)2000-01-312001-01-17Nucleic acids, proteins, and antibodies
PCT/US2001/001357WO2001055208A1 (en)2000-01-312001-01-17Nucleic acids, proteins, and antibodies
PCT/US2001/001359WO2001055328A2 (en)2000-01-312001-01-17Nucleic acids, proteins, and antibodies
PCT/US2001/001326WO2001055315A2 (en)2000-01-312001-01-17Nucleic acids, proteins, and antibodies
PCT/US2001/001335WO2001055319A2 (en)2000-01-312001-01-17Endocrine related nucleic acids, proteins and antibodies
PCT/US2001/001327WO2001055203A1 (en)2000-01-312001-01-17Nucleic acids, proteins, and antibodies
PCT/US2001/001348WO2001055368A1 (en)2000-01-312001-01-17Nucleic acids, proteins, and antibodies
PCT/US2001/001310WO2001055387A1 (en)2000-01-312001-01-17Nucleic acids, proteins, and antibodies

Family Applications Before (11)

Application NumberTitlePriority DateFiling Date
PCT/US2001/001350WO2001055350A1 (en)2000-01-312001-01-17Nucleic acids, proteins, and antibodies
PCT/US2001/001349WO2001054474A2 (en)2000-01-312001-01-17Nucleic acids, proteins, and antibodies
PCT/US2001/001314WO2001055310A2 (en)2000-01-312001-01-17Nucleic acids, proteins, and antibodies
PCT/US2001/001343WO2001055323A2 (en)2000-01-312001-01-17Nucleic acids, proteins, and antibodies
PCT/US2001/001302WO2001055304A2 (en)2000-01-312001-01-17Nucleic acids, proteins, and antibodies
PCT/US2001/001339WO2001055320A2 (en)2000-01-312001-01-17Nucleic acids, proteins, and antibodies
PCT/US2001/001308WO2001055364A2 (en)2000-01-312001-01-17Nucleic acids, proteins, and antibodies
PCT/US2001/001340WO2001055321A2 (en)2000-01-312001-01-17Nucleic acids, proteins, and antibodies
PCT/US2001/001328WO2001055316A2 (en)2000-01-312001-01-17Nucleic acids, proteins, and antibodies
PCT/US2001/001325WO2001055202A1 (en)2000-01-312001-01-17Nucleic acids, proteins, and antibodies
PCT/US2001/001315WO2001055311A2 (en)2000-01-312001-01-17Nucleic acids, proteins, and antibodies

Family Applications After (36)

Application NumberTitlePriority DateFiling Date
PCT/US2001/001332WO2001055318A2 (en)2000-01-312001-01-17Nucleic acids, proteins, and antibodies
PCT/US2001/001317WO2001055201A1 (en)2000-01-312001-01-17Nucleic acids, proteins, and antibodies
PCT/US2001/001345WO2001055325A2 (en)2000-01-312001-01-17Nucleic acids, proteins, and antibodies
PCT/US2001/001330WO2001055447A1 (en)2000-01-312001-01-17Nucleic acids, proteins, and antibodies
PCT/US2001/001316WO2001054473A2 (en)2000-01-312001-01-17Nucleic acids, proteins, and antibodies
PCT/US2001/001301WO2001055303A2 (en)2000-01-312001-01-17Nucleic acids, proteins, and antibodies
PCT/US2001/001353WO2001055206A1 (en)2000-01-312001-01-17Nucleic acids, proteins, and antibodies
PCT/US2001/001337WO2001055205A1 (en)2000-01-312001-01-17Nucleic acids, proteins, and antibodies
PCT/US2001/001306WO2001055307A2 (en)2000-01-312001-01-17Nucleic acids, proteins, and antibodies
PCT/US2001/001309WO2001055308A2 (en)2000-01-312001-01-17Nucleic acids, proteins, and antibodies
PCT/US2001/001324WO2001055314A2 (en)2000-01-312001-01-17Digestive system related nucleic acids, proteins and antibodies
PCT/US2001/001352WO2001055327A2 (en)2000-01-312001-01-17Nucleic acids, proteins, and antibodies
PCT/US2001/001344WO2001055324A2 (en)2000-01-312001-01-17Nucleic acids, proteins, and antibodies
PCT/US2001/001322WO2001055343A1 (en)2000-01-312001-01-17Nucleic acids, proteins, and antibodies
PCT/US2001/001354WO2001057182A2 (en)2000-01-312001-01-17Nucleic acids, proteins, and antibodies
PCT/US2001/001336WO2001055204A1 (en)2000-01-312001-01-17Nucleic acids, proteins, and antibodies
PCT/US2001/001239WO2001055301A2 (en)2000-01-312001-01-17Nucleic acids, proteins, and antibodies
PCT/US2001/001312WO2001054733A1 (en)2000-01-312001-01-17Nucleic acids, proteins and antibodies
PCT/US2001/001342WO2001059064A2 (en)2000-01-312001-01-17Nucleic acids, proteins, and antibodies
PCT/US2001/001321WO2001055312A2 (en)2000-01-312001-01-17Nucleic acids, proteins, and antibodies
PCT/US2001/001358WO2001055163A1 (en)2000-01-312001-01-17Nucleic acids, proteins, and antibodies
PCT/US2001/001356WO2001055173A2 (en)2000-01-312001-01-17Nucleic acids, proteins, and antibodies
PCT/US2001/001313WO2001055200A1 (en)2000-01-312001-01-17Nucleic acids, proteins, and antibodies
PCT/US2001/001240WO2001055302A2 (en)2000-01-312001-01-17Nucleic acids, proteins, and antibodies
PCT/US2001/001311WO2001055309A2 (en)2000-01-312001-01-17Nucleic acids, proteins, and antibodies
PCT/US2001/001355WO2001055207A1 (en)2000-01-312001-01-17Nucleic acids, proteins, and antibodies
PCT/US2001/001338WO2001055367A1 (en)2000-01-312001-01-17Nucleic acids, proteins, and antibodies
PCT/US2001/001333WO2001055448A1 (en)2000-01-312001-01-17Nucleic acids, proteins, and antibodies
PCT/US2001/001341WO2001055322A2 (en)2000-01-312001-01-17Nucleic acids, proteins, and antibodies
PCT/US2001/001357WO2001055208A1 (en)2000-01-312001-01-17Nucleic acids, proteins, and antibodies
PCT/US2001/001359WO2001055328A2 (en)2000-01-312001-01-17Nucleic acids, proteins, and antibodies
PCT/US2001/001326WO2001055315A2 (en)2000-01-312001-01-17Nucleic acids, proteins, and antibodies
PCT/US2001/001335WO2001055319A2 (en)2000-01-312001-01-17Endocrine related nucleic acids, proteins and antibodies
PCT/US2001/001327WO2001055203A1 (en)2000-01-312001-01-17Nucleic acids, proteins, and antibodies
PCT/US2001/001348WO2001055368A1 (en)2000-01-312001-01-17Nucleic acids, proteins, and antibodies
PCT/US2001/001310WO2001055387A1 (en)2000-01-312001-01-17Nucleic acids, proteins, and antibodies

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